Glafenine (BioDeep_00000179426)

   

human metabolite blood metabolite


代谢物信息卡片


4-(2-beta,gamma-Dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline

化学式: C19H17ClN2O4 (372.0876792)
中文名称: 格拉非宁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)OCC(CO)O)NC2=C3C=CC(=CC3=NC=C2)Cl
InChI: InChI=1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22)

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
N - Nervous system > N02 - Analgesics

同义名列表

21 个代谢物同义名

4-(2-beta,gamma-Dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline; 4-((2-Carboxyphenyl)amino)-7-chloroquinoline alpha-monoglyceride; 2,3-Dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoic acid; 4-(2-Β,γ-dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline; 4-(2-b,g-Dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline; 4-((2-Carboxyphenyl)amino)-7-chloroquinoline α-monoglyceride; 2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl) anthranilic acid; 4-((2-Carboxyphenyl)amino)-7-chloroquinoline a-monoglyceride; 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate; 2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl) anthranilate; Glycerylaminophenaquine; Glaphenine; Glafeninum; Glaphenin; glafenine; Glafenina; Glicafan; Glifanan; Glafenin; Exidol; Glifan



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Birgitta C Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt. Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. The Journal of pharmacology and experimental therapeutics. 2017 09; 362(3):450-458. doi: 10.1124/jpet.117.241406. [PMID: 28630284]
  • Anthony M Chiu, Jake J Mandziuk, Sampath K Loganathan, Kumari Alka, Joseph R Casey. High Throughput Assay Identifies Glafenine as a Corrector for the Folding Defect in Corneal Dystrophy-Causing Mutants of SLC4A11. Investigative ophthalmology & visual science. 2015 Dec; 56(13):7739-53. doi: 10.1167/iovs.15-17802. [PMID: 26641551]
  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Daphna Laifenfeld, Luping Qiu, Rachel Swiss, Jennifer Park, Michael Macoritto, Yvonne Will, Husam S Younis, Michael Lawton. Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):234-48. doi: 10.1093/toxsci/kft232. [PMID: 24136188]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • J R Goldsmith, Christian Jobin. Think small: zebrafish as a model system of human pathology. Journal of biomedicine & biotechnology. 2012; 2012(?):817341. doi: 10.1155/2012/817341. [PMID: 22701308]
  • Renaud Robert, Graeme W Carlile, Jie Liao, Haouaria Balghi, Pierre Lesimple, Na Liu, Bart Kus, Daniela Rotin, Martina Wilke, Hugo R de Jonge, Bob J Scholte, David Y Thomas, John W Hanrahan. Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine. Molecular pharmacology. 2010 Jun; 77(6):922-30. doi: 10.1124/mol.109.062679. [PMID: 20200141]
  • Ekram M Hassan, Azza A Gazy, Mohamed H Abdel-Hay, Tarek S Belal. High-performance liquid chromatographic determination of proquazone and its m-hydroxy metabolite in spiked human plasma and urine. Journal of AOAC International. 2007 Jul; 90(4):971-6. doi: NULL. [PMID: 17760334]
  • Guillaume Ravel, Marielle Christ, Françoise Horand, Jacques Descotes. Cytokine release does not improve the sensitivity and specificity of the direct popliteal lymph node assay. Toxicology. 2004 Aug; 200(2-3):247-54. doi: 10.1016/j.tox.2004.03.010. [PMID: 15212820]
  • N Venisse, P Marquet, E Duchoslav, J L Dupuy, G Lachâtre. A general unknown screening procedure for drugs and toxic compounds in serum using liquid chromatography-electrospray-single quadrupole mass spectrometry. Journal of analytical toxicology. 2003 Jan; 27(1):7-14. doi: 10.1093/jat/27.1.7. [PMID: 12587676]
