Niclosamide (BioDeep_00000017925)
human metabolite blood metabolite
代谢物信息卡片
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
化学式: C13H8Cl2N2O4 (325.9861108)
中文名称: 氯硝柳胺
谱图信息:
最多检出来源 Homo sapiens(blood) 2.72%
分子结构信息
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChI: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
描述信息
Niclosamide is used for the treatment of most tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals.
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02D - Anticestodals > P02DA - Salicylic acid derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D010575 - Pesticides > D008975 - Molluscacides
D016573 - Agrochemicals
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:7553
- PubChem: 4477
- HMDB: HMDB0015679
- DrugBank: DB06803
- ChEMBL: CHEMBL1448
- Wikipedia: Niclosamide
- MeSH: Niclosamide
- chemspider: 4322
- CAS: 50-65-7
- PMhub: MS000001207
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xianglin Chen, Shangyue Yang, Biran Zhu, Mengyuan Zhang, Na Zheng, Jianghuan Hua, Ruiwen Li, Jian Han, Lihua Yang, Bingsheng Zhou. Effects of environmentally relevant concentrations of niclosamide on lipid metabolism and steroid hormone synthesis in adult female zebrafish.
The Science of the total environment.
2024 Feb; 910(?):168737. doi:
10.1016/j.scitotenv.2023.168737. [PMID: 37992841] - Yi Liu, David Quintanar Guerrero, David Lechuga-Ballesteros, Mingdian Tan, Faiz Ahmad, Bilal Aleiwi, Edmund Lee Ellsworth, Bin Chen, Mei-Sze Chua, Samuel So. Lipid-Based Self-Microemulsion of Niclosamide Achieved Enhanced Oral Delivery and Anti-Tumor Efficacy in Orthotopic Patient-Derived Xenograft of Hepatocellular Carcinoma in Mice.
International journal of nanomedicine.
2024; 19(?):2639-2653. doi:
10.2147/ijn.s442143. [PMID: 38500681] - Hao Wu, Xiping Yuan, Min Xie, Jinwei Gao, Zhenzhen Xiong, Rui Song, Zhonggui Xie, Dongsheng Ou. The Impact of Niclosamide Exposure on the Activity of Antioxidant Enzymes and the Expression of Glucose and Lipid Metabolism Genes in Black Carp (Mylopharyngodon piceus).
Genes.
2023 Dec; 14(12):. doi:
10.3390/genes14122196. [PMID: 38137017] - Shengjie Feng, Cristina Puchades, Juyeon Ko, Hao Wu, Yifei Chen, Eric E Figueroa, Shuo Gu, Tina W Han, Brandon Ho, Tong Cheng, Junrui Li, Brian Shoichet, Yuh Nung Jan, Yifan Cheng, Lily Yeh Jan. Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nature communications.
2023 Aug; 14(1):4874. doi:
10.1038/s41467-023-40410-x. [PMID: 37573365] - Jing Xiang, Hao Wu, Jinwei Gao, Weimin Jiang, Xing Tian, Zhonggui Xie, Tao Zhang, Jia Feng, Rui Song. Niclosamide exposure disrupts antioxidant defense, histology, and the liver and gut transcriptome of Chinese soft-shelled turtle (Pelodiscus sinensis).
Ecotoxicology and environmental safety.
2023 Jul; 260(?):115081. doi:
10.1016/j.ecoenv.2023.115081. [PMID: 37262966] - Amruta Prabhakar Padakanti, Sachin Dattaram Pawar, Pramod Kumar, Naveen Chella. Development and validation of HPLC method for simultaneous estimation of erlotinib and niclosamide from liposomes optimized by screening design.
Journal of liposome research.
2023 Jan; ?(?):1-15. doi:
10.1080/08982104.2022.2162540. [PMID: 36594184] - Biran Zhu, Lei Lei, Yumiao Sun, Xiongjie Shi, Kaiyu Fu, Jianghuan Hua, Christopher J Martyniuk, Jian Han, Lihua Yang, Bingsheng Zhou. Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male Zebrafish.
Environmental science & technology.
2022 08; 56(16):11516-11526. doi:
10.1021/acs.est.2c02712. [PMID: 35901075] - Shivani Singh, Anne Weiss, James Goodman, Marie Fisk, Spoorthy Kulkarni, Ing Lu, Joanna Gray, Rona Smith, Morten Sommer, Joseph Cheriyan. Niclosamide-A promising treatment for COVID-19.
