Imidazole citrate (BioDeep_00000179969)
human metabolite blood metabolite
代谢物信息卡片
7-hydroxy-4,9,12-trioxa-3,11-diazatricyclo[5.4.3.0^{3,10}]tetradeca-1,10-diene-5,8,13-trione
化学式: C9H6N2O7 (254.0175006)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 64%
分子结构信息
SMILES: C1C(=O)OC2=CN3C(=N2)OC(=O)C1(CC(=O)O3)O
InChI: InChI=1S/C9H6N2O7/c12-5-1-9(15)2-6(13)18-11-3-4(16-5)10-8(11)17-7(9)14/h3,15H,1-2H2
描述信息
D004791 - Enzyme Inhibitors
同义名列表
12 个代谢物同义名
7-hydroxy-4,9,12-trioxa-3,11-diazatricyclo[5.4.3.0^{3,10}]tetradeca-1,10-diene-5,8,13-trione; Imidazole conjugate monoacid; Imidazole monohydrochloride; Imidazole monophosphonate; Imidazole citric acid; Imidazolium chloride; Imidazole acetate; Imidazole citrate; Imidazole sodium; Al-imidazole; Cu-imidazole; imidazole
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Isaac Duah Boateng, Xiao-Ming Yang, Hengbo Yin, Weimin Liu. Separation and purification of polyprenols from Ginkgo biloba leaves by silver ion anchored on imidazole-based ionic liquid functionalized mesoporous MCM-41 sorbent.
Food chemistry.
2024 Aug; 450(?):139284. doi:
10.1016/j.foodchem.2024.139284. [PMID: 38640543] - Yali Yang, Jia Chen, Xiaojing Liang, Bei Liu, Kaijun Quan, Xiuhui Liu, Hongdeng Qiu. Adjustable chromatographic performance of silica-based mixed-mode stationary phase through the control of co-grafting amounts of imidazole and C18 chain.
Journal of chromatography. A.
2024 May; 1722(?):464889. doi:
10.1016/j.chroma.2024.464889. [PMID: 38598894] - Ju Liu, Jing Ren, Simin Li, Hongyan He, Yanlei Wang. Protein Interface Regulating the Inserting Process of Imidazole Ionic Liquids into the Cell Membrane.
The journal of physical chemistry. B.
2024 May; 128(18):4456-4463. doi:
10.1021/acs.jpcb.3c08451. [PMID: 38691101] - Subhankar Mandal, Prashantha Kumar Br, Md Tanjim Alam, Prem Prakash Tripathi, Bhavya Channappa. Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays.
ACS chemical neuroscience.
2022 05; 13(9):1433-1445. doi:
10.1021/acschemneuro.2c00076. [PMID: 35417128] - Yan Song, Yuan Sun, Minglu Tang, Zhengya Yue, Jiatong Ni, Junge Zhao, Wenxin Wang, Tiedong Sun, Lianxu Shi, Lei Wang. Polyoxometalate Modified by Zeolite Imidazole Framework for the pH-Responsive Electrodynamic/Chemodynamic Therapy.
ACS applied materials & interfaces.
2022 Feb; 14(4):4914-4920. doi:
10.1021/acsami.1c19985. [PMID: 35050579] - Wen-Yi Low, Shuhua Thong, Shu-Sin Chng. ATP disrupts lipid-binding equilibrium to drive retrograde transport critical for bacterial outer membrane asymmetry.
Proceedings of the National Academy of Sciences of the United States of America.
2021 12; 118(50):. doi:
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Mikrochimica acta.
2021 11; 188(12):427. doi:
10.1007/s00604-021-05096-2. [PMID: 34812945] - Katarzyna Gałczyńska, Karol Ciepluch, Krystyna Kurdziel, Ralf Biehl, Michał Arabski. Spectroscopic and Small-angle X-ray scattering analysis of binding between Copper(II) -1-allylimidazole complex, a potential anti-tumor agent, and bovine serum albumin.
Bioorganic chemistry.
