Isepamicine (BioDeep_00000179675)
human metabolite blood metabolite
代谢物信息卡片
3-amino-N-(5-amino-4-{[6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy}-2-{[3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl)-2-hydroxypropanamide
化学式: C22H43N5O12 (569.2908078)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(C(C(C(O3)CN)O)O)O)N)NC(=O)C(CN)O)O
InChI: InChI=1S/C22H43N5O12/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34)
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- G Samonis, S Maraki, E K Vouloumanou, G G Georgantzi, D P Kofteridis, M E Falagas. Antimicrobial susceptibility of non-fermenting Gram-negative isolates to isepamicin in a region with high antibiotic resistance.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2012 Nov; 31(11):3191-8. doi:
10.1007/s10096-012-1684-9. [PMID: 22752194] - Katsumi Shigemura, Minori Matsumoto, Kazushi Tanaka, Masuo Yamashita, Soichi Arakawa, Masato Fujisawa. Efficacy of combination use of Beta-lactamase inhibitor with penicillin and fluoroquinolones for antibiotic prophylaxis in transrectal prostate biopsy.
Korean journal of urology.
2011 Apr; 52(4):289-92. doi:
10.4111/kju.2011.52.4.289. [PMID: 21556218] - Bum Sik Chin, Sang Hoon Han, Suk Hoon Choi, Han Sung Lee, Su Jin Jeong, Hee Kyung Choi, Jun Yong Choi, Young Goo Song, Chang Ki Kim, Dongeun Yong, Kyungwon Lee, June Myung Kim. The characteristics of metallo-β-lactamase-producing gram-negative bacilli isolated from sputum and urine: a single center experience in Korea.
Yonsei medical journal.
2011 Mar; 52(2):351-7. doi:
10.3349/ymj.2011.52.2.351. [PMID: 21319358] - Lei Wang, Juanjuan Peng, Zhengwen Liu, Youqiu He. Resonance Rayleigh-scattering spectral method for the determination of some aminoglycoside antibiotics using CdTe quantum dots as a probe.
Luminescence : the journal of biological and chemical luminescence.
2010 Nov; 25(6):424-30. doi:
10.1002/bio.1170. [PMID: 19743528] - Sara Romano, Fabien Aujoulat, Estelle Jumas-Bilak, Agnès Masnou, Jean-Luc Jeannot, Enevold Falsen, Hélène Marchandin, Corinne Teyssier. Multilocus sequence typing supports the hypothesis that Ochrobactrum anthropi displays a human-associated subpopulation.
BMC microbiology.
2009 Dec; 9(?):267. doi:
10.1186/1471-2180-9-267. [PMID: 20021660] - Shin Hosokawa, Katsunori Nakamura, Yukiyoshi Fujita, Ryuya Horiuchi, Koujirou Yamamoto. Determination of isepamicin in human plasma by HPLC with fluorescence detection after derivatization using 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate.
Biological & pharmaceutical bulletin.
2008 Oct; 31(10):1866-9. doi:
10.1248/bpb.31.1866. [PMID: 18827345] - S Alfandari, C Bonenfant, L Depretere, G Beaucaire. Use of 27 parenteral antimicrobial agents in north of France hospitals.
Medecine et maladies infectieuses.
2007 Feb; 37(2):103-7. doi:
10.1016/j.medmal.2006.10.010. [PMID: 17303361] - J C Yombi, P Wallemacq, T Leal, J L Gala, B Vandercam. Key pharmacokinetic parameters of isepamicin in febrile neutropenic cancer patients and in women with acute pelvic inflammatory disease.
Journal of chemotherapy (Florence, Italy).
2005 Oct; 17(5):521-6. doi:
10.1179/joc.2005.17.5.521. [PMID: 16323441] - Nam-Hee Ryoo, Jung-Sook Ha, Dong-Seok Jeon, Jae-Ryong Kim, Hyun-Chul Kim. A case of pneumonia caused by Ewingella americana in a patient with chronic renal failure.
Journal of Korean medical science.
2005 Feb; 20(1):143-5. doi:
10.3346/jkms.2005.20.1.143. [PMID: 15716620] - Gianluca Aguiari, Manuela Banzi, Stefania Gessi, Yiqiang Cai, Emanuela Zeggio, Elisa Manzati, Roberta Piva, Elisabetta Lambertini, Luisa Ferrari, Dorien J Peters, Francesco Lanza, Peter C Harris, Pier Andrea Borea, Stefan Somlo, Laura Del Senno. Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004 May; 18(7):884-6. doi:
10.1096/fj.03-0687fje. [PMID: 15001556] - Toyoji Okubo, Shizuko Iyobe. [Antibacterial activities and PK/PD parameters of aminoglycosides against recent clinical isolates of gram-negative rods].
The Japanese journal of antibiotics.
2002 Oct; 55(5):514-23. doi:
NULL. [PMID: 12532635] - E Boselli, D Breilh, J C Bel, R Debon, M C Saux, D Chassard, B Allaouchiche. Diffusion of isepamicin into cancellous and cortical bone tissue.
Journal of chemotherapy (Florence, Italy).
2002 Aug; 14(4):361-5. doi:
10.1179/joc.2002.14.4.361. [PMID: 12420853] - Tomoko Yazaki, Yuji Yoshiyama, Paul Wong, Denis Beauchamp, Motoko Kanke. Protective effect of fleroxacin against the nephrotoxicity of isepamicin in rats.
Biological & pharmaceutical bulletin.
2002 Apr; 25(4):516-9. doi:
10.1248/bpb.25.516. [PMID: 11995935] - H C Maltezou, M Baka, N Gombakis, D E Koliouskas, H Kosmidou, E Malaka-Zafiriou, D A Kafetzis. Comparison of isepamicin with amikacin for the empirical treatment of febrile neutropenic children with malignancies.
International journal of antimicrobial agents.
2001 Oct; 18(4):383-6. doi:
10.1016/s0924-8579(01)00420-4. [PMID: 11691573] - F Fauvelle, J M Coulaud, K Lecointre, D Tardy, J F Poussel, G Trape. Comparison of two methods to obtain a desired first isepamicin peak in intensive care patients.
Fundamental & clinical pharmacology.
2001 Apr; 15(2):151-6. doi:
10.1046/j.1472-8206.2001.00020.x. [PMID: 11468025]