  • Mariusz Swiader, Kinga K Borowicz, Jacek Porebiak, Zdzisław Kleinrok, Stanisław J Czuczwar. Influence of agents affecting voltage-dependent calcium channels and dantrolene on the anticonvulsant action of the AMPA/kainate receptor antagonist LY 300164 in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2002 Aug; 12(4):311-9. doi: 10.1016/s0924-977x(02)00045-7. [PMID: 12126870]
  • Claudia Müller, Patrick Schäfer, Mylène Störtzel, Susanne Vogt, Wolfgang Weinmann. Ion suppression effects in liquid chromatography-electrospray-ionisation transport-region collision induced dissociation mass spectrometry with different serum extraction methods for systematic toxicological analysis with mass spectra libraries. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Jun; 773(1):47-52. doi: 10.1016/s1570-0232(02)00142-3. [PMID: 12015269]
  • S S Hassan, E M Elnemma, A B Abbas. Determination of glafenine in dosage forms and serum by thin layer densitometry and high performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 1997 Oct; 16(2):215-21. doi: 10.1016/s0731-7085(97)00019-8. [PMID: 9408836]
  • M Fernandez-Rivas, B de la Hoz, M Cuevas, I Davila, S Quirce, E Losada. Hypersensitivity reactions to anthranilic acid derivatives. Annals of allergy. 1993 Dec; 71(6):515-8. doi: . [PMID: 7903514]
  • N Vermerie, D Kusielewicz, M Tod, P Nicolas, G Perret, F Fauvelle, O Petitjean. Pharmacokinetics of glafenine and glafenic acid in patients with cirrhosis, compared to healthy volunteers. Fundamental & clinical pharmacology. 1992; 6(4-5):197-203. doi: 10.1111/j.1472-8206.1992.tb00112.x. [PMID: 1358775]
  • J Cledes, P Kermanach, M P Guillodo, J P Hervé. [Acute kidney failure after ingestion of glafenine. The role of associated alcoholic absorption]. Presse medicale (Paris, France : 1983). 1990 Feb; 19(7):333. doi: NULL. [PMID: 1969157]
  • A López Navidad, J Cadafalch, J Farrerons. [Glafenine hepatotoxicity]. Medicina clinica. 1988 Oct; 91(12):475. doi: NULL. [PMID: 2905403]
  • L Offerhaus. [Glafenine: more cons than pros?]. Nederlands tijdschrift voor geneeskunde. 1988 Oct; 132(40):1853-7. doi: NULL. [PMID: 2903454]
  • Z Jerbi, M Amamou, N Ben Saleh, M Yacoub. [Acute renal insufficiency due to intentional glafenine poisoning]. La Tunisie medicale. 1988 Aug; 66(8-9):637-9. doi: NULL. [PMID: 2905089]
  • A Ennachachibi, P Nicolas, F Fauvelle, G Perret, O Petitjean. Effective high-performance liquid chromatographic determination of glafenine in plasma: pharmacokinetic application. Journal of chromatography. 1988 Jun; 427(2):307-14. doi: 10.1016/0378-4347(88)80133-6. [PMID: 2900842]
  • R Jordana, J Gavaldá, J Costa, J L Tovar. [Glafenine hepatotoxicity]. Medicina clinica. 1988 Feb; 90(7):306-7. doi: NULL. [PMID: 2896284]
  • P Teillac, M Daudon, O de Dreuzy, H V Nguyen, R J Reveillaud, A Le Duc. [13 cases of drug-induced calculi]. Annales d'urologie. 1988; 22(4):278-81. doi: NULL. [PMID: 2903714]
  • A Tracqui, P Kintz, P Mangin, A A Lugnier, A J Chaumont. Simultaneous determination of glafenine and floctafenine in human plasma using high-performance liquid chromatography. Annales de biologie clinique. 1988; 46(8):665-7. doi: NULL. [PMID: 2905872]
  • J I Roodnat, R H Kauffmann, W B Gerrits, A M van Zijl. [Glaphenine-induced intravascular hemolysis with acute kidney insufficiency as a consequence of IgG anti-glaphenine antibodies]. Nederlands tijdschrift voor geneeskunde. 1987 Dec; 131(50):2316-20. doi: NULL. [PMID: 2892141]
  • E Albengres, S Urien, P Riant, G A Marcel, J P Tillement. Binding of two anthranilic acid derivatives to human albumin, erythrocytes, and lipoproteins: evidence for glafenic acid high affinity binding. Molecular pharmacology. 1987 Mar; 31(3):294-300. doi: NULL. [PMID: 2882410]
