Mebendazole (BioDeep_00000017923)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester
化学式: C16H13N3O3 (295.0956868)
中文名称: 甲苯咪唑
谱图信息:
最多检出来源 Rattus norvegicus(blood) 7.35%
分子结构信息
SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1
InChI: InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
描述信息
Mebendazole is only found in individuals that have used or taken this drug. It is a benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02C - Antinematodal agents > P02CA - Benzimidazole derivatives
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
同义名列表
40 个代谢物同义名
(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester; (5-Benzoyl-1H-benzimidazol-2-yl)-carbamate methyl ester; methyl N-(6-benzoyl-1H-1,3-benzodiazol-2-yl)carbamate; Abello farmacia brand OF mebendazole; Healthypharm brand OF mebendazole; Tedec meiji brand OF mebendazole; Leidapharm brand OF mebendazole; Ardeypharm brand OF mebendazole; Taxandria brand OF mebendazole; Streger brand OF mebendazole; Janssen brand OF mebendazole; Degorts brand OF mebendazole; Norgine brand OF mebendazole; Pfizer brand OF mebendazole; Esteve brand OF mebendazole; Boots brand OF mebendazole; Elfar brand OF mebendazole; Boots threadworm treatment; Diba brand OF mebendazole; SSL Brand OF mebendazole; Pripsen mebendazole; mebendazole; Anti worm; Anti-worm; Wormkuur; Vermicol; Bantenol; Mebenvet; Mebendan; Madicure; Vermidil; Banworm; Surfont; Lomper; Telmin; Vermin; Vermox; Sqworm; Sufil; MBDZ
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:6704
- PubChem: 4030
- HMDB: HMDB0014781
- DrugBank: DB00643
- ChEMBL: CHEMBL685
- Wikipedia: Mebendazole
- MeSH: Mebendazole
- chemspider: 3890
- CAS: 31431-39-7
- PMhub: MS000001199
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenrong He, Hai An Truong, Ling Zhang, Min Cao, Neal Arakawa, Yao Xiao, Kaizhen Zhong, Yingnan Hou, Wolfgang Busch. Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles.
Cell reports.
2024 Feb; 43(2):113763. doi:
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2023 Jun; 47(2):409-419. doi:
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2022 Jul; 12(1):11582. doi:
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Chemosphere.
2016 Aug; 157(?):10-7. doi:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2016 Aug; 49(?):59-61. doi:
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American journal of therapeutics.
2016 Jul; 23(4):e1025-31. doi:
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Journal of helminthology.
2016 May; 90(3):298-302. doi:
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Mutagenesis.
2016 05; 31(3):309-21. doi:
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Veterinary parasitology.
2016 Mar; 218(?):66-72. doi:
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Veterinary parasitology.
2016 Feb; 217(?):95-100. doi:
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The Pan African medical journal.
2016; 25(?):45. doi:
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International journal for parasitology. Drugs and drug resistance.
2015 12; 5(3):178-84. doi:
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Pakistan journal of pharmaceutical sciences.
2015 Nov; 28(6):2115-8. doi:
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Acta tropica.
2015 Sep; 149(?):155-62. doi:
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Acta tropica.
2015 Aug; 148(?):89-96. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2015 Aug; 21(15):3462-3470. doi:
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Turkiye parazitolojii dergisi.
2015 Jun; 39(2):164-6. doi:
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Clinical pharmacokinetics.
2015 Apr; 54(4):371-83. doi:
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The Lancet. Infectious diseases.
2015 Mar; 15(3):277-84. doi:
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Journal of biomaterials science. Polymer edition.
2015; 26(13):868-80. doi:
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Annals of parasitology.
2015; 61(2):125-7. doi:
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MMW Fortschritte der Medizin.
2014 Dec; 156(21-22):44. doi:
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Parasites & vectors.
2014 Dec; 7(?):589. doi:
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PLoS neglected tropical diseases.
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Scientific reports.
2014 Sep; 4(?):6437. doi:
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Tropical medicine & international health : TM & IH.
2014 Jul; 19(7):812-24. doi:
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Gastroenterology.
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Veterinary parasitology.
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Mar; 53(?):17-27. doi:
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Drug design, development and therapy.
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PLoS neglected tropical diseases.
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Meditsinskaia parazitologiia i parazitarnye bolezni.
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International journal of pharmaceutics.
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Bioresource technology.
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Acta tropica.
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Acta tropica.
2013 Aug; 127(2):112-7. doi:
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Tropical medicine & international health : TM & IH.
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Pathogens and global health.
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The American journal of tropical medicine and hygiene.
2013 Feb; 88(2):364-6. doi:
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Parasitology research.
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Parasitology research.
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Asian Pacific journal of tropical medicine.
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BMC veterinary research.
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Parasites & vectors.
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The Korean journal of parasitology.
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Veterinary parasitology.
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BMC infectious diseases.
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PLoS neglected tropical diseases.
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PLoS neglected tropical diseases.
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Chemotherapy.
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Mediterranean journal of hematology and infectious diseases.
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PLoS neglected tropical diseases.
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