Iloperidone (BioDeep_00000179958)
human metabolite blood metabolite
代谢物信息卡片
化学式: C24H27FN2O4 (426.1954754)
中文名称: 伊潘立酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
InChI: InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics
Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms[1][2].
同义名列表
10 个代谢物同义名
1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone; 1-(4-{3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethan-1-one; 4-(3-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3-methoxyacetophenone; Iloperidonum; Iloperidone; Iloperidona; Fanapta; Zomaril; Fanapt; HP 873
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:65173
- PubChem: 71360
- HMDB: HMDB0253402
- DrugBank: DB04946
- ChEMBL: CHEMBL14376
- Wikipedia: Iloperidone
- CAS: 133454-47-4
- medchemexpress: HY-17410
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Przemysław J Danek, Wojciech Kuban, Władysława A Daniel. The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168447. [PMID: 34445153] - Arjun Narala, Dinesh Suram, Kishan Veerabrahma. Pharmacokinetic and pharmacodynamic studies of iloperidone-loaded lipid nanoemulsions via oral route of administration.
Drug development and industrial pharmacy.
2021 Apr; 47(4):618-625. doi:
10.1080/03639045.2021.1908332. [PMID: 33784221] - Vaishali Y Londhe, Bhavya Bhasin. Transdermal lipid vesicular delivery of iloperidone: Formulation, in vitro and in vivo evaluation.
Colloids and surfaces. B, Biointerfaces.
2019 Nov; 183(?):110409. doi:
10.1016/j.colsurfb.2019.110409. [PMID: 31386933] - Ch Gangu Naidu, R Nageswara Rao, A V Prasada Rao, K Nagesh Kumar, Raju Padiya, V Madhusudhan Rao. Supported liquid extraction and LC-MS-MS determination of iloperidone and olanzapine in rat plasma: Application to a pharmacokinetic study.
Journal of chromatographic science.
2018 Nov; 56(10):879-887. doi:
10.1093/chromsci/bmy063. [PMID: 29982313] - Jacob S Ballon, Utpal B Pajvani, Laurel Es Mayer, Zachary Freyberg, Robin Freyberg, Ignacio Contreras, Michael Rosenbaum, Rudolph L Leibel, Jeffrey A Lieberman. Pathophysiology of drug induced weight and metabolic effects: findings from an RCT in healthy volunteers treated with olanzapine, iloperidone, or placebo.
Journal of psychopharmacology (Oxford, England).
2018 05; 32(5):533-540. doi:
10.1177/0269881118754708. [PMID: 29444618] - Qi Pei, Lu Huang, Jie Huang, Jing-Kai Gu, Yun Kuang, Xiao-Cong Zuo, Jun-Jie Ding, Hong-Yi Tan, Cheng-Xian Guo, Shi-Kun Liu, Guo-Ping Yang. Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis.
Acta pharmacologica Sinica.
2016 Nov; 37(11):1499-1508. doi:
10.1038/aps.2016.96. [PMID: 27665849] - Leenata Mandpe, Varsha Pokharkar. Quality by design approach to understand the process of optimization of iloperidone nanostructured lipid carriers for oral bioavailability enhancement.
Pharmaceutical development and technology.
2015 May; 20(3):320-9. doi:
10.3109/10837450.2013.867445. [PMID: 24328553] - Mengmeng Jia, Jie Li, Xiaomeng He, Mingzhou Liu, Ying Zhou, Yue Fan, Weiyong Li. Simultaneous determination of iloperidone and its two active metabolites in human plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Jun; 928(?):52-7. doi:
10.1016/j.jchromb.2013.03.026. [PMID: 23618742] - Jignesh M Parekh, Mallika Sanyal, Manish Yadav, Pranav S Shrivastav. Stable-isotope dilution LC-MS/MS assay for determination of iloperidone and its two major metabolites, P 88 and P 95, in human plasma: application to a bioequivalence study.
Bioanalysis.
2013 Mar; 5(6):669-86. doi:
10.4155/bio.13.25. [PMID: 23484785] - Andrew J Cutler, Amir H Kalali, Greg W Mattingly, Jelena Kunovac, Xiangyi Meng. Long-term safety and tolerability of iloperidone: results from a 25-week, open-label extension trial.
CNS spectrums.
2013 Feb; 18(1):43-54. doi:
10.1017/s1092852912000764. [PMID: 23312567] - William V Bobo. Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.
Expert review of clinical pharmacology.
2013 Jan; 6(1):61-91. doi:
10.1586/ecp.12.70. [PMID: 23272794] - Marc De Hert, Weiping Yu, Johan Detraux, Kim Sweers, Ruud van Winkel, Christoph U Correll. Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.
CNS drugs.
2012 Sep; 26(9):733-59. doi:
10.2165/11634500-000000000-00000. [PMID: 22900950] - Sally A Arif, Melissa M Mitchell. Iloperidone: A new drug for the treatment of schizophrenia.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2011 Feb; 68(4):301-8. doi:
10.2146/ajhp100079. [PMID: 21289324] - H Y Meltzer, B W Massey. The role of serotonin receptors in the action of atypical antipsychotic drugs.
Current opinion in pharmacology.
2011 Feb; 11(1):59-67. doi:
10.1016/j.coph.2011.02.007. [PMID: 21420906] - Leslie Citrome. Iloperidone: a clinical overview.
The Journal of clinical psychiatry.
2011; 72 Suppl 1(?):19-23. doi:
10.4088/jcp.10075su1.04. [PMID: 22217439] - Leslie Citrome. Iloperidone: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion.
Expert opinion on drug metabolism & toxicology.
2010 Dec; 6(12):1551-64. doi:
10.1517/17425255.2010.531259. [PMID: 21034370] - J J Sheehan, J K Sliwa, J C Amatniek, A Grinspan, C M Canuso. Atypical antipsychotic metabolism and excretion.
Current drug metabolism.
2010 Jul; 11(6):516-25. doi:
10.2174/138920010791636202. [PMID: 20540690] - Peter J Weiden, Andrew J Cutler, Mihael H Polymeropoulos, Curt D Wolfgang. Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials.
Journal of clinical psychopharmacology.
2008 Apr; 28(2 Suppl 1):S12-9. doi:
10.1097/jcp.0b013e3181694f5a. [PMID: 18334908] - Lawrence James Albers, Alessandro Musenga, Maria Augusta Raggi. Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market?.
Expert opinion on investigational drugs.
2008 Jan; 17(1):61-75. doi:
10.1517/13543784.17.1.61. [PMID: 18095919] - A E Mutlib, J T Klein. Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone.
The Journal of pharmacology and experimental therapeutics.
1998 Sep; 286(3):1285-93. doi:
NULL. [PMID: 9732390] - A E Mutlib, J T Strupczewski. Picogram determination of iloperidone in human plasma by solid-phase extraction and by high-performance liquid chromatography-selected-ion monitoring electrospray mass spectrometry.
Journal of chromatography. B, Biomedical applications.
1995 Jul; 669(2):237-46. doi:
10.1016/0378-4347(95)00114-x. [PMID: 7581900] - H Y Meltzer, S Matsubara, J C Lee. The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs.
Psychopharmacology bulletin.
1989; 25(3):390-2. doi:
. [PMID: 2576319]