  • F Cabral, J Cruz, S P Ponce, F Carvalho, L P Gonçalves, R Proença. [Acute renal insufficiency caused by glaphenine. Presentation of a case and review of the literature]. Acta medica portuguesa. 1986 Sep; 7(5-6):203-5. doi: NULL. [PMID: 2888263]
  • D Kleinknecht, P Landais, B Goldfarb. Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study. Clinical nephrology. 1986 Jun; 25(6):275-81. doi: NULL. [PMID: 2873910]
  • D Kleinknecht, P Landais, B Goldfarb. [Acute renal failure associated with drugs or iodinated contrast media. Results of a cooperative multicentric study by the Nephrology Society]. Nephrologie. 1986; 7(2):41-6. doi: NULL. [PMID: 2874511]
  • J Carmichael, S W Shankel. Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function. The American journal of medicine. 1985 Jun; 78(6 Pt 1):992-1000. doi: 10.1016/0002-9343(85)90223-2. [PMID: 2861741]
  • M Normand, J L Cayotte, M G Normand, C Patouraux. [Renal calculi containing glaphenine metabolites in a male patient]. Nephrologie. 1985; 6(1):33. doi: NULL. [PMID: 2860577]
  • J P Ducroix, M Andrejak, A T Vovan, J Delobel, J Baillet. [Intravascular coagulation and immunoallergic complication after ingestion of glafenine]. Presse medicale (Paris, France : 1983). 1984 May; 13(19):1220. doi: NULL. [PMID: 6144096]
  • M Daudon, M F Protat, R J Reveillaud. [Renal toxicity of glafenine in man: renal stones and acute renal failure]. Annales de biologie clinique. 1983; 41(2):105-11. doi: NULL. [PMID: 6136242]
  • J C Poirier, P Cardot, A Marcelli-Barge, C Bismuth, B Le Mire, P Gervais. [Anti-glafenine circulating antibodies: demonstration and frequency in acute renal insufficiency following intake of glafenine in toxic doses]. Nephrologie. 1983; 4(3):107-10. doi: NULL. [PMID: 6138721]
  • J P Fendler, A Bruet, L Abel, P Marichez. [Radiologic aspects of renal lithiasis induced by glafenine]. La Nouvelle presse medicale. 1982 Oct; 11(42):3142. doi: NULL. [PMID: 6129613]
  • D Ganeval, J P Grünfeld, L Eloy, B Lacour, F Russo-Marie, L H Noël, T Anagnostopoulos. Glaphenine-induced acute renal failure in the rat: a new experimental model. The American journal of physiology. 1982 Oct; 243(4):F416-23. doi: 10.1152/ajprenal.1982.243.4.f416. [PMID: 6127034]
  • M Kessler, N Mertens, B Hurault de Ligny, C Huriet. [Acute renal failure linked to treatment with glafenine and its derivatives]. Therapie. 1982 Jul; 37(4):455-60. doi: NULL. [PMID: 6127819]
  • W Proesmans, J K Sina, P Debucquoy, A M Renoirte, R Eeckels. Recurrent acute renal failure due to nonaccidental poisoning with glafenin in a child. Clinical nephrology. 1981 Oct; 16(4):207-10. doi: NULL. [PMID: 6117386]
  • P Bovy, M A Beaujean, G Rorive. [Acute renal insufficiency secondary to the use of glaphenine]. Revue medicale de Liege. 1980 Jun; 35(11):454-9. doi: NULL. [PMID: 6109367]
  • R J Réveillaud, M Daudon, M F Protat, M Rymer, E Amar, J Pottier. [Renal pelvis stones made of glafenic acid in two patients under prolonged treatment with analgesics (author's transl)]. Nephrologie. 1980; 1(1):3-8. doi: NULL. [PMID: 6117808]
  • M Peterfalvi, R Deraedt, J Pottier, B Vannier, J R Boissier. [Mechanism of the renal effects of high doses of glafenine in the rat]. Therapie. 1979 May; 34(3):377-91. doi: NULL. [PMID: 42987]
  • M Estenne, R Naeije, P Ketelbant-Balasse, P Gausset, J C Demanet. [Acute renal insufficiency caused by glafenine poisoning (proceedings)]. Journal d'urologie et de nephrologie. 1979 Apr; 85(4-5):342. doi: NULL. [PMID: 39179]
  • M Estenne, R Naeije, P Ketelbant-Balasse, P Gausset, J C Demanet. [Acute toxicity of glafenine (Glifanan)]. Acta clinica Belgica. 1979; 34(4):208-13. doi: 10.1080/22953337.1979.11718688. [PMID: 43061]
  • J Pottier, M Busigny, J P Raynaud. Biotransformations of glafenine in the rat and in man. European journal of drug metabolism and pharmacokinetics. 1979; 4(2):109-15. doi: 10.1007/bf03189410. [PMID: 39763]
