Gramicidin S (BioDeep_00000179585)
human metabolite blood metabolite
代谢物信息卡片
9,27-bis(3-aminopropyl)-3,21-dibenzyl-6,24-bis(2-methylpropyl)-12,30-bis(propan-2-yl)-1,4,7,10,13,19,22,25,28,31-decaazatricyclo[31.3.0.0^{15,19}]hexatriacontane-2,5,8,11,14,20,23,26,29,32-decone
化学式: C60H92N12O10 (1140.7059012)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3CCCC3C(=O)NC(C(=O)NC(C(=O)N1)CCCN)C(C)C)CC4=CC=CC=C4)CC(C)C)CCCN)C(C)C)CC5=CC=CC=C5
InChI: InChI=1S/C60H92N12O10/c1-35(2)31-43-53(75)67-45(33-39-19-11-9-12-20-39)59(81)71-29-17-25-47(71)55(77)70-50(38(7)8)58(80)64-42(24-16-28-62)52(74)66-44(32-36(3)4)54(76)68-46(34-40-21-13-10-14-22-40)60(82)72-30-18-26-48(72)56(78)69-49(37(5)6)57(79)63-41(23-15-27-61)51(73)65-43/h9-14,19-22,35-38,41-50H,15-18,23-34,61-62H2,1-8H3,(H,63,79)(H,64,80)(H,65,73)(H,66,74)(H,67,75)(H,68,76)(H,69,78)(H,70,77)
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
4 个代谢物同义名
9,27-bis(3-aminopropyl)-3,21-dibenzyl-6,24-bis(2-methylpropyl)-12,30-bis(propan-2-yl)-1,4,7,10,13,19,22,25,28,31-decaazatricyclo[31.3.0.0^{15,19}]hexatriacontane-2,5,8,11,14,20,23,26,29,32-decone; 9,27-bis(3-aminopropyl)-3,21-dibenzyl-12,30-diisopropyl-6,24-bis(2-methylpropyl)-1,4,7,10,13,19,22,25,28,31-decaazatricyclo[31.3.0.0^{15,19}]hexatriacontane-2,5,8,11,14,20,23,26,29,32-decone; Gramicidin S; Gramicidin C
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 3851247
- HMDB: HMDB0252932
- Wikipedia: Gramicidin S
- MeSH: Gramicidin
- chemspider: 3076403
- RefMet: Gramicidin S
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohammad Ashrafuzzaman, Roger E Koeppe, Olaf S Andersen. Intrinsic Lipid Curvature and Bilayer Elasticity as Regulators of Channel Function: A Comparative Single-Molecule Study.
International journal of molecular sciences.
2024 Feb; 25(5):. doi:
10.3390/ijms25052758. [PMID: 38474005] - Yukun Chen, Gábor Méhes, Bingfu Liu, Liyun Gao, Mingyin Cui, Chenliang Lin, Yoko Hirono-Hara, Kiyotaka Y Hara, Noriyo Mitome, Takeo Miyake. Proton Logic Gate Based on a Gramicidin-ATP Synthase Integrated Biotransducer.
ACS applied materials & interfaces.
2024 Feb; 16(6):7480-7488. doi:
10.1021/acsami.3c15251. [PMID: 38295806] - Tatiana K Rostovtseva, Michael Weinrich, Daniel Jacobs, William M Rosencrans, Sergey M Bezrukov. Dimeric Tubulin Modifies Mechanical Properties of Lipid Bilayer, as Probed Using Gramicidin A Channel.
International journal of molecular sciences.
2024 Feb; 25(4):. doi:
10.3390/ijms25042204. [PMID: 38396879] - Farzaneh Pourmasoumi, Sundar Hengoju, Katharina Beck, Philipp Stephan, Lukas Klopfleisch, Maria Hoernke, Miriam A Rosenbaum, Hajo Kries. Analysing Megasynthetase Mutants at High Throughput Using Droplet Microfluidics.
Chembiochem : a European journal of chemical biology.
2023 12; 24(24):e202300680. doi:
10.1002/cbic.202300680. [PMID: 37804133] - Md Moniruzzaman, Mohammad Abu Sayem Karal, Md Abdul Wadud, Md Mamun Or Rashid. Increase in anionic Fe3O4 nanoparticle-induced membrane poration and vesicle deformation due to membrane potential - an experimental study.
Physical chemistry chemical physics : PCCP.
2023 Aug; 25(34):23111-23124. doi:
10.1039/d3cp02702c. [PMID: 37602684] - Alison Rodger, Junya Kitamura, Akihiro Sato, Ping Shao. Couette flow fluorescence detected linear dichroism for analytes in lipid bilayers.
Chirality.
2023 08; 35(8):498-504. doi:
10.1002/chir.23554. [PMID: 36895102] - Xiao Li, Xinyuan Sun, Zhongyi Yan, Zhenxiang Zhao, Zhaojun Pang, Han Yang, Xiaoxin Ji, Yi Lei, Zixiang Zhu, Xiangqian Guo, Xin Mu. New role of gramicidin A in RIG-I-like receptors-mediated IFN signalling.
