Thioridazine (BioDeep_00000017998)
human metabolite blood metabolite
代谢物信息卡片
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine
化学式: C21H26N2S2 (370.1537316)
中文名称: 硫利达嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 3.73%
分子结构信息
SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
InChI: InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
描述信息
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618)
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AC - Phenothiazines with piperidine structure
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
同义名列表
45 个代谢物同义名
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine; 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-methylsulphanyl-phenothiazine; 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine; 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine; 3-Methylmercapto-N-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine; Neurazpharm brand OF thioridazine hydrochloride; Alphapharm brand OF thioridazine hydrochloride; AWD.pharma brand OF thioridazine hydrochloride; Arzneimittelwerk dresden brand OF thioridazine; Pinewood brand OF thioridazine hydrochloride; Clonmel brand OF thioridazine hydrochloride; Roxane brand OF thioridazine hydrochloride; Apotex brand OF thioridazine hydrochloride; DDSA brand OF thioridazine hydrochloride; Novartis brand OF thioridazine; Thioridazine novartis brand; Thioridazine hydrochloride; Thioridazine-neurazpharm; Thioridazine neurazpharm; Thioridazineneurazpharm; Thioridazine chloride; Thioridazine HCL; Apo thioridazine; Apo-thioridazine; ApoThioridazine; Thioridazinum; thioridazine; Melleretten; Tioridazina; Thioridazin; Mellerette; Mellaril-S; Mellerets; Mellaril; Melleryl; Malloryl; Melleril; Thiozine; Aldazine; Mallorol; Sonapax; Melzine; Rideril; Orsanil; Meleril
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:9566
- PubChem: 5452
- HMDB: HMDB0014817
- DrugBank: DB00679
- ChEMBL: CHEMBL479
- Wikipedia: Thioridazine
- MeSH: Thioridazine
- chemspider: 5253
- CAS: 107388-89-6
- CAS: 50-52-2
- PMhub: MS000001586
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Bioorganic & medicinal chemistry.
2023 03; 81(?):117212. doi:
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Environmental science and pollution research international.
2022 Nov; ?(?):. doi:
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Journal of chromatography. A.
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European journal of pharmacology.
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Materials science & engineering. C, Materials for biological applications.
2014 Apr; 37(?):342-7. doi:
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Cell death & disease.
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10.1038/cddis.2014.35. [PMID: 24556678] - Wojciech Kopec, Himanshu Khandelia. Reinforcing the membrane-mediated mechanism of action of the anti-tuberculosis candidate drug thioridazine with molecular simulations.
Journal of computer-aided molecular design.
2014 Feb; 28(2):123-34. doi:
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In vivo (Athens, Greece).
2014 Jan; 28(1):33-8. doi:
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