Holotoxin A1 (BioDeep_00000179795)

   

human metabolite blood metabolite


代谢物信息卡片


16-({5-[(4-{[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy]-2-({5-[(4-{[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl)oxy]-3,4-dihydroxy-6-methyloxan-2-yl}oxy)-4-hydroxyoxan-3-yl}oxy)-2,6,13,17,17-pentamethyl-6-(4-methylpent-4-en-1-yl)-7-oxapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-11-ene-4,8-dione

化学式: C66H104O31 (1392.6561234)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(C(C(CO2)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC)O)O)O)OC5CCC6(C(C5(C)C)CCC7C6=CCC89C7(CC(=O)C8C(OC9=O)(C)CCCC(=C)C)C)C)O)O)OC1C(C(C(CO1)O)OC1C(C(C(C(O1)CO)O)OC)O)O
InChI: InChI=1S/C66H104O31/c1-26(2)12-11-17-65(8)54-30(70)20-64(7)29-13-14-36-62(4,5)37(16-18-63(36,6)28(29)15-19-66(54,64)61(82)97-65)92-53-41(75)35(91-57-47(81)52(40(74)34(23-69)88-57)95-59-46(80)51(84-10)39(73)33(22-68)90-59)25-86-60(53)96-56-43(77)42(76)48(27(3)87-56)93-55-44(78)49(31(71)24-85-55)94-58-45(79)50(83-9)38(72)32(21-67)89-58/h15,27,29,31-60,67-69,71-81H,1,11-14,16-25H2,2-10H3

描述信息

D011838 - Radiation-Sensitizing Agents

同义名列表

8 个代谢物同义名

16-({5-[(4-{[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy]-2-({5-[(4-{[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl)oxy]-3,4-dihydroxy-6-methyloxan-2-yl}oxy)-4-hydroxyoxan-3-yl}oxy)-2,6,13,17,17-pentamethyl-6-(4-methylpent-4-en-1-yl)-7-oxapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-11-ene-4,8-dione; Stichoposide a1; Stichoposide a; Stichoposide C; Holotoxin A1; Stichoposide; Holotoxin b1; Holotoxins



