1H-Indole-2-carbonitrile, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-3-iodo- (BioDeep_00000179929)
human metabolite blood metabolite
代谢物信息卡片
4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-3-iodo-1H-indole-2-carbonitrile
化学式: C15H18IN3O2 (399.0444)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 50%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=CC2=C1C(=C(N2)C#N)I)O
InChI: InChI=1S/C15H18IN3O2/c1-9(2)18-7-10(20)8-21-13-5-3-4-11-14(13)15(16)12(6-17)19-11/h3-5,9-10,18-20H,7-8H2,1-2H3
描述信息
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 68618
- HMDB: HMDB0253370
- MeSH: Iodocyanopindolol
- chemspider: 61882
- CAS: 83498-72-0
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Biochemical and biophysical research communications.
1988 Dec; 157(3):921-9. doi:
10.1016/s0006-291x(88)80962-8. [PMID: 2849947] - M C Michel, A Daul, O Galal, X L Wang, O E Brodde. Are alpha- and beta-adrenoceptor changes in patients with essential hypertension genetically determined?.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1988 Dec; 6(4):S575-7. doi:
10.1097/00004872-198812040-00180. [PMID: 2853761] - P R Sundaresan, S L Kelvie. Beta-adrenergic receptor coupled adenylate cyclase in rat kidney. Differential coupling in glomeruli and tubules.
Biochemical pharmacology.
1988 Dec; 37(23):4513-22. doi:
10.1016/0006-2952(88)90667-3. [PMID: 2849448] - P Engfeldt, J Hellmér, H Wahrenberg, P Arner. Effects of insulin on adrenoceptor binding and the rate of catecholamine-induced lipolysis in isolated human fat cells.
The Journal of biological chemistry.
1988 Oct; 263(30):15553-60. doi:
10.1016/s0021-9258(19)37624-0. [PMID: 2844816] - P Muzzin, J Seydoux, J P Giacobino, J C Venter, C Fraser. Discrepancies between the affinities of binding and action of the novel beta-adrenergic agonist BRL 37344 in rat brown adipose tissue.
Biochemical and biophysical research communications.
1988 Oct; 156(1):375-82. doi:
10.1016/s0006-291x(88)80851-9. [PMID: 2902858] - A O Davies. Exercise-induced fall in coupling of human beta 2-adrenergic receptors.
Metabolism: clinical and experimental.
1988 Oct; 37(10):916-8. doi:
10.1016/0026-0495(88)90146-1. [PMID: 2845229] - P A Janssens, J A Grigg. Binding of adrenergic ligands to liver plasma membrane preparations from the axolotl, Ambystoma mexicanum; the toad, Xenopus laevis; and the Australian lungfish, Neoceratodus forsteri.
General and comparative endocrinology.
1988 Sep; 71(3):524-30. doi:
10.1016/0016-6480(88)90283-3. [PMID: 2847957] - J M Stadel, S T Crooke. Differential effects of fluoride on adenylate cyclase activity and guanine nucleotide regulation of agonist high-affinity receptor binding.
The Biochemical journal.
1988 Aug; 254(1):15-20. doi:
10.1042/bj2540015. [PMID: 2845943] - M Oriold Dereski, P Grammas, F Giacomelli, C Diglio, J Wiener. Autonomic receptor characterization in cultured adult rat cardiac myocytes: morphologic-functional correlation.
Journal of molecular and cellular cardiology.
1988 Aug; 20(8):701-10. doi:
10.1016/s0022-2828(88)80015-4. [PMID: 2851663] - F Sanae, K Miyamoto, R Koshiura. A comparison of adrenergic receptors of rat ascites hepatoma AH130 cells with those of normal rat hepatocytes.
Cancer letters.
1988 Apr; 39(3):267-73. doi:
10.1016/0304-3835(88)90069-9. [PMID: 3359420] - J R Jasper, H J Motulsky, P A Insel. Characterization of a bromoacetylated derivative of pindolol as a high affinity, irreversible beta adrenergic antagonist in cultured cells.
The Journal of pharmacology and experimental therapeutics.
1988 Mar; 244(3):820-4. doi:
NULL. [PMID: 2908047] - E J McMurchie, G S Patten, P L McLennan, J S Charnock, P J Nestel. The influence of dietary lipid supplementation on cardiac beta-adrenergic receptor adenylate cyclase activity in the marmoset monkey.
