Pipemidic acid (BioDeep_00000017928)

   

human metabolite


代谢物信息卡片


5,8-Dihydro-8-ethyl-5-oxo-2-(1-piperazinyl)pyrido(2,3-D)pyrimidine-6-carboxylic acid

化学式: C14H17N5O3 (303.1331)
中文名称: 吡哌酸
谱图信息: 最多检出来源 Rattus norvegicus(not specific) 1.53%

分子结构信息

SMILES: CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCNCC3)C(=O)O
InChI: InChI=1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)

描述信息

Pipemidic acid is a member of the pyridopyrimidine class of antibacterials, which display some overlap in mechanism of action with analogous pyridone-containing quinolones.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
C254 - Anti-Infective Agent > C255 - Urinary Anti-Infective Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents

同义名列表

28 个代谢物同义名

5,8-Dihydro-8-ethyl-5-oxo-2-(1-piperazinyl)pyrido(2,3-D)pyrimidine-6-carboxylic acid; 8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-D)pyrimidine-6-carboxylic acid; 8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-D)pyrimidine-6-carboxylate; 8-ethyl-5-oxo-2-(piperazin-1-yl)-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxylic acid; 5,8-Dihydro-8-ethyl-5-oxo-2-(1-piperazinyl)pyrido(2,3-D)pyrimidine-6-carboxylate; Rhône-poulenc brand OF pipemidic acid; Tedec meiji brand OF pipemidic acid; Almirall brand OF pipemidic acid; Aventis brand OF pipemidic acid; Madaus brand OF pipemidic acid; AF brand OF pipemidic acid; Pipemidic acid hydrate; Acidum pipemidicum; Acide pipemidique; Acido pipemidico; Acid, piperamic; Acid, pipemidic; Piperamic acid; Pipemidic acid; Pipemidate; Uropipemid; Deblaston; Galusan; Urisan; Pipram; Palin; Nuril; PPA



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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  • Priscila Reina Siliano, Lillian Andrade Rocha, José Osmar Medina-Pestana, Ita Pfeferman Heilberg. The role of host factors and bacterial virulence genes in the development of pyelonephritis caused by Escherichia coli in renal transplant recipients. Clinical journal of the American Society of Nephrology : CJASN. 2010 Jul; 5(7):1290-7. doi: 10.2215/cjn.06740909. [PMID: 20448070]
  • Adrienne B Hoeglund, Heidi E Bostic, Angela L Howard, Irene W Wanjala, Michael D Best, Daniel L Baker, Abby L Parrill. Optimization of a pipemidic acid autotaxin inhibitor. Journal of medicinal chemistry. 2010 Feb; 53(3):1056-66. doi: 10.1021/jm9012328. [PMID: 20041668]
  • Hanwen Sun, Liqing Li, Ming Su. Simultaneous determination of proline and pipemidic acid in human urine by capillary electrophoresis with electrochemiluminescence detection. Journal of clinical laboratory analysis. 2010; 24(5):327-33. doi: 10.1002/jcla.20284. [PMID: 20872568]
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  • Yao-Dong Liang, Wei Gao, Jun-Feng Song. Electrochemiluminescence determination of pipemidic acid using sulfite as energy transfer mediator. Bioorganic & medicinal chemistry letters. 2006 Oct; 16(20):5328-33. doi: 10.1016/j.bmcl.2006.07.084. [PMID: 16908137]
  • Jin Sun, Yoshiharu Deguchi, Yoshihiko Tauchi, Zhonggui He, Gang Cheng, Kazuhiro Morimoto. Distribution characteristics of orally administered olamufloxacin, a newly synthesized fluoroquinolone antibacterial, in lung epithelial lining fluid and alveolar macrophage in rats. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2006 Oct; 64(2):238-45. doi: 10.1016/j.ejpb.2006.04.009. [PMID: 16875808]
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  • E J Llorent-Martínez, P Ortega-Barrales, A Molina-Díaz. Multicommuted optosensor for the determination of pipemidic acid in biological fluids. Analytical biochemistry. 2005 Dec; 347(2):330-2. doi: 10.1016/j.ab.2005.09.021. [PMID: 16259938]
  • Xia Li, Hong Qiang, Xiao-li Wang, Shi-lü Chen, Hui-chun Zhao. [A study on europium sensitized chemiluminescence of pipemidic acid]. Guang pu xue yu guang pu fen xi = Guang pu. 2004 Dec; 24(12):1518-20. doi: NULL. [PMID: 15828315]
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  • C Liu, H Zhao, L Jin. [Study of the fluorescence of terbium-pipemidic acid system and the determination of pipemidic acid in urine and serum]. Guang pu xue yu guang pu fen xi = Guang pu. 1999 Jun; 19(3):447-9. doi: NULL. [PMID: 15819087]
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  • M Telting-Diaz, A J Miranda Ordieres, A Costa Garcia, P Tuñón Blanco, D Diamond, M R Smyth. Adsorptive stripping voltammetric determination of pipemidic acid in human urine. The Analyst. 1990 Sep; 115(9):1215-7. doi: 10.1039/an9901501215. [PMID: 2091490]
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  • A H Staib, S Harder, U Fuhr, C Wack. Interaction of quinolones with the theophylline metabolism in man: investigations with lomefloxacin and pipemidic acid. International journal of clinical pharmacology, therapy, and toxicology. 1989 Jun; 27(6):289-3. doi: . [PMID: 2737798]
  • T Izumi, T Kitagawa. Protein binding of quinolonecarboxylic acids. I. Cinoxacin, nalidixic acid and pipemidic acid. Chemical & pharmaceutical bulletin. 1989 Mar; 37(3):742-5. doi: 10.1248/cpb.37.742. [PMID: 2752487]
  • T Izumi, T Nagayama, T Kitagawa. Protein binding of quinolonecarboxylic acids. II. Spectral changes on the interaction of cinoxacin, nalidixic acid and pipemidic acid with human and rat albumins. Chemical & pharmaceutical bulletin. 1989 Mar; 37(3):746-52. doi: 10.1248/cpb.37.746. [PMID: 2752488]
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  • M Cruciani, V Monzillo, A Navarra, C Tinelli, E Concia. Antibacterial activity after a single-dose of norfloxacin, ofloxacin and pipemidic acid detected in urine of volunteers. Drugs under experimental and clinical research. 1988; 14(8):533-7. doi: NULL. [PMID: 3150350]
  • E C Meyer, H S Schoeman. A comparative study of pipemidic acid and nitrofurantoin in the treatment of uncomplicated urinary tract infections. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1987 Nov; 72(10):663-5. doi: NULL. [PMID: 3686263]
  • Y Niki, R Soejima, H Kawane, M Sumi, S Umeki. New synthetic quinolone antibacterial agents and serum concentration of theophylline. Chest. 1987 Oct; 92(4):663-9. doi: 10.1378/chest.92.4.663. [PMID: 3477409]
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