Ilmofosine (BioDeep_00000179956)
human metabolite blood metabolite
代谢物信息卡片
化学式: C26H56NO5PS (525.3616616)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 81.17%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCSCC(COC)COP(=O)([O-])OCC[N+](C)(C)C
InChI: InChI=1S/C26H56NO5PS/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-34-25-26(23-30-5)24-32-33(28,29)31-21-20-27(2,3)4/h26H,6-25H2,1-5H3
描述信息
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
D000970 - Antineoplastic Agents
同义名列表
11 个代谢物同义名
[2-(Hexadecylsulphanylmethyl)-3-methoxypropyl] 2-(trimethylazaniumyl)ethyl phosphoric acid; [2-(Hexadecylsulfanylmethyl)-3-methoxypropyl] 2-(trimethylazaniumyl)ethyl phosphoric acid; [2-(Hexadecylsulphanylmethyl)-3-methoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate; 3-(hexadecylsulfanyl)-2-(methoxymethyl)propyl 2-(trimethylazaniumyl)ethyl phosphate; 1-Hexadecylmercapto-2-methoxymethyl-3-propylphosphoric acid monocholine ester; 1-Mercaptohexadecyl-2-methoxymethyl-syn-glycero-3-phosphocholine; Ilmofosine, hydroxide inner salt, (+-)-isomer; SH-MM-Lysolecithin; Ilmofosine; BM 41.440; HMMPAM
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Christa Buechler, Charalampos Aslanidis. Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 05; 1865(5):158658. doi:
10.1016/j.bbalip.2020.158658. [PMID: 32058031] - José Batista, Tim Friedrichson, Georg Schlechtingen, Tobias Braxmeier, Gary Jennings, Jürgen Bajorath. Computational screening for membrane-directed inhibitors of mast cell activation.
European journal of medicinal chemistry.
2010 Jun; 45(6):2700-4. doi:
10.1016/j.ejmech.2010.01.061. [PMID: 20153565] - Ricardo M Santa-Rita, Andréa Henriques-Pons, Helene S Barbosa, Solange L de Castro. Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis.
The Journal of antimicrobial chemotherapy.
2004 Oct; 54(4):704-10. doi:
10.1093/jac/dkh380. [PMID: 15329361] - Bruce J Giantonio, Christine Derry, Cecilia McAleer, Joseph J McPhillips, Peter J O'Dwyer. Phase I and pharmacokinetic study of the cytotoxic ether lipid ilmofosine administered by weekly two-hour infusion in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2004 Feb; 10(4):1282-8. doi:
10.1158/1078-0432.ccr-0837-02. [PMID: 14977826] - N Grosman. Influence of probes for calcium-calmodulin and protein kinase C signalling on the plasma membrane Ca2+-ATPase activity of rat synaptosomes and leukocyte membranes.
Immunopharmacology.
1998 Aug; 40(2):163-71. doi:
10.1016/s0162-3109(98)00042-3. [PMID: 9826030] - F Civoli, L W Daniel. Quaternary ammonium analogs of ether lipids inhibit the activation of protein kinase C and the growth of human leukemia cell lines.
Cancer chemotherapy and pharmacology.
1998; 42(4):319-26. doi:
10.1007/s002800050824. [PMID: 9744778] - D Berkovic, W Hiddemann, J Kuduz, E A Fleer. Expression of two 50 kDa proteins is associated with sensitivity towards etherlipid analogues in the human leukaemia cell line HL 60.
European journal of cancer (Oxford, England : 1990).
1997 Oct; 33(11):1875-80. doi:
10.1016/s0959-8049(97)00234-7. [PMID: 9470850] - E A Fleer, D Berkovic, U Grunwald, W Hiddemann. Induction of resistance to hexadecylphosphocholine in the highly sensitive human epidermoid tumour cell line KB.
European journal of cancer (Oxford, England : 1990).
1996 Mar; 32A(3):506-11. doi:
10.1016/0959-8049(95)00566-8. [PMID: 8814699] - M von Mehren, B J Giantonio, C McAleer, R Schilder, J McPhillips, P J O'Dwyer. Phase I trial of ilmofosine as a 24 hour infusion weekly.
