Golvatinib (BioDeep_00000179568)

   

human metabolite blood metabolite


代谢物信息卡片


N1-{2-fluoro-4-[(2-{[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

化学式: C33H37F2N7O4 (633.2874946)
中文名称: N-[2-氟-4-[[2-[[[4-(4-甲基哌嗪-1-基)哌啶-1-基]羰基]氨基]吡啶-4-基]氧基]苯基]-N-(4-氟苯基)环丙烷-1,1-二甲酰胺
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: CN1CCN(CC1)C1CCN(CC1)C(=O)NC1=CC(OC2=CC=C(NC(=O)C3(CC3)C(=O)NC3=CC=C(F)C=C3)C(F)=C2)=CC=N1
InChI: InChI=1S/C33H37F2N7O4/c1-40-16-18-41(19-17-40)24-9-14-42(15-10-24)32(45)39-29-21-26(8-13-36-29)46-25-6-7-28(27(35)20-25)38-31(44)33(11-12-33)30(43)37-23-4-2-22(34)3-5-23/h2-8,13,20-21,24H,9-12,14-19H2,1H3,(H,37,43)(H,38,44)(H,36,39,45)

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor

同义名列表

7 个代谢物同义名

N1-{2-fluoro-4-[(2-{[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N1-[2-fluoro-4-({2-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonylamino]pyridin-4-yl}oxy)phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; N-(2-fluoro-4-((2-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)carbonylaminopyridin-4-yl)oxy)phenyl)-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; Golvatinib (E7050); e-7050E7050; Golvatinib; e7050 CPD



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tsung-Teng Huang, Chuan-Mu Chen, Song-Shu Lin, Ying-Wei Lan, Hsu-Chen Cheng, Kong-Bung Choo, Ching-Chiung Wang, Tse-Hung Huang, Kowit-Yu Chong. E7050 Suppresses the Growth of Multidrug-Resistant Human Uterine Sarcoma by Inhibiting Angiogenesis via Targeting of VEGFR2-Mediated Signaling Pathways. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119606. [PMID: 37298555]
  • Tsung-Teng Huang, Chuan-Mu Chen, Ying-Wei Lan, Song-Shu Lin, Kong-Bung Choo, Kowit-Yu Chong. Blockade of c-Met-Mediated Signaling Pathways by E7050 Suppresses Growth and Promotes Apoptosis in Multidrug-Resistant Human Uterine Sarcoma Cells. International journal of molecular sciences. 2022 Nov; 23(23):. doi: 10.3390/ijms232314884. [PMID: 36499211]
  • Kisho Ikeda, Tetsuro Kusaba, Aya Tomita, Noriko Watanabe-Uehara, Tomoharu Ida, Takashi Kitani, Noriyuki Yamashita, Masahiro Uehara, Satoaki Matoba, Tadaaki Yamada, Keiichi Tamagaki. Diverse Receptor Tyrosine Kinase Phosphorylation in Urine-Derived Tubular Epithelial Cells from Autosomal Dominant Polycystic Kidney Disease Patients. Nephron. 2020; 144(10):525-536. doi: 10.1159/000509419. [PMID: 32799196]
  • L Rhoda Molife, Emma Jane Dean, Montserrat Blanco-Codesido, Matthew G Krebs, Andre T Brunetto, Alastair Peter Greystoke, Gennaro Daniele, Lucy Lee, Galina Kuznetsov, Khin Than Myint, Karen Wood, Begoña de Las Heras, Malcolm Richard Ranson. A phase I, dose-escalation study of the multitargeted receptor tyrosine kinase inhibitor, golvatinib, in patients with advanced solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Dec; 20(24):6284-94. doi: 10.1158/1078-0432.ccr-14-0409. [PMID: 25278451]
  • Lei Shi, Ting-Ting Wu, Zhi Wang, Jia-Yu Xue, Yun-Gen Xu. Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2. Bioorganic & medicinal chemistry. 2014 Sep; 22(17):4735-44. doi: 10.1016/j.bmc.2014.07.008. [PMID: 25082515]
  • C D Scher, G J Todaro. Selective growth of human neoplastic cells in medium lacking serum growth factor. Experimental cell research. 1971 Oct; 68(2):479-81. doi: 10.1016/0014-4827(71)90181-9. [PMID: 5288227]