Cilazapril (BioDeep_00000017964)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C22H31N3O5 (417.2263596)
中文名称: 西拉普利
谱图信息:
最多检出来源 Homo sapiens(blood) 2.31%
分子结构信息
SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC2CCCN3CCCC(N3C2=O)C(=O)O
InChI: InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
描述信息
Cilazapril is only found in individuals that have used or taken this drug. It is one of the angiotensin-converting enzyme inhibitors (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. [PubChem]Cilazapri, as a pyridazine ACE inhibitor, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase II, an enzyme which degrades the vasodilator bradykinin, is identical to ACE and may also be inhibited.
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
19 个代谢物同义名
(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid; Monohydrobromide, cilazapril; Cilazapril monohydrobromide; Monohydrate, cilazapril; Cilazapril, (s*)-isomer; Cilazapril Monohydrate; Anhydrous, cilazapril; Cilazapril, anhydrous; Cilazapril anhydrous; Hydrate, cilazapril; Cilazapril hydrate; Cilazaprilum; Ro 31-2848; Ro 34-2848; Cilazapril; Inhibace; Vascace; Vascase; Dynorm
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:3698
- PubChem: 56330
- PubChem: 2751
- HMDB: HMDB0015433
- DrugBank: DB01340
- ChEMBL: CHEMBL515606
- Wikipedia: Cilazapril
- MeSH: Cilazapril
- chemspider: 50831
- CAS: 88768-40-5
- PMhub: MS000001476
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Krzysztof Łukawski, Tomasz Jakubus, Agnieszka Janowska, Grzegorz Raszewski, Stanisław J Czuczwar. Enalapril enhances the anticonvulsant activity of lamotrigine in the test of maximal electroshock.
Pharmacological reports : PR.
2013; 65(4):1012-7. doi:
10.1016/s1734-1140(13)71083-1
. [PMID: 24145096] - Krzysztof Łukawski, Tomasz Jakubus, Agnieszka Janowska, Stanisław J Czuczwar. Interactions between ACE inhibitors and classical antiepileptic drugs in the mouse maximal electroshock seizures.
Pharmacology, biochemistry, and behavior.
2011 Nov; 100(1):152-6. doi:
10.1016/j.pbb.2011.06.030
. [PMID: 21741989] - Filomila Kolocouri, Yannis Dotsikas, Constantinos Apostolou, Constantinos Kousoulos, Georgios-Stefanos Soumelas, Yannis L Loukas. Advantages of automation in plasma sample preparation prior to HPLC/MS/MS quantification: application to the determination of cilazapril and cilazaprilat in a bioequivalence study.
Journal of AOAC International.
2011 May; 94(3):758-64. doi:
. [PMID: 21797003]
- Jae Il Shin, Beom Jin Lim, Pyung Kil Kim, Jae Seung Lee, Hyeon Joo Jeong, Ji Hong Kim. Effects of cyclosporin A therapy combined with steroids and angiotensin converting enzyme inhibitors on childhood IgA nephropathy.
Journal of Korean medical science.
2010 May; 25(5):723-7. doi:
10.3346/jkms.2010.25.5.723
. [PMID: 20436708] - Fs Tian, R Luo, Zq Zhao, Y Wu, Dj Ban. Blockade of the RAS increases plasma adiponectin in subjects with metabolic syndrome and enhances differentiation and adiponectin expression of human preadipocytes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2010 Apr; 118(4):258-65. doi:
10.1055/s-0029-1237706
. [PMID: 19856251] - Aleksander Skoczylas, Marcin Adamczak, Jerzy Chudek, Andrzej Wiecek. Cilazapril increases plasma ghrelin concentration in obese patients with arterial hypertension.
Endokrynologia Polska.
2010 Jan; 61(1):21-7. doi:
NULL
. [PMID: 20205100] - Shao-Sung Huang, Tao-Cheng Wu, Shing-Jong Lin, Jaw-Wen Chen. Combination of an ACE inhibitor and indapamide improves blood pressure control, but attenuates the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension.
Circulation journal : official journal of the Japanese Circulation Society.
