2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide (BioDeep_00000179684)

   

human metabolite blood metabolite


代谢物信息卡片


2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)-N-[4-(propan-2-yl)phenyl]acetamide

化学式: C18H21N5O3 (355.1644)
中文名称: 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C
InChI: InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)

描述信息

同义名列表

4 个代谢物同义名

2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)-N-[4-(propan-2-yl)phenyl]acetamide; 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-isopropylphenyl)acetamide; HC-030031



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Rupinder Kaur Sodhi, Hemant Kumar, Raghunath Singh, Yashika Bansal, Yuvraj Singh, Kanthi Kiran Kondepudi, Mahendra Bishnoi, Anurag Kuhad. Allyl isothiocyanate, a TRPA1 agonist, protects against olanzapine-induced hypothalamic and hepatic metabolic aberrations in female mice. Biochemical pharmacology. 2024 Apr; 222(?):116074. doi: 10.1016/j.bcp.2024.116074. [PMID: 38395265]
  • Fei Deng, Heping Zhang, Wei Zhou, Shijie Ma, Yuwei Kang, Wei Yang, Liangbin Zhao, Wei Qin. TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage. Journal of translational medicine. 2023 Oct; 21(1):695. doi: 10.1186/s12967-023-04351-9. [PMID: 37798747]
  • Daniel J Conklin, Yiru Guo, Matthew A Nystoriak, Ganapathy Jagatheesan, Detlef Obal, Peter J Kilfoil, Joseph David Hoetker, Luping Guo, Roberto Bolli, Aruni Bhatnagar. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. American journal of physiology. Heart and circulatory physiology. 2019 04; 316(4):H889-H899. doi: 10.1152/ajpheart.00106.2018. [PMID: 30735434]
  • Chenqiu Du, Jun Kang, Wei Yu, Mingqing Chen, Baizhan Li, Hong Liu, Han Wang. Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma. Respirology (Carlton, Vic.). 2019 03; 24(3):238-245. doi: 10.1111/resp.13433. [PMID: 30440113]
  • Yan Xu, Ji Jia, Chuangbo Xie, Youping Wu, Weifeng Tu. Transient Receptor Potential Ankyrin 1 and Substance P Mediate the Development of Gastric Mucosal Lesions in a Water Immersion Restraint Stress Rat Model. Digestion. 2018; 97(3):228-239. doi: 10.1159/000484980. [PMID: 29428952]
  • Daniel J Conklin, Petra Haberzettl, Ganapathy Jagatheesan, Maiying Kong, Gary W Hoyle. Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. Toxicology and applied pharmacology. 2017 06; 324(?):61-72. doi: 10.1016/j.taap.2016.08.028. [PMID: 27592100]
  • Sayaka Suzawa, Kenji Takahashi, Takahisa Shimada, Toshio Ohta. Carbonyl stress-induced 5-hydroxytriptamine secretion from RIN-14B, rat pancreatic islet tumor cells, via the activation of transient receptor potential ankyrin 1. Brain research bulletin. 2016 07; 125(?):181-6. doi: 10.1016/j.brainresbull.2016.07.005. [PMID: 27423812]
  • Katrin Kistner, Norbert Siklosi, Alexandru Babes, Mohammad Khalil, Tudor Selescu, Katharina Zimmermann, Stefan Wirtz, Christoph Becker, Markus F Neurath, Peter W Reeh, Matthias A Engel. Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain. Scientific reports. 2016 06; 6(?):28621. doi: 10.1038/srep28621. [PMID: 27356469]
