2-[4-[2-[(2,4-Difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulfanyl-2-methylpropanoic acid (BioDeep_00000179634)

   

human metabolite blood metabolite


代谢物信息卡片


2-{[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)amino}ethyl)phenyl]sulfanyl}-2-methylpropanoic acid

化学式: C26H34F2N2O3S (492.2258078000001)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCN(CCC1=CC=C(C=C1)SC(C)(C)C(=O)O)C(=O)NC2=C(C=C(C=C2)F)F
InChI: InChI=1S/C26H34F2N2O3S/c1-4-5-6-7-8-16-30(25(33)29-23-14-11-20(27)18-22(23)28)17-15-19-9-12-21(13-10-19)34-26(2,3)24(31)32/h9-14,18H,4-8,15-17H2,1-3H3,(H,29,33)(H,31,32)

描述信息

同义名列表

5 个代谢物同义名

2-{[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)amino}ethyl)phenyl]sulfanyl}-2-methylpropanoic acid; 2-[4-[2-[(2,4-Difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulphanyl-2-methylpropanoic acid; 2-[4-[2-[(2,4-Difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulfanyl-2-methylpropanoic acid; 2-[4-[2-[(2,4-Difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulphanyl-2-methylpropanoate; 2-[4-[2-[(2,4-Difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulfanyl-2-methylpropanoate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Klaus Urbahns, Michael Woltering, Susanne Nikolic, Josef Pernerstorfer, Hilmar Bischoff, Elke Dittrich-Wengenroth, Klemens Lustig. Glycine amides as PPARalpha agonists. Bioorganic & medicinal chemistry letters. 2010 Jun; 20(11):3376-9. doi: 10.1016/j.bmcl.2010.04.019. [PMID: 20452212]
  • Jay M Matthews, Xiaoli Chen, Ellen Cryan, Dennis J Hlasta, Philip J Rybczynski, Kim Strauss, Yuting Tang, June Z Xu, Maria Yang, Lubing Zhou, Keith T Demarest. Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. Bioorganic & medicinal chemistry letters. 2007 Dec; 17(24):6773-8. doi: 10.1016/j.bmcl.2007.10.041. [PMID: 18029176]
  • Takafumi Nakamachi, Takashi Nomiyama, Florence Gizard, Elizabeth B Heywood, Karrie L Jones, Yue Zhao, Lucia Fuentes, Kohzo Takebayashi, Yoshimasa Aso, Bart Staels, Toshihiko Inukai, Dennis Bruemmer. PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes. Diabetes. 2007 Jun; 56(6):1662-70. doi: 10.2337/db06-1177. [PMID: 17360982]
  • Hee Oon Han, Seung Hae Kim, Kyoung-Hee Kim, Gwong-Cheung Hur, Hyeon Joo Yim, Hee-Kyung Chung, Sung Ho Woo, Ki Dong Koo, Chang-Seok Lee, Jong Sung Koh, Geun Tae Kim. Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists. Bioorganic & medicinal chemistry letters. 2007 Feb; 17(4):937-41. doi: 10.1016/j.bmcl.2006.11.050. [PMID: 17157019]
  • Phillip C C Liu, Reid Huber, Mark D Stow, Karen L Schlingmann, Paul Collier, Boshan Liao, John Link, Tim C Burn, Greg Hollis, Peter R Young, Ranjan Mukherjee. Induction of endogenous genes by peroxisome proliferator activated receptor alpha ligands in a human kidney cell line and in vivo. The Journal of steroid biochemistry and molecular biology. 2003 May; 85(1):71-9. doi: 10.1016/s0960-0760(03)00135-3. [PMID: 12798359]
  • Tal M Lewin, Cynthia G Van Horn, Skaidrite K Krisans, Rosalind A Coleman. Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. Archives of biochemistry and biophysics. 2002 Aug; 404(2):263-70. doi: 10.1016/s0003-9861(02)00247-3. [PMID: 12147264]
  • B E Gould Rothberg, S S Sundseth, V A DiPippo, P J Brown, D A Winegar, W K Gottshalk, S G Shenoy, J M Rothberg. The characterization of PPAR alpha ligand drug action in an in vivo model by comprehensive differential gene expression profiling. Functional & integrative genomics. 2001 Sep; 1(5):294-304. doi: 10.1007/s101420000022. [PMID: 11793248]
  • P J Brown, L W Stuart, K P Hurley, M C Lewis, D A Winegar, J G Wilson, W O Wilkison, O R Ittoop, T M Willson. Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. Bioorganic & medicinal chemistry letters. 2001 May; 11(9):1225-7. doi: 10.1016/s0960-894x(01)00188-3. [PMID: 11354382]
  • M Guerre-Millo, P Gervois, E Raspé, L Madsen, P Poulain, B Derudas, J M Herbert, D A Winegar, T M Willson, J C Fruchart, R K Berge, B Staels. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. The Journal of biological chemistry. 2000 Jun; 275(22):16638-42. doi: 10.1074/jbc.275.22.16638. [PMID: 10828060]
  • P J Brown, D A Winegar, K D Plunket, L B Moore, M C Lewis, J G Wilson, S S Sundseth, C S Koble, Z Wu, J M Chapman, J M Lehmann, S A Kliewer, T M Willson. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. Journal of medicinal chemistry. 1999 Sep; 42(19):3785-8. doi: 10.1021/jm9903601. [PMID: 10508427]
  • K K Brown, B R Henke, S G Blanchard, J E Cobb, R Mook, I Kaldor, S A Kliewer, J M Lehmann, J M Lenhard, W W Harrington, P J Novak, W Faison, J G Binz, M A Hashim, W O Oliver, H R Brown, D J Parks, K D Plunket, W Q Tong, J A Menius, K Adkison, S A Noble, T M Willson. A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes. 1999 Jul; 48(7):1415-24. doi: 10.2337/diabetes.48.7.1415. [PMID: 10389847]