2009 Dec; 73(12):2282-7. doi:
10.1253/circj.cj-09-0387
. [PMID: 19789415] - Marcin Renke, Leszek Tylicki, Narcyz Knap, Przemyslaw Rutkowski, Alexander Neuwelt, Andriy Petranyuk, Wojciech Larczynski, Michał Wozniak, Boleslaw Rutkowski. High-dose angiotensin-converting enzyme inhibitor attenuates oxidative stress in patients with chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Feb; 24(2):689-90. doi:
10.1093/ndt/gfn665
. [PMID: 19054799] - Jicheng Lv, Hong Zhang, Yuqing Chen, Guangtao Li, Lei Jiang, Ajay K Singh, Haiyan Wang. Combination therapy of prednisone and ACE inhibitor versus ACE-inhibitor therapy alone in patients with IgA nephropathy: a randomized controlled trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2009 Jan; 53(1):26-32. doi:
10.1053/j.ajkd.2008.07.029
. [PMID: 18930568] - Giovanni F M Strippoli, Ausilia Maione, Francesco P Schena, G Tognoni, Jonathan C Craig. IgA nephropathy: a disease in search of a large-scale clinical trial to reliably inform practice.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2009 Jan; 53(1):5-8. doi:
10.1053/j.ajkd.2008.10.035
. [PMID: 19101396] - Marcin Renke, Leszek Tylicki, Narcyz Knap, Przemyslaw Rutkowski, Alexander Neuwelt, Wojciech Larczynski, Michal Wozniak, Boleslaw Rutkowski. Spironolactone attenuates oxidative stress in patients with chronic kidney disease.
Hypertension (Dallas, Tex. : 1979).
2008 Nov; 52(5):e132-3; author reply e134. doi:
10.1161/hypertensionaha.108.120568
. [PMID: 18824658] - Ilka Knütter, Claudia Wollesky, Gabor Kottra, Martin G Hahn, Wiebke Fischer, Katja Zebisch, Reinhard H H Neubert, Hannelore Daniel, Matthias Brandsch. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.
The Journal of pharmacology and experimental therapeutics.
2008 Nov; 327(2):432-41. doi:
10.1124/jpet.108.143339
. [PMID: 18713951] - Nikola Radović, Snjezan Cuzić, Mladen Knotek. Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule and interstitial cell apoptosis in rats.
Croatian medical journal.
2008 Oct; 49(5):600-7. doi:
10.3325/cmj.2008.5.600
. [PMID: 18925693] - Leszek Tylicki, Przemysław Rutkowski, Marcin Renke, Wojciech Larczyński, Ewa Aleksandrowicz, Wiesława Lysiak-Szydlowska, Bolesław Rutkowski. Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2008 Sep; 52(3):486-93. doi:
10.1053/j.ajkd.2008.02.297
. [PMID: 18423812] - Shih-Hsien Sung, Tao-Cheng Wu, Shing-Jong Lin, Jaw-Wen Chen. Efficacy of a very-low-dose combination of perindopril and indapamide--preterax compared with cilazapril monotherapy in patients with inadequate blood pressure control--a randomized, double-blind, add-on study.
Journal of the Chinese Medical Association : JCMA.
2008 May; 71(5):247-53. doi:
10.1016/s1726-4901(08)70115-1
. [PMID: 18490229] - Alper Sonmez, Mahmut Ilker Yilmaz, Ahmet Korkmaz, Turgut Topal, Kayser Caglar, Ayper Kaya, Tayfun Eyileten, Mujdat Yenicesu, Yusuf Oguz, Seref Basal, Osman Metin Ipcioglu, Abdulgaffar Vural. Hyperbaric oxygen treatment augments the efficacy of cilazapril and simvastatin regimens in an experimental nephrotic syndrome model.
Clinical and experimental nephrology.
2008 Apr; 12(2):110-118. doi:
10.1007/s10157-007-0017-2
. [PMID: 18175058] - Eduardo Cantoni Rosa, Maria Tereza Zanella, Nárcia Elisa Bellucci Kohlmann, Sandra Roberta Gouveia Ferreira, Frida Liane Plavnik, Artur Beltrame Ribeiro, Osvaldo Kohlmann. Blood pressure and cardiorenal responses to antihypertensive therapy in obese women.
Arquivos brasileiros de endocrinologia e metabologia.
2008 Feb; 52(1):65-75. doi:
10.1590/s0004-27302008000100010
. [PMID: 18345398] - Seetha U Monrad, Paul D Killen, Marc R Anderson, Amanda Bradke, Mariana J Kaplan. The role of aldosterone blockade in murine lupus nephritis.
Arthritis research & therapy.
2008; 10(1):R5. doi:
10.1186/ar2353
. [PMID: 18197980] - Leszek Tylicki, Marcin Renke, Przemysław Rutkowski, Wojciech Larczyński, Ewa Aleksandrowicz, Wiesława Lysiak-Szydlowska, Bolesław Rutkowski. Dual blockade of the renin-angiotensin-aldosterone system with high-dose angiotensin-converting enzyme inhibitor for nephroprotection: an open, controlled, randomized study.
Scandinavian journal of urology and nephrology.
2008; 42(4):381-8. doi:
10.1080/00365590801905943
. [PMID: 19230172] - L Tylicki, P Rutkowski, M Renke, B Rutkowski. Addition of aldosterone receptor blocker to dual renin-angiotensin-aldosterone blockade leads to limitation of tubulointerstitial injury of kidney.
