Halopemide (BioDeep_00000179671)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


N-{2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)piperidin-1-yl]ethyl}-4-fluorobenzamide

化学式: C21H22ClFN4O2 (416.1415234)
中文名称: 卤丙胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCNC(=O)C4=CC=C(C=C4)F
InChI: InChI=1S/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)

描述信息

C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent[1][2].
Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent[1][2].

同义名列表

3 个代谢物同义名

N-{2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)piperidin-1-yl]ethyl}-4-fluorobenzamide; Halopemide; Halopemide



数据库引用编号

6 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Alex G Waterson, Sarah A Scott, Nathan R Kett, Anna L Blobaum, H Alex Brown, Craig W Lindsley. Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives. Bioorganic & medicinal chemistry letters. 2018 12; 28(23-24):3670-3673. doi: 10.1016/j.bmcl.2018.10.033. [PMID: 30528979]
  • Wenjuan Su, Oladapo Yeku, Srinivas Olepu, Alyssa Genna, Jae-Sook Park, Hongmei Ren, Guangwei Du, Michael H Gelb, Andrew J Morris, Michael A Frohman. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Molecular pharmacology. 2009 Mar; 75(3):437-46. doi: 10.1124/mol.108.053298. [PMID: 19064628]
  • Sarah A Scott, Paige E Selvy, Jason R Buck, Hyekyung P Cho, Tracy L Criswell, Ashley L Thomas, Michelle D Armstrong, Carlos L Arteaga, Craig W Lindsley, H Alex Brown. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature chemical biology. 2009 Feb; 5(2):108-17. doi: 10.1038/nchembio.140. [PMID: 19136975]
  • Jose de Leon, Francisco J Diaz, Richard C Josiassen, George M Simpson. Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment. European archives of psychiatry and clinical neuroscience. 2004 Oct; 254(5):318-25. doi: 10.1007/s00406-004-0505-2. [PMID: 15365707]
  • M Goiny, K Uvnäs-Moberg, S Cekan. Bromocriptine and apomorphine stimulation of cortisol secretion in conscious dogs; evidence for a stimulatory site located outside the blood brain barrier. Psychopharmacology. 1986; 89(1):108-12. doi: 10.1007/bf00175200. [PMID: 3090584]
  • H H van Rooij, R L Waterman, J C Kraak. Dynamic cation-exchange systems for the separation of drugs derived from butyrophenone and diphenylpiperidine by high-performance liquid chromatography and applied in the determination of halopemide in plasma. Journal of chromatography. 1979 Oct; 164(2):177-85. doi: 10.1016/s0378-4347(00)81186-x. [PMID: 541408]