Fodipir (BioDeep_00000179174)

   

human metabolite blood metabolite


代谢物信息卡片


2-({2-[(carboxymethyl)({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]ethyl}({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino)acetic acid

化学式: C22H32N4O14P2 (638.1390192)
中文名称: 福地吡
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: CC1=C(O)C(CN(CCN(CC(O)=O)CC2=C(COP(O)(O)=O)C=NC(C)=C2O)CC(O)=O)=C(COP(O)(O)=O)C=N1
InChI: InChI=1S/C22H32N4O14P2/c1-13-21(31)17(15(5-23-13)11-39-41(33,34)35)7-25(9-19(27)28)3-4-26(10-20(29)30)8-18-16(12-40-42(36,37)38)6-24-14(2)22(18)32/h5-6,31-32H,3-4,7-12H2,1-2H3,(H,27,28)(H,29,30)(H2,33,34,35)(H2,36,37,38)

描述信息

同义名列表

16 个代谢物同义名

2-({2-[(carboxymethyl)({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]ethyl}({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino)acetic acid; ({2-[(carboxymethyl)({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]ethyl}({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino)acetic acid; 2-({2-[(carboxymethyl)({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]ethyl}({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino)acetate; N,N-bis(pyridoxal-5-phosphate)ethylenediamine-N,n-diacetic acid; Nycomed brand OF mangafodipir trisodium; Mangafodipir trisodium, anhydrous; Manganese dipyridoxyl diphosphate; Mangafodipir trisodium; Calmangafodipir; Manganese-DPDP; Ca4MN(DPDP)5; Mangafodipir; Teslascan; Fodipir; MN-DPDP; DPDP