Kidney international.
2007 Nov; 72(9):1164-5. doi:
10.1038/sj.ki.5002511
. [PMID: 17943159] - Takashi Nagai, Makoto Imamura, Daishiro Kobayashi, Masatomo Mori. A case report of a diabetic nephropathy patient with cirrhotic ascites treated by peritoneal dialysis.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2007 Feb; 11(1):74-7. doi:
10.1111/j.1744-9987.2007.00464.x
. [PMID: 17309579] - Heon-Woo Lee, Wan-Su Park, Sung-Hee Cho, Min-Hwan Kim, Ji-Hyung Seo, Yong-Won Kim, Sung-Su Kim, Yong-Sup Lee, Kyung-Tae Lee. A liquid chromatography/positive ion tandem mass spectrometry method for the determination of cilazapril and cilazaprilat in human plasma.
Talanta.
2007 Jan; 71(1):62-7. doi:
10.1016/j.talanta.2006.03.020
. [PMID: 19071268] - David G Levitt, Rik C Schoemaker. Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.
BMC clinical pharmacology.
2006 Jan; 6(?):1. doi:
10.1186/1472-6904-6-1
. [PMID: 16398929] - Zhan Averbukh, Sylvia Berman, Shai Efrati, Elena Manevits, Rosa Rosenberg, Ela Malcev, Elena Galperin, Joshua Weissgarten. Blockade of renin-angiotensin system reduces QT dispersion and improves intracellular Ca/Mg status in hemodialysis patients.
Nephron. Clinical practice.
2006; 104(4):c176-84. doi:
10.1159/000095853
. [PMID: 17003569] - Wei-min Li, Wei Han, Zi-jun Liang, Dong-lai Wu, Yong-lin Huang, Shang-jin Cui, Yue Li. [Effect of Cilazapril on endothelial cell function and fibrinolysis system in the canine atrial fibrillation models].
Zhonghua xin xue guan bing za zhi.
2005 May; 33(5):469-72. doi:
NULL
. [PMID: 15932713] - Masaki Asai, Toshiaki Monkawa, Takeshi Marumo, Seiichi Fukuda, Mihoko Tsuji, Jun Yoshino, Hiroshi Kawachi, Fujio Shimizu, Matsuhiko Hayashi, Takao Saruta. Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis.
Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Dec; 27(12):971-8. doi:
10.1291/hypres.27.971
. [PMID: 15894838] - Ruan-Jian Ye, Quan-Ying He, Jun Gai, Ying Shang. [A prospective study on the cough mechanism induced by angiotensin-converting enzyme inhibitors in patients with hypertension].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2004 Sep; 27(9):581-4. doi:
NULL
. [PMID: 15498266] - Chaim Yosefy, Eliahu Magen, Ada Kiselevich, Rita Priluk, Daniel London, Lior Volchek, Reuven J Viskoper. Rosiglitazone improves, while Glibenclamide worsens blood pressure control in treated hypertensive diabetic and dyslipidemic subjects via modulation of insulin resistance and sympathetic activity.
Journal of cardiovascular pharmacology.
2004 Aug; 44(2):215-22. doi:
10.1097/00005344-200408000-00011
. [PMID: 15243303] - R Rachmani, I Slavachevsky, M Amit, Z Levi, Y Kedar, M Berla, M Ravid. The effect of spironolactone, cilazapril and their combination on albuminuria in patients with hypertension and diabetic nephropathy is independent of blood pressure reduction: a randomized controlled study.
Diabetic medicine : a journal of the British Diabetic Association.
2004 May; 21(5):471-5. doi:
10.1111/j.1464-5491.2004.01194.x
. [PMID: 15089793] - Hiroto Matsuda, Koichi Hayashi, Shu Wakino, Eiji Kubota, Masanori Honda, Hirobumi Tokuyama, Ichiro Takamatsu, Satoru Tatematsu, Takao Saruta. Role of endothelium-derived hyperpolarizing factor in ACE inhibitor-induced renal vasodilation in vivo.
Hypertension (Dallas, Tex. : 1979).
2004 Mar; 43(3):603-9. doi:
10.1161/01.hyp.0000118053.42262.71
. [PMID: 14769805] - Koh-Ichi Sugimoto, Shuichi Tsuruoka, Akio Fujimura. Sustained plasma fibrinogen elevation in subtotal nephrectomized rats: effect of cilazapril, an angiotensin-converting enzyme inhibitor.
Journal of pharmacological sciences.