Biochimica et biophysica acta.
1988 Jan; 937(2):347-58. doi:
10.1016/0005-2736(88)90257-x. [PMID: 2827774] - P Valet, C Damase-Michel, M Taouis, J L Montastruc, J Cotonat, P Montastruc. Acute release of catecholamines on circulating blood cell adrenoceptors and metabolic indices in dog.
Fundamental & clinical pharmacology.
1988; 2(4):267-76. doi:
10.1111/j.1472-8206.1988.tb00638.x. [PMID: 3220423] - D Ratge, A Wiedemann, K P Kohse, H Wisser. Alterations of beta-adrenoceptors on human leukocyte subsets induced by dynamic exercise: effect of prednisone.
Clinical and experimental pharmacology & physiology.
1988 Jan; 15(1):43-53. doi:
10.1111/j.1440-1681.1988.tb01007.x. [PMID: 2856048] - T Kaila, R Penttinen, J Peltonen. Cultured neurofibromatosis tumor fibroblasts lack beta-adrenergic receptors.
Neurofibromatosis.
1988; 1(1):37-42. doi:
NULL. [PMID: 2856202] - D Reinhardt, J Ludwig, D Braun, G Kusenbach, M Griese. Effects of the antiallergic drug ketotifen on bronchial resistance and beta-adrenoceptor density of lymphocytes in children with exercise-induced asthma.
Developmental pharmacology and therapeutics.
1988; 11(3):180-8. doi:
10.1159/000457686. [PMID: 2838231] - C Y Kwan, A Osterroth, S N Sipos, P Kosta, J S Beazley, Y Y Guan, E E Daniel. Interactions of saponin with microsomal membranes isolated from vascular smooth muscle.
Archives internationales de pharmacodynamie et de therapie.
1988 Jan; 291(?):55-67. doi:
". [PMID: 2835023] - J Marty, Y Nivoche, M Nimier, C Rocchiccioli, F Luscombe, D Henzel, A Loiseau, J M Desmonts. The effects of halothane on the human beta-adrenergic receptor of lymphocyte membranes.
Anesthesiology.
1987 Dec; 67(6):974-8. doi:
10.1097/00000542-198712000-00016. [PMID: 2825566] - C Y Kwan, S N Sipos, A Osterroth, E E Daniel. Beta adrenoreceptor in vascular smooth muscle with special reference to subcellular localization and number of binding sites.
The Journal of pharmacology and experimental therapeutics.
1987 Dec; 243(3):1074-81. doi:
NULL. [PMID: 2826753] - P R Sundaresan, T L Fortin, S L Kelvie. Alpha- and beta-adrenergic receptors in proximal tubules of rat kidney.
The American journal of physiology.
1987 Nov; 253(5 Pt 2):F848-56. doi:
10.1152/ajprenal.1987.253.5.f848. [PMID: 2825536] - F Bree, T Souchet, R Baatard, C Fontenaille, F Lhoste, J P Tillement. Inhibition of (-) [125I]-iodocyanopindolol binding to rat lung beta adrenoceptors by uremic plasma ultrafiltrates.
Biochemical pharmacology.
1987 Oct; 36(19):3121-5. doi:
10.1016/0006-2952(87)90621-6. [PMID: 2822046] - H Wahrenberg, P Engfeldt, J Bolinder, P Arner. Acute adaptation in adrenergic control of lipolysis during physical exercise in humans.
The American journal of physiology.
1987 Oct; 253(4 Pt 1):E383-90. doi:
10.1152/ajpendo.1987.253.4.e383. [PMID: 2821823] - S M Graham, P A Herring, I J Arinze. Age-associated alterations in hepatic beta-adrenergic receptor/adenylate cyclase complex.
The American journal of physiology.
1987 Sep; 253(3 Pt 1):E277-82. doi:
10.1152/ajpendo.1987.253.3.e277. [PMID: 2820236] - K Nakagawa, M Matsubara, K Akikawa, M Kubo. Beta-adrenergic receptor in heart of starved rats.
Endocrinologia japonica.
1987 Jun; 34(3):381-5. doi:
10.1507/endocrj1954.34.381. [PMID: 2820705]