Immunology.
2023 06; 169(2):219-228. doi:
10.1111/imm.13626. [PMID: 36683251] - Thasin A Peyear, Olaf S Andersen. Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function.
The Journal of general physiology.
2023 04; 155(4):. doi:
10.1085/jgp.202213247. [PMID: 36763053] - Vladimir I Novoderezhkin, Tatyana I Rokitskaya, Elena A Kotova, Yuri N Antonenko. Synchronization of opening and closing of two gramicidin A channels pulled together by a linker: possible relevance to channel clustering.
Physical chemistry chemical physics : PCCP.
2023 Feb; 25(5):3752-3757. doi:
10.1039/d2cp04884a. [PMID: 36644888] - Alexander M Firsov, Juergen Pfeffermann, Anton S Benditkis, Tatyana I Rokitskaya, Anton S Kozlov, Elena A Kotova, Alexander A Krasnovsky, Peter Pohl, Yuri N Antonenko. Photodynamic activity rather than drilling causes membrane damage by a light-powered molecular nanomotor.
Journal of photochemistry and photobiology. B, Biology.
2023 Feb; 239(?):112633. doi:
10.1016/j.jphotobiol.2022.112633. [PMID: 36608401] - Shang-Ting Fang, Shu-Hsiang Huang, Chin-Hao Yang, Jen-Wen Liou, Hemalatha Mani, Yi-Cheng Chen. Effects of Calcium Ions on the Antimicrobial Activity of Gramicidin A.
Biomolecules.
2022 12; 12(12):. doi:
10.3390/biom12121799. [PMID: 36551225] - Marcus Fletcher, Jinbo Zhu, Roger Rubio-Sánchez, Sarah E Sandler, Kareem Al Nahas, Lorenzo Di Michele, Ulrich F Keyser, Ran Tivony. DNA-Based Optical Quantification of Ion Transport across Giant Vesicles.
ACS nano.
2022 10; 16(10):17128-17138. doi:
10.1021/acsnano.2c07496. [PMID: 36222833] - Svetlana S Efimova, Vera A Martynyuk, Anastasiia A Zakharova, Natalia M Yudintceva, Nikita M Chernov, Igor P Yakovlev, Olga S Ostroumova. Chromone-Containing Allylmorpholines Influence Ion Channels in Lipid Membranes via Dipole Potential and Packing Stress.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911554. [PMID: 36232854] - Aleksandra Buta, Ewa Nazaruk, Damian Dziubak, Adam Szewczyk, Renata Bilewicz. Properties of electrode-supported lipid cubic mesophase films with embedded gramicidin A: structure and ion-transport studies.
Bioelectrochemistry (Amsterdam, Netherlands).
2022 Apr; 144(?):108042. doi:
10.1016/j.bioelechem.2021.108042. [PMID: 34942573] - Amani Alghalayini, Charles G Cranfield, Bruce A Cornell, Stella M Valenzuela. Preparing Ion Channel Switch Membrane-Based Biosensors.
Methods in molecular biology (Clifton, N.J.).
2022; 2402(?):13-20. doi:
10.1007/978-1-0716-1843-1_2. [PMID: 34854032] - Aldrin V Vasco, Manuel G Ricardo, Daniel G Rivera, Ludger A Wessjohann. Ligation, Macrocyclization, and Simultaneous Functionalization of Peptides by Multicomponent Reactions (MCR).
Methods in molecular biology (Clifton, N.J.).
2022; 2371(?):143-157. doi:
10.1007/978-1-0716-1689-5_8. [PMID: 34596847] - Mohammad-Reza Ghovanloo, Samuel J Goodchild, Peter C Ruben. Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study.
PloS one.
2022; 17(8):e0271801. doi:
10.1371/journal.pone.0271801. [PMID: 35913948] - Oleg V Kondrashov, Tatyana I Rokitskaya, Oleg V Batishchev, Elena A Kotova, Yuri N Antonenko, Sergey A Akimov. Peptide-induced membrane elastic deformations decelerate gramicidin dimer-monomer equilibration.
Biophysical journal.
2021 12; 120(23):5309-5321. doi:
10.1016/j.bpj.2021.10.030. [PMID: 34715080] - Radda Rusinova, Changhao He, Olaf S Andersen. Mechanisms underlying drug-mediated regulation of membrane protein function.
Proceedings of the National Academy of Sciences of the United States of America.
2021 11; 118(46):. doi:
10.1073/pnas.2113229118. [PMID: 34753824] - Juergen Pfeffermann, Barbara Eicher, Danila Boytsov, Christof Hannesschlaeger, Timur R Galimzyanov, Toma N Glasnov, Georg Pabst, Sergey A Akimov, Peter Pohl. Photoswitching of model ion channels in lipid bilayers.
Journal of photochemistry and photobiology. B, Biology.