2004 Jan; 94(1):67-72. doi:
10.1254/jphs.94.67
. [PMID: 14745120] - Hui Lin, Songmin Huang, Xuhua Mi, Zhaohui Sha. [Effects of cilazapril on the expression of vascular endothelial growth factor and intercellular adhesion molecule-1 in diabetic rat glomeruli].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2003 Oct; 34(4):694-7. doi:
NULL
. [PMID: 14619584] - Osamah Hussein, Arman Radan, Viskoper Reuven. Effect of cilazapril with or without low dose thiazide on LDL peroxidation in [correction of peroxidationin] hypertensive patients.
American journal of hypertension.
2003 Sep; 16(9 Pt 1):734-8. doi:
10.1016/s0895-7061(03)00977-4
. [PMID: 12944031] - Su-min Yang, Quan-ying He, Yi-de Miao. [The relationship between polymorphism of angiotensin converting enzyme gene and cough caused by angiotensin converting enzyme inhibitors].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2003 Apr; 26(4):203-5. doi:
NULL
. [PMID: 12901825] - Noboru Fukuda, Mari Nakayama, Teng Jian, Chikara Satoh, Tomohiro Nakayama, Masayoshi Soma, Yoichi Izumi, Katsuo Kanmatsuse. Leukocyte angiotensin II levels inpatients with essential hypertension:relation to insulin resistance.
American journal of hypertension.
2003 Feb; 16(2):129-34. doi:
10.1016/s0895-7061(02)03145-x
. [PMID: 12559679] - Shuei-Liong Lin, Yung-Ming Chen, Chiang-Ting Chien, Wen-Chih Chiang, Chien-Chen Tsai, Tun-Jun Tsai. Pentoxifylline attenuated the renal disease progression in rats with remnant kidney.
Journal of the American Society of Nephrology : JASN.
2002 Dec; 13(12):2916-29. doi:
10.1097/01.asn.0000034909.10994.8a
. [PMID: 12444210] - Islam Khan, Khaled K Al-Qattan, Majed A Alnaqeeb, Muslim Ali. Altered expression of Na(+)/H(+) exchanger isoforms 1 and 3 in clipped and unclipped kidneys of a 2-kidney-1-clip Goldblatt model of hypertension.
Nephron.
2002 Oct; 92(2):346-55. doi:
10.1159/000063308
. [PMID: 12218313] - Hirobumi Tokuyama, Koichi Hayashi, Hiroto Matsuda, Eiji Kubota, Masanori Honda, Ken Okubo, Ichiro Takamatsu, Satoru Tatematsu, Yuri Ozawa, Shu Wakino, Takao Saruta. Differential regulation of elevated renal angiotensin II in chronic renal ischemia.
Hypertension (Dallas, Tex. : 1979).
2002 Jul; 40(1):34-40. doi:
10.1161/01.hyp.0000022060.13995.ed
. [PMID: 12105135] - Jing Chen, Yong Gu, Fan Lin, Haichun Yang, Weiyu Zhu, Ji Ma, Shanyan Lin. Endothelin receptor antagonist combined with a calcium channel blocker attenuates renal injury in spontaneous hypertensive rats with diabetes.
Chinese medical journal.
2002 Jul; 115(7):972-8. doi:
NULL
. [PMID: 12150723] - Imran Ahmed Bhutto, Zhong-Yang Lu, Yumiko Takami, Tsugio Amemiya. Retinal and choroidal vasculature in rats with spontaneous diabetes type 2 treated with the angiotensin-converting enzyme inhibitor cilazapril: corrosion cast and electron-microscopic study.
Ophthalmic research.
2002 Jul; 34(4):220-31. doi:
10.1159/000063877
. [PMID: 12297695] - Norio Komai, Mitsuru Ohishi, Ryuichi Morishita, Atsushi Moriguchi, Masaharu Kaibe, Keiko Matsumoto, Hiromi Rakugi, Jitsuo Higaki, Toshio Ogihara. Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients.
American journal of hypertension.
2002 Jun; 15(6):499-506. doi:
10.1016/s0895-7061(02)02274-4
. [PMID: 12074350] - Masashi Namba, Shokei Kim, Yumei Zhan, Takafumi Nakao, Hiroshi Iwao. Combination treatment with a calcium channel blocker and an angiotensin blocker in a rat systolic heart failure model with hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
2002 May; 25(3):461-6. doi:
10.1291/hypres.25.461
. [PMID: 12135327] - Kohji Takara, Mikio Kakumoto, Yusuke Tanigawara, Junko Funakoshi, Toshiyuki Sakaeda, Katsuhiko Okumura. Interaction of digoxin with antihypertensive drugs via MDR1.
Life sciences.
2002 Feb; 70(13):1491-500. doi:
10.1016/s0024-3205(01)01494-1
. [PMID: 11895100] - Yong Gu, Jing Chen, Haichun Yang, Weiyu Zhu, Fan Lin, Chunxiao Zhu, Shantan Lin. [The effects of endothelin blockade on renal expression of angiotensin II type 1 receptor in diabetic hypertensive rats].