2021 11; 116(?):105327. doi:
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Communications biology.
2021 06; 4(1):720. doi:
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2021 04; 64(8):4709-4729. doi:
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Analytical and bioanalytical chemistry.
2021 Mar; 413(7):1827-1836. doi:
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International journal of biological macromolecules.
2021 Jan; 167(?):1076-1090. doi:
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Pharmaceutical development and technology.
2020 Nov; 25(9):1150-1161. doi:
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Chemical communications (Cambridge, England).
2020 Sep; 56(76):11271-11274. doi:
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2020 Jul; 12(29):32278-32288. doi:
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2020 Jul; 25(13):. doi:
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Biomolecules.
2020 06; 10(6):. doi:
10.3390/biom10060907. [PMID: 32549280] - Heba E Hashem, Abd El-Galil E Amr, Eman S Nossier, Elsayed A Elsayed, Eman M Azmy. Synthesis, Antimicrobial Activity and Molecular Docking of Novel Thiourea Derivatives Tagged with Thiadiazole, Imidazole and Triazine Moieties as Potential DNA Gyrase and Topoisomerase IV Inhibitors.
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2020 06; 8(21):4642-4647. doi:
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Journal of separation science.
2020 Jun; 43(11):2154-2161. doi:
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Journal of applied microbiology.
2020 May; 128(5):1236-1247. doi:
10.1111/jam.14575. [PMID: 31922640] - Madhu Tippannanavar, Ankita Verma, Rajesh Kumar, Robin Gogoi, Aditi Kundu, Neeraj Patanjali. Preparation of Nanofungicides Based on Imidazole Drugs and Their Antifungal Evaluation.
Journal of agricultural and food chemistry.
2020 Apr; 68(16):4566-4578. doi:
10.1021/acs.jafc.9b06387. [PMID: 32227935] - Iqubal Singh, Vijay Luxami, Kamaldeep Paul. Synthesis, cytotoxicity, pharmacokinetic profile, binding with DNA and BSA of new imidazo[1,2-a]pyrazine-benzo[d]imidazol-5-yl hybrids.
Scientific reports.
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Science advances.
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Journal of clinical pharmacology.
2019 12; 59(12):1669-1677. doi:
10.1002/jcph.1474. [PMID: 31243790] - Anne B Kim, William K Milsom. pH regulation in hibernation: Implications for ventilatory and metabolic control.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
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Molecules (Basel, Switzerland).
2019 Sep; 24(17):. doi:
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Biomolecules.
2019 06; 9(6):. doi:
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European journal of medicinal chemistry.
2019 May; 170(?):276-289. doi:
10.1016/j.ejmech.2019.03.015. [PMID: 30921693] - Burak Kuzu, Meltem Tan, Parham Taslimi, İlhami Gülçin, Mehmet Taşpınar, Nurettin Menges. Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases.
Bioorganic chemistry.
2019 05; 86(?):187-196. doi:
10.1016/j.bioorg.2019.01.044. [PMID: 30711701] - Jan Frömmel, Radka Končitíková, David Kopečný, Miroslav Soural, Marek Šebela. Oxidation of imidazole- and pyrazole-derived aldehydes by plant aldehyde dehydrogenases from the family 2 and 10.
Chemico-biological interactions.
2019 May; 304(?):194-201. doi:
10.1016/j.cbi.2019.02.008. [PMID: 30768969] - Agnieszka Hryniewicka, Marta Malinowska, Tomasz Hauschild, Katarzyna Pieczul, Jacek W Morzycki. Synthesis and antimicrobial properties of steroid-based imidazolium salts.
The Journal of steroid biochemistry and molecular biology.
2019 05; 189(?):65-72. doi:
10.1016/j.jsbmb.2019.02.006. [PMID: 30797035] - Ruchika Saroa, Deepender Kaushik, Upma Bagai, Sukhbir Kaur, Deepak B Salunke. Efficacy of TLR7 agonistic imidazoquinoline as immunochemotherapeutic agent against P. Berghei ANKA infected rodent host.