  • J Rozen, J C Homberg, G Offenstadt, P Hericord, C Damecour, F Duron. [Acute kidney failure caused by glafenine. Demonstration of antibody by Coombs' test in presence of the drug]. La Nouvelle presse medicale. 1978 Oct; 7(36):3255-6. doi: NULL. [PMID: 32524]
  • D Ganeval, F Bournerias, F Daniel, J Rozen, J C Homberg, B Habibi. [Hemolysis caused by anti-glafenine antibodies with acute kidney failure]. La Nouvelle presse medicale. 1978 Oct; 7(36):3254-5. doi: NULL. [PMID: 32523]
  • J H Saurat, L Galloppin, C Ponvert, J Paupe. Leucocyte migration test and hypersensitivity to glafenin. Allergy. 1978 Jun; 33(3):125-9. doi: 10.1111/j.1398-9995.1978.tb01521.x. [PMID: 30331]
  • D Kleinknecht, A Kanfer, L Morel-Maroger, J P Méry. Immunologically mediated drug-induced acute renal failure. Contributions to nephrology. 1978; 10(?):42-52. doi: 10.1159/000401522. [PMID: 27331]
  • K Geboes, E Stevens, H Bossaert, T Dooms. Renal injury associated with 'Glafenine' overdose. Acta clinica Belgica. 1978; 33(6):401-2. doi: 10.1080/22953337.1978.11718657. [PMID: 35914]
  • P Bouletreau, R Ducluzeau, B Bui-Xuan, P Petit, J Motin. Acute renal complications of acute intoxications. Acta pharmacologica et toxicologica. 1977; 41 Suppl 2(?):49-63. doi: NULL. [PMID: 19924]
  • P Bovy, M A Beaujean, G Rorive. Acute renal failure induced by glafenin. Acta clinica Belgica. 1977; 32(4):281-3. doi: NULL. [PMID: 24972]
  • R Mallein, M Boucherat, J Rondelet, J P Fillastre, O Mantel. [Pharmacokinetics of glaphenine in subjects with normal renal function and in patients with chronic renal insufficiency]. Therapie. 1976 Nov; 31(6):739-45. doi: NULL. [PMID: 16357]
  • L R Canta. [Letter: Glaphenine and nephrotoxicity; a side effect?]. Nederlands tijdschrift voor geneeskunde. 1976 Apr; 120(16):719-20. doi: NULL. [PMID: 4738]
  • A Luyckx, H Van Cauwenberge. [Therapeutic news of 1975]. Revue medicale de Liege. 1976 Apr; 31(8):267-80. doi: NULL. [PMID: 13473]
  • F Maesen, M J Mol. [Letter: Glafenin and nephrotoxicity]. Nederlands tijdschrift voor geneeskunde. 1976 Mar; 120(13):593. doi: NULL. [PMID: 3743]
  • J Stork. [Glaphenine and nephrotoxicity]. Nederlands tijdschrift voor geneeskunde. 1976 Feb; 120(8):338-40. doi: NULL. [PMID: 2886]
  • S Dechezleprêtre, P Lechat, M Wickelholz. Comparison of the biological effects in rat of high doses of two 4-amino-7-chloroquinoline derivatives: chloroquine and glafenine. Archives of toxicology. 1975 Dec; 34(4):309-14. doi: 10.1007/bf00353850. [PMID: 3153]
  • P Dequiedt, P Vanhille, B Devulder, D Furon, A Tacquet. [Acute renal insufficiency caused by glaphenine]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille. 1975 Oct; 20(8):708-14. doi: NULL. [PMID: 3703]
  • J C Rénier, M Boasson, M Pitois, P H Alquier. [Letter: Recurrent acute renal insufficiency after ingestion of glaphenine in therapeutic doses]. La Nouvelle presse medicale. 1975 Mar; 4(9):670-1. doi: NULL. [PMID: 236546]
  • F Vachon, C Gibert, F Trémolières, C Manuel, J Marsac, J J Pocidalo, V Vic-Dupont. [Resuscitation in 1975]. La Revue du praticien. 1975 Feb; 25(11):741-75. doi: NULL. [PMID: 241113]
  • S Dechezleprêtre, P Lechat. [Concomitant variations in the weight of adrenals and uremia during kidney provocation by high doses of glafenine]. Archives internationales de pharmacodynamie et de therapie. 1975 Jan; 213(1):170-6. doi: NULL. [PMID: 239646]
  • D Chivrac, R Marti, A Fournier, N Faille, J Messerschmitt, A Lorriaux. [Letter: Immunoallergic hemolysis complicated by acute renal insufficiency after ingestion of glaphenine]. La Nouvelle presse medicale. 1974 Nov; 3(41-43):2578. doi: NULL. [PMID: 4157043]