Gepirone (BioDeep_00000179393)

   

human metabolite blood metabolite


代谢物信息卡片


4,4-dimethyl-1-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}piperidine-2,6-dione

化学式: C19H29N5O2 (359.2321134)
中文名称: 吉哌隆
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)CC(=O)N(CCCCN2CCN(CC2)C2=NC=CC=N2)C(=O)C1
InChI: InChI=1S/C19H29N5O2/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18/h5-7H,3-4,8-15H2,1-2H3

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
Gepirone is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research[1].

同义名列表

7 个代谢物同义名

4,4-dimethyl-1-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}piperidine-2,6-dione; 4,4-Dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-2,6-piperidinedione; Gepirone monohydrochloride; BMY-13805gepirone; ORG-13011variza; gepirone; Ariza



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Judith R Homberg, Olga J G Schiepers, Anton N M Schoffelmeer, Edwin Cuppen, Louk J M J Vanderschuren. Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats. Psychopharmacology. 2007 Dec; 195(2):175-82. doi: 10.1007/s00213-007-0895-8. [PMID: 17661017]
  • C J Timmer, J M A Sitsen. Pharmacokinetic evaluation of gepirone immediate-release capsules and gepirone extended-release tablets in healthy volunteers. Journal of pharmaceutical sciences. 2003 Sep; 92(9):1773-8. doi: 10.1002/jps.10421. [PMID: 12949996]
  • Donald S Robinson, J M Ad Sitsen, Michael Gibertini. A review of the efficacy and tolerability of immediate-release and extended-release formulations of gepirone. Clinical therapeutics. 2003 Jun; 25(6):1618-33. doi: 10.1016/s0149-2918(03)80159-5. [PMID: 12860488]
  • Pierre Blier, Nick M Ward. Is there a role for 5-HT1A agonists in the treatment of depression?. Biological psychiatry. 2003 Feb; 53(3):193-203. doi: 10.1016/s0006-3223(02)01643-8. [PMID: 12559651]
  • G K Matheson, A Knowles, D Gage, C Michel, D Guthrie, C Bauer, J Blackbourne, D Weinzapfel. Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat. Pharmacology. 1997 Aug; 55(2):59-65. doi: 10.1159/000139513. [PMID: 9323305]
  • L K Tay, M A Sciacca, M B Sostrin, R H Farmen, K A Pittman. Effect of food on the bioavailability of gepirone in humans. Journal of clinical pharmacology. 1993 Jul; 33(7):631-5. doi: 10.1002/j.1552-4604.1993.tb04715.x. [PMID: 8103528]
  • L Pan, F Gilbert. Activation of 5-HT1A receptor subtype in the paraventricular nuclei of the hypothalamus induces CRH and ACTH release in the rat. Neuroendocrinology. 1992 Dec; 56(6):797-802. doi: 10.1159/000126332. [PMID: 1369587]
  • L K Tay, F Dixon, M B Sostrin, W H Barr, R H Farmen, K A Pittman. The site of gastrointestinal absorption of gepirone in humans. Journal of clinical pharmacology. 1992 Sep; 32(9):827-32. doi: 10.1002/j.1552-4604.1992.tb03890.x. [PMID: 1358923]
  • D Kelder, S B Ross. Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist. Naunyn-Schmiedeberg's archives of pharmacology. 1992 Aug; 346(2):121-6. doi: 10.1007/bf00165292. [PMID: 1448177]
  • S W Jenkins, N A Warfield, J D Blaine, J Cornish, W Ling, M I Rosen, H Urschel, D Wesson, D Ziedonis. A pilot trial of gepirone vs. placebo in the treatment of cocaine dependency. Psychopharmacology bulletin. 1992; 28(1):21-6. doi: NULL. [PMID: 1609038]
  • A E Walsh, C J Ware, P J Cowen. Lithium and 5-HT1A receptor sensitivity: a neuroendocrine study in healthy volunteers. Psychopharmacology. 1991; 105(4):568-72. doi: 10.1007/bf02244382. [PMID: 1663254]
  • J L Rausch, S M Stahl, R L Hauger. Cortisol and growth hormone responses to the 5-HT1A agonist gepirone in depressed patients. Biological psychiatry. 1990 Jul; 28(1):73-8. doi: 10.1016/0006-3223(90)90434-4. [PMID: 1973905]
  • P J Cowen, I M Anderson, D G Grahame-Smith. Neuroendocrine effects of azapirones. Journal of clinical psychopharmacology. 1990 Jun; 10(3 Suppl):21S-25S. doi: 10.1097/00004714-199006001-00005. [PMID: 1973937]
  • M Franklin. Determination of plasma buspirone by high-performance liquid chromatography with coulometric detection. Journal of chromatography. 1990 Apr; 526(2):590-6. doi: 10.1016/s0378-4347(00)82545-1. [PMID: 1972942]
  • I M Anderson, P J Cowen, D G Grahame-Smith. The effects of gepirone on neuroendocrine function and temperature in humans. Psychopharmacology. 1990; 100(4):498-503. doi: 10.1007/bf02244002. [PMID: 2157231]
  • G K Matheson, D Gage-White, G White, D Guthrie, J Rhoades, V Dixon. The effects of gepirone and 1-(2-pyrimidinyl)-piperazine on levels of corticosterone in rat plasma. Neuropharmacology. 1989 Apr; 28(4):329-34. doi: 10.1016/0028-3908(89)90026-9. [PMID: 2747846]
  • J F Nash, H Y Meltzer. Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat. The Journal of pharmacology and experimental therapeutics. 1989 Apr; 249(1):236-41. doi: NULL. [PMID: 2565390]
  • G Bianchi, S Caccia. Simultaneous determination of buspirone, gepirone, ipsapirone and their common metabolite 1-(2-pyrimidinyl)piperazine in rat plasma and brain by high-performance liquid chromatography. Journal of chromatography. 1988 Oct; 431(2):477-80. doi: 10.1016/s0378-4347(00)83123-0. [PMID: 2907515]
  • G Bianchi, S Caccia, F Della Vedova, S Garattini. The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP). European journal of pharmacology. 1988 Jul; 151(3):365-71. doi: 10.1016/0014-2999(88)90532-8. [PMID: 2905658]
  • J I Koenig, H Y Meltzer, G A Gudelsky. 5-Hydroxytryptamine1A receptor-mediated effects of buspirone, gepirone and ipsapirone. Pharmacology, biochemistry, and behavior. 1988 Apr; 29(4):711-5. doi: 10.1016/0091-3057(88)90192-x. [PMID: 2901112]
  • F Gilbert, C Brazell, M D Tricklebank, S M Stahl. Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration. European journal of pharmacology. 1988 Mar; 147(3):431-9. doi: 10.1016/0014-2999(88)90178-1. [PMID: 2897920]
  • F Gilbert, C T Dourish, C Brazell, S McClue, S M Stahl. Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats. Psychoneuroendocrinology. 1988; 13(6):471-8. doi: 10.1016/0306-4530(88)90032-7. [PMID: 2907164]
  • A Ia Korneev, M I Faktor, E Iu Gliuske. [Effect of anxiolytics--buspirone and diazepam--on the prolactin, thyrotropin and cortisol content of the blood in the green monkey]. Biulleten' eksperimental'noi biologii i meditsiny. 1986 Dec; 102(12):726-9. doi: . [PMID: 2879573]