Doxylamine (BioDeep_00000017980)

   

human metabolite Chemicals and Drugs


代谢物信息卡片


2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine

化学式: C17H22N2O (270.1732042)
中文名称: 多西拉敏
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C
InChI: InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3

描述信息

Doxylamine is a sedating antihistamine that can be used by itself as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief. It is a member of the ethanolamine class of antihistamines and has anti-allergy power superior to almost every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most effective over-the-counter sedative available in North America, and more sedating than some prescription hypnotics. In a study, it was found that doxylamine succinate is possibly more effective than the barbiturate, phenobarbital for use as a sedative. For this reason, doxylamine has sometimes been used off label in a manner similar to diphenhydramine for the reduction of anxiety symptoms; Doxylamine succinate is used by itself as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug, and a preparation is prescribed in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women. In Commonwealth countries, doxylamine is available prepared with paracetamol/acetaminophen and codeine under the brand name Syndol or Mersyndol, as treatment for tension headache and other types of pain, or as a general OTC sleep-aid branded as Somnil, Donormyl, DSozile and Restavit containing Doxylamine Succinate only. [HMDB]
Doxylamine is a sedating antihistamine that can be used by itself as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief. It is a member of the ethanolamine class of antihistamines and has anti-allergy power superior to almost every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most effective over-the-counter sedative available in North America, and more sedating than some prescription hypnotics. In a study, it was found that doxylamine succinate is possibly more effective than the barbiturate, phenobarbital for use as a sedative. For this reason, doxylamine has sometimes been used off label in a manner similar to diphenhydramine for the reduction of anxiety symptoms; Doxylamine succinate is used by itself as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug, and a preparation is prescribed in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women. In Commonwealth countries, doxylamine is available prepared with paracetamol/acetaminophen and codeine under the brand name Syndol or Mersyndol, as treatment for tension headache and other types of pain, or as a general OTC sleep-aid branded as Somnil, Donormyl, DSozile and Restavit containing Doxylamine Succinate only.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents

同义名列表

21 个代谢物同义名

2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine; dimethyl({2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl})amine; N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine; Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether; 2-(Α-(2-(dimethylamino)ethoxy)-α-methylbenzyl)pyridine; 2-(a-(2-(Dimethylamino)ethoxy)-a-methylbenzyl)pyridine; Phenyl-2-pyridylmethyl-b-N,N-dimethylaminoethyl ether; Phenyl-2-pyridylmethyl-β-N,N-dimethylaminoethyl ether; 2-Dimethylaminoethoxyphenylmethyl-2-picoline; Doxylamine hydrogen succinate; Doxylamine succinate (1:1); DOXYLAMINE SUCCINATE; Decapryn succinate; Doxylaminum; Dossilamina; doxylamine; Doxilamina; Doxilminio; Mereprine; Alsadorm; Decapryn



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

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COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Jiu-Qiang Xiong, Pengfei Cui, Shaoguo Ru, Sanjay P Govindwar, Mayur B Kurade, Min Jang, Sang-Hyoun Kim, Byong-Hun Jeon. Unravelling metabolism and microbial community of a phytobed co-planted with Typha angustifolia and Ipomoea aquatica for biodegradation of doxylamine from wastewater. Journal of hazardous materials. 2021 01; 401(?):123404. doi: 10.1016/j.jhazmat.2020.123404. [PMID: 32659588]
  • Sophie Allard, Pierre-Marie Allard, Isabelle Morel, Thomas Gicquel. Application of a molecular networking approach for clinical and forensic toxicology exemplified in three cases involving 3-MeO-PCP, doxylamine, and chlormequat. Drug testing and analysis. 2019 May; 11(5):669-677. doi: 10.1002/dta.2550. [PMID: 30468699]
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  • Marjorie Chèze, Aurélie Muckensturm, Guillaume Hoizey, Gilbert Pépin, Marc Deveaux. A tendency for re-offending in drug-facilitated crime. Forensic science international. 2010 Mar; 196(1-3):14-7. doi: 10.1016/j.forsciint.2009.12.037. [PMID: 20116946]
  • Eun-jung Lee, Sun-cheun Kim, In-kwan Hwang, Hee-jin Yang, Youn-shin Kim, Myun-soo Han, Moon-sik Yang, Yang-han Lee. The identification of ingested dandelion juice in gastric contents of a deceased person by direct sequencing and GC-MS methods. Journal of forensic sciences. 2009 May; 54(3):721-7. doi: 10.1111/j.1556-4029.2009.01019.x. [PMID: 19432748]
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  • Matthew P Juhascik, Adam Negrusz, Diana Faugno, Linda Ledray, Pam Greene, Alice Lindner, Barbara Haner, R E Gaensslen. An estimate of the proportion of drug-facilitation of sexual assault in four U.S. localities. Journal of forensic sciences. 2007 Nov; 52(6):1396-400. doi: 10.1111/j.1556-4029.2007.00583.x. [PMID: 18093069]
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