5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (BioDeep_00000179637)

   

human metabolite blood metabolite


代谢物信息卡片


5-({3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl}methyl)pyrimidine-2,4-diamine

  化学式: C20H22N4O3 (366.1692)
中文名称: GW2580
  谱图信息: 最多检出来源 Homo sapiens(blood) 33.33%

分子结构信息

SMILES: COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
InChI: InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)


描述信息

同义名列表

3 个代谢物同义名

5-({3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl}methyl)pyrimidine-2,4-diamine; 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine; GW2580



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Allison Y Louie, Justin S Kim, Jenny Drnevich, Payam Dibaeinia, Hisami Koito, Saurabh Sinha, Daniel B McKim, Katiria Soto-Diaz, Romana A Nowak, Aditi Das, Andrew J Steelman. Influenza A virus infection disrupts oligodendrocyte homeostasis and alters the myelin lipidome in the adult mouse. Journal of neuroinflammation. 2023 Aug; 20(1):190. doi: 10.1186/s12974-023-02862-2. [PMID: 37596606]
  • Xuan Deng, Qian Yang, Yuxi Wang, Cheng Zhou, Yi Guo, Zhizhi Hu, Wenhui Liao, Gang Xu, Rui Zeng. CSF-1R inhibition attenuates ischemia-induced renal injury and fibrosis by reducing Ly6C+ M2-like macrophage infiltration. International immunopharmacology. 2020 Nov; 88(?):106854. doi: 10.1016/j.intimp.2020.106854. [PMID: 32771945]
  • Yasutaka Miyachi, Kyoichiro Tsuchiya, Kumiko Shiba, Kentaro Mori, Chikara Komiya, Naomi Ogasawara, Yoshihiro Ogawa. A reduced M1-like/M2-like ratio of macrophages in healthy adipose tissue expansion during SGLT2 inhibition. Scientific reports. 2018 10; 8(1):16113. doi: 10.1038/s41598-018-34305-x. [PMID: 30382157]
  • Samantha A Chalmers, Jing Wen, Justine Shum, Jessica Doerner, Leal Herlitz, Chaim Putterman. CSF-1R inhibition attenuates renal and neuropsychiatric disease in murine lupus. Clinical immunology (Orlando, Fla.). 2017 12; 185(?):100-108. doi: 10.1016/j.clim.2016.08.019. [PMID: 27570219]
  • Nozha Borjini, Mercedes Fernández, Luciana Giardino, Laura Calzà. Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. Journal of neuroinflammation. 2016 11; 13(1):291. doi: 10.1186/s12974-016-0757-6. [PMID: 27846891]
  • Samantha A Chalmers, Violeta Chitu, Leal C Herlitz, Ranjit Sahu, E Richard Stanley, Chaim Putterman. Macrophage depletion ameliorates nephritis induced by pathogenic antibodies. Journal of autoimmunity. 2015 Feb; 57(?):42-52. doi: 10.1016/j.jaut.2014.11.007. [PMID: 25554644]