  • Yoko Kogure, Shenglan Wang, Koh-Ichi Tanaka, Yongbiao Hao, Satoshi Yamamoto, Nobuyoshi Nishiyama, Koichi Noguchi, Yi Dai. Elevated H2 O2 levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel. Journal of gastroenterology and hepatology. 2016 Jun; 31(6):1147-53. doi: 10.1111/jgh.13226. [PMID: 26574143]
  • Kiichiro Yamaguchi, Kentaro Ono, Suzuro Hitomi, Misa Ito, Tomotaka Nodai, Tetsuya Goto, Nozomu Harano, Seiji Watanabe, Hiromasa Inoue, Kanako Miyano, Yasuhito Uezono, Motohiro Matoba, Kiyotoshi Inenaga. Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. Pain. 2016 May; 157(5):1004-1020. doi: 10.1097/j.pain.0000000000000498. [PMID: 26808144]
  • Saulo J F Mendes, Fernanda I A B Sousa, Domingos M S Pereira, Thiago A F Ferro, Ione C P Pereira, Bruna L R Silva, Aruanã J M C R Pinheiro, Adriana Q S Mouchrek, Valério Monteiro-Neto, Soraia K P Costa, José L M Nascimento, Marcos A G Grisotto, Robson da Costa, Elizabeth S Fernandes. Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms. International immunopharmacology. 2016 May; 34(?):60-70. doi: 10.1016/j.intimp.2016.02.012. [PMID: 26922677]
  • Qin Kang, Chang-Yu Jiang, Tsugumi Fujita, Eiichi Kumamoto. Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (-)-carvone and (+)-carvone which activate different types of TRP channel. Biochemical and biophysical research communications. 2015 Apr; 459(3):498-503. doi: 10.1016/j.bbrc.2015.02.135. [PMID: 25747716]
  • Hana Moon, Min Jung Kim, Hee Jin Son, Hae-Jin Kweon, Jung Tae Kim, Yiseul Kim, Jaewon Shim, Byung-Chang Suh, Mee-Ra Rhyu. Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. PloS one. 2015; 10(5):e0127060. doi: 10.1371/journal.pone.0127060. [PMID: 25978436]
  • Lisa Rooney, Agnès Vidal, Anne-Marie D'Souza, Nick Devereux, Brian Masick, Valerie Boissel, Ryan West, Victoria Head, Rowan Stringer, Jianmin Lao, Matt J Petrus, Ardem Patapoutian, Mark Nash, Natalie Stoakley, Moh Panesar, J Martin Verkuyl, Andrew M Schumacher, H Michael Petrassi, David C Tully. Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. Journal of medicinal chemistry. 2014 Jun; 57(12):5129-40. doi: 10.1021/jm401986p. [PMID: 24884675]
  • Manabu Soya, Masaki Sato, Ubaidus Sobhan, Maki Tsumura, Tatsuya Ichinohe, Masakazu Tazaki, Yoshiyuki Shibukawa. Plasma membrane stretch activates transient receptor potential vanilloid and ankyrin channels in Merkel cells from hamster buccal mucosa. Cell calcium. 2014 Apr; 55(4):208-18. doi: 10.1016/j.ceca.2014.02.015. [PMID: 24642224]
  • G Chung, S T Im, Y H Kim, S J Jung, M-R Rhyu, S B Oh. Activation of transient receptor potential ankyrin 1 by eugenol. Neuroscience. 2014 Mar; 261(?):153-60. doi: 10.1016/j.neuroscience.2013.12.047. [PMID: 24384226]
  • Hsien-Yu Peng, Chou-Ming Yeh, Jen-Kun Cheng, Yat-Pang Chau, Ting Ruan, Gin-Den Chen, Ming-Chun Hsieh, Cheng-Yuan Lai, Tzer-Bin Lin. Acute uterine irritation provokes colonic motility via transient receptor potential A(1)-dependent spinal NR2B phosphorylation in rats. Anesthesiology. 2014 Feb; 120(2):436-46. doi: 10.1097/aln.0b013e3182a66e94. [PMID: 23941865]
  • Ari Koivisto, Hugh Chapman, Niina Jalava, Timo Korjamo, Marja Saarnilehto, Ken Lindstedt, Antti Pertovaara. TRPA1: a transducer and amplifier of pain and inflammation. Basic & clinical pharmacology & toxicology. 2014 Jan; 114(1):50-5. doi: 10.1111/bcpt.12138. [PMID: 24102997]
