Impromidine (BioDeep_00000179987)

   

human metabolite blood metabolite


代谢物信息卡片


N-[3-(1H-imidazol-5-yl)propyl]-N-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine

化学式: C14H23N7S (321.17355580000003)
中文名称: 英普咪定
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: CC1=C(CSCCNC(N)=NCCCC2=CN=CN2)N=CN1
InChI: InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D017442 - Histamine Agonists

同义名列表

11 个代谢物同义名

N-[3-(1H-imidazol-5-yl)propyl]-N-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine; N-[3-(3H-imidazol-4-yl)propyl]-N-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine; Trihydrochloride, impromidine; Impromidine trihydrochloride; Hydrochloride, impromidine; Impromidine oxalate (1:2); Impromidine hydrochloride; SK And F 92676; SK And F-92676; SK And F92676; Impromidine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • G Coruzzi, E Poli, C Pozzoli, G Bertaccini, H Timmerman. Histamine receptor-independent muscle relaxation elicited by a series of histamine H2-receptor agonists on the isolated guinea pig duodenum: a study into the mechanism of action. General pharmacology. 1998 Oct; 31(4):643-51. doi: 10.1016/s0306-3623(98)00077-9. [PMID: 9792230]
  • E Brenna, Y Tielemans, P M Kleveland, A K Sandvik, G Willems, H L Waldum. Effect of the histamine-2 agonist impromidine on stem cell proliferation of rat oxyntic mucosa. Scandinavian journal of gastroenterology. 1995 Apr; 30(4):311-4. doi: 10.3109/00365529509093282. [PMID: 7610344]
  • S B Boertje, D Le Beau, S Ward. Impromidine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats. Research communications in chemical pathology and pharmacology. 1990 Aug; 69(2):249-52. doi: NULL. [PMID: 1975703]
  • W Krone, D Müller-Wieland, B Behnke, H Greten. Regulation of sterol synthesis by histamine in human mononuclear leukocytes: roles of H1- and H2-receptors. European journal of clinical pharmacology. 1988; 34(1):29-33. doi: 10.1007/bf01061413. [PMID: 2896127]
  • J Bugajski, A Gadek. Hyperlipemic responses induced by centrally administered histamine H1- and H2-receptor agonists in rats. Agents and actions. 1987 Apr; 20(3-4):255-7. doi: 10.1007/bf02074684. [PMID: 2955677]
  • J Bugajski, A Gadek. Effect of intracerebroventricular impromidine on pituitary-adrenocortical response to stress in rats. Agents and actions. 1984 Jun; 14(5-6):569-73. doi: 10.1007/bf01978888. [PMID: 6236678]
  • J Bugajski, Z Janusz. Central histaminergic stimulation of pituitary--adrenocortical response in the rat. Life sciences. 1983 Sep; 33(12):1179-89. doi: 10.1016/0024-3205(83)90023-1. [PMID: 6224995]
  • P H Guth, K Hirabayashi. The effect of histamine on microvascular permeability in the muscularis externa of rat small intestine. Microvascular research. 1983 May; 25(3):322-32. doi: 10.1016/0026-2862(83)90022-5. [PMID: 6222248]
  • L Dufy-Barbe, D Verrier, J Arsaut, D Bioka, B Dufy. [Histamine and prolactin liberation in the rhesus monkey]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1983; 177(2):158-65. doi: NULL. [PMID: 6224536]
  • G B Leslie, D A Owen, F D Pollitt, T J Sutton, T F Walker. Short-term toxicological studies with impromidine (SK&F 92676): a specific histamine H2-receptor agonist. Journal of applied toxicology : JAT. 1982 Oct; 2(5):265-8. doi: 10.1002/jat.2550020510. [PMID: 6223952]
  • R E Birch, S H Polmar. Pharmacological modification of immunoregulatory T lymphocytes. I. Effect of adenosine, H1 and H2 histamine agonists upon T lymphocyte regulation of B lymphocyte differentiation in vitro. Clinical and experimental immunology. 1982 Apr; 48(1):218-30. doi: NULL. [PMID: 6211316]
  • T Biegański, Z Osińska, C Maśliński. Inhibition of plant and mammalian diamine oxidases by hydrazine and guanidine compounds. The International journal of biochemistry. 1982; 14(10):949-53. doi: 10.1016/0020-711x(82)90080-5. [PMID: 6215274]
  • V Schusdziarra, W Stapelfeldt, M Klier, V Maier, E F Pfeiffer. Effect of histamine H2-receptor stimulation on postprandial pancreatic and gastric endocrine function in dogs. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. 1982; 181(3):253-7. doi: 10.1007/bf01851198. [PMID: 6131510]
  • P C Sharpe, M A Melvin, J G Mills, W L Burland, G V Groom. Prolactin responses to histamine H2 receptor antagonists. Acta endocrinologica. 1980 Nov; 95(3):308-13. doi: 10.1530/acta.0.0950308. [PMID: 6108034]
  • H E Aksulu, Z S Ercan, R K Türker. A comparative study with impromidine (SKF 92676), a potent agonist for histamine H2-receptors. Agents and actions. 1979 Dec; 9(5-6):461-6. doi: 10.1007/bf01968111. [PMID: 161854]