[2-Amino-2-(hydroxymethyl)-5-(4-octylphenyl)pentyl] dihydrogen phosphate (BioDeep_00000179242)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H36NO5P (401.2331)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCC1=CC=C(C=C1)CCCC(CO)(COP(=O)(O)O)N
InChI: InChI=1S/C20H36NO5P/c1-2-3-4-5-6-7-9-18-11-13-19(14-12-18)10-8-15-20(21,16-22)17-26-27(23,24)25/h11-14,22H,2-10,15-17,21H2,1H3,(H2,23,24,25)
描述信息
同义名列表
9 个代谢物同义名
2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol monodihydrogen phosphate ester; [2-Amino-2-(hydroxymethyl)-5-(4-octylphenyl)pentyl] dihydrogen phosphoric acid; [2-Amino-2-(hydroxymethyl)-5-(4-octylphenyl)pentyl] dihydrogen phosphate; {2-amino-3-hydroxy-2-[3-(4-octylphenyl)propyl]propoxy}phosphonic acid; 2-amino-3-hydroxy-2-[3-(4-octylphenyl)propyl]propoxyphosphonic acid; FTY720 phosphate; FTY720-p; FTY 720P; FTY-720P
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Reem Rida, Sawsan Kreydiyyeh. Effect of FTY720P on lipid accumulation in HEPG2 cells.
Scientific reports.
2023 11; 13(1):19716. doi:
10.1038/s41598-023-46011-4
. [PMID: 37953311] - Leiye Yu, Licong He, Bing Gan, Rujuan Ti, Qingjie Xiao, Hongli Hu, Lizhe Zhu, Sheng Wang, Ruobing Ren. Structural insights into sphingosine-1-phosphate receptor activation.
Proceedings of the National Academy of Sciences of the United States of America.
2022 04; 119(16):e2117716119. doi:
10.1073/pnas.2117716119
. [PMID: 35412894] - Elisabetta Coppi, Federica Cherchi, Irene Fusco, Ilaria Dettori, Lisa Gaviano, Giada Magni, Daniela Catarzi, Vittoria Colotta, Flavia Varano, Francesca Rossi, Caterina Bernacchioni, Chiara Donati, Paola Bruni, Felicita Pedata, Francesca Cencetti, Anna Maria Pugliese. Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway.
Biochemical pharmacology.
2020 07; 177(?):113956. doi:
10.1016/j.bcp.2020.113956
. [PMID: 32251679] - Timothy D Rohrbach, Amon Asgharpour, Melissa A Maczis, David Montefusco, L Ashley Cowart, Pierre Bedossa, Arun J Sanyal, Sarah Spiegel. FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.
Journal of lipid research.
2019 07; 60(7):1311-1322. doi:
10.1194/jlr.m093799
. [PMID: 31110049] - Weina Wang, Aimei Wang, Guochang Luo, Fengqiao Ma, Xiaoming Wei, Yongyi Bi. S1P1 receptor inhibits kidney epithelial mesenchymal transition triggered by ischemia/reperfusion injury via the PI3K/Akt pathway.
Acta biochimica et biophysica Sinica.
2018 Jul; 50(7):651-657. doi:
10.1093/abbs/gmy058
. [PMID: 29901713] - Jing Yin, Yu-Ming Guo, Ping Chen, He Xiao, Xing-Huan Wang, Michael E DiSanto, Xin-Hua Zhang. Testosterone regulates the expression and functional activity of sphingosine-1-phosphate receptors in the rat corpus cavernosum.
Journal of cellular and molecular medicine.
2018 03; 22(3):1507-1516. doi:
10.1111/jcmm.13416
. [PMID: 29266713] - Shaymaa Mohamed Mohamed Badawy, Taro Okada, Taketoshi Kajimoto, Takeshi Ijuin, Shun-Ichi Nakamura. DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling.
Scientific reports.
2017 11; 7(1):16552. doi:
10.1038/s41598-017-16457-4
. [PMID: 29185452] - Patrick M Reeves, Yuan-Lin Kang, Tom Kirchhausen. Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway.
Traffic (Copenhagen, Denmark).
2016 Jan; 17(1):40-52. doi:
10.1111/tra.12343
. [PMID: 26481905] - Suzanne Attiori Essis, Marie-Elaine Laurier-Laurin, Élise Pépin, Michel Cyr, Guy Massicotte. GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P.
Brain research.
2015 Oct; 1624(?):349-358. doi:
10.1016/j.brainres.2015.07.055
. [PMID: 26260438] - Matthias Schröder, Olga Arlt, Helmut Schmidt, Andrea Huwiler, Carlo Angioni, Josef M Pfeilschifter, Anja Schwiebs, Heinfried H Radeke. Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application.
Biological chemistry.
2015 Jun; 396(6-7):795-802. doi:
10.1515/hsz-2014-0287
. [PMID: 25720062] - Susann Fayyaz, Janin Henkel, Lukasz Japtok, Stephanie Krämer, Georg Damm, Daniel Seehofer, Gerhard P Püschel, Burkhard Kleuser. Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype.
Diabetologia.
2014 Feb; 57(2):373-82. doi:
10.1007/s00125-013-3123-6
. [PMID: 24292566] - N Ferreirós, S Labocha, M Schröder, H H Radeke, G Geisslinger. LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Mar; 887-888(?):122-7. doi:
10.1016/j.jchromb.2012.01.023
. [PMID: 22341683] - Lauren P Saunders, Wenxiang Cao, William C Chang, Ronald A Albright, Demetrios T Braddock, Enrique M De La Cruz. Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution.
The Journal of biological chemistry.
2011 Aug; 286(34):30130-41. doi:
10.1074/jbc.m111.246884
. [PMID: 21719699] - Robert Bucki, Alina Kulakowska, Fitzroy J Byfield, Malgorzata Zendzian-Piotrowska, Marcin Baranowski, Michal Marzec, Jessamine P Winer, Nicholas J Ciccarelli, Jan Górski, Wieslaw Drozdowski, Robert Bittman, Paul A Janmey. Plasma gelsolin modulates cellular response to sphingosine 1-phosphate.
American journal of physiology. Cell physiology.
2010 Dec; 299(6):C1516-23. doi:
10.1152/ajpcell.00051.2010
. [PMID: 20810916] - William J Valentine, Gyöngyi N Kiss, Jianxiong Liu, Shuyu E, Mari Gotoh, Kimiko Murakami-Murofushi, Truc Chi Pham, Daniel L Baker, Abby L Parrill, Xuequan Lu, Chaode Sun, Robert Bittman, Nigel J Pyne, Gabor Tigyi. (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.
Cellular signalling.
2010 Oct; 22(10):1543-53. doi:
10.1016/j.cellsig.2010.05.023
. [PMID: 20566326] - Laurens A van Meeteren, Volker Brinkmann, Jean Sébastien Saulnier-Blache, Kevin R Lynch, Wouter H Moolenaar. Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
Cancer letters.
2008 Aug; 266(2):203-8. doi:
10.1016/j.canlet.2008.02.052
. [PMID: 18378389] - C G Jung, H J Kim, V E Miron, S Cook, T E Kennedy, C A Foster, J P Antel, B Soliven. Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells.
Glia.
2007 Dec; 55(16):1656-67. doi:
10.1002/glia.20576
. [PMID: 17876806]