Bioorganic & medicinal chemistry letters.
2019 05; 29(9):1099-1105. doi:
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European journal of medicinal chemistry.
2019 Apr; 168(?):232-252. doi:
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Journal of agricultural and food chemistry.
2019 Apr; 67(13):3535-3545. doi:
10.1021/acs.jafc.8b06242. [PMID: 30835115] - Yannick Hövelmann, Maria Hahn, Florian Hübner, Hans-Ulrich Humpf. Detection of Novel Cytotoxic Imidazole Alkaloids in Tomato Products by LC-MS/MS.
Journal of agricultural and food chemistry.
2019 Apr; 67(13):3670-3678. doi:
10.1021/acs.jafc.9b00461. [PMID: 30860836] - Lei Liu, Yang Hu, Jianfei Lu, Gaoxue Wang. An imidazole coumarin derivative enhances the antiviral response to spring viremia of carp virus infection in zebrafish.
Virus research.
2019 04; 263(?):112-118. doi:
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Chemical biology & drug design.
2019 04; 93(4):511-521. doi:
10.1111/cbdd.13442. [PMID: 30422400] - Sumanta Ghosh, Anindita Mahapatra, Krishnananda Chattopadhyay. Modulation of α-Synuclein Aggregation by Cytochrome c Binding and Hetero-dityrosine Adduct Formation.
ACS chemical neuroscience.
2019 03; 10(3):1300-1310. doi:
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Journal of the American Chemical Society.
2019 01; 141(2):1054-1061. doi:
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Chemosphere.
2018 Dec; 213(?):358-367. doi:
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Environmental science and pollution research international.
2018 Dec; 25(35):35594-35601. doi:
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Analytical and bioanalytical chemistry.
2018 Nov; 410(28):7357-7371. doi:
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Fish & shellfish immunology.
2018 Oct; 81(?):57-66. doi:
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Journal of pharmaceutical and biomedical analysis.
2018 Sep; 158(?):38-46. doi:
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Journal of peptide science : an official publication of the European Peptide Society.
2018 Aug; 24(8-9):e3097. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2018 Jul; 46(7):934-942. doi:
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Bioorganic & medicinal chemistry.
2018 05; 26(8):2009-2016. doi:
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Free radical biology & medicine.
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Environmental pollution (Barking, Essex : 1987).
2017 Oct; 229(?):362-370. doi:
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Molecular cancer therapeutics.
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Journal of natural products.
2017 09; 80(9):2556-2560. doi:
10.1021/acs.jnatprod.7b00452. [PMID: 28837335] - Lakkoji Satish, Sabera Millan, Harekrushna Sahoo. Spectroscopic insight into the interaction of bovine serum albumin with imidazolium-based ionic liquids in aqueous solution.
Luminescence : the journal of biological and chemical luminescence.
2017 Aug; 32(5):695-705. doi:
10.1002/bio.3239. [PMID: 27808452] - Jefferson A Rocha, Ivanilza M Andrade, Leiz M C Véras, Patrick V Quelemes, David F Lima, Maria J S Soares, Pedro L S Pinto, Simon J Mayo, Galya Ivanova, Maria Rangel, Manuela Correia, Ana Carolina Mafud, Yvonne P Mascarenhas, Cristina Delerue-Matos, Josué de Moraes, Peter Eaton, José R S A Leite. Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves.
Phytotherapy research : PTR.
2017 Apr; 31(4):624-630. doi:
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Physical chemistry chemical physics : PCCP.
2017 Mar; 19(9):6406-6415. doi:
10.1039/c6cp08773f. [PMID: 28198894] - Gen Liu, Yan Xu, Yide Han, Junbiao Wu, Junli Xu, Hao Meng, Xia Zhang. Immobilization of lysozyme proteins on a hierarchical zeolitic imidazolate framework (ZIF-8).
Dalton transactions (Cambridge, England : 2003).
