N-Formyl-met-leu-phe-lys (BioDeep_00000179178)

   

human metabolite blood metabolite


代谢物信息卡片


6-amino-2-(2-{2-[2-formamido-4-(methylsulfanyl)butanamido]-4-methylpentanamido}-3-phenylpropanamido)hexanoic acid

化学式: C27H43N5O6S (565.2933898000001)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 98.25%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCSC)NC=O
InChI: InChI=1S/C27H43N5O6S/c1-18(2)15-22(31-24(34)20(29-17-33)12-14-39-3)25(35)32-23(16-19-9-5-4-6-10-19)26(36)30-21(27(37)38)11-7-8-13-28/h4-6,9-10,17-18,20-23H,7-8,11-16,28H2,1-3H3,(H,29,33)(H,30,36)(H,31,34)(H,32,35)(H,37,38)

描述信息

同义名列表

6 个代谢物同义名

6-amino-2-(2-{2-[2-formamido-4-(methylsulfanyl)butanamido]-4-methylpentanamido}-3-phenylpropanamido)hexanoic acid; N-Formylmethionyl-leucyl-phenylalanyl-lysine; N-Formylmethionylleucylphenylalanyllysine; N-Formyl-Met-Leu-Phe-Lys; F-Met-leu-phe-lys; FMLPL



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Irundika H K Dias, John B Matthews, Iain L C Chapple, Helen J Wright, Christopher R Dunston, Helen R Griffiths. Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines. Journal of clinical periodontology. 2011 Jan; 38(1):1-7. doi: 10.1111/j.1600-051x.2010.01628.x. [PMID: 20964702]
  • Marcia Riesselman, Heini M Miettinen, Jeannie M Gripentrog, Connie I Lord, Brendan Mumey, Edward A Dratz, Jamal Stie, Ross M Taylor, Algirdas J Jesaitis. C-terminal tail phosphorylation of N-formyl peptide receptor: differential recognition of two neutrophil chemoattractant receptors by monoclonal antibodies NFPR1 and NFPR2. Journal of immunology (Baltimore, Md. : 1950). 2007 Aug; 179(4):2520-31. doi: 10.4049/jimmunol.179.4.2520. [PMID: 17675514]
  • Rita M Heuertz, Gregory P Schneider, Lawrence A Potempa, Robert O Webster. Native and modified C-reactive protein bind different receptors on human neutrophils. The international journal of biochemistry & cell biology. 2005 Feb; 37(2):320-35. doi: 10.1016/j.biocel.2004.07.002. [PMID: 15474978]
  • Steffi Kopprasch, Jens Pietzsch, Juergen Graessler. The protective effects of HDL and its constituents against neutrophil respiratory burst activation by hypochlorite-oxidized LDL. Molecular and cellular biochemistry. 2004 Mar; 258(1-2):121-7. doi: 10.1023/b:mcbi.0000012842.19059.c5. [PMID: 15030176]
  • Dominique A Daels-Rakotoarison, Gisèle Kouakou, Bernard Gressier, Thierry Dine, Claude Brunet, Michel Luyckx, François Bailleul, Francis Trotin. Effects of a caffeine-free Cola nitida nuts extract on elastase/alpha-1-proteinase inhibitor balance. Journal of ethnopharmacology. 2003 Nov; 89(1):143-50. doi: 10.1016/s0378-8741(03)00279-4. [PMID: 14522446]
  • Gwenny M Fuhler, Floris Hooijenga, A Lyndsay Drayer, Edo Vellenga. Reduced expression of flavocytochrome b558, a component of the NADPH oxidase complex, in neutrophils from patients with myelodysplasia. Experimental hematology. 2003 Sep; 31(9):752-9. doi: 10.1016/s0301-472x(03)00188-7. [PMID: 12962720]
  • I V Klyubin, K M Kirpichnikova, A M Ischenko, A V Zhakhov, I A Gamaley. The role of reactive oxygen species in membrane potential changes in macrophages and astrocytes. Membrane & cell biology. 2000; 13(4):557-66. doi: NULL. [PMID: 10926373]
  • H Schneeweiss, L Renwrantz. Analysis of the attraction of haemocytes from Mytilus edulis by molecules of bacterial origin. Developmental and comparative immunology. 1993 Sep; 17(5):377-87. doi: 10.1016/0145-305x(93)90029-p. [PMID: 8270090]
  • R A Allen, R W Erickson, A J Jesaitis. Identification of a human neutrophil protein of Mr 24 000 that binds N-formyl peptides: co-sedimentation with specific granules. Biochimica et biophysica acta. 1989 Apr; 991(1):123-33. doi: 10.1016/0304-4165(89)90037-8. [PMID: 2653446]
  • D E Van Epps, S L Kutvirt. Modulation of human neutrophil adherence by beta-endorphin and met-enkephalin. Journal of neuroimmunology. 1987 Jul; 15(3):219-28. doi: 10.1016/0165-5728(87)90117-2. [PMID: 2954999]
  • S L Lewis, D E Van Epps, D E Chenoweth. C5a receptor modulation on neutrophils and monocytes from chronic hemodialysis and peritoneal dialysis patients. Clinical nephrology. 1986 Jul; 26(1):37-44. doi: NULL. [PMID: 3488153]