  • Rodrigo José de Siqueira, Karilane Maria Silvino Rodrigues, Moisés Tolentino Bento da Silva, Carlos Antônio Barros Correia Junior, Gloria Pinto Duarte, Pedro Jorge Caldas Magalhães, Armênio Aguiar dos Santos, José Guilherme Soares Maia, Pergentino José Sousa da Cunha, Saad Lahlou. Linalool-rich rosewood oil induces vago-vagal bradycardic and depressor reflex in rats. Phytotherapy research : PTR. 2014 Jan; 28(1):42-8. doi: 10.1002/ptr.4953. [PMID: 23447129]
  • Letizia Albarrán, Jose J Lopez, Natalia Dionisio, Tarik Smani, Gines M Salido, Juan A Rosado. Transient receptor potential ankyrin-1 (TRPA1) modulates store-operated Ca(2+) entry by regulation of STIM1-Orai1 association. Biochimica et biophysica acta. 2013 Dec; 1833(12):3025-3034. doi: 10.1016/j.bbamcr.2013.08.014. [PMID: 23994313]
  • Gabriela Trevisan, Serena Materazzi, Camilla Fusi, Alessandra Altomare, Giancarlo Aldini, Maura Lodovici, Riccardo Patacchini, Pierangelo Geppetti, Romina Nassini. Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade. Cancer research. 2013 May; 73(10):3120-31. doi: 10.1158/0008-5472.can-12-4370. [PMID: 23477783]
  • Noriyuki Hatano, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki. Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin. American journal of physiology. Cell physiology. 2013 Feb; 304(4):C354-61. doi: 10.1152/ajpcell.00096.2012. [PMID: 23220116]
  • L M S Pereira, R C P Lima-Júnior, A X C Bem, C G Teixeira, L S Grassi, R P Medeiros, R D Marques-Neto, R B Callado, K S Aragão, D V T Wong, M L Vale, G A C Brito, R A Ribeiro. Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system. European journal of pain (London, England). 2013 Feb; 17(2):223-33. doi: 10.1002/j.1532-2149.2012.00177.x. [PMID: 22689151]
  • Min Jung Kim, Hee Jin Son, Seo Hyeon Song, Myungji Jung, Yiseul Kim, Mee-Ra Rhyu. The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying. PloS one. 2013; 8(8):e71603. doi: 10.1371/journal.pone.0071603. [PMID: 23990963]
  • David A Andersson, Clive Gentry, Emily Light, Nisha Vastani, Julie Vallortigara, Angelika Bierhaus, Thomas Fleming, Stuart Bevan. Methylglyoxal evokes pain by stimulating TRPA1. PloS one. 2013; 8(10):e77986. doi: 10.1371/journal.pone.0077986. [PMID: 24167592]
  • Lintao Qu, Yumei Li, Xinghua Pan, Pu Zhang, Robert H LaMotte, Chao Ma. Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Jul; 32(28):9554-62. doi: 10.1523/jneurosci.6355-11.2012. [PMID: 22787041]
  • Phillip Edward Kunkler, Carrie Jo Ballard, Gerry Stephen Oxford, Joyce Harts Hurley. TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation. Pain. 2011 Jan; 152(1):38-44. doi: 10.1016/j.pain.2010.08.021. [PMID: 21075522]
  • Ana I Caceres, Marian Brackmann, Maxwell D Elia, Bret F Bessac, Donato del Camino, Marc D'Amours, JoAnn S Witek, Chistopher M Fanger, Jayhong A Chong, Neil J Hayward, Robert J Homer, Lauren Cohn, Xiaozhu Huang, Magdalene M Moran, Sven-Eric Jordt. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proceedings of the National Academy of Sciences of the United States of America. 2009 Jun; 106(22):9099-104. doi: 10.1073/pnas.0900591106. [PMID: 19458046]