British journal of pharmacology.
2022 07; 179(13):3250-3267. doi:
10.1111/bph.15843. [PMID: 35348204] - Kunlakanya Jitobaom, Chompunuch Boonarkart, Suwimon Manopwisedjaroen, Nuntaya Punyadee, Suparerk Borwornpinyo, Arunee Thitithanyanont, Panisadee Avirutnan, Prasert Auewarakul. Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations.
BMC pharmacology & toxicology.
2022 06; 23(1):41. doi:
10.1186/s40360-022-00580-8. [PMID: 35717393] - Andres Hernandez-Clavijo, Kevin Y Gonzalez-Velandia, Uday Rangaswamy, Giorgia Guarneri, Paolo Boscolo-Rizzo, Margherita Tofanelli, Nicoletta Gardenal, Remo Sanges, Michele Dibattista, Giancarlo Tirelli, Anna Menini. Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2022 Jun; 56(3):254-269. doi:
10.33594/000000531. [PMID: 35670331] - Taotao Lu, Xinyu Zheng, Fei Mao, Qiao Cao, Qin Cao, Jin Zhu, Xiaokang Li, Lefu Lan, Baoli Li, Jian Li. Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
European journal of medicinal chemistry.
2022 Jun; 236(?):114318. doi:
10.1016/j.ejmech.2022.114318. [PMID: 35398731] - Min Shi, Shuya Xue, Jingkun Xu, Shuxian Chen, Jin Zou, Yansha Gao, Shuwu Liu, Xuemin Duan, Limin Lu. Amplified electrochemical determination of niclosamide in food based on carbon nanohorn@MWCNT composite.
Analytical and bioanalytical chemistry.
2022 Jun; 414(14):4119-4127. doi:
10.1007/s00216-022-04060-0. [PMID: 35449471] - Yu-Pu Juang, Yu-Ting Chou, Ru-Xian Lin, Hsiu-Hua Ma, Tai-Ling Chao, Jia-Tsrong Jan, Sui-Yuan Chang, Pi-Hui Liang. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2.
European journal of medicinal chemistry.
2022 May; 235(?):114295. doi:
10.1016/j.ejmech.2022.114295. [PMID: 35344901] - Anne Weiss, Emilie Delavenne, Carina Matias, Heimo Lagler, Daniel Simon, Ping Li, Jon U Hansen, Teresa Pires Dos Santos, Bimal Jana, Petra Priemel, Christine Bangert, Martin Bauer, Sabine Eberl, Alina Nussbaumer-Pröll, Zoe Anne Österreicher, Peter Matzneller, Tamara Quint, Maria Weber, Hanne Mørck Nielsen, Thomas Rades, Helle Krogh Johansen, Henrik Westh, Wooseong Kim, Eleftherios Mylonakis, Christian Friis, Luca Guardabassi, John Pace, Carina Vingsbo Lundberg, Fatima M'Zali, Pascal Butty, Nikolaj Sørensen, Henrik Bjørn Nielsen, Rasmus Toft-Kehler, Emma Guttman-Yassky, Georg Stingl, Markus Zeitlinger, Morten Sommer. Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial.
Clinical and translational medicine.
2022 05; 12(5):e790. doi:
10.1002/ctm2.790. [PMID: 35522900] - Ni Jiang, Shi-Zhu Li, Yang-Wen-Qing Zhang, Mohamed R Habib, Tao Xiong, Sha Xu, Huifen Dong, Qin-Ping Zhao. The identification of alternative oxidase in intermediate host snails of Schistosoma and its potential role in protecting Oncomelania hupensis against niclosamide-induced stress.
Parasites & vectors.
2022 Mar; 15(1):97. doi:
10.1186/s13071-022-05227-5. [PMID: 35313980] - Yangyang Guo, Hengyue Zhu, Yanyi Xiao, Hangcheng Guo, Miaomiao Lin, Ziwei Yuan, Xuejia Yang, Youze Huang, Qiyu Zhang, Yongheng Bai. The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression.
Cell death & disease.
2022 02; 13(2):112. doi:
10.1038/s41419-022-04573-7. [PMID: 35115509] - Dana M Cairns, Dorothy Dulko, Jeffrey K Griffiths, Yoav Golan, Theodora Cohen, Ludovic Trinquart, Lori Lyn Price, Kirthana R Beaulac, Harry P Selker. Efficacy of Niclosamide vs Placebo in SARS-CoV-2 Respiratory Viral Clearance, Viral Shedding, and Duration of Symptoms Among Patients With Mild to Moderate COVID-19: A Phase 2 Randomized Clinical Trial.
