Gemcabene (BioDeep_00000179375)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H30O5 (302.2093)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(CCCCOCCCCC(C)(C)C(=O)O)C(=O)O
InChI: InChI=1S/C16H30O5/c1-15(2,13(17)18)9-5-7-11-21-12-8-6-10-16(3,4)14(19)20/h5-12H2,1-4H3,(H,17,18)(H,19,20)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98150 - Fibrate Antilipidemic Agent
Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 157692
- HMDB: HMDB0252669
- DrugBank: DB05123
- ChEMBL: CHEMBL2110686
- CAS: 183293-82-5
- medchemexpress: HY-109567
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Daniel Gaudet, Ronen Durst, Norman Lepor, Rebecca Bakker-Arkema, Charles Bisgaier, Liz Masson, Lee Golden, John J Kastelein, Robert A Hegele, Evan Stein. Usefulness of Gemcabene in Homozygous Familial Hypercholesterolemia (from COBALT-1).
The American journal of cardiology.
2019 12; 124(12):1876-1880. doi:
10.1016/j.amjcard.2019.09.010. [PMID: 31685212] - Robert A Hegele, Sotirios Tsimikas. Lipid-Lowering Agents.
Circulation research.
2019 02; 124(3):386-404. doi:
10.1161/circresaha.118.313171. [PMID: 30702996] - Rai Ajit K Srivastava, Joseph A Cornicelli, Bruce Markham, Charles L Bisgaier. Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism.
Molecular and cellular biochemistry.
2018 Dec; 449(1-2):167-183. doi:
10.1007/s11010-018-3353-5. [PMID: 29644527] - Charles L Bisgaier, Daniela C Oniciu, Rai Ajit K Srivastava. Comparative Evaluation of Gemcabene and Peroxisome Proliferator-Activated Receptor Ligands in Transcriptional Assays of Peroxisome Proliferator-Activated Receptors: Implication for the Treatment of Hyperlipidemia and Cardiovascular Disease.
Journal of cardiovascular pharmacology.
2018 07; 72(1):3-10. doi:
10.1097/fjc.0000000000000580. [PMID: 29621036] - Ezim Ajufo, Daniel J Rader. New Therapeutic Approaches for Familial Hypercholesterolemia.
Annual review of medicine.
2018 01; 69(?):113-131. doi:
10.1146/annurev-med-051215-030943. [PMID: 29414257] - Daniela Carmen Oniciu, Taishi Hashiguchi, Yuichiro Shibazaki, Charles L Bisgaier. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH.
PloS one.
2018; 13(5):e0194568. doi:
10.1371/journal.pone.0194568. [PMID: 29847555] - Haodan Yuan, Bo Feng, Ying Yu, Jonathan Chupka, Jenny Y Zheng, Timothy G Heath, Brian R Bond. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril.
The Journal of pharmacology and experimental therapeutics.
2009 Jul; 330(1):191-7. doi:
10.1124/jpet.108.149476. [PMID: 19349522] - Jaap W Mandema, David Hermann, Wenping Wang, Tim Sheiner, Mark Milad, Rebecca Bakker-Arkema, Daniel Hartman. Model-based development of gemcabene, a new lipid-altering agent.
The AAPS journal.
2005 Oct; 7(3):E513-22. doi:
10.1208/aapsj070352. [PMID: 16353929] - Jonathan N Bauman, Theunis C Goosen, Meera Tugnait, Vincent Peterkin, Susan I Hurst, Lee C Menning, Mark Milad, Michael H Court, J Andrew Williams. Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Sep; 33(9):1349-54. doi:
10.1124/dmd.105.005108. [PMID: 15980101] - Harold E Bays, James M McKenney, Carlos A Dujovne, Helmut G Schrott, Michael J Zema, Jack Nyberg, Diane E MacDougall. Effectiveness and tolerability of a new lipid-altering agent, gemcabene, in patients with low levels of high-density lipoprotein cholesterol.
The American journal of cardiology.
2003 Sep; 92(5):538-43. doi:
10.1016/s0002-9149(03)00721-5. [PMID: 12943873] - N H Huang, J R Kagel, D T Rossi. Automated solid-phase extraction workstations combined with quantitative bioanalytical LC/MS.
Journal of pharmaceutical and biomedical analysis.
1999 Mar; 19(3-4):613-20. doi:
10.1016/s0731-7085(98)00289-1. [PMID: 10704127] - C L Bisgaier, A D Essenburg, B C Barnett, B J Auerbach, S Haubenwallner, T Leff, A D White, P Creger, M E Pape, T J Rea, R S Newton. A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor.
Journal of lipid research.
1998 Jan; 39(1):17-30. doi:
10.1016/s0022-2275(20)34199-7. [PMID: 9469582]
