Ilaprazole (BioDeep_00000179950)
human metabolite blood metabolite
代谢物信息卡片
2-[(4-Methoxy-3-methylpyridin-2-yl)methanesulphinyl]-6-(1H-pyrrol-1-yl)-1H-1,3-benzodiazole
化学式: C19H18N4O2S (366.11504080000003)
中文名称: 艾普拉唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=C(N2)C=C(C=C3)N4C=CC=C4)OC
InChI: InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29723 - Proton Pump Inhibitor
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135544
- PubChem: 214351
- HMDB: HMDB0253394
- DrugBank: DB11964
- ChEMBL: CHEMBL2106370
- Wikipedia: Ilaprazole
- chemspider: 185839
- CAS: 172152-36-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yi-Chang Zhao, Xiao-Bin Lin, Bi-Kui Zhang, Yi-Wen Xiao, Ping Xu, Feng Wang, Da-Xiong Xiang, Xu-Biao Xie, Feng-Hua Peng, Miao Yan. Predictors of Adverse Events and Determinants of the Voriconazole Trough Concentration in Kidney Transplantation Recipients.
Clinical and translational science.
2021 03; 14(2):702-711. doi:
10.1111/cts.12932. [PMID: 33202102] - Guiqiu Zhang, Kaijing Guo, Pengfei Wang, Yingbo Shan, Chen Ma. Identification of the New In Vivo Metabolites of Ilaprazole in Rat Plasma after Oral Administration by LC-MS: In Silico Prediction of the H+/K+-ATPase Inhibitor.
Molecules (Basel, Switzerland).
2021 Jan; 26(2):. doi:
10.3390/molecules26020459. [PMID: 33467211] - Tianxiang Shen, Xindong Jiang, Zhaolei Jin, Qiuzhi Ji, Chunlong Li, Qingpo Li, Hongxin Long, Weigen Qiu, Wei Wang, Xuemei Hou, Jian You. The study of intestinal absorption and biodistribution in vivo of proton pump inhibitors.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2020 Apr; 149(?):135-144. doi:
10.1016/j.ejpb.2020.01.015. [PMID: 32007590] - Hongyun Wang, Feng Shao, Xuemei Liu, Wen Xu, Ning Ou, Xianghong Qin, Fang Liu, Xuemei Hou, Haitang Hu, Ji Jiang. Efficacy, safety and pharmacokinetics of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control.
British journal of clinical pharmacology.
2019 11; 85(11):2547-2558. doi:
10.1111/bcp.14076. [PMID: 31332820] - Li Fan, Qin Xianghong, Wang Ling, Han Ying, Xia Jielai, Hu Haitang. Ilaprazole Compared With Rabeprazole in the Treatment of Duodenal Ulcer: A Randomized, Double-blind, Active-controlled, Multicenter Study.
Journal of clinical gastroenterology.
2019 10; 53(9):641-647. doi:
10.1097/mcg.0000000000001186. [PMID: 30789856] - Jie Ying, Liu-Cheng Li, Cui-Yun Wu, Zhen-Wei Yu, Lian-Di Kan. The status of proton pump inhibitor use: a prescription survey of 45 hospitals in China.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.
2019 Oct; 111(10):738-743. doi:
10.17235/reed.2019.6155/2019. [PMID: 31373505] - Jie Pu, Fen Wang, Wei Tang, Mingshe Zhu. Biotransformation of Ilaprazole in Human Liver Microsomes and Human: Role of CYP3A4 in Ilaprazole Clearance and Drug-Drug Interaction.
Drug metabolism and disposition: the biological fate of chemicals.
2018 10; 46(10):1453-1461. doi:
10.1124/dmd.118.081570. [PMID: 30002078] - A P Dewani, A S Tripathi, P G Shelke, R L Bakal, D S Mohale, A V Chandewar. Development of Solid-Phase Extraction and HPLC Method for Simultaneous Estimation of Ilaprazole and Glimepiride in Rat Plasma: Application to Pharmacokinetic Studies.
Journal of chromatographic science.
2017 03; 55(3):327-333. doi:
10.1093/chromsci/bmw189. [PMID: 28069690] - Hongyun Wang, Ning Ou, Liwei Lang, Ruihua Shi, Pei Hu, Ji Jiang. Pharmacokinetics and pharmacodynamics of intravenous ilaprazole in healthy subjects after single ascending doses.
Xenobiotica; the fate of foreign compounds in biological systems.
2016 Dec; 46(12):1133-1141. doi:
10.3109/00498254.2016.1156185. [PMID: 26998954] - Edoardo Savarino, Andrea Ottonello, Irene Martinucci, Pietro Dulbecco, Vincenzo Savarino. Ilaprazole for the treatment of gastro-esophageal reflux.