JAMA network open.
2022 02; 5(2):e2144942. doi:
10.1001/jamanetworkopen.2021.44942. [PMID: 35138402] - Theo Rein. Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development efforts.
Journal of cellular biochemistry.
2022 02; 123(2):155-160. doi:
10.1002/jcb.30166. [PMID: 34668225] - Jiraporn Ousingsawat, Raquel Centeio, Inês Cabrita, Khaoula Talbi, Oliver Zimmer, Moritz Graf, Achim Göpferich, Rainer Schreiber, Karl Kunzelmann. Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031085. [PMID: 35163010] - David Needham. The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections.
Pharmaceutical research.
2022 Jan; 39(1):115-141. doi:
10.1007/s11095-021-03112-x. [PMID: 34962625] - Yao Fu, Nan Hu, Ming Cao, Wen-Feng Li, Xin-Rui Yang, Jin-Lai Gao, Jing Zhao, Man Jiang, Ming-Hui Ma, Zhi-Jie Sun, De-Li Dong. Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice.
European journal of pharmacology.
2021 Dec; 912(?):174614. doi:
10.1016/j.ejphar.2021.174614. [PMID: 34736968] - N Sanoj Rejinold, Huiyan Piao, Geun-Woo Jin, Goeun Choi, Jin-Ho Choy. Injectable niclosamide nanohybrid as an anti-SARS-CoV-2 strategy.
Colloids and surfaces. B, Biointerfaces.
2021 Dec; 208(?):112063. doi:
10.1016/j.colsurfb.2021.112063. [PMID: 34482191] - Hayder M Al-Kuraishy, Ali I Al-Gareeb, Khalid J Alzahrani, Athanasios Alexiou, Gaber El-Saber Batiha. Niclosamide for Covid-19: bridging the gap.
Molecular biology reports.
2021 Dec; 48(12):8195-8202. doi:
10.1007/s11033-021-06770-7. [PMID: 34664162] - Hae-In Choi, Taeheon Kim, Seung-Won Lee, Jin Woo Kim, Yoon Ju Noh, Gwan-Young Kim, Hyun- Jin Park, Yoon-Jee Chae, Kyeong-Ryoon Lee, Soo-Jin Kim, Tae-Sung Koo. Bioanalysis of niclosamide in plasma using liquid chromatography-tandem mass and application to pharmacokinetics in rats and dogs.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Aug; 1179(?):122862. doi:
10.1016/j.jchromb.2021.122862. [PMID: 34332199] - Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-E-Jahan Gulzar, Thomas S van Zanten, Dhruv Sheth, Neeraja Subhash, Anchal Chandra, Akshatha Shivaraj, Patricia Panikulam, Ibrahim U, Vijay Kumar Nuthakki, Theja Parassini Puthiyapurayil, Riyaz Ahmed, Ashaq Hussain Najar, Sai Manoz Lingamallu, Snigdhadev Das, Bhagyashri Mahajan, Praveen Vemula, Sandip B Bharate, Parvinder Pal Singh, Ram Vishwakarma, Arjun Guha, Varadharajan Sundaramurthy, Satyajit Mayor. Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors.
PLoS pathogens.
2021 07; 17(7):e1009706. doi:
10.1371/journal.ppat.1009706. [PMID: 34252168] - Nils C Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Robert Lorenz Chua, Jakob Trimpert, Nicolas Heinemann, Christine Niemeyer, Friderike Weege, Katja Hönzke, Tom Aschman, Daniel E Heinz, Katja Weckmann, Tim Ebert, Andreas Zellner, Martina Lennarz, Emanuel Wyler, Simon Schroeder, Anja Richter, Daniela Niemeyer, Karen Hoffmann, Thomas F Meyer, Frank L Heppner, Victor M Corman, Markus Landthaler, Andreas C Hocke, Markus Morkel, Nikolaus Osterrieder, Christian Conrad, Roland Eils, Helena Radbruch, Patrick Giavalisco, Christian Drosten, Marcel A Müller. SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nature communications.
