3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole (BioDeep_00000179603)

   

human metabolite blood metabolite


代谢物信息卡片


3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole

化学式: C23H28N4O4S (456.18311680000005)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1=NOC(=N1)N1CCC(COC2=CC=C(N=C2)C2=CC=C(C=C2)S(C)(=O)=O)CC1
InChI: InChI=1S/C23H28N4O4S/c1-16(2)22-25-23(31-26-22)27-12-10-17(11-13-27)15-30-19-6-9-21(24-14-19)18-4-7-20(8-5-18)32(3,28)29/h4-9,14,16-17H,10-13,15H2,1-3H3

描述信息

同义名列表

4 个代谢物同义名

3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole; 2-(4-methanesulfonylphenyl)-5-({1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}methoxy)pyridine; 5-{[1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]methoxy}-2-(4-methanesulfonylphenyl)pyridine; (1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methyl methanesulfonate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Koji Matsumoto, Tomomi Yoshitomi, Yoko Ishimoto, Naomi Tanaka, Kanako Takahashi, Akiko Watanabe, Katsuyoshi Chiba. DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats. The Journal of pharmacology and experimental therapeutics. 2018 12; 367(3):509-517. doi: 10.1124/jpet.118.250019. [PMID: 30217957]
  • Yuanying Fang, Jun Xu, Zhifeng Li, Zunhua Yang, Lijuan Xiong, Yi Jin, Qi Wang, Saisai Xie, Wufu Zhu, Sheng Chang. Design and synthesis of novel pyrimido[5,4-d]pyrimidine derivatives as GPR119 agonist for treatment of type 2 diabetes. Bioorganic & medicinal chemistry. 2018 08; 26(14):4080-4087. doi: 10.1016/j.bmc.2018.06.035. [PMID: 30100020]
  • Suhong Fu, Wei Xiang, Jinying Chen, Liang Ma, Lijuan Chen. Synthesis and biological evaluation of 1, 2, 4-oxadiazole derivatives as novel GPR119 agonists. Chemical biology & drug design. 2017 05; 89(5):815-819. doi: 10.1111/cbdd.12890. [PMID: 27779815]
  • Umakant Ashok Bahirat, Rekha Raghuveer Shenoy, Rajan Naresh Goel, Kumar V S Nemmani. APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice. European journal of pharmacology. 2017 Apr; 801(?):35-45. doi: 10.1016/j.ejphar.2017.02.043. [PMID: 28274625]
  • Jin Won Yang, Hyo Seon Kim, Ji Hye Im, Ji Won Kim, Dae Won Jun, Sung Chul Lim, Kyeong Lee, Jong Min Choi, Sang Kyum Kim, Keon Wook Kang. GPR119: a promising target for nonalcoholic fatty liver disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Jan; 30(1):324-35. doi: 10.1096/fj.15-273771. [PMID: 26399788]
  • Derek J Nunez, Mark A Bush, David A Collins, Susan L McMullen, Dawn Gillmor, Glen Apseloff, George Atiee, Leonor Corsino, Linda Morrow, Paul L Feldman. Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies. PloS one. 2014; 9(4):e92494. doi: 10.1371/journal.pone.0092494. [PMID: 24699248]
  • Joseph W Polli, Elizabeth Hussey, Mark Bush, Grant Generaux, Glenn Smith, David Collins, Susan McMullen, Nancy Turner, Derek J Nunez. Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design. Xenobiotica; the fate of foreign compounds in biological systems. 2013 Jun; 43(6):498-508. doi: 10.3109/00498254.2012.739719. [PMID: 23256625]
  • D Böning, U Meier, W Skipka, W R Külpmann, K A Meurer. Some evidence for aldosterone action on 2,3-diphosphoglycerate level in human red cells. Metabolism: clinical and experimental. 1976 Jan; 25(1):9-14. doi: 10.1016/0026-0495(76)90154-2. [PMID: 1630]