2021 Nov; 224(?):112320. doi:
10.1016/j.jphotobiol.2021.112320. [PMID: 34600201] - Elizabeth G Kelley, Paul D Butler, Michihiro Nagao. Collective dynamics in lipid membranes containing transmembrane peptides.
Soft matter.
2021 Jun; 17(23):5671-5681. doi:
10.1039/d1sm00314c. [PMID: 33942045] - Wei-Wei Haoyang, Qi Xiao, Zhongju Ye, Yonghong Fu, Dan-Wei Zhang, Jian Li, Lehui Xiao, Zhan-Ting Li, Jun-Li Hou. Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis.
Chemical communications (Cambridge, England).
2021 Feb; 57(9):1097-1100. doi:
10.1039/d0cc08073j. [PMID: 33443269] - Chengfei Hu, Quan Wen, Shuhui Huang, Saisai Xie, Yuanying Fang, Yi Jin, Rémy Campagne, Valérie Alezra, Emeric Miclet, Jinhua Zhu, Yang Wan. Gramicidin-S-Inspired Cyclopeptidomimetics as Potent Membrane-Active Bactericidal Agents with Therapeutic Potential.
ChemMedChem.
2021 01; 16(2):368-376. doi:
10.1002/cmdc.202000568. [PMID: 33026182] - Delin Sun, Stewart He, W F Drew Bennett, Camille L Bilodeau, Olaf S Andersen, Felice C Lightstone, Helgi I Ingólfsson. Atomistic Characterization of Gramicidin Channel Formation.
Journal of chemical theory and computation.
2021 Jan; 17(1):7-12. doi:
10.1021/acs.jctc.0c00989. [PMID: 33378617] - Isabel U Foreman-Ortiz, Dongyue Liang, Elizabeth D Laudadio, Jorge D Calderin, Meng Wu, Puspam Keshri, Xianzhi Zhang, Michael P Schwartz, Robert J Hamers, Vincent M Rotello, Catherine J Murphy, Qiang Cui, Joel A Pedersen. Anionic nanoparticle-induced perturbation to phospholipid membranes affects ion channel function.
Proceedings of the National Academy of Sciences of the United States of America.
2020 11; 117(45):27854-27861. doi:
10.1073/pnas.2004736117. [PMID: 33106430] - Delin Sun, Thasin A Peyear, W F Drew Bennett, Matthew Holcomb, Stewart He, Fangqiang Zhu, Felice C Lightstone, Olaf S Andersen, Helgi I Ingólfsson. Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based In Silico and In Vitro Assays.
Journal of medicinal chemistry.
2020 10; 63(20):11809-11818. doi:
10.1021/acs.jmedchem.0c00958. [PMID: 32945672] - Yuri Takada, Hiroaki Itoh, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library.
Nature communications.
2020 10; 11(1):4935. doi:
10.1038/s41467-020-18711-2. [PMID: 33004797] - Amani Alghalayini, Lele Jiang, Xi Gu, Guan Heng Yeoh, Charles G Cranfield, Victoria Timchenko, Bruce A Cornell, Stella M Valenzuela. Real-time monitoring of heat transfer between gold nanoparticles and tethered bilayer lipid membranes.
Biochimica et biophysica acta. Biomembranes.
2020 09; 1862(9):183334. doi:
10.1016/j.bbamem.2020.183334. [PMID: 32380171] - Qinkun Guan, Kaisen Chen, Qiang Chen, Jianguo Hu, Keguang Cheng, Chengfei Hu, Jibao Zhu, Yi Jin, Emeric Miclet, Valérie Alezra, Yang Wan. Development of Therapeutic Gramicidin S Analogues Bearing Plastic β,γ-Diamino Acids.
ChemMedChem.
2020 06; 15(12):1089-1100. doi:
10.1002/cmdc.202000097. [PMID: 32233075] - Joana Paulino, Myunggi Yi, Ivan Hung, Zhehong Gan, Xiaoling Wang, Eduard Y Chekmenev, Huan-Xiang Zhou, Timothy A Cross. Functional stability of water wire-carbonyl interactions in an ion channel.
Proceedings of the National Academy of Sciences of the United States of America.
2020 06; 117(22):11908-11915. doi:
10.1073/pnas.2001083117. [PMID: 32414918] - Masato Nishio, Yurina Teranishi, Kazuhiro Morioka, Akio Yanagida, Atsushi Shoji. Real-time assay for exosome membrane fusion with an artificial lipid membrane based on enhancement of gramicidin A channel conductance.
Biosensors & bioelectronics.
2020 Feb; 150(?):111918. doi:
10.1016/j.bios.2019.111918. [PMID: 31818753] - Ji Mao, Hiroaki Itoh, Kaori Sakurai, Masayuki Inoue. Phospholipid-Dependent Functions of a Macrocyclic Analogue of the Ion-Channel-Forming Antibiotic Gramicidin A.
Chemical & pharmaceutical bulletin.