2021 06; 12(1):3818. doi:
10.1038/s41467-021-24007-w. [PMID: 34155207] - Miguel O Jara, Zachary N Warnken, Sawittree Sahakijpijarn, Chaeho Moon, Esther Y Maier, Dale J Christensen, John J Koleng, Jay I Peters, Sarah D Hackman Maier, Robert O Williams Iii. Niclosamide inhalation powder made by thin-film freezing: Multi-dose tolerability and exposure in rats and pharmacokinetics in hamsters.
International journal of pharmaceutics.
2021 Jun; 603(?):120701. doi:
10.1016/j.ijpharm.2021.120701. [PMID: 33989748] - Yuchun Cai, Hongyue Zhan, Wenci Weng, Yao Wang, Pengxun Han, Xuewen Yu, Mumin Shao, Huili Sun. Niclosamide ethanolamine ameliorates diabetes-related muscle wasting by inhibiting autophagy.
Skeletal muscle.
2021 06; 11(1):15. doi:
10.1186/s13395-021-00272-7. [PMID: 34107998] - Khalida Shamim, Miao Xu, Xin Hu, Emily M Lee, Xiao Lu, Ruili Huang, Pranav Shah, Xin Xu, Catherine Z Chen, Min Shen, Hui Guo, Lu Chen, Zina Itkin, Richard T Eastman, Paul Shinn, Carleen Klumpp-Thomas, Sam Michael, Anton Simeonov, Donald C Lo, Guo-Li Ming, Hongjun Song, Hengli Tang, Wei Zheng, Wenwei Huang. Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Bioorganic & medicinal chemistry letters.
2021 05; 40(?):127906. doi:
10.1016/j.bmcl.2021.127906. [PMID: 33689873] - Hongyuan Zhao, Yuqi Chang, Runqiang Liu, Bo Li, Fang Li, Fulong Zhang, Mingwang Shi, Lin Zhou, Xiaoguang Li. Facile synthesis of Vulcan XC-72 nanoparticles-decorated halloysite nanotubes for the highly sensitive electrochemical determination of niclosamide.
Food chemistry.
2021 May; 343(?):128484. doi:
10.1016/j.foodchem.2020.128484. [PMID: 33129617] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Khanit Sa-Ngiamsuntorn, Ampa Suksatu, Yongyut Pewkliang, Piyanoot Thongsri, Phongthon Kanjanasirirat, Suwimon Manopwisedjaroen, Sitthivut Charoensutthivarakul, Patompon Wongtrakoongate, Supaporn Pitiporn, Jarinya Chaopreecha, Supasek Kongsomros, Kedchin Jearawuttanakul, Warawuth Wannalo, Phisit Khemawoot, Somchai Chutipongtanate, Suparerk Borwornpinyo, Arunee Thitithanyanont, Suradej Hongeng. Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives.
Journal of natural products.
2021 04; 84(4):1261-1270. doi:
10.1021/acs.jnatprod.0c01324. [PMID: 33844528] - James J Hobson, Alison C Savage, Andrew B Dwyer, Catherine Unsworth, Jonathan Massam, Usman Arshad, Henry Pertinez, Helen Box, Lee Tatham, Rajith K R Rajoli, Megan Neary, Joanne Sharp, Anthony Valentijn, Christopher David, Paul Curley, Neill J Liptrott, Tom O McDonald, Andrew Owen, Steve P Rannard. Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection.
Nanoscale.
2021 Apr; 13(13):6410-6416. doi:
10.1039/d1nr00309g. [PMID: 33885522] - Mamta Parikh, Chengfei Liu, Chun-Yi Wu, Christopher P Evans, Marc Dall'Era, Daniel Robles, Primo N Lara, Neeraj Agarwal, Allen C Gao, Chong-Xian Pan. Phase Ib trial of reformulated niclosamide with abiraterone/prednisone in men with castration-resistant prostate cancer.
Scientific reports.
2021 03; 11(1):6377. doi:
10.1038/s41598-021-85969-x. [PMID: 33737681] - Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park. Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3.
Journal of translational medicine.
2021 02; 19(1):86. doi:
10.1186/s12967-021-02760-2. [PMID: 33632240] - Hyun-Jun Kim, Ji-Hyung Lee, Seon-Wook Kim, Sang-Hoon Lee, Da-Woon Jung, Darren R Williams. Investigation of niclosamide as a repurposing agent for skeletal muscle atrophy.
PloS one.
2021; 16(5):e0252135. doi:
10.1371/journal.pone.0252135. [PMID: 34038481] - Ashlee D Brunaugh, Hyojong Seo, Zachary Warnken, Li Ding, Sang Heui Seo, Hugh D C Smyth. Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae.