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tal Noy-Porat, Ronit Rosenfeld, Naomi Ariel, Eyal Epstein, Ron Alcalay, Anat Zvi, Chanoch Kronman, Arie Ordentlich, Ohad Mazor. Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates. Toxins. 2016 Mar; 8(3):. doi: 10.3390/toxins8030064. [PMID: 26950154]
  • Seong-Hoon Yun, Eun-Seon Park, Sung-Won Shin, Mi-Ha Ju, Jin-Yeong Han, Jin-Sook Jeong, Sung-Hyun Kim, Valentin A Stonik, Jong-Young Kwak, Joo-In Park. By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts. Oncotarget. 2015 Sep; 6(29):27596-612. doi: 10.18632/oncotarget.4820. [PMID: 26318294]
  • Ofer Cohen, Adva Mechaly, Tamar Sabo, Ron Alcalay, Ronit Aloni-Grinstein, Nehama Seliger, Chanoch Kronman, Ohad Mazor. Characterization and epitope mapping of the polyclonal antibody repertoire elicited by ricin holotoxin-based vaccination. Clinical and vaccine immunology : CVI. 2014 Nov; 21(11):1534-40. doi: 10.1128/cvi.00510-14. [PMID: 25209559]
  • A N Mazeĭka, E Ia Kostetskiĭ, N M Sanina, A M Popov, V I Kalinin, I A Li. [Elaboration of immune stimulating lipid-saponin subunit antigen carrier based on glycolipid monogalactosyldiacylglycerol from sea macrophytes and triterpene glycosides from Cucumaria japonica]. Biofizika. 2013 Sep; 58(5):786-95. doi: ". [PMID: 25481946]
  • I A Lee, A M Popov, E Ia Kostetskiĭ, N M Sanina, A N Mazeĭka, V M Boguslavskiĭ. [Membranotropic effect of some triterpene glycosides possessing immunostimulating properties]. Biofizika. 2008 May; 53(3):462-9. doi: ". [PMID: 18634319]
  • Elizabeth Grimaldi, Erwin A W Claassen, J Michael Lord, Daniel C Smith, Andrew J Easton. Stimulation of pneumovirus-specific CD8+ T-cells using a non-toxic recombinant ricin delivery system. Molecular immunology. 2007 Feb; 44(5):993-8. doi: 10.1016/j.molimm.2006.03.008. [PMID: 16650896]
  • Yoko Ueno, Masaru Ohara, Toru Kawamoto, Tamaki Fujiwara, Hitoshi Komatsuzawa, Eric Oswald, Motoyuki Sugai. Biogenesis of the Actinobacillus actinomycetemcomitans cytolethal distending toxin holotoxin. Infection and immunity. 2006 Jun; 74(6):3480-7. doi: 10.1128/iai.00739-05. [PMID: 16714579]
  • Y Hagiwara, T Iwasaki, H Asanuma, Y Sato, T Sata, C Aizawa, T Kurata, S Tamura. Effects of intranasal administration of cholera toxin (or Escherichia coli heat-labile enterotoxin) B subunits supplemented with a trace amount of the holotoxin on the brain. Vaccine. 2001 Feb; 19(13-14):1652-60. doi: 10.1016/s0264-410x(00)00412-6. [PMID: 11166888]
  • K Hashigucci, S Tamura, T Kurata, H Kamiya, T Ishidate. [Efficacy of nasal influenza vaccine combined with Escherichia coli heat-labile enterotoxin B subunit containing a trace amount of the holotoxin in healthy volunteers]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 1997 Feb; 71(2):153-61. doi: 10.11150/kansenshogakuzasshi1970.71.153. [PMID: 9077073]
  • K Hashigucci, H Ogawa, T Ishidate, R Yamashita, H Kamiya, K Watanabe, N Hattori, T Sato, Y Suzuki, T Nagamine, C Aizawa, S Tamura, T Kurata, A Oya. Antibody responses in volunteers induced by nasal influenza vaccine combined with Escherichia coli heat-labile enterotoxin B subunit containing a trace amount of the holotoxin. Vaccine. 1996 Feb; 14(2):113-9. doi: 10.1016/0264-410x(95)00174-y. [PMID: 8852406]
  • S Tamura, H Asanuma, T Tomita, K Komase, K Kawahara, H Danbara, N Hattori, K Watanabe, Y Suzuki, T Nagamine. Escherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine. Vaccine. 1994 Sep; 12(12):1083-9. doi: 10.1016/0264-410x(94)90177-5. [PMID: 7998417]
  • D L Aminin, A V Lebedev, D O Levitskiĭ. [The effect of holotoxin A1 on transport of calcium ions across the lipid models of biological membranes]. Biokhimiia (Moscow, Russia). 1990 Feb; 55(2):270-5. doi: ". [PMID: 2160291]
  • A S Ivanov, E M Khalilov, E F Solov'eva, V A Stonik, I I Mal'tsev. [Analysis of free cholesterol levels in human serum using holotoxin A1]. Voprosy meditsinskoi khimii. 1986 Sep; 32(5):132-4. doi: NULL. [PMID: 3776109]
  • A A Popov, N I Kalinovskaia, T A Kuznetsova, I G Agafonova, M M Anisimov. [Role of sterols in the membranotropic activity of triterpene glycosides]. Antibiotiki. 1983 Sep; 28(9):656-9. doi: ". [PMID: 6638979]
  • A M Popov, Iu G Rovin, M M Anisimov, G N Likhatskaia, L I Strigina. [Effect of triterpene glycosides on the stability of bilayer lipid membranes, containing different sterols]. Biofizika. 1982 Sep; 27(5):827-31. doi: . [PMID: 7138933]
  • A M Popov, M M Anisimov, A S Ivanov, E A Korepanova, V F Antonov. [Characteristics of membrane activity of triterpene glycosides]. Antibiotiki. 1982 Apr; 27(4):276-80. doi: . [PMID: 7092199]