Grapiprant (BioDeep_00000179590)

   

human metabolite blood metabolite


代谢物信息卡片


2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)-N-(4-methylbenzenesulphonyl)ethane-1-carbamimidic acid

化学式: C26H29N5O3S (491.1991004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=NC2=C(C)N=C(C)C=C2N1C1=CC=C(CCNC(=O)NS(=O)(=O)C2=CC=C(C)C=C2)C=C1
InChI: InChI=1S/C26H29N5O3S/c1-5-24-29-25-19(4)28-18(3)16-23(25)31(24)21-10-8-20(9-11-21)14-15-27-26(32)30-35(33,34)22-12-6-17(2)7-13-22/h6-13,16H,5,14-15H2,1-4H3,(H2,27,30,32)

描述信息

C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
C177182 - Prostaglandin Receptor Antagonist
C274 - Antineoplastic Agent

同义名列表

9 个代谢物同义名

2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)-N-(4-methylbenzenesulphonyl)ethane-1-carbamimidic acid; 2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)-N-(4-methylbenzenesulphonyl)ethane-1-carbamimidate; 2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)-N-(4-methylbenzenesulfonyl)ethane-1-carbamimidate; 3-[2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)ethyl]-1-(4-methylbenzenesulfonyl)urea; 3-[2-(4-{2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl}phenyl)ethyl]-1-(4-methylbenzenesulfonyl)urea; 1-(2-(4-(2-Ethyl-4,6-dimethylimidazo(4,5-c)pyridin-1-yl)phenyl)ethyl)-3-(4-methylphenyl)sulfonylurea; AAT-007CJ-023grapiprant; RQ-7MR10a7; Grapiprant



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Paula Rodriguez, Joanne R Paul-Murphy, Heather K Knych, Tracy L Drazenovich, Michelle G Hawkins. Absorption of grapiprant in red-tailed hawks (Buteo jamaicensis) is decreased when administered with food. American journal of veterinary research. 2022 May; 83(6):. doi: 10.2460/ajvr.21.10.0170. [PMID: 35524955]
  • Mark C Heit, Katrina L Mealey, Stephen B King. Tolerance and Pharmacokinetics of Galliprant™ Administered Orally to Collies Homozygous for MDR1-1Δ. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):705-713. doi: 10.1111/jvp.12984. [PMID: 34219249]
  • Heather K Knych, Kelsey Seminoff, Dan S McKemie. Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses. Drug testing and analysis. 2018 Mar; ?(?):. doi: 10.1002/dta.2378. [PMID: 29575649]
  • B Lebkowska-Wieruszewska, V De Vito, H Owen, A Poapholatep, M Giorgi. Pharmacokinetics of grapiprant, a selective EP4 prostaglandin PGE2 receptor antagonist, after 2 mg/kg oral and i.v. administrations in cats. Journal of veterinary pharmacology and therapeutics. 2017 Dec; 40(6):e11-e15. doi: 10.1111/jvp.12414. [PMID: 28459136]
  • A Nagahisa, T Okumura. Pharmacology of grapiprant, a novel EP4 antagonist: receptor binding, efficacy in a rodent postoperative pain model, and a dose estimation for controlling pain in dogs. Journal of veterinary pharmacology and therapeutics. 2017 Jun; 40(3):285-292. doi: 10.1111/jvp.12349. [PMID: 27597397]
  • B Łebkowska-Wieruszewska, G Barsotti, A Lisowski, A Gazzano, H Owen, M Giorgi. Pharmacokinetics and estimated bioavailability of grapiprant, a novel selective prostaglandin E2 receptor antagonist, after oral administration in fasted and fed dogs. New Zealand veterinary journal. 2017 Jan; 65(1):19-23. doi: 10.1080/00480169.2016.1241727. [PMID: 27691904]
  • Virgina De Vito, Alessandro Saba, Hong-Ki Lee, Helen Owen, Amnart Poapolathep, Mario Giorgi. Detection and quantification of the selective EP4 receptor antagonist CJ-023423 (grapiprant) in canine plasma by HPLC with spectrofluorimetric detection. Journal of pharmaceutical and biomedical analysis. 2016 Jan; 118(?):251-258. doi: 10.1016/j.jpba.2015.11.004. [PMID: 26580822]