PloS one.
2021; 16(2):e0246803. doi:
10.1371/journal.pone.0246803. [PMID: 33571320] - Anne Weiss, Franck Touret, Cecile Baronti, Magali Gilles, Bruno Hoen, Antoine Nougairède, Xavier de Lamballerie, Morten O A Sommer. Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2).
PloS one.
2021; 16(12):e0260958. doi:
10.1371/journal.pone.0260958. [PMID: 34855904] - Tsukasa Suzuki, Momoko Kojima, Yu Matsumoto, Ken-Ichi Kobayashi, Jun Inoue, Yuji Yamamoto. Niclosamide activates the AMP-activated protein kinase complex containing the β2 subunit independently of AMP.
Biochemical and biophysical research communications.
2020 12; 533(4):758-763. doi:
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Life sciences.
2020 Nov; 261(?):118458. doi:
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Nature communications.
2020 08; 11(1):4320. doi:
10.1038/s41467-020-18104-5. [PMID: 32859916] - Yurui Jiao, Chenglong Chen, Xijian Hu, Xu Feng, Zhenqi Shi, Jie Cao, Qing Li, Yikun Zhu. Niclosamide and its derivative DK-520 inhibit RANKL-induced osteoclastogenesis.
FEBS open bio.
2020 08; 10(8):1685-1697. doi:
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Transboundary and emerging diseases.
2020 Jul; 67 Suppl 2(?):69-81. doi:
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Nanomedicine (London, England).
2020 07; 15(16):1551-1565. doi:
10.2217/nnm-2020-0003. [PMID: 32618501] - Qiang Fu, Xin Jin, Zhenhai Zhang, Huixia Lv. Preparation and in vitro antitumor effects on MDA-MB-231 cells of niclosamide nanocrystals stabilized by poloxamer188 and PBS.
International journal of pharmaceutics.
2020 Jun; 584(?):119432. doi:
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Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.00819-20. [PMID: 32366720] - Jimin Xu, Pei-Yong Shi, Hongmin Li, Jia Zhou. Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.
ACS infectious diseases.
2020 05; 6(5):909-915. doi:
10.1021/acsinfecdis.0c00052. [PMID: 32125140] - Biran Zhu, Wei He, Fan Yang, Lianguo Chen. High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo.
Chemosphere.
2020 Apr; 244(?):125468. doi:
10.1016/j.chemosphere.2019.125468. [PMID: 31790986] - Satya P Gupta. Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2.
Current topics in medicinal chemistry.
2020; 20(26):2362-2378. doi:
10.2174/1568026620666200922112300. [PMID: 32962613] - Rui Ma, Zhen-Gang Ma, Jin-Lai Gao, Yu Tai, Lan-Jun Li, Hai-Bin Zhu, Li Li, De-Li Dong, Zhi-Jie Sun. Injectable pegylated niclosamide (polyethylene glycol-modified niclosamide) for cancer therapy.
Journal of biomedical materials research. Part A.
2020 01; 108(1):30-38. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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Viruses.
2019 10; 11(10):. doi:
10.3390/v11100964. [PMID: 31635418] - Jili Zhang, Yubin Bai, Bing Li, Xuzheng Zhou, Hongfei Si, Jiyu Zhang. Determination and pharmacokinetics study of oxyclozanide suspension in cattle by LC-MS/MS.
BMC veterinary research.
2019 Jun; 15(1):210. doi:
10.1186/s12917-019-1963-0. [PMID: 31234851] - Kjell De Vriese, Ellie Himschoot, Kai Dünser, Long Nguyen, Andrzej Drozdzecki, Alex Costa, Moritz K Nowack, Jürgen Kleine-Vehn, Dominique Audenaert, Tom Beeckman, Steffen Vanneste. Identification of Novel Inhibitors of Auxin-Induced Ca2+ Signaling via a Plant-Based Chemical Screen.
Plant physiology.
2019 05; 180(1):480-496. doi:
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Luminescence : the journal of biological and chemical luminescence.
2019 Feb; 34(1):48-54. doi:
10.1002/bio.3575. [PMID: 30450817] - Jingjing Guo, Hanlin Tao, Amer Alasadi, Qingrong Huang, Shengkan Jin. Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice.
Eating and weight disorders : EWD.
2019 Feb; 24(1):91-96. doi:
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Drug development and industrial pharmacy.