Zhonghua yi xue za zhi.
2002 Jan; 82(1):10-3. doi:
NULL
. [PMID: 11953118] - Jessica C Song, C Michael White. Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update.
Clinical pharmacokinetics.
2002; 41(3):207-24. doi:
10.2165/00003088-200241030-00005
. [PMID: 11929321] - N Lakusić, D Mahović, N Ciglenecki, R Kurnik, D Cerovec, M Majsec. [Reversible impairment of renal function during treatment with lisinopril, an ACE-inhibitor (case report)].
Lijecnicki vjesnik.
2001 Sep; 123(9-10):245-8. doi:
NULL
. [PMID: 11845579] - R Veelken, C Delles, K F Hilgers, R E Schmieder. Outcome survey in unselected hypertensive patients with type 2 diabetes mellitus: effects of ACE inhibition.
American journal of hypertension.
2001 Jul; 14(7 Pt 1):672-8. doi:
10.1016/s0895-7061(01)01300-0
. [PMID: 11465652] - J A Prieto, U Akesolo, R M Jiménez, R M Alonso. Capillary zone electrophoresis applied to the determination of the angiotensin-converting enzyme inhibitor cilazapril and its active metabolite in pharmaceuticals and urine.
Journal of chromatography. A.
2001 May; 916(1-2):279-88. doi:
10.1016/s0021-9673(01)00565-9
. [PMID: 11382302] - D Micic, Lj Bojovic. [Effect of cilazapril on insulin sensitivity in patients with essential arterial hypertension].
Srpski arhiv za celokupno lekarstvo.
2001 May; 129(5-6):124-8. doi:
NULL
. [PMID: 11797459] - J A Prieto, R M Jiménez, R M Alonso, E Ortiz. Determination of the antihypertensive drug cilazapril and its active metabolite cilazaprilat in pharmaceuticals and urine by solid-phase extraction and high-performance liquid chromatography with photometric detection.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 754(1):23-34. doi:
10.1016/s0378-4347(00)00580-6
. [PMID: 11318420] - T Takahashi, E Yamaguchi, K Furuya, Y Kawakami. The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage.
Respiratory medicine.
2001 Feb; 95(2):130-5. doi:
10.1053/rmed.2000.1005
. [PMID: 11217909] - K K Al-Qattan, I Khan, M A Alnaqeeb, M Ali. Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: a possible mechanism of the garlic induced hypotension.
Prostaglandins, leukotrienes, and essential fatty acids.
2001 Jan; 64(1):5-10. doi:
10.1054/plef.2000.0232
. [PMID: 11161580] - O Harmankaya, Y Oztürk, T Bastürk, A Obek. Urinary excretion of N-acetyl-beta-D-glucosaminidase in newly diagnosed essential hypertensive patients and its changes with effective antihypertensive therapy.
International urology and nephrology.
2001; 32(4):583-4. doi:
10.1023/a:1014443217611
. [PMID: 11989546] - K K Al-Qattan. Different levels of hypertension induce opposite diuretic behaviors from the nonclipped kidney in the rat two-kidney, one-clip model.
Kidney & blood pressure research.
2001; 24(1):44-51. doi:
10.1159/000054205
. [PMID: 11174006] - L Barber, J Barrio, M D de Rojas, F Ibañez, C Añó, R Alepuz, R Montero. [Refractory hypotension sustained during general anesthesia due to chronic treatment with angiotensin-converting enzyme inhibitors].
Revista espanola de anestesiologia y reanimacion.
2001 Jan; 48(1):34-7. doi:
NULL
. [PMID: 11234604] - T Fujita, A Satomura, M Hidaka, I Ohsawa, M Endo, H Ohi. Angiotensin-converting enzyme inhibitors improve nephrosis more quickly than calcium antagonists in diabetic patients.
Nephron.
2000 Dec; 86(4):526-8. doi:
10.1159/000045854
. [PMID: 11124614] - H Tomiyama, Y Kimura, Y Sakuma, K Matuno, H Yoshida, N Doba. The effects of monotherapy or combined therapy with an angiotensin converting enzyme inhibitor following initial treatment with calcium channel blockers on residual cardiovascular abnormalities.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2000 Jul; 22(5):493-506. doi:
10.1081/ceh-100100086
. [PMID: 10937840] - C Schmitz, M Gotthardt, S Hinderlich, J R Leheste, V Gross, H Vorum, E I Christensen, F C Luft, S Takahashi, T E Willnow. Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor.
The Journal of biological chemistry.
