Aprindine (BioDeep_00000017951)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-[3-(diethylamino)propyl]-N-phenyl-2,3-dihydro-1H-inden-2-amine

化学式: C22H30N2 (322.240886)
中文名称: 茚丙胺
谱图信息: 最多检出来源 Homo sapiens(blood) 0.52%

分子结构信息

SMILES: CCN(CC)CCCN(C1CC2=CC=CC=C2C1)C1=CC=CC=C1
InChI: InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3

描述信息

Aprindine is only found in individuals that have used or taken this drug. It is a cardiac depressant used in arrhythmias. [PubChem]
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BB - Antiarrhythmics, class ib
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators

同义名列表

10 个代谢物同义名

N-[3-(diethylamino)propyl]-N-phenyl-2,3-dihydro-1H-inden-2-amine; Christiaens brand OF aprindine hydrochloride; Nycomed brand OF aprindine hydrochloride; PCR Brand OF aprindine hydrochloride; Compound 99170; Aprinidine; APRINDINE; Aprindin; Amidonal; Fiboran



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Hadi Ar Hadi, Alawi A Alsheikh-Ali, Wael Al Mahmeed, Jassim M Al Suwaidi. Inflammatory cytokines and atrial fibrillation: current and prospective views. Journal of inflammation research. 2010; 3(?):75-97. doi: 10.2147/jir.s10095. [PMID: 22096359]
  • Yanjun Hong, Yihong Tang, Su Zeng. Enantioselective plasma protein binding of propafenone: mechanism, drug interaction, and species difference. Chirality. 2009 Jul; 21(7):692-8. doi: 10.1002/chir.20666. [PMID: 18937289]
  • Atsushi Tamura, Takehiko Ogura, Hiroko Uemura, Yoshie Reien, Takashi Kishimoto, Toshio Nagai, Issei Komuro, Masaru Miyazaki, Haruaki Nakaya. Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current. Journal of pharmacological sciences. 2009 Jun; 110(2):150-9. doi: 10.1254/jphs.08312fp. [PMID: 19498275]
  • Yoshimasa Tsuchishita, Kyoko Fukumoto, Masaaki Kusumoto, Kazuyuki Ueno. Relationship between serum aprindine concentration and neurologic side effects in Japanese. Biological & pharmaceutical bulletin. 2009 Apr; 32(4):637-9. doi: 10.1248/bpb.32.637. [PMID: 19336897]
  • Takahiro Iwamoto, Yasuhide Watanabe, Satomi Kita, Mordecai P Blaustein. Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovascular & hematological disorders drug targets. 2007 Sep; 7(3):188-98. doi: 10.2174/187152907781745288. [PMID: 17896959]
  • Akira Fujiki, Tamotsu Sakamoto, Kunihiro Nishida, Koichi Mizumaki, Hiroshi Inoue. Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Journal of cardiovascular pharmacology. 2007 Sep; 50(3):264-6. doi: 10.1097/fjc.0b013e318074f952. [PMID: 17878753]
  • Masato Taguchi, Akira Fujiki, Jotaro Iwamoto, Hiroshi Inoue, Katsutoshi Tahara, Katsuya Saigusa, Isao Horiuchi, Yukari Oshima, Yukiya Hashimoto. Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias. Biological & pharmaceutical bulletin. 2006 Mar; 29(3):517-21. doi: 10.1248/bpb.29.517. [PMID: 16508157]
  • Mikiko Shimizu, Toshikuni Ohota, Mutumi Kishida, Hiroyasu Ogata. Nonlinear pharmacokinetics of aprindine in guinea pigs. Drug metabolism and pharmacokinetics. 2002; 17(4):292-9. doi: 10.2133/dmpk.17.292. [PMID: 15618680]
  • M Shimizu, K Takatori, M Kajiwara, H Ogata. Isolation of a major metabolite (i-OHAP) of aprindine and its identification as N-[3-(N,N-diethylamino)propyl]-N-phenyl-2-aminoindan-5-ol. Biological & pharmaceutical bulletin. 1998 May; 21(5):530-4. doi: 10.1248/bpb.21.530. [PMID: 9635514]
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  • A V Pisciotta, C Cronkite. Aprindine-induced agranulocytosis. Evidence for immunologic mechanism. Archives of internal medicine. 1983 Feb; 143(2):241-3. doi: NULL. [PMID: 6401987]
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