Hydroxyfasudil (BioDeep_00000179852)
human metabolite blood metabolite
代谢物信息卡片
5-(1,4-Diazepane-1-sulphonyl)isoquinolin-1-ol
化学式: C14H17N3O3S (307.0991)
中文名称: 羟基法舒
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O
InChI: InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 3064778
- HMDB: HMDB0253268
- DrugBank: DB04707
- ChEMBL: CHEMBL1233300
- chemspider: 2325236
- CAS: 105628-72-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Guo-Guo Chu, Jing Wang, Zhi-Bin Ding, Jin-Zhu Yin, Li-Juan Song, Qing Wang, Jian-Jun Huang, Bao-Guo Xiao, Cun-Gen Ma. Hydroxyfasudil regulates immune balance and suppresses inflammatory responses in the treatment of experimental autoimmune encephalomyelitis.
International immunopharmacology.
2023 Aug; 124(Pt A):110791. doi:
10.1016/j.intimp.2023.110791. [PMID: 37619413] - Andrew J Streets, Philipp P Prosseda, Albert Cm Ong. Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling.
JCI insight.
2020 08; 5(16):. doi:
10.1172/jci.insight.135385. [PMID: 32663194] - Jing Wang, Ruo-Xuan Sui, Qiang Miao, Qing Wang, Li-Juan Song, Jie-Zhong Yu, Yan-Hua Li, Bao-Guo Xiao, Cun-Gen Ma. Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model.
Clinical immunology (Orlando, Fla.).
2019 04; 201(?):35-47. doi:
10.1016/j.clim.2019.01.006. [PMID: 30660624] - Aliseydi Bozkurt, Harun Budak, Huseyin Serkan Erol, Serpil Can, Tolga Mercantepe, Yigit Akin, Isa Ozbey, Murat Cankaya, Mesut Bunyamin Halici, T Abdulkadir Coban. A novel therapeutics agent: antioxidant effects of hydroxylfasudil on rat kidney and liver tissues in a protamine sulphate-induced cystitis rat model; preliminary results.
Artificial cells, nanomedicine, and biotechnology.
2018; 46(sup2):9-14. doi:
10.1080/21691401.2018.1449120. [PMID: 29523028] - Itsuko Baba, Yasuhiro Egi, Hiroyuki Utsumi, Tetsuhiro Kakimoto, Kazuo Suzuki. Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction.
Molecular medicine reports.
2015 Dec; 12(6):8010-20. doi:
10.3892/mmr.2015.4467. [PMID: 26498136] - Yigit Akin, Aliseydi Bozkurt, Huseyin S Erol, Mesut Halici, Fikret Celebi, Kubra A T Kapakin, Hakan Gulmez, Mutlu Ates, Abdulkadir Coban, Baris Nuhoglu. Impact of Rho-Kinase Inhibitor Hydroxyfasudil in Protamine Sulphate Induced Cystitis Rat Bladder.
Lower urinary tract symptoms.
2015 May; 7(2):108-14. doi:
10.1111/luts.12058. [PMID: 26663691] - Dominik Kentrup, Stefan Reuter, Uta Schnöckel, Alexander Grabner, Bayram Edemir, Hermann Pavenstädt, Otmar Schober, Michael Schäfers, Eberhard Schlatter, Eckhart Büssemaker. Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.
PloS one.
2011; 6(10):e26419. doi:
10.1371/journal.pone.0026419. [PMID: 22031832] - Huaying Chen, Yang Lin, Min Han, Shugong Bai, Shaojun Wen. Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2010 Jun; 52(2):242-8. doi:
10.1016/j.jpba.2009.12.028. [PMID: 20080374] - Carole Deyts, Beatriz Galan-Rodriguez, Elodie Martin, Nicolas Bouveyron, Emmanuel Roze, Delphine Charvin, Jocelyne Caboche, Sandrine Bétuing. Dopamine D2 receptor stimulation potentiates PolyQ-Huntingtin-induced mouse striatal neuron dysfunctions via Rho/ROCK-II activation.
PloS one.
2009 Dec; 4(12):e8287. doi:
10.1371/journal.pone.0008287. [PMID: 20016831] - Shuhei Kawahara, Yasuaki Hata, Takeshi Kita, Ryoichi Arita, Muneki Miura, Shintaro Nakao, Yasutaka Mochizuki, Hiroshi Enaida, Tadahisa Kagimoto, Yoshinobu Goto, Ali Hafezi-Moghadam, Tatsuro Ishibashi. Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins.
Diabetes.
2008 Oct; 57(10):2784-93. doi:
10.2337/db08-0302. [PMID: 18599521] - Keisuke Ina, Hirokazu Kitamura, Shuji Tatsukawa, Takashi Miyazaki, Hirokazu Abe, Yoshihisa Fujikura. Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model.
Virchows Archiv : an international journal of pathology.
2007 Nov; 451(5):911-21. doi:
10.1007/s00428-007-0511-7. [PMID: 17899181] - Bao Hua Jiang, Shunsuke Tawara, Kohtaro Abe, Aya Takaki, Yoshihiro Fukumoto, Hiroaki Shimokawa. Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.
Journal of cardiovascular pharmacology.
2007 Feb; 49(2):85-9. doi:
10.1097/fjc.0b013e31802df112. [PMID: 17312448] - Shin-ichi Satoh, Yoshinori Toshima, Ichiro Ikegaki, Masakazu Iwasaki, Toshio Asano. Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
Brain research.
2007 Jan; 1128(1):175-80. doi:
10.1016/j.brainres.2006.10.027. [PMID: 17123488] - Paolo Gelosa, Mauro Cimino, Alice Pignieri, Elena Tremoli, Uliano Guerrini, Luigi Sironi. The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation.
Vascular health and risk management.
2007; 3(5):567-77. doi:
". [PMID: 18078008] - Takatoshi Hizume, Keiko Morikawa, Aya Takaki, Kohtaro Abe, Kenji Sunagawa, Mutsuki Amano, Kozo Kaibuchi, Chiharu Kubo, Hiroaki Shimokawa. Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo: a possible link between stress and coronary vasospasm.
Circulation research.
2006 Sep; 99(7):767-75. doi:
10.1161/01.res.0000244093.69985.2f. [PMID: 16960099] - Takeshi Kanda, Shu Wakino, Koichiro Homma, Kyoko Yoshioka, Satoru Tatematsu, Kazuhiro Hasegawa, Ichiro Takamatsu, Naoki Sugano, Koichi Hayashi, Takao Saruta. Rho-kinase as a molecular target for insulin resistance and hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2006 Jan; 20(1):169-71. doi:
10.1096/fj.05-4197fje. [PMID: 16267124] - Yusei Hanada, Hiroshi Kudo, Eiji Kohmura. Chronologic changes of fasudil hydrochloride and hydroxyfasudil in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2005 Mar; 14(2):47-9. doi:
10.1016/j.jstrokecerebrovasdis.2004.10.006. [PMID: 17903999] - Shin-ichi Satoh, Tamami Yamaguchi, Asako Hitomi, Norihiro Sato, Kazumi Shiraiwa, Ichiro Ikegaki, Toshio Asano, Hiroaki Shimokawa. Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction.
European journal of pharmacology.
2002 Nov; 455(2-3):169-74. doi:
10.1016/s0014-2999(02)02619-5. [PMID: 12445583]
