N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide (BioDeep_00000179961)
human metabolite blood metabolite
代谢物信息卡片
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
化学式: C15H8ClF6NO2 (383.014773)
中文名称: IMD-0354
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O
InChI: InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:93310
- KEGG: C77350
- PubChem: 5081913
- HMDB: HMDB0253408
- ChEMBL: CHEMBL536151
- chemspider: 4258263
- CAS: 634914-41-3
- CAS: 978-62-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yongmei Feng, Gaurav Pathria, Susanne Heynen-Genel, Michael Jackson, Brian James, Jun Yin, David A Scott, Ze'ev A Ronai. Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma.
Molecular cancer therapeutics.
2021 05; 20(5):816-832. doi:
10.1158/1535-7163.mct-20-0354. [PMID: 33632871] - Fumihiro Kato, Shutoku Matsuyama, Miyuki Kawase, Takayuki Hishiki, Hiroshi Katoh, Makoto Takeda. Antiviral activities of mycophenolic acid and IMD-0354 against SARS-CoV-2.
Microbiology and immunology.
2020 Sep; 64(9):635-639. doi:
10.1111/1348-0421.12828. [PMID: 32579258] - William T Barker, Ansley M Nemeth, Sara M Brackett, Akash K Basak, Courtney E Chandler, Leigh A Jania, William J Zuercher, Roberta J Melander, Beverly H Koller, Robert K Ernst, Christian Melander. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria.
ACS infectious diseases.
2019 10; 5(10):1764-1771. doi:
10.1021/acsinfecdis.9b00212. [PMID: 31434474] - Cynthia Navarro-Mabarak, Irma Beatriz Mitre-Aguilar, Rafael Camacho-Carranza, Clorinda Arias, Alejandro Zentella-Dehesa, Jesús Javier Espinosa-Aguirre. Role of NF-κB in cytochrome P450 epoxygenases down-regulation during an inflammatory process in astrocytes.
Neurochemistry international.
2019 10; 129(?):104499. doi:
10.1016/j.neuint.2019.104499. [PMID: 31271766] - Tianqi Wang, Jing Zhang, Teng Hou, Xiaolan Yin, Na Zhang. Selective targeting of tumor cells and tumor associated macrophages separately by twin-like core-shell nanoparticles for enhanced tumor-localized chemoimmunotherapy.
Nanoscale.
2019 Aug; 11(29):13934-13946. doi:
10.1039/c9nr03374b. [PMID: 31305839] - Huihui Ti, Yang Zhou, Xue Liang, Runfeng Li, Ke Ding, Xin Zhao. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs).
Journal of medicinal chemistry.
2019 07; 62(13):5944-5978. doi:
10.1021/acs.jmedchem.8b01520. [PMID: 30682248] - Qing Sun, Guoqing Zhang, Rucheng Chen, Ran Li, Huanhuan Wang, Apei Jiang, Zhenwei Li, Liya Kong, Laura K Fonken, Sanjay Rajagopalan, Qinghua Sun, Cuiqing Liu. Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism Dysfunction in Mice With Type II Diabetes.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 07; 164(1):240-249. doi:
10.1093/toxsci/kfy079. [PMID: 29635361] - Juri Olkkonen, Vesa-Petteri Kouri, Joel Hynninen, Yrjö T Konttinen, Jami Mandelin. Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis.
PloS one.
2015; 10(12):e0145279. doi:
10.1371/journal.pone.0145279. [PMID: 26710124] - Vasili Stegajev, Vesa-Petteri Kouri, Abdelhakim Salem, Stanislav Rozov, Holger Stark, Dan C E Nordström, Yrjö T Konttinen. Activation of histamine H4 receptor inhibits TNFα/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells.
Apoptosis : an international journal on programmed cell death.
2014 Dec; 19(12):1702-11. doi:
10.1007/s10495-014-1036-6. [PMID: 25239604] - Wenjuan He, Min Zhang, Min Zhao, Linda S Davis, Timothy S Blackwell, Fiona Yull, Matthew D Breyer, Chuan-Ming Hao. Increased dietary sodium induces COX2 expression by activating NFκB in renal medullary interstitial cells.
Pflugers Archiv : European journal of physiology.
2014 Feb; 466(2):357-367. doi:
10.1007/s00424-013-1328-7. [PMID: 23900806] - Wei Zhang, Xue-Jun Li, Xin Zeng, Dong-Yan Shen, Chang-Qin Liu, Hui-Jie Zhang, Cang-Bao Xu, Xiao-Ying Li. Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro.
Toxicology letters.
2012 Mar; 209(2):107-12. doi:
10.1016/j.toxlet.2011.12.005. [PMID: 22207076] - Cang-Bao Xu, Jian-Pu Zheng, Wei Zhang, Yaping Zhang, Lars Edvinsson. Lipid-soluble smoke particles upregulate vascular smooth muscle ETB receptors via activation of mitogen-activating protein kinases and NF-kappaB pathways.
Toxicological sciences : an official journal of the Society of Toxicology.
2008 Dec; 106(2):546-55. doi:
10.1093/toxsci/kfn173. [PMID: 18718921] - Yasuyuki Onai, Jun-Ichi Suzuki, Yasuhiro Maejima, Go Haraguchi, Susumu Muto, Akiko Itai, Mitsuaki Isobe. Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction.
American journal of physiology. Heart and circulatory physiology.
2007 Jan; 292(1):H530-8. doi:
10.1152/ajpheart.00549.2006. [PMID: 16920808] - Junji Kamon, Toshimasa Yamauchi, Susumu Muto, Sato Takekawa, Yusuke Ito, Yusuke Hada, Wataru Ogawa, Akiko Itai, Masato Kasuga, Kazuyuki Tobe, Takashi Kadowaki. A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
Biochemical and biophysical research communications.
2004 Oct; 323(1):242-8. doi:
10.1016/j.bbrc.2004.08.083. [PMID: 15351728]