2019 Feb; 45(2):304-313. doi:
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Scientific reports.
2019 01; 9(1):881. doi:
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Artificial cells, nanomedicine, and biotechnology.
2018 Dec; 46(8):1926-1934. doi:
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Bioorganic & medicinal chemistry.
2018 11; 26(20):5435-5442. doi:
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The Journal of parasitology.
2018 10; 104(5):574-575. doi:
10.1645/17-93. [PMID: 30019983] - Pengxun Han, Hongyue Zhan, Mumin Shao, Wenjing Wang, Gaofeng Song, Xuewen Yu, Chunlei Zhang, Na Ge, Tiegang Yi, Shunmin Li, Huili Sun. Niclosamide ethanolamine improves kidney injury in db/db mice.
Diabetes research and clinical practice.
2018 Oct; 144(?):25-33. doi:
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Nature communications.
2018 09; 9(1):3931. doi:
10.1038/s41467-018-05805-1. [PMID: 30258081] - Jeong Mi Yun, Seon Min Woo, Seung Un Seo, Kyoung-Jin Min, Dong Eun Kim, Taeg Kyu Kwon. Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells.
Molecules (Basel, Switzerland).
2018 Sep; 23(9):. doi:
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Oncogene.
2018 09; 37(39):5292-5304. doi:
10.1038/s41388-018-0340-y. [PMID: 29855616] - Ying Liu, Yue-Hang Geng, Hui Yang, Han Yang, Yan-Ting Zhou, Hong-Quan Zhang, Xin-Xia Tian, Wei-Gang Fang. Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
Cancer letters.
2018 08; 430(?):1-10. doi:
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PLoS neglected tropical diseases.
2018 08; 12(8):e0006715. doi:
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International journal of antimicrobial agents.
2018 Jun; 51(6):897-904. doi:
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British journal of pharmacology.
2018 05; 175(10):1707-1718. doi:
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BMC cancer.
2018 03; 18(1):297. doi:
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BMC public health.
2018 01; 18(1):186. doi:
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PloS one.
2018; 13(6):e0198389. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 47(3):957-971. doi:
10.1159/000490140. [PMID: 29843133] - He Liang-Cai, Wang Jia-Song, Rong Xian-Bing, Yuan Mei-Zhi, Li Tian-Yan, Liao Qiang, Tan Xian-Yu, Hu Hehua, Tian Ke-Qing, Liu Xiong, Zhang Xia, Su Wen, Cui Cai-Xia, Tian Rong. [Effects and cost of four formulations of niclosamide ethanolamine salt in Oncomelania hupensis snail control in field].
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control.
2017 Dec; 29(6):765-769. doi:
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Kidney international.
2017 09; 92(3):612-624. doi:
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Molecular medicine reports.
2017 Aug; 16(2):1810-1816. doi:
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Materials science & engineering. C, Materials for biological applications.
2017 Aug; 77(?):352-359. doi:
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Investigative ophthalmology & visual science.
2017 06; 58(7):3118-3126. doi:
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Eating and weight disorders : EWD.
2017 Jun; 22(2):339-344. doi:
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Bulletin of environmental contamination and toxicology.
2016 Mar; 96(3):289-94. doi:
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Oncotarget.
2016 Feb; 7(8):8993-9006. doi:
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Scientific reports.
2016 Feb; 6(?):21209. doi:
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Antimicrobial agents and chemotherapy.
2016 01; 60(1):323-31. doi:
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2015 Dec; 27(6):608-11. doi:
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Bioorganic & medicinal chemistry.
2015 Sep; 23(17):5829-38. doi:
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Transplantation proceedings.
2015 Sep; 47(7):2243-4. doi:
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Biochemical and biophysical research communications.
2015 Aug; 464(1):221-228. doi:
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Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases.
2015 Apr; 33(2):101-4. doi:
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Mikrobiyoloji bulteni.
2015 Jan; 49(1):135-8. doi:
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Drug development and industrial pharmacy.
2015; 41(9):1416-24. doi:
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Journal of microencapsulation.
2015; 32(5):496-502. doi:
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Nature medicine.
2014 Nov; 20(11):1263-9. doi:
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PLoS neglected tropical diseases.
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PloS one.
2014; 9(1):e85887. doi:
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PloS one.
2014; 9(12):e113239. doi:
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2013 Dec; 25(6):623-6. doi:
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2013 Dec; 25(6):590-3. doi:
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