Expert opinion on pharmacotherapy.
2016 Oct; 17(15):2107-13. doi:
10.1080/14656566.2016.1232389. [PMID: 27598861] - J S Shin, J Y Lee, K H Cho, H L Park, M Kukulka, J-T Wu, D Y Kim, S-H Park. The pharmacokinetics, pharmacodynamics and safety of oral doses of ilaprazole 10, 20 and 40 mg and esomeprazole 40 mg in healthy subjects: a randomised, open-label crossover study.
Alimentary pharmacology & therapeutics.
2014 Sep; 40(5):548-61. doi:
10.1111/apt.12860. [PMID: 25041486] - Nicola de Bortoli, Irene Martinucci, Maria Giacchino, Corrado Blandizzi, Santino Marchi, Vincenzo Savarino, Edoardo Savarino. The pharmacokinetics of ilaprazole for gastro-esophageal reflux treatment.
Expert opinion on drug metabolism & toxicology.
2013 Oct; 9(10):1361-9. doi:
10.1517/17425255.2013.813018. [PMID: 23802731] - Hoon Cho, Min-Koo Choi, Doo-Yeon Cho, Chang-Woo Yeo, Hye-Eun Jeong, Ji-Hong Shon, Jun-Yeoun Lee, Jae-Soo Shin, Mong Cho, Dong-Yeon Kim, Jae-Gook Shin. Effect of CYP2C19 genetic polymorphism on pharmacokinetics and pharmacodynamics of a new proton pump inhibitor, ilaprazole.
Journal of clinical pharmacology.
2012 Jul; 52(7):976-84. doi:
10.1177/0091270011408611. [PMID: 21593280] - Lijun Zhou, Jinglai Li, Xiaoying Wang, Jianzhong Qiao, Zhenqing Zhang. [Determination of ilaprazole in beagle plasma and its pharmaeokineties by high performance liquid chromatography-mass spectrometry].
Se pu = Chinese journal of chromatography.
2012 May; 30(5):452-6. doi:
10.3724/sp.j.1123.2011.12081. [PMID: 22934406] - Yuping Zhang, Shuyun Shi, Xiaoqin Chen, Wei Zhang, Kelong Huang, Mijun Peng. Investigation on the interaction between ilaprazole and bovine serum albumin without or with different C-ring flavonoids from the viewpoint of food-drug interference.
Journal of agricultural and food chemistry.
2011 Aug; 59(15):8499-506. doi:
10.1021/jf201796x. [PMID: 21732691] - Gan Zhou, Shuyun Shi, Wei Zhang, Zhirong Tan, Yao Chen, Dong Guo, Honghao Zhou, Haitang Hu, Jin Tan. Identification of ilaprazole metabolites in human urine by HPLC-ESI-MS/MS and HPLC-NMR experiments.
Biomedical chromatography : BMC.
2010 Oct; 24(10):1130-5. doi:
10.1002/bmc.1416. [PMID: 20352613] - Gan Zhou, Zhi-rong Tan, Wei Zhang, Dong-sheng Ou-Yang, Yao Chen, Dong Guo, Ying-zi Liu, Lan Fan, Han-wu Deng. An improved LC-MS/MS method for quantitative determination of ilaprazole and its metabolites in human plasma and its application to a pharmacokinetic study.
Acta pharmacologica Sinica.
2009 Sep; 30(9):1330-6. doi:
10.1038/aps.2009.120. [PMID: 19701234] - Yalin Li, Wei Zhang, Dong Guo, Gan Zhou, Honghao Zhou, Zhousheng Xiao. Pharmacokinetics of the new proton pump inhibitor ilaprazole in Chinese healthy subjects in relation to CYP3A5 and CYP2C19 genotypes.
Clinica chimica acta; international journal of clinical chemistry.
2008 May; 391(1-2):60-7. doi:
10.1016/j.cca.2008.02.003. [PMID: 18319058] - B J Kil, I W Kim, C Y Shin, J H Jeong, C H Jun, S M Lee, D Y Kim, I H Huh, U D Sohn. Comparison of IY81149 with omeprazole in rat reflux oesophagitis.
Journal of autonomic pharmacology.
2000 Oct; 20(5-6):291-6. doi:
10.1046/j.1365-2680.2000.00192.x. [PMID: 11350494] - S W Myung, H K Min, C Jin, M Kim, S M Lee, G J Chung, S J Park, D Y Kim, H W Cho. Identification of IY81149 and its metabolites in the rat plasma using the on-line HPLC/ESI mass spectrometry.
Archives of pharmacal research.
1999 Apr; 22(2):189-93. doi:
10.1007/bf02976545. [PMID: 10230511]