2-[[3-[[2-(Dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline (BioDeep_00000179345)

   

human metabolite blood metabolite


代谢物信息卡片


2-[(3-{[2-(dimethylamino)phenyl]methyl}-2-(pyridin-4-yl)-1,3-diazinan-1-yl)methyl]-N,N-dimethylaniline

化学式: C27H35N5 (429.28923100000003)
中文名称: 2,2-[[二氢-2-(4-吡啶基)-1,3(2H,4H)-嘧啶二基]二(亚甲基)]二[N,N-二甲基苯胺]
谱图信息: 最多检出来源 Homo sapiens(blood) 97.01%

分子结构信息

SMILES: CN(C)C1=CC=CC=C1CN1CCCN(CC2=CC=CC=C2N(C)C)C1C1=CC=NC=C1
InChI: InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3

描述信息

同义名列表

5 个代谢物同义名

2-[(3-{[2-(dimethylamino)phenyl]methyl}-2-(pyridin-4-yl)-1,3-diazinan-1-yl)methyl]-N,N-dimethylaniline; 2-[[3-[[2-(Dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline; NSC 136476; GANT 61; GANT-61



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yonghong Hu, Xinyu Bao, Zheng Zhang, Long Chen, Yue Liang, Yan Qu, Qun Zhou, Xiaoxi Zhou, Jing Fang, Zhun Xiao, Yadong Fu, Hailin Yang, Wei Liu, Ying Lv, Hongyan Cao, Gaofeng Chen, Jian Ping, Hua Zhang, Yongping Mu, Chenghai Liu, Chao-Po Lin, Jian Wu, Ping Liu, Jiamei Chen. Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling. Theranostics. 2024; 14(6):2379-2395. doi: 10.7150/thno.91572. [PMID: 38646644]
  • Valeria Tosello, Deborah Bongiovanni, Ludovica Di Martino, Cinzia Franchin, Paola Zanovello, Giorgio Arrigoni, Erich Piovan. Responsiveness to Hedgehog Pathway Inhibitors in T-Cell Acute Lymphoblastic Leukemia Cells Is Highly Dependent on 5'AMP-Activated Kinase Inactivation. International journal of molecular sciences. 2021 Jun; 22(12):. doi: 10.3390/ijms22126384. [PMID: 34203724]
  • Kuai-Qiang Zhang, Xiang-Dong Chu. GANT61 plays antitumor effects by inducing oxidative stress through the miRNA-1286/RAB31 axis in osteosarcoma. Cell biology international. 2021 Jan; 45(1):61-73. doi: 10.1002/cbin.11467. [PMID: 32936498]
  • Tao Ruan, Jing Sun, Wei Liu, Richard A Prinz, Daxin Peng, Xiufan Liu, Xiulong Xu. H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells. Cell reports. 2020 06; 31(13):107801. doi: 10.1016/j.celrep.2020.107801. [PMID: 32610119]
  • Zhihua Zhang, Rongjuan Zhang, Changlai Hao, Xiaochuan Pei, Jundong Li, Lihong Wang. GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2020 Feb; 26(?):e920541. doi: 10.12659/msm.920541. [PMID: 32054823]
  • Bonan Zhang, Hong Xu, Yi Zhang, Xue Yi, Guizhen Zhang, Xin Zhang, Dingjie Xu, Xuemin Gao, Shifeng Li, Ying Zhu, Hui Zhang, Zhongqiu Wei, Shumin Li, Lijuan Zhang, Ruimin Wang, Fang Yang. Targeting the RAS axis alleviates silicotic fibrosis and Ang II-induced myofibroblast differentiation via inhibition of the hedgehog signaling pathway. Toxicology letters. 2019 Oct; 313(?):30-41. doi: 10.1016/j.toxlet.2019.05.023. [PMID: 31181250]
  • Qingbai Liu, Zaifeng Wu, Dianlei Hu, Lin Zhang, Laijie Wang, Gang Liu. Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis. Gene. 2019 Sep; 712(?):143959. doi: 10.1016/j.gene.2019.143959. [PMID: 31278964]
  • Poommaree Namchaiw, Han Wen, Florian Mayrhofer, Olga Chechneva, Sangita Biswas, Wenbin Deng. Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro. Stem cell research & therapy. 2019 08; 10(1):272. doi: 10.1186/s13287-019-1374-y. [PMID: 31455382]
  • Luciane M Silva, Damon T Jacobs, Bailey A Allard, Timothy A Fields, Madhulika Sharma, Darren P Wallace, Pamela V Tran. Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells. Scientific reports. 2018 03; 8(1):4985. doi: 10.1038/s41598-018-23341-2. [PMID: 29563577]
  • Hui Li, Suping Qin, Dexu Sun, Wei Pan, Xiangyang Li, Fanyun Kong, Kuiyang Zhen, Renxian Tang. [Sonic hedgehog (SHH) promotes the proliferation of synovial fibroblasts of rats with collagen-induced arthritis]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2016 May; 32(5):630-4. doi: NULL. [PMID: 27126942]
  • Suping Qin, Dexu Sun, Hui Li, Xiangyang Li, Wei Pan, Chao Yan, Renxian Tang, Xiaomei Liu. The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis. Inflammation. 2016 Apr; 39(2):503-12. doi: 10.1007/s10753-015-0273-3. [PMID: 26552406]
  • Jiancheng Zhou, Guodong Zhu, Jun Huang, Lei Li, Yuefeng Du, Yang Gao, Dapeng Wu, Xinyang Wang, Jer-Tsong Hsieh, Dalin He, Kaijie Wu. Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target. Cancer letters. 2016 Jan; 370(2):313-23. doi: 10.1016/j.canlet.2015.11.006. [PMID: 26577809]
  • Rafael Kramann, Susanne V Fleig, Rebekka K Schneider, Steven L Fabian, Derek P DiRocco, Omar Maarouf, Janewit Wongboonsin, Yoichiro Ikeda, Dirk Heckl, Steven L Chang, Helmut G Rennke, Sushrut S Waikar, Benjamin D Humphreys. Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. The Journal of clinical investigation. 2015 Aug; 125(8):2935-51. doi: 10.1172/jci74929. [PMID: 26193634]
  • Jasmin Wellbrock, Emily Latuske, Julian Köhler, Katharina Wagner, Hauke Stamm, Eik Vettorazzi, Gabi Vohwinkel, Marianne Klokow, Roswitha Uibeleisen, Patrick Ehm, Kristoffer Riecken, Sonja Loges, Felicitas Thol, Claudia Schubert, Michael Amling, Manfred Jücker, Carsten Bokemeyer, Michael Heuser, Jürgen Krauter, Walter Fiedler. Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 May; 21(10):2388-98. doi: 10.1158/1078-0432.ccr-14-1059. [PMID: 25745035]
  • Jiancheng Zhou, Kaijie Wu, Dexuan Gao, Guodong Zhu, Dapeng Wu, Xinyang Wang, Yule Chen, Yuefeng Du, Wenbin Song, Zhenkun Ma, Craig Authement, Debabrata Saha, Jer-Tsong Hsieh, Dalin He. Reciprocal regulation of hypoxia-inducible factor 2α and GLI1 expression associated with the radioresistance of renal cell carcinoma. International journal of radiation oncology, biology, physics. 2014 Nov; 90(4):942-51. doi: 10.1016/j.ijrobp.2014.06.065. [PMID: 25585786]
  • Lamia Ghezali, Bertrand Liagre, Youness Limami, Jean-Louis Beneytout, David Yannick Leger. Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells. PloS one. 2014; 9(4):e95016. doi: 10.1371/journal.pone.0095016. [PMID: 24740159]