2020; 68(2):173-178. doi:
10.1248/cpb.c19-00967. [PMID: 32009085] - Sarvinoz I Rustamova, Nargiza A Tsiferova, Ozoda J Khamidova, Ranokhon Sh Kurbannazarova, Petr G Merzlyak, Zainab A Khushbaktova, Vladimir N Syrov, Erkin Kh Botirov, Kamila A Eshbakova, Ravshan Z Sabirov. Effect of plant flavonoids on the volume regulation of rat thymocytes under hypoosmotic stress.
Pharmacological reports : PR.
2019 Dec; 71(6):1079-1087. doi:
10.1016/j.pharep.2019.05.023. [PMID: 31629088] - Ulrich Sternberg, Raiker Witter. Investigation of backbone dynamics and local geometry of bio-molecules using calculated NMR chemical shifts and anisotropies.
Journal of biomolecular NMR.
2019 Dec; 73(12):727-741. doi:
10.1007/s10858-019-00284-y. [PMID: 31646420] - Renate Reiter, Ekaterina Zaitseva, Gerhard Baaken, Ibrahim Halimeh, Jan C Behrends, Andreas Zumbuehl. Activity of the Gramicidin A Ion Channel in a Lipid Membrane with Switchable Physical Properties.
Langmuir : the ACS journal of surfaces and colloids.
2019 11; 35(46):14959-14966. doi:
10.1021/acs.langmuir.9b02752. [PMID: 31645105] - Benoît Roux. Calculating the Effect of Membrane Thickness on the Lifetime of the Gramicidin A Channel: A Landmark.
Biophysical journal.
2019 11; 117(10):1779-1780. doi:
10.1016/j.bpj.2019.10.005. [PMID: 31668331] - Delin Sun, Thasin A Peyear, W F Drew Bennett, Olaf S Andersen, Felice C Lightstone, Helgi I Ingólfsson. Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness.
Biophysical journal.
2019 11; 117(10):1831-1844. doi:
10.1016/j.bpj.2019.09.044. [PMID: 31676135] - Soohyung Park, Min Sun Yeom, Olaf S Andersen, Richard W Pastor, Wonpil Im. Quantitative Characterization of Protein-Lipid Interactions by Free Energy Simulation between Binary Bilayers.
Journal of chemical theory and computation.
2019 Nov; 15(11):6491-6503. doi:
10.1021/acs.jctc.9b00815. [PMID: 31560853] - Elnaz Mirtaheri, Ata Dolatmoradi, Bilal El-Zahab. Thermally Assisted Acoustofluidic Separation Based on Membrane Protein Content.
Analytical chemistry.
2019 11; 91(21):13953-13961. doi:
10.1021/acs.analchem.9b03485. [PMID: 31590489] - Subhadeep Koner, Joseph S Najem, Md Sakib Hasan, Stephen A Sarles. Memristive plasticity in artificial electrical synapses via geometrically reconfigurable, gramicidin-doped biomembranes.
Nanoscale.
2019 Oct; 11(40):18640-18652. doi:
10.1039/c9nr07288h. [PMID: 31584592] - Chunying Li, Hui Chen, Li Zhou, Hui Shi, Xiaoxiao He, Xiaohai Yang, Kemin Wang, Jianbo Liu. Single-stranded DNA designed lipophilic G-quadruplexes as transmembrane channels for switchable potassium transport.
Chemical communications (Cambridge, England).
2019 Oct; 55(80):12004-12007. doi:
10.1039/c9cc04176a. [PMID: 31503273] - Yunjeong Park, Byunggil Kang, Cheol Hyoun Ahn, Hyung Koun Cho, Hyukjoon Kwon, Sungsu Park, Junhwan Kwon, Myunghwan Choi, Changgu Lee, Kyunghoon Kim. Bionanoelectronic platform with a lipid bilayer/CVD-grown MoS2 hybrid.
Biosensors & bioelectronics.
2019 Oct; 142(?):111512. doi:
10.1016/j.bios.2019.111512. [PMID: 31336225] - Manuel G Ricardo, Aldrin V Vasco, Daniel G Rivera, Ludger A Wessjohann. Stabilization of Cyclic β-Hairpins by Ugi-Reaction-Derived N-Alkylated Peptides: The Quest for Functionalized β-Turns.
Organic letters.
2019 09; 21(18):7307-7310. doi:
10.1021/acs.orglett.9b02592. [PMID: 31482710] - Qinkun Guan, Shuhui Huang, Yi Jin, Rémy Campagne, Valérie Alezra, Yang Wan. Recent Advances in the Exploration of Therapeutic Analogues of Gramicidin S, an Old but Still Potent Antimicrobial Peptide.
Journal of medicinal chemistry.
2019 09; 62(17):7603-7617. doi:
10.1021/acs.jmedchem.9b00156. [PMID: 30938996] - Marta Gambucci, Pier Luigi Gentili, Paola Sassi, Loredana Latterini. A multi-spectroscopic approach to investigate the interactions between Gramicidin A and silver nanoparticles.
Soft matter.
2019 Aug; 15(32):6571-6580. doi:
10.1039/c9sm01110b. [PMID: 31364666] - Lawrence R Walker, Elaine M Marzluff, Julia A Townsend, William C Resager, Michael T Marty. Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly.