2017 Feb; 46(7):2114-2121. doi:
10.1039/c6dt04582k. [PMID: 28119966] - Youngsu You, Hee Sun Kim, Il Hak Bae, Seung Gi Lee, Min Hyeok Jee, Gyochang Keum, Sung Key Jang, B Moon Kim. New potent biaryl sulfate-based hepatitis C virus inhibitors.
European journal of medicinal chemistry.
2017 Jan; 125(?):87-100. doi:
10.1016/j.ejmech.2016.09.031. [PMID: 27657807] - Takuya Kanno, Kaori Yasutake, Kazunori Tanaka, Shinji Hadano, Joh-E Ikeda. A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection.
PloS one.
2017; 12(10):e0186227. doi:
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Toxins.
2016 12; 9(1):. doi:
10.3390/toxins9010002. [PMID: 28025502] - Roberta J Melander, Hong-Bing Liu, Matthew D Stephens, Carole A Bewley, Christian Melander. Marine sponge alkaloids as a source of anti-bacterial adjuvants.
Bioorganic & medicinal chemistry letters.
2016 12; 26(24):5863-5866. doi:
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Langmuir : the ACS journal of surfaces and colloids.
2016 12; 32(48):12579-12592. doi:
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Journal of applied microbiology.
2016 Aug; 121(2):445-52. doi:
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Journal of biomolecular structure & dynamics.
2016 Aug; 34(8):1751-62. doi:
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Biophysical journal.
2016 Jul; 111(2):312-322. doi:
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Journal of inorganic biochemistry.
2016 07; 160(?):94-105. doi:
10.1016/j.jinorgbio.2015.12.010. [PMID: 26795497] - Wenying Li, Weiping Zhao, Xiaohong Liu, Xiaohua Huang, Omar D Lopez, John E Leet, R Marcus Fancher, Van Nguyen, Jason Goodrich, John Easter, Yang Hong, Janet Caceres-Cortes, Shu Y Chang, Li Ma, Makonen Belema, Lawrence G Hamann, Min Gao, Mingshe Zhu, Yue-Zhong Shu, W Griffith Humphreys, Benjamin M Johnson. Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.
Drug metabolism and disposition: the biological fate of chemicals.
2016 06; 44(6):809-20. doi:
10.1124/dmd.115.068866. [PMID: 27029743] - Jianghong Dong, Shengwei Chen, Runfeng Li, Wei Cui, Haiming Jiang, Yixia Ling, Zifeng Yang, Wenhui Hu. Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus.
European journal of medicinal chemistry.
2016 Jan; 108(?):605-615. doi:
10.1016/j.ejmech.2015.12.013. [PMID: 26722757] - Yuanyuan Yue, Qiao Dong, Yajie Zhang, Xiaoge Li, Xuyang Yan, Yahui Sun, Jianming Liu. Synthesis of imidazole derivatives and the spectral characterization of the binding properties towards human serum albumin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2016 Jan; 153(?):688-703. doi:
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Bioorganic & medicinal chemistry.
2015 Sep; 23(18):6087-99. doi:
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Scientific reports.
2015 Aug; 5(?):13101. doi:
10.1038/srep13101. [PMID: 26287982] - Tahereh Khajvand, Olia Alijanpour, Mohammad Javad Chaichi, Majid Vafaeezadeh, Mohammad Mahmoodi Hashemi. Imidazolium-based ionic liquid derivative/Cu(II) complexes as efficient catalysts of the lucigenin chemiluminescence system and its application to H2O 2 and glucose detection.
Analytical and bioanalytical chemistry.
2015 Aug; 407(20):6127-36. doi:
10.1007/s00216-015-8795-y. [PMID: 26163131] - Marion Raters, Paul W Elsinghorst, Stephanie Goetze, Anna Dingel, Reinhard Matissek. Determination of 2-Methylimidazole, 4-Methylimidazole, and 2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in Licorice Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry Stable-Isotope Dilution Analysis.
Journal of agricultural and food chemistry.