2000 May; 275(20):15357-62. doi:
10.1074/jbc.275.20.15357
. [PMID: 10809771] - F Otsuka, T Ogura, T Yamauchi, M Sato, H Kataoka, J Kageyama, H Makino. Chronic treatment with angiotensin II type 1 receptor antagonist suppresses glomerular activator protein-1 activity in salt-sensitive hypertensive rats.
Kidney & blood pressure research.
2000; 23(1):35-41. doi:
10.1159/000025952
. [PMID: 10567852] - S Paterna, P Di Pasquale, G Parrinello, A Tuttolomondo, G Follone, A Cardinale, A Ortoleva, F Giambanco, G Abruzzese, D Colomba, P Bologna, P Fernández, A Giubilato, L Valdes, V Albano, G Licata. Comparison of the effects of felodipine and cilazapril on exercise performance in patients with mild to moderate hypertension. A crossover study.
Drugs under experimental and clinical research.
2000; 26(4):125-31. doi:
NULL
. [PMID: 11109512] - E Mervaala, B Dehmel, V Gross, A Lippoldt, J Bohlender, A F Milia, D Ganten, F C Luft. Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes.
Journal of the American Society of Nephrology : JASN.
1999 Aug; 10(8):1669-80. doi:
10.1681/asn.v1081669
. [PMID: 10446934] - K Matsumoto, R Morishita, A Moriguchi, N Tomita, Y Yo, T Nishii, T Nakamura, J Higaki, T Ogihara. Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
1999 Aug; 34(2):279-84. doi:
10.1161/01.hyp.34.2.279
. [PMID: 10454454] - M Kihara, M K Mitsui, Y Mitsui, K Okuda, Y Nakasaka, M Takahashi, J D Schmelzer. Altered vasoreactivity to angiotensin II in experimental diabetic neuropathy: role of nitric oxide.
Muscle & nerve.
1999 Jul; 22(7):920-5. doi:
10.1002/(sici)1097-4598(199907)22:7<920::aid-mus16>3.0.co;2-p
. [PMID: 10398211] - M Clozel, C Qiu, R Osterwalder, A Roeckel, P Bruneval, D Heudes, J P Clozel. Effects of nonpeptide endothelin receptor antagonists in rats with reduced renal mass.
Journal of cardiovascular pharmacology.
1999 Apr; 33(4):611-8. doi:
10.1097/00005344-199904000-00014
. [PMID: 10218732] - T Nakamura, J Obata, H Kimura, S Ohno, Y Yoshida, H Kawachi, F Shimizu. Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis.
Kidney international.
1999 Mar; 55(3):877-89. doi:
10.1046/j.1523-1755.1999.055003877.x
. [PMID: 10027924] - I Ebihara, T Nakamura, N Shimada, H Koide. Increased plasma metalloproteinase-9 concentrations precede development of microalbuminuria in non-insulin-dependent diabetes mellitus.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1998 Oct; 32(4):544-50. doi:
10.1016/s0272-6386(98)70015-0
. [PMID: 9774113] - R Rachmani, Z Levi, I Slavachevsky, E Half-Onn, M Ravid. Effect of an alpha-adrenergic blocker, and ACE inhibitor and hydrochlorothiazide on blood pressure and on renal function in type 2 diabetic patients with hypertension and albuminuria. A randomized cross-over study.
Nephron.
1998 Oct; 80(2):175-82. doi:
10.1159/000045163
. [PMID: 9736816] - J Yee. Plasma matrix metalloproteinase-9 and diabetic microalbuminuria: tip of the iceberg?.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1998 Oct; 32(4):669-71. doi:
10.1016/s0272-6386(98)70035-6
. [PMID: 9774133] - J A Prieto, R M Jiménez, R M Alonso. Quantitative determination of the angiotensin-converting enzyme inhibitor cilazapril and its active metabolite cilazaprilat in pharmaceuticals and urine by high-performance liquid chromatography with amperometric detection.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Sep; 714(2):285-92. doi:
10.1016/s0378-4347(98)00226-6
. [PMID: 9766868] - F Otsuka, T Yamauchi, H Kataoka, Y Mimura, T Ogura, H Makino. Effects of chronic inhibition of ACE and AT1 receptors on glomerular injury in dahl salt-sensitive rats.
The American journal of physiology.
1998 06; 274(6):R1797-806. doi:
10.1152/ajpregu.1998.274.6.r1797
. [PMID: 9841488] - K K al-Qattan, A M Safer, D K al-Hajri. Distention of the lateral intercellular spaces (LIS) in the proximal tubule cells of the non-stenosed kidney of the 2K-1C Goldblatt model of hypertension as evidence of pressure diuresis.
Anatomia, histologia, embryologia.