Analytical chemistry.
2019 07; 91(14):9284-9291. doi:
10.1021/acs.analchem.9b02261. [PMID: 31251560] - Milka Doktorova, Frederick A Heberle, Drew Marquardt, Radda Rusinova, R Lea Sanford, Thasin A Peyear, John Katsaras, Gerald W Feigenson, Harel Weinstein, Olaf S Andersen. Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles.
Biophysical journal.
2019 03; 116(5):860-873. doi:
10.1016/j.bpj.2019.01.016. [PMID: 30755300] - Ruchi Kapoor, Thasin A Peyear, Roger E Koeppe, Olaf S Andersen. Antidepressants are modifiers of lipid bilayer properties.
The Journal of general physiology.
2019 03; 151(3):342-356. doi:
10.1085/jgp.201812263. [PMID: 30796095] - Ayush Jain, Bhupinder Singh Kalra, Siddharth Srivastava, Shalini Chawla. Effect of sofosbuvir and daclatasvir on lipid profile, glycemic control and quality of life index in chronic hepatitis C, genotype 3 patients.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.
2019 Feb; 38(1):39-43. doi:
10.1007/s12664-019-00935-w. [PMID: 30710219] - Ljudmila S Khailova, Tatyana I Rokitskaya, Sergey I Kovalchuk, Еlena А Kotova, Alexandra I Sorochkina, Yuri N Antonenko. Role of mitochondrial outer membrane in the uncoupling activity of N-terminally glutamate-substituted gramicidin A.
Biochimica et biophysica acta. Biomembranes.
2019 01; 1861(1):281-287. doi:
10.1016/j.bbamem.2018.06.013. [PMID: 29940153] - Alexander M Firsov, Irina D Pogozheva, Sergey I Kovalchuk, Elena A Kotova, Yuri N Antonenko. Effect of Site-Specific Intermolecular Lysine-Tryptophan Interactions on the Aggregation of Gramicidin-Based Peptides Leading to Pore Formation in Lipid Membranes.
The Journal of membrane biology.
2018 12; 251(5-6):633-640. doi:
10.1007/s00232-018-0040-0. [PMID: 29995247] - István P Sugár, Alexander P Bonanno, Parkson Lee-Gau Chong. Gramicidin Lateral Distribution in Phospholipid Membranes: Fluorescence Phasor Plots and Statistical Mechanical Model.
International journal of molecular sciences.
2018 Nov; 19(11):. doi:
10.3390/ijms19113690. [PMID: 30469389] - Sergey Milikisiyants, Alexander A Nevzorov, Alex I Smirnov. Photonic band-gap resonators for high-field/high-frequency EPR of microliter-volume liquid aqueous samples.
Journal of magnetic resonance (San Diego, Calif. : 1997).
2018 11; 296(?):152-164. doi:
10.1016/j.jmr.2018.09.006. [PMID: 30268940] - Michaela Wenzel, Marina Rautenbach, J Arnold Vosloo, Tjalling Siersma, Christopher H M Aisenbrey, Ekaterina Zaitseva, Wikus E Laubscher, Wilma van Rensburg, Jan C Behrends, Burkhard Bechinger, Leendert W Hamoen. The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S.
mBio.
2018 10; 9(5):. doi:
10.1128/mbio.00802-18. [PMID: 30301848] - Oleg V Kondrashov, Timur R Galimzyanov, Konstantin V Pavlov, Elena A Kotova, Yuri N Antonenko, Sergey A Akimov. Membrane Elastic Deformations Modulate Gramicidin A Transbilayer Dimerization and Lateral Clustering.
Biophysical journal.
2018 08; 115(3):478-493. doi:
10.1016/j.bpj.2018.07.004. [PMID: 30049405] - Yang Wan, Andrii Stanovych, Didier Gori, Séverine Zirah, Cyrille Kouklovsky, Valérie Alezra. β,γ-diamino acids as building blocks for new analogues of Gramicidin S: Synthesis and biological activity.
European journal of medicinal chemistry.
2018 Apr; 149(?):122-128. doi:
10.1016/j.ejmech.2018.02.053. [PMID: 29499484] - Masao Sugawara. Transmembrane Signaling with Lipid-Bilayer Assemblies as a Platform for Channel-Based Biosensing.
Chemical record (New York, N.Y.).
2018 Apr; 18(4):433-444. doi:
10.1002/tcr.201700046. [PMID: 29135061] - Xu Yang, Ahmed E Yousef. Antimicrobial peptides produced by Brevibacillus spp.: structure, classification and bioactivity: a mini review.
World journal of microbiology & biotechnology.
2018 Mar; 34(4):57. doi:
10.1007/s11274-018-2437-4. [PMID: 29594558] - Elise Azar, Doru Constantin, Dror E Warschawski. The effect of gramicidin inclusions on the local order of membrane components.
The European physical journal. E, Soft matter.