2015 Jul; 63(25):5930-4. doi:
10.1021/acs.jafc.5b01493. [PMID: 26073294] - Franziska Bezold, Johannes Goll, Mirjana Minceva. Study of the applicability of non-conventional aqueous two-phase systems in counter-current and centrifugal partition chromatography.
Journal of chromatography. A.
2015 Apr; 1388(?):126-32. doi:
10.1016/j.chroma.2015.02.021. [PMID: 25736304] - Hwankyu Lee, Tae-Joon Jeon. The binding and insertion of imidazolium-based ionic surfactants into lipid bilayers: the effects of the surfactant size and salt concentration.
Physical chemistry chemical physics : PCCP.
2015 Feb; 17(8):5725-33. doi:
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Inorganic chemistry.
2015 Feb; 54(4):1728-36. doi:
10.1021/ic502663p. [PMID: 25634699] - Kilani Ben Rejeb, Maâli Benzarti, Ahmed Debez, Christophe Bailly, Arnould Savouré, Chedly Abdelly. NADPH oxidase-dependent H2O2 production is required for salt-induced antioxidant defense in Arabidopsis thaliana.
Journal of plant physiology.
2015 Feb; 174(?):5-15. doi:
10.1016/j.jplph.2014.08.022. [PMID: 25462961] - Kamla Rawat, H B Bohidar. Heparin-like native protein aggregate dissociation by 1-alkyl-3-methyl imidazolium chloride ionic liquids.
International journal of biological macromolecules.
2015 Feb; 73(?):23-30. doi:
10.1016/j.ijbiomac.2014.10.057. [PMID: 25445684] - Zuzanna Pietralik, Żaneta Kołodziejska, Marek Weiss, Maciej Kozak. Gemini Surfactants Based on Bis-Imidazolium Alkoxy Derivatives as Effective Agents for Delivery of Nucleic Acids: A Structural and Spectroscopic Study.
PloS one.
2015; 10(12):e0144373. doi:
10.1371/journal.pone.0144373. [PMID: 26641889] - Mei Qiao, Jiawei Sun, Na Liu, Tianjie Sun, Gang Liu, Shengfang Han, Chunyan Hou, Dongmei Wang. Changes of Nitric Oxide and Its Relationship with H2O2 and Ca2+ in Defense Interactions between Wheat and Puccinia Triticina.
PloS one.
2015; 10(7):e0132265. doi:
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Prikladnaia biokhimiia i mikrobiologiia.
2014 Nov; 50(6):593-8. doi:
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Food chemistry.
2014 Sep; 159(?):445-50. doi:
10.1016/j.foodchem.2014.03.042. [PMID: 24767080] - Nan Zhang, Zhaohui Zhang, Iris L K Wong, Shengbiao Wan, Larry M C Chow, Tao Jiang. 4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.
European journal of medicinal chemistry.
2014 Aug; 83(?):74-83. doi:
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Chemistry (Weinheim an der Bergstrasse, Germany).
2014 Aug; 20(32):9998-10004. doi:
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Se pu = Chinese journal of chromatography.
2014 May; 32(5):543-6. doi:
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Gastroenterology.
2014 May; 146(5):1325-38. doi:
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Molecular and cellular biochemistry.
2014 Apr; 389(1-2):293-300. doi:
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Rapid communications in mass spectrometry : RCM.
2014 Feb; 28(3):256-64. doi:
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Journal of molecular biology.
2014 Feb; 426(3):570-85. doi:
10.1016/j.jmb.2013.10.025. [PMID: 24513106] - Jijin Gu, Xinyi Chen, Hongliang Xin, Xiaoling Fang, Xianyi Sha. Serum-resistant complex nanoparticles functionalized with imidazole-rich polypeptide for gene delivery to pulmonary metastatic melanoma.
International journal of pharmaceutics.
2014 Jan; 461(1-2):559-69. doi:
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Current pharmaceutical biotechnology.
2014; 15(8):738-78. doi:
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PloS one.
2014; 9(1):e87074. doi:
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