7-Aminonitrazepam (BioDeep_00000017946)

   

human metabolite Endogenous


代谢物信息卡片


7-amino-5-phenyl-3H-1,4-benzodiazepin-2-ol

化学式: C15H13N3O (251.1058568)
中文名称: 7-氨基硝基安定
谱图信息: 最多检出来源 Bos taurus(endogenous) 66.67%

分子结构信息

SMILES: C1C(=O)NC2=C(C=C(C=C2)N)C(=N1)C3=CC=CC=C3
InChI: InChI=1S/C15H13N3O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9,16H2,(H,18,19)

描述信息

7-aminonitrazepam belongs to the family of Benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms).

同义名列表

2 个代谢物同义名

7-amino-5-phenyl-3H-1,4-benzodiazepin-2-ol; 7-Aminonitrazepam



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chifang Peng, Xiaohui Duan, Shanshan Song, Feng Xue. Parts per trillion detection of 7-aminonitrazepam by nano-enhanced ELISA. International journal of molecular sciences. 2013 Sep; 14(10):19474-83. doi: 10.3390/ijms141019474. [PMID: 24071944]
  • Sarah J Glover, Keith R Allen. Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay. Annals of clinical biochemistry. 2010 Mar; 47(Pt 2):111-7. doi: 10.1258/acb.2009.009172. [PMID: 19969595]
  • Hua Kuang, Qiusheng Li, Chongyu Shen, Jinzhong Xu, Yuan Yuan, Chuanlai Xu, Wuyang Wang. A highly sensitive method for the determination of 7-aminonitrazepam, a metabolite of nitrazepam, in human urine using high-performance electrospray liquid chromatography tandem mass spectrometry. Biomedical chromatography : BMC. 2009 Jul; 23(7):740-4. doi: 10.1002/bmc.1178. [PMID: 19319833]
  • Fumio Moriya, Yoshiaki Hashimoto. Tissue distribution of nitrazepam and 7-aminonitrazepam in a case of nitrazepam intoxication. Forensic science international. 2003 Jan; 131(2-3):108-12. doi: 10.1016/s0379-0738(02)00421-8. [PMID: 12590048]
  • Yu Zhu, Jia-Yi Tan, Yu-Qing Sun. [Analysis of 7-aminonitrazepam in urine by trimethylsilyl derivatization-gas chromatography/mass spectrometry]. Se pu = Chinese journal of chromatography. 2002 Sep; 20(5):394-7. doi: NULL. [PMID: 16358686]
  • M Tomita, T Okuyama, S Sato, H Ishizu. Simultaneous determination of nitrazepam and its metabolites in urine by micellar electrokinetic capillary chromatography. Journal of chromatography. 1993 Nov; 621(2):249-55. doi: 10.1016/0378-4347(93)80102-a. [PMID: 8294546]
  • S Takeno, Y Hirano, A Kitamura, T Sakai. Comparative developmental toxicity and metabolism of nitrazepam in rats and mice. Toxicology and applied pharmacology. 1993 Aug; 121(2):233-8. doi: 10.1006/taap.1993.1150. [PMID: 8346540]
  • T Inoue, T Niwaguchi. Determination of nitrazepam and its main metabolites in urine by thin-layer chromatography and direct densitometry. Journal of chromatography. 1985 Apr; 339(1):163-9. doi: 10.1016/s0378-4347(00)84638-1. [PMID: 4019664]
  • T Kozu. High-performance liquid chromatographic determination of nitrazepam and its metabolites in human urine. Journal of chromatography. 1984 Sep; 310(1):213-8. doi: 10.1016/0378-4347(84)80085-7. [PMID: 6501518]
  • O O Barriga. Depression of cell-mediated immunity following inoculation of Trichinella spiralis extract in the mouse. Immunology. 1978 Jan; 34(1):167-73. doi: NULL. [PMID: 23994]
  • G E Levin, D N Baron. Leucocyte intracellular pH in patients with the metabolic acidosis of renal failure. Clinical science and molecular medicine. 1977 Mar; 52(3):325-8. doi: 10.1042/cs0520325. [PMID: 14806]