2018 Mar; 41(3):44. doi:
10.1140/epje/i2018-11644-5. [PMID: 29582214] - Florent Bories, Doru Constantin, Paolo Galatola, Jean-Baptiste Fournier. Coupling between Inclusions and Membranes at the Nanoscale.
Physical review letters.
2018 Mar; 120(12):128104. doi:
10.1103/physrevlett.120.128104. [PMID: 29694104] - Young Hun Kim, Leibniz Hang, Jessica L Cifelli, David Sept, Michael Mayer, Jerry Yang. Frequency-Based Analysis of Gramicidin A Nanopores Enabling Detection of Small Molecules with Picomolar Sensitivity.
Analytical chemistry.
2018 02; 90(3):1635-1642. doi:
10.1021/acs.analchem.7b02961. [PMID: 29266927] - Verena C Schulze Greiving, Hans L de Boer, Johan G Bomer, Albert van den Berg, Séverine Le Gac. Integrated microfluidic biosensing platform for simultaneous confocal microscopy and electrophysiological measurements on bilayer lipid membranes and ion channels.
Electrophoresis.
2018 02; 39(3):496-503. doi:
10.1002/elps.201700346. [PMID: 29193178] - Marc-Antoine Sani, Frances Separovic. Antimicrobial Peptide Structures: From Model Membranes to Live Cells.
Chemistry (Weinheim an der Bergstrasse, Germany).
2018 Jan; 24(2):286-291. doi:
10.1002/chem.201704362. [PMID: 29068097] - Walter F Paxton, Patrick T McAninch, Komandoor E Achyuthan, Sun Hae Ra Shin, Haley L Monteith. Monitoring and modulating ion traffic in hybrid lipid/polymer vesicles.
Colloids and surfaces. B, Biointerfaces.
2017 Nov; 159(?):268-276. doi:
10.1016/j.colsurfb.2017.07.091. [PMID: 28800466] - Elizabeth Vaca, Claire Behrens, Tiju Theccanat, Jun-Yong Choe, John V Dean. Mechanistic differences in the uptake of salicylic acid glucose conjugates by vacuolar membrane-enriched vesicles isolated from Arabidopsis thaliana.
Physiologia plantarum.
2017 Nov; 161(3):322-338. doi:
10.1111/ppl.12602. [PMID: 28665551] - Kevin Lum, Helgi I Ingólfsson, Roger E Koeppe, Olaf S Andersen. Exchange of Gramicidin between Lipid Bilayers: Implications for the Mechanism of Channel Formation.
Biophysical journal.
2017 Oct; 113(8):1757-1767. doi:
10.1016/j.bpj.2017.08.049. [PMID: 29045870] - Andrew H Beaven, Alexander J Sodt, Richard W Pastor, Roger E Koeppe, Olaf S Andersen, Wonpil Im. Characterizing Residue-Bilayer Interactions Using Gramicidin A as a Scaffold and Tryptophan Substitutions as Probes.
Journal of chemical theory and computation.
2017 Oct; 13(10):5054-5064. doi:
10.1021/acs.jctc.7b00400. [PMID: 28870079] - Jun Li, Michele R Richards, Elena N Kitova, John S Klassen. Delivering Transmembrane Peptide Complexes to the Gas Phase Using Nanodiscs and Electrospray Ionization.
Journal of the American Society for Mass Spectrometry.
2017 10; 28(10):2054-2065. doi:
10.1007/s13361-017-1735-7. [PMID: 28681358] - Karl F Herold, Olaf S Andersen, Hugh C Hemmings. Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.
European biophysics journal : EBJ.
2017 Oct; 46(7):617-626. doi:
10.1007/s00249-017-1239-1. [PMID: 28695248] - David Argudo, Neville P Bethel, Frank V Marcoline, Charles W Wolgemuth, Michael Grabe. New Continuum Approaches for Determining Protein-Induced Membrane Deformations.
Biophysical journal.
2017 May; 112(10):2159-2172. doi:
10.1016/j.bpj.2017.03.040. [PMID: 28538153] - Dmitry K Chistyulin, Tatyana I Rokitskaya, Sergey I Kovalchuk, Alexandra I Sorochkina, Alexander M Firsov, Elena A Kotova, Yuri N Antonenko. pH-Dependent properties of ion channels formed by N-terminally glutamate substituted gramicidin A in planar lipid bilayers.
Biochimica et biophysica acta. Biomembranes.
2017 May; 1859(5):896-902. doi:
10.1016/j.bbamem.2017.02.004. [PMID: 28188740] - Richard M Venable, Helgi I Ingólfsson, Michael G Lerner, B Scott Perrin, Brian A Camley, Siewert J Marrink, Frank L H Brown, Richard W Pastor. Lipid and Peptide Diffusion in Bilayers: The Saffman-Delbrück Model and Periodic Boundary Conditions.
The journal of physical chemistry. B.