1998 Jun; 27(3):197-204. doi:
10.1111/j.1439-0264.1998.tb00180.x
. [PMID: 9652149] - S L Burnard, E J McMurchie, W R Leifert, G S Patten, R Muggli, D Raederstorff, R J Head. Cilazapril and dietary gamma-linolenic acid prevent the deficit in sciatic nerve conduction velocity in the streptozotocin diabetic rat.
Journal of diabetes and its complications.
1998 Mar; 12(2):65-73. doi:
10.1016/s1056-8727(97)00072-x
. [PMID: 9559483] - M Imanishi, K Yoshioka, M Okumura, Y Konishi, S Tanaka, S Fujii, G Kimura. Mechanism of decreased albuminuria caused by angiotensin converting enzyme inhibitor in early diabetic nephropathy.
Kidney international. Supplement.
1997 Dec; 63(?):S198-200. doi:
NULL
. [PMID: 9407458] - S Kim, H Wanibuchi, A Hamaguchi, K Miura, S Yamanaka, H Iwao. Angiotensin blockade improves cardiac and renal complications of type II diabetic rats.
Hypertension (Dallas, Tex. : 1979).
1997 Nov; 30(5):1054-61. doi:
10.1161/01.hyp.30.5.1054
. [PMID: 9369255] - Y Sahin, O Kontaş, I I Müderris, M Cankurtaran. Effects of angiotensin converting enzyme inhibitor cilazapril and angiotensin II antagonist saralasin in ovarian hyperstimulation syndrome in the rabbit.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
1997 Aug; 11(4):231-6. doi:
10.3109/09513599709152539
. [PMID: 9272418] - R E Schmieder, R Veelken, H Schobel, P Dominiak, J F Mann, F C Luft. Glomerular hyperfiltration during sympathetic nervous system activation in early essential hypertension.
Journal of the American Society of Nephrology : JASN.
1997 Jun; 8(6):893-900. doi:
10.1681/asn.v86893
. [PMID: 9189855] - Y Hattori, S Atsushi, F Hiroaki, J Toyama. Effects of cilazapril on ventricular arrhythmia in patients with congestive heart failure.
Clinical therapeutics.
1997 May; 19(3):481-6. doi:
10.1016/s0149-2918(97)80132-4
. [PMID: 9220212] - N Futrakul, C Pochanugool, V Sitprija, V Singkhwa, P Futrakul, S Yenrudi, R Sensirivatana, D Watana, M Poshyachinda. Renal dysfunction in glomerulonephropathy associated with rapid onset renal failure.
Renal failure.
1997 Jan; 19(1):77-84. doi:
10.3109/08860229709026262
. [PMID: 9044454] - A Trifiletti, N Barbera, R Scamardi, L Bagnato, M A Pizzoleo, A Nevoso, A Lasco, M Pedullà, N Frisina. Effects of medium-term antihypertensive therapy on haemostatic parameters in patients with essential hypertension.
Haemostasis.
1997 Jan; 27(1):35-8. doi:
10.1159/000217431
. [PMID: 9097084] - B Waeber, P Weidmann, D Wohler, Y Le Bloch. Albuminuria in diabetes mellitus: relation to ambulatory versus office blood pressure and effects of cilazapril.
American journal of hypertension.
1996 Dec; 9(12 Pt 1):1220-7. doi:
10.1016/s0895-7061(96)00055-6
. [PMID: 8972894] - H J Kloke, R J Ambros, H W Van Hamersvelt, J F Wetzels, R A Koene, F T Huysmans. Pharmacokinetics and haemodynamic effects of the angiotensin converting enzyme inhibitor cilazapril in hypertensive patients with normal and impaired renal function.
British journal of clinical pharmacology.
1996 Nov; 42(5):615-20. doi:
10.1111/j.1365-2125.1996.tb00117.x
. [PMID: 8951193] - D Tsagadopoulos, H Antonakoudis, T Makris, V Votteas, G Vyssoulis, A Manolis, D Babalis, N Lefkos, A Achimastos, P Toutouzas. Effect of antihypertensive treatment on lipids and fibrinogen: Greek multicentre study of cilazapril.
Cardiology.
1996 Nov; 87(6):524-8. doi:
10.1159/000177149
. [PMID: 8904681] - J S Li, P Sventek, E L Schiffrin. Effect of antihypertensive treatment and N omega-nitro-L-arginine methyl ester on cardiovascular structure in deoxycorticosterone acetate-salt hypertensive rats.
Journal of hypertension.
1996 Nov; 14(11):1331-9. doi:
10.1097/00004872-199611000-00012
. [PMID: 8934362] - R E Schmieder, H P Schobel, C E Gatzka, W Häuser, P Dominiak, J F Mann, F C Luft. Effects of angiotensin converting enzyme inhibitor on renal haemodynamics during mental stress.
Journal of hypertension.