Investigational new drugs.
1995; 13(3):205-10. doi:
10.1007/bf00873801. [PMID: 8729947] - L L Trulla, A Magistrelli, M Salmona, M T Tacconi. Effect of cell density on cytotoxicity of ether lipid analogues in variants of B16 murine melanoma.
Lipids.
1993 May; 28(5):403-6. doi:
10.1007/bf02535937. [PMID: 8316047] - E S Petersen, E E Kelley, E J Modest, C P Burns. Membrane lipid modification and sensitivity of leukemic cells to the thioether lipid analogue BM 41.440.
Cancer research.
1992 Nov; 52(22):6263-9. doi:
NULL. [PMID: 1423272] - B A Wagner, G R Buettner, C P Burns. Membrane peroxidative damage enhancement by the ether lipid class of antineoplastic agents.
Cancer research.
1992 Nov; 52(21):6045-51. doi:
". [PMID: 1394229] - A R Hanauske, D Degen, M H Marshall, S G Hilsenbeck, J J McPhillips, D D Von Hoff. Preclinical activity of ilmofosine against human tumor colony forming units in vitro.
Anti-cancer drugs.
1992 Feb; 3(1):43-6. doi:
10.1097/00001813-199202000-00008. [PMID: 1623215] - M Winkelmann, K Ebeling, G Strohmeyer, G Hottenrott, Z Mechl, W Berges, T Scholten, M Westerhausen, G Schlimok, R Sterz. Treatment results of the thioether lipid ilmofosine in patients with malignant tumours.
Journal of cancer research and clinical oncology.
1992; 118(6):405-7. doi:
10.1007/bf01629421. [PMID: 1320033] - H A Neumann, R Lichtinghagen, D Borchardt, M Kissler. [Cytotoxicity of lipid ether ilmofosine in combination with radiotherapy in vitro].
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].
1991 Apr; 167(4):250-3. doi:
". [PMID: 2028404] - J Hofmann, F Ueberall, L Posch, K Maly, D B Herrmann, H Grunicke. Synergistic enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C.
Lipids.
1989 Apr; 24(4):312-7. doi:
10.1007/bf02535169. [PMID: 2755309] - K Oishi, B Zheng, J F White, W R Vogler, J F Kuo. Inhibition of Na,K-ATPase and sodium pump by anticancer ether lipids and protein kinase C inhibitors ET-18-OCH3 and BM 41.440.
Biochemical and biophysical research communications.
1988 Dec; 157(3):1000-6. doi:
10.1016/s0006-291x(88)80973-2. [PMID: 2849926] - D B Herrmann, E Besenfelder, U Bicker, W Pahlke, E Böhm. Pharmacokinetics of the thioether phospholipid analogue BM 41.440 in rats.
Lipids.
1987 Nov; 22(11):952-4. doi:
10.1007/bf02535562. [PMID: 3444391] - G A Storme, E A Bruyneel, D C Schallier, J G Bolscher, W E Berdel, M M Mareel. Effect of lipid derivatives on invasion in vitro and on surface glycoproteins of three rodent cell types.
Lipids.
1987 Nov; 22(11):847-50. doi:
10.1007/bf02535542. [PMID: 3444376] - D B Herrmann, H A Neumann, W E Berdel, M E Heim, M Fromm, D Boerner, U Bicker. Phase I trial of the thioether phospholipid analogue BM 41.440 in cancer patients.
Lipids.
1987 Nov; 22(11):962-6. doi:
10.1007/bf02535565. [PMID: 3328028] - G H Leder, H H Fiebig, E Wallbrecher, B R Winterhalter, G W Löhr. In vitro and in vivo cytotoxicity of alkyl lysophospholipid ET-18-OCH3 and thioether lipid BM 41.440.
Lipids.
1987 Nov; 22(11):958-61. doi:
10.1007/bf02535564. [PMID: 3444393]