2017 04; 121(15):3443-3457. doi:
10.1021/acs.jpcb.6b09111. [PMID: 27966982] - Ebrahim Hassan-Zadeh, Fazle Hussain, Juyang Huang. Gramicidin Peptides Alter Global Lipid Compositions and Bilayer Thicknesses of Coexisting Liquid-Ordered and Liquid-Disordered Membrane Domains.
Langmuir : the ACS journal of surfaces and colloids.
2017 04; 33(13):3324-3332. doi:
10.1021/acs.langmuir.6b03688. [PMID: 28267920] - Andrew H Beaven, Andreia M Maer, Alexander J Sodt, Huan Rui, Richard W Pastor, Olaf S Andersen, Wonpil Im. Gramicidin A Channel Formation Induces Local Lipid Redistribution I: Experiment and Simulation.
Biophysical journal.
2017 Mar; 112(6):1185-1197. doi:
10.1016/j.bpj.2017.01.028. [PMID: 28355546] - Alexander J Sodt, Andrew H Beaven, Olaf S Andersen, Wonpil Im, Richard W Pastor. Gramicidin A Channel Formation Induces Local Lipid Redistribution II: A 3D Continuum Elastic Model.
Biophysical journal.
2017 Mar; 112(6):1198-1213. doi:
10.1016/j.bpj.2017.01.035. [PMID: 28355547] - Karl F Herold, R Lea Sanford, William Lee, Olaf S Andersen, Hugh C Hemmings. Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.
Proceedings of the National Academy of Sciences of the United States of America.
2017 03; 114(12):3109-3114. doi:
10.1073/pnas.1611717114. [PMID: 28265069] - Philip A Gurnev, Torri C Roark, Horia I Petrache, Alexander J Sodt, Sergey M Bezrukov. Cation-Selective Channel Regulated by Anions According to Their Hofmeister Ranking.
Angewandte Chemie (International ed. in English).
2017 03; 56(13):3506-3509. doi:
10.1002/anie.201611335. [PMID: 28198582] - Djalma Medeiros, Laíz da Costa Silva-Gonçalves, Annielle Mendes Brito da Silva, Marcia Perez Dos Santos Cabrera, Manoel Arcisio-Miranda. Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism.
Scientific reports.
2017 01; 7(?):41362. doi:
10.1038/srep41362. [PMID: 28128290] - Mark T Agasid, Troy J Comi, S Scott Saavedra, Craig A Aspinwall. Enhanced Temporal Resolution with Ion Channel-Functionalized Sensors Using a Conductance-Based Measurement Protocol.
Analytical chemistry.
2017 01; 89(2):1315-1322. doi:
10.1021/acs.analchem.6b04226. [PMID: 27981836] - Svetlana S Efimova, Anastasiia A Zakharova, Ludmila V Schagina, Olga S Ostroumova. Local Anesthetics Affect Gramicidin A Channels via Membrane Electrostatic Potentials.
The Journal of membrane biology.
2016 12; 249(6):781-787. doi:
10.1007/s00232-016-9926-x. [PMID: 27592116] - Ge Su, Min Zhang, Wen Si, Zhan-Ting Li, Jun-Li Hou. Directional Potassium Transport through a Unimolecular Peptide Channel.
Angewandte Chemie (International ed. in English).
2016 11; 55(47):14678-14682. doi:
10.1002/anie.201608428. [PMID: 27754610] - Zahra Hemmatian, Scott Keene, Erik Josberger, Takeo Miyake, Carina Arboleda, Jessica Soto-Rodríguez, François Baneyx, Marco Rolandi. Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin.
Nature communications.
2016 10; 7(?):12981. doi:
10.1038/ncomms12981. [PMID: 27713411] - Subhadip Ghatak, Jilong Li, Yuk C Chan, Surya C Gnyawali, Erin Steen, Bryant C Yung, Savita Khanna, Sashwati Roy, Robert J Lee, Chandan K Sen. AntihypoxamiR functionalized gramicidin lipid nanoparticles rescue against ischemic memory improving cutaneous wound healing.
Nanomedicine : nanotechnology, biology, and medicine.
2016 10; 12(7):1827-1831. doi:
10.1016/j.nano.2016.03.004. [PMID: 27033464] - Sangbaek Choi, Sunhee Yoon, Hyunil Ryu, Sun Min Kim, Tae-Joon Jeon. Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film.
Journal of visualized experiments : JoVE.
2016 07; ?(113):. doi:
10.3791/54258. [PMID: 27501114] - Hao Li, Nuttapat Anuwongcharoen, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenamat. Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides.
International journal of molecular sciences.
2016 Jun; 17(7):. doi:
10.3390/ijms17071023. [PMID: 27376281] - John W Patrick, Roberto C Gamez, David H Russell. The Influence of Lipid Bilayer Physicochemical Properties on Gramicidin A Conformer Preferences.
Biophysical journal.
2016 04; 110(8):1826-1835. doi:
10.1016/j.bpj.2016.03.020. [PMID: 27119642] - Van A Ngo, Ilsoo Kim, Toby W Allen, Sergei Y Noskov. Estimation of Potentials of Mean Force from Nonequilibrium Pulling Simulations Using Both Minh-Adib Estimator and Weighted Histogram Analysis Method.