1996 Oct; 14(10):1201-7. doi:
10.1097/00004872-199610000-00008
. [PMID: 8906519] - A Himmelmann, L Hansson, B G Hansson, H Hedstrand, K Skogström, J Ohrvik, A Furängen. Long-term renal preservation in essential hypertension. Angiotensin converting enzyme inhibition is superior to beta-blockade.
American journal of hypertension.
1996 Sep; 9(9):850-3. doi:
10.1016/s0895-7061(96)00176-8
. [PMID: 8879340] - K Skov, J Fenger-Grøn, M J Mulvany. Effects of an angiotensin-converting enzyme inhibitor, a calcium antagonist, and an endothelin receptor antagonist on renal afferent arteriolar structure.
Hypertension (Dallas, Tex. : 1979).
1996 Sep; 28(3):464-71. doi:
10.1161/01.hyp.28.3.464
. [PMID: 8794834] - M Campelo, J Polónia, P Serrão, M Cerqueira-Gomes. Evaluation of the sympathetic nervous system using heart rate variability and plasma hormones in hypertensive patients treated with cilazapril and atenolol.
Cardiology.
1996 Sep; 87(5):402-8. doi:
10.1159/000177128
. [PMID: 8894261] - J Buján, J M Bellón, F Jurado, B Dominguez, M J Gimeno, N García-Honduvilla, A Hernando. Inhibitor of angiotensin-converting enzyme modifies myointimal origin in an arterial autograft model.
Journal of cardiovascular pharmacology.
1996 Aug; 28(2):285-93. doi:
10.1097/00005344-199608000-00016
. [PMID: 8856486] - T Ashida, H Yoshimi, Y Kawano, H Matsuoka, T Omae. Effects of dietary salt and angiotensin-converting enzyme inhibitor on ATP-driven Ca pump and Na/Ca exchange in aortic rings of Dahl rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1996 Aug; 18(6):851-71. doi:
10.3109/10641969609081784
. [PMID: 8842567] - M Uusitupa, M Korhonen, H Litmanen, L Niskanen, S Väisänen, R Rauramaa. Effects of moderate salt restriction alone and in combination with cilazapril on office and ambulatory blood pressure.
Journal of human hypertension.
1996 May; 10(5):319-26. doi:
NULL
. [PMID: 8817406] - T Oishi, T Ogura, T Yamauchi, K Harada, Z Ota. Effect of renin-angiotensin inhibition on glomerular injuries in DOCA-salt hypertensive rats.
Regulatory peptides.
1996 Apr; 62(2-3):89-95. doi:
10.1016/0167-0115(95)00166-2
. [PMID: 8795070] - L Paul, J Muralidharan, H Benediktsson. Glomerulosclerosis in kidney transplants: pathophysiologic mechanisms.
Transplantation proceedings.
1996 Feb; 28(1):480-1. doi:
NULL
. [PMID: 8644319] - T Ebihara, K Sekizawa, T Ohrui, H Nakazawa, H Sasaki. Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs.
American journal of respiratory and critical care medicine.
1996 Feb; 153(2):812-9. doi:
10.1164/ajrccm.153.2.8564137
. [PMID: 8564137] - M Velussi, E Brocco, F Frigato, M Zolli, B Muollo, M Maioli, A Carraro, G Tonolo, P Fresu, A M Cernigoi, P Fioretto, R Nosadini. Effects of cilazapril and amlodipine on kidney function in hypertensive NIDDM patients.
Diabetes.
1996 Feb; 45(2):216-22. doi:
10.2337/diab.45.2.216
. [PMID: 8549868] - S Kuriyama, H Tomonari, O Sakai. Effect of cilazapril on hyperdipsia in hemodialyzed patients.
Blood purification.
1996; 14(1):35-41. doi:
10.1159/000170239
. [PMID: 8718563] - P J Anderson, J A Critchley, B Tomlinson. A comparison of the pharmacokinetics and pharmacodynamics of cilazapril between Chinese and Caucasian healthy, normotensive volunteers.
European journal of clinical pharmacology.
1996; 50(1-2):57-62. doi:
10.1007/s002280050069
. [PMID: 8739812] - M Kohzuki, M Yasujima, M Kanazawa, K Yoshida, T Sato, K Abe. Do kinins mediate cardioprotective and renoprotective effects of cilazapril in spontaneously hypertensive rats with renal ablation?.
Clinical and experimental pharmacology & physiology. Supplement.
1995 Dec; 22(1):S357-9. doi:
10.1111/j.1440-1681.1995.tb02953.x
. [PMID: 9072427] - M R Ogborn, S Sareen, G Pinette. Cilazapril delays progression of hypertension and uremia in rat polycystic kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1995 Dec; 26(6):942-6. doi:
10.1016/0272-6386(95)90059-4
. [PMID: 7503069]