Hexyl 2,5-dichlorophenylphosphoroamidate (BioDeep_00000179771)
human metabolite blood metabolite
代谢物信息卡片
化学式: C12H18Cl2NO3P (325.0401)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 7.01%
分子结构信息
SMILES: CCCCCCOP(=O)(NC1=C(C=CC(=C1)Cl)Cl)O
InChI: InChI=1S/C12H18Cl2NO3P/c1-2-3-4-5-8-18-19(16,17)15-12-9-10(13)6-7-11(12)14/h6-7,9H,2-5,8H2,1H3,(H2,15,16,17)
描述信息
同义名列表
9 个代谢物同义名
[(2,5-dichlorophenyl)amino](hexyloxy)phosphinic acid; (2,5-dichlorophenyl)amino(hexyloxy)phosphinic acid; [(2,5-Dichlorophenyl)amino](hexyloxy)phosphinate; O-Hexyl O-2,5-dichlorophenylphosphoroamidate; Hexyl 2,5-dichlorophenylphosphoroamidic acid; O-Hexyl O-2,5-dichlorophenyl phosphoramidate; Hexyl 2,5-dichlorophenylphosphoroamidate; Hexyl-DCP; HDCP CPD
数据库引用编号
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Antonio Monroy-Noyola, Miguel Angel Sogorb, Damianys Almenares-Lopez, Eugenio Vilanova. DAEH N-terminal sequence of avian serum albumins as catalytic center of Cu (II)-dependent organophosphorus hydrolyzing A-esterase activity.
Chemico-biological interactions.
2021 Aug; 345(?):109524. doi:
10.1016/j.cbi.2021.109524. [PMID: 34022193] - Antonio Monroy-Noyola, Eugenio Vilanova, Freda Campos, Pedro Mederos, Neyra Rendon, Jaqueline Garcia-Hernandez, José Alfredo Castillo-Guerrero, Camilo Ríos. O-hexyl O-2,5-dichlorophenyl phosphoramidate as a substrate for domestic and sea bird serum A-esterases: Hydrolysis levels, Cu2+- and Zn2+-dependence and stereoselectivity.
Chemico-biological interactions.
2019 Sep; 310(?):108727. doi:
10.1016/j.cbi.2019.108727. [PMID: 31251899] - Antonio Monroy-Noyola, Miguel Angel Sogorb, Eugenio Vilanova. Albumin, the responsible protein of the Cu2+-dependent hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) by chicken serum "antagonistic stereoselectivity".
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Oct; 120(?):523-527. doi:
10.1016/j.fct.2018.07.047. [PMID: 30056146] - Antonio Monroy-Noyola, Bertín Trujillo, Petra Yescas, Fernanda Martínez-Salazar, Sara García-Jiménez, Camilo Ríos, Eugenio Vilanova. Stereospecific hydrolysis of a phosphoramidate used as an OPIDP model by human sera with PON1 192 alloforms.
Archives of toxicology.
2015 Oct; 89(10):1801-9. doi:
10.1007/s00204-014-1327-2. [PMID: 25112958] - Miguel A Sogorb, Eugenio Vilanova. Serum albumins and detoxication of anti-cholinesterase agents.
Chemico-biological interactions.
2010 Sep; 187(1-3):325-9. doi:
10.1016/j.cbi.2010.03.001. [PMID: 20211614] - Antonio Monroy-Noyola, Patricia Rojas, Eugenio Vilanova, Miguel A Sogorb. Comparative hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate and paraoxon in different tissues of vertebrates.
Archives of toxicology.
2007 Oct; 81(10):689-95. doi:
10.1007/s00204-007-0197-2. [PMID: 17396245] - A Monroy-Noyola, M A Sogorb, E Vilanova. Stereospecific hydrolysis of a phosphoramidate as a model to understand the role of biotransformation in the neurotoxicity of chiral organophosphorus compounds.
Toxicology letters.
2007 Apr; 170(2):157-64. doi:
10.1016/j.toxlet.2007.03.002. [PMID: 17420104] - M A Sogorb, I Sánchez, M López-Rivadulla, V Céspedes, E Vilanova. EDTA-resistant and sensitive phosphotriesterase activities associated with albumin and lipoproteins in rabbit serum.
Drug metabolism and disposition: the biological fate of chemicals.
1999 Jan; 27(1):53-9. doi:
. [PMID: 9884309] - M A Sogorb, N Díaz-Alejo, M A Escudero, E Vilanova. Phosphotriesterase activity identified in purified serum albumins.
Archives of toxicology.
1998 Mar; 72(4):219-26. doi:
10.1007/s002040050492. [PMID: 9587017] - N Díaz-Alejo, A Monroy, E Vilanova, J L Vicedo, M A Sogorb. A stereospecific phosphotriesterase in hen liver and brain.
Chemico-biological interactions.
1998 Jan; 108(3):187-96. doi:
10.1016/s0009-2797(97)00106-3. [PMID: 9528689] - N Díaz-Alejo, M A Sogorb, J L Vicedo, J Barril, E Vilanova. Non-calcium dependent activity hydrolysing organophosphorus compounds in hen plasma.
Comparative biochemistry and physiology. Pharmacology, toxicology and endocrinology.
1994 Feb; 107(2):213-9. doi:
10.1016/1367-8280(94)90043-4. [PMID: 7749589] - N Díaz-Alejo, E Vilanova. Chiral high-performance liquid chromatography and gas chromatography of the stereoisomers of hexyl 2,5-dichlorophenyl phosphoramidate.
Journal of chromatography.
1993 Dec; 622(2):179-86. doi:
10.1016/0378-4347(93)80264-5. [PMID: 8150866] - M A Sogorb, E Vilanova, N Díaz-Alejo. The kinetics of O-hexyl O-2,5-dichlorophenyl phosphoramidate hydrolysing activity in hen plasma.
Chemico-biological interactions.
1993 Jun; 87(1-3):117-25. doi:
10.1016/0009-2797(93)90032-t. [PMID: 8343971] - M A Sogorb, N Díaz-Alejo, E Vilanova, J L Vicedo, V Carrera. Effect of some metallic cations and organic compounds on the O-hexyl O-2,5-dichlorophenyl phosphoramidate hydrolysing activity in hen plasma.
Archives of toxicology.
1993; 67(6):416-21. doi:
10.1007/bf01977403. [PMID: 8215911] - N Diaz-Alejo, M C Pellin, J L Vicedo, E Vilanova. Hen liver and plasma can metabolize hexyl-DCP phosphoramidate at a rate comparable to that of rat.
Neurotoxicology and teratology.
1990 Nov; 12(6):615-7. doi:
10.1016/0892-0362(90)90072-k. [PMID: 2255303]