Journal of chemical theory and computation.
2016 Mar; 12(3):1000-10. doi:
10.1021/acs.jctc.5b01050. [PMID: 26799775] - Sergei V Sychev, Stanislav V Sukhanov, Irina N Telezhinskaya, Tatiana V Ovchinnikova. Effective lipid-detergent system for study of membrane active peptides in fluid liposomes.
Journal of peptide science : an official publication of the European Peptide Society.
2016 Feb; 22(2):98-105. doi:
10.1002/psc.2845. [PMID: 26751806] - Shintaro Kubota, Osamu Shirai, Yuki Kitazumi, Kenji Kano. Analysis of Ion Transport through a Single Channel of Gramicidin A in Bilayer Lipid Membranes.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2016; 32(2):189-92. doi:
10.2116/analsci.32.189. [PMID: 26860564] - Daichi Okuno, Minako Hirano, Hiroaki Yokota, Yukiko Onishi, Junya Ichinose, Toru Ide. A Simple Method for Ion Channel Recordings Using Fine Gold Electrode.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2016; 32(12):1353-1357. doi:
10.2116/analsci.32.1353. [PMID: 27941267] - Lucia Becucci, Rolando Guidelli. Can gramicidin ion channel affect the dipole potential of neighboring phospholipid headgroups?.
Bioelectrochemistry (Amsterdam, Netherlands).
2015 Dec; 106(Pt B):343-52. doi:
10.1016/j.bioelechem.2015.06.008. [PMID: 26190793] - Hwankyu Lee, Sun Min Kim, Tae-Joon Jeon. Effects of imidazolium-based ionic liquids on the stability and dynamics of gramicidin A and lipid bilayers at different salt concentrations.
Journal of molecular graphics & modelling.
2015 Sep; 61(?):53-60. doi:
10.1016/j.jmgm.2015.06.016. [PMID: 26188795] - Upendra Kumar Singh, Neeraj Dohare, Prabhash Mishra, Prashant Singh, Himadri B Bohidar, Rajan Patel. Effect of pyrrolidinium based ionic liquid on the channel form of gramicidin in lipid vesicles.
Journal of photochemistry and photobiology. B, Biology.
2015 Aug; 149(?):1-8. doi:
10.1016/j.jphotobiol.2015.04.011. [PMID: 26025771] - Hyunil Ryu, Hwankyu Lee, Seigo Iwata, Sangbaek Choi, Moon Ki Kim, Young-Rok Kim, Shinsaku Maruta, Sun Min Kim, Tae-Joon Jeon. Investigation of Ion Channel Activities of Gramicidin A in the Presence of Ionic Liquids Using Model Cell Membranes.
Scientific reports.
2015 Jul; 5(?):11935. doi:
10.1038/srep11935. [PMID: 26189604] - Soohyung Park, Andrew H Beaven, Jeffery B Klauda, Wonpil Im. How Tolerant are Membrane Simulations with Mismatch in Area per Lipid between Leaflets?.
Journal of chemical theory and computation.
2015 Jul; 11(7):3466-77. doi:
10.1021/acs.jctc.5b00232. [PMID: 26575780] - Yuri N Antonenko, Grigory S Gluhov, Alexander M Firsov, Irina D Pogozheva, Sergey I Kovalchuk, Evgeniya V Pechnikova, Elena A Kotova, Olga S Sokolova. Gramicidin A disassembles large conductive clusters of its lysine-substituted derivatives in lipid membranes.
Physical chemistry chemical physics : PCCP.
2015 Jul; 17(26):17461-70. doi:
10.1039/c5cp02047f. [PMID: 26077982] - T I Rokitskaya, A M Firsov, E A Kotova, Y N Antonenko. Photodynamic inactivation of gramicidin channels in bilayer lipid membranes: protective efficacy of singlet oxygen quenchers depends on photosensitizer location.
Biochemistry. Biokhimiia.
2015 Jun; 80(6):745-51. doi:
10.1134/s0006297915060097. [PMID: 26531019] - Marina Berditsch, Sergii Afonin, Anna Steineker, Nataliia Orel, Igor Jakovkin, Christian Weber, Anne S Ulrich. Fermentation and Cost-Effective 13C/15N Labeling of the Nonribosomal Peptide Gramicidin S for Nuclear Magnetic Resonance Structure Analysis.
Applied and environmental microbiology.
2015 Jun; 81(11):3593-603. doi:
10.1128/aem.00229-15. [PMID: 25795666] - Benjamin J Wylie, Boris G Dzikovski, Shane Pawsey, Marc Caporini, Melanie Rosay, Jack H Freed, Ann E McDermott. Dynamic nuclear polarization of membrane proteins: covalently bound spin-labels at protein-protein interfaces.
Journal of biomolecular NMR.
2015 Apr; 61(3-4):361-7. doi:
10.1007/s10858-015-9919-6. [PMID: 25828256]