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Per Jynge, Arne M Skjold, Ursula Falkmer, Rolf G G Andersson, John G Seland, Morten Bruvold, Viggo Blomlie, Willy Eidsaunet, Jan O G Karlsson. MnDPDP: Contrast Agent for Imaging and Protection of Viable Tissue. Contrast media & molecular imaging. 2020; 2020(?):3262835. doi: 10.1155/2020/3262835. [PMID: 32994754]
  • Xianghui Wang, Li Xu, Zhanying Ren, Mingxia Fan, Jie Zhang, Hongxin Qi, Min Xu. A novel manganese chelated macromolecular MRI contrast agent based on O-carboxymethyl chitosan derivatives. Colloids and surfaces. B, Biointerfaces. 2019 Nov; 183(?):110452. doi: 10.1016/j.colsurfb.2019.110452. [PMID: 31473409]
  • Jan-Erik Karlsson, Walid El-Saadi, Mustafa Ali, Werner Puskar, Patrik Skogvard, Jan E Engvall, Rolf G Andersson, Eva Maret, Per Jynge. Mangafodipir as a cardioprotective adjunct to reperfusion therapy: a feasibility study in patients with ST-segment elevation myocardial infarction. European heart journal. Cardiovascular pharmacotherapy. 2015 01; 1(1):39-45. doi: 10.1093/ehjcvp/pvu021. [PMID: 27533964]
  • Xiang Gao, Monica Sandberg, My Quach, Birgitta Bodin, Lars Johansson, Leif Jansson. Effects of Mn-DPDP and manganese chloride on hemodynamics and glucose tolerance in anesthetized rats. Acta radiologica (Stockholm, Sweden : 1987). 2014 Apr; 55(3):328-34. doi: 10.1177/0284185113499327. [PMID: 23963152]
  • Romain Coriat, Jérôme Alexandre, Carole Nicco, Laurent Quinquis, Evelyne Benoit, Christiane Chéreau, Hervé Lemaréchal, Olivier Mir, Didier Borderie, Jean-Marc Tréluyer, Bernard Weill, Joel Coste, François Goldwasser, Frédéric Batteux. Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir. The Journal of clinical investigation. 2014 Jan; 124(1):262-72. doi: 10.1172/jci68730. [PMID: 24355920]
  • Ismail Ben Mosbah, Yann Mouchel, Julie Pajaud, Catherine Ribault, Catherine Lucas, Alexis Laurent, Karim Boudjema, Fabrice Morel, Anne Corlu, Philippe Compagnon. Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat. PloS one. 2012; 7(11):e50235. doi: 10.1371/journal.pone.0050235. [PMID: 23226251]
  • Romain Coriat, Mahaut Leconte, Niloufar Kavian, Sassia Bedda, Carole Nicco, Christiane Chereau, Claire Goulvestre, Bernard Weill, Alexis Laurent, Frédéric Batteux. Mangafodipir protects against hepatic ischemia-reperfusion injury in mice. PloS one. 2011; 6(11):e27005. doi: 10.1371/journal.pone.0027005. [PMID: 22073237]
  • Paul S Tofts, Andre Porchia, Ying Jin, Robin Roberts, Bruce A Berkowitz. Toward clinical application of manganese-enhanced MRI of retinal function. Brain research bulletin. 2010 Feb; 81(2-3):333-8. doi: 10.1016/j.brainresbull.2009.06.002. [PMID: 19524028]
  • Déborah Hirt, Jean-Philippe Richardet, Saïk Urien, Joël Poupon, Philippe Sogni, Frédéric Batteux, Alexis Laurent, Silvana Pavlovic, Marcel Debray, Jean-Marc Treluyer, Bernard Weill. Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis. Therapeutic drug monitoring. 2009 Oct; 31(5):557-65. doi: 10.1097/ftd.0b013e3181affd6d. [PMID: 19834427]
  • Juha Halavaara, Usama Abo-Ramadan, Antti Markkola, Hannu Aronen, Anna-Maija Häkkinen. MnDPDP-enhanced magnetization transfer MR imaging: implications for effective liver imaging. Magnetic resonance imaging. 2003 Jan; 21(1):47-50. doi: 10.1016/s0730-725x(02)00633-1. [PMID: 12620545]
  • Peter P Schmidt, Kim G Toft, Tore Skotland, KristofferK Andersson. Stability and transmetallation of the magnetic resonance contrast agent MnDPDP measured by EPR. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2002 Mar; 7(3):241-8. doi: 10.1007/s007750100290. [PMID: 11935348]
  • Koenraad J Mortelé, Walter Wiesner, Bernard de Hemptinne, Andre Elewaut, Marleen Praet, Pablo R Ros. Multifocal inflammatory pseudotumor of the liver: dynamic gadolinium-enhanced, ferumoxides-enhanced, and mangafodipir trisodium-enhanced MR imaging findings. European radiology. 2002 Feb; 12(2):304-8. doi: 10.1007/s003300101015. [PMID: 11870426]
  • J O Karlsson, H Brurok, M Eriksen, R Towart, K G Toft, O Moen, B Engebretsen, P Jynge, H Refsum. Cardioprotective effects of the MR contrast agent MnDPDP and its metabolite MnPLED upon reperfusion of the ischemic porcine myocardium. Acta radiologica (Stockholm, Sweden : 1987). 2001 Nov; 42(6):540-7. doi: 10.1080/028418501127347340. [PMID: 11736698]
  • K G Toft, A H Myrset, T Skotland. Dephosphorylation of MnDPDP and related compounds by acid and alkaline phosphatase. Journal of pharmaceutical and biomedical analysis. 2001 Jun; 25(3-4):613-8. doi: 10.1016/s0731-7085(00)00587-2. [PMID: 11377042]
  • J Grimm, S Müller-Hülsbeck, J Blume, J Biederer, M Heller. [Comparison of biphasic spiral CT and MnDPDP-enhanced MRI in the detection and characterization of liver lesions]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 2001 Mar; 173(3):266-72. doi: 10.1055/s-2001-11596. [PMID: 11293872]
  • D Högemann, P Flemming, H Kreipe, M Galanski. Correlation of MRI and CT findings with histopathology in hepatic angiomyolipoma. European radiology. 2001; 11(8):1389-95. doi: 10.1007/s003300000750. [PMID: 11519547]
  • G Jung, W Heindel, T Krahe, H Kugel, C Walter, R Fischbach, H Klaus, K Lackner. Influence of the hepatobiliary contrast agent mangafodipir trisodium (MN-DPDP) on the imaging properties of abdominal organs. Magnetic resonance imaging. 1998 Oct; 16(8):925-31. doi: 10.1016/s0730-725x(98)00086-1. [PMID: 9814775]
  • R Materne, B E Van Beers, J F Gigot, Y Horsmans, M Lacrosse, J Pringot. Inflammatory pseudotumor of the liver: MRI with mangafodipir trisodium. Journal of computer assisted tomography. 1998 Jan; 22(1):82-4. doi: 10.1097/00004728-199801000-00014. [PMID: 9448766]
  • S O Hustvedt, D Grant, T E Southon, K Zech. Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration. Acta radiologica (Stockholm, Sweden : 1987). 1997 Jul; 38(4 Pt 2):690-9. doi: NULL. [PMID: 9245964]
  • K G Toft, S O Hustvedt, D Grant, I Martinsen, P B Gordon, G A Friisk, A J Korsmo, T Skotland. Metabolism and pharmacokinetics of MnDPDP in man. Acta radiologica (Stockholm, Sweden : 1987). 1997 Jul; 38(4 Pt 2):677-89. doi: NULL. [PMID: 9245963]
  • C Wang, P B Gordon, S O Hustvedt, D Grant, A T Sterud, I Martinsen, H Ahlström, A Hemmingsson. MR imaging properties and pharmacokinetics of MnDPDP in healthy volunteers. Acta radiologica (Stockholm, Sweden : 1987). 1997 Jul; 38(4 Pt 2):665-76. doi: NULL. [PMID: 9245962]
  • P Jynge, H Brurok, A Asplund, R Towart, H Refsum, J O Karlsson. Cardiovascular safety of MnDPDP and MnCl2. Acta radiologica (Stockholm, Sweden : 1987). 1997 Jul; 38(4 Pt 2):740-9. doi: NULL. [PMID: 9245970]
  • J O Karlsson, E Mortensen, H K Pedersen, G Sager, H Refsum. Cardiovascular effects of MnDPDP and MnCl2 in dogs with acute ischaemic heart failure. Acta radiologica (Stockholm, Sweden : 1987). 1997 Jul; 38(4 Pt 2):750-8. doi: NULL. [PMID: 9245971]
  • Y Ni, C Petré, H Bosmans, Y Miao, D Grant, A L Baert, G Marchal. Comparison of manganese biodistribution and MR contrast enhancement in rats after intravenous injection of MnDPDP and MnCl2. Acta radiologica (Stockholm, Sweden : 1987). 1997 Jul; 38(4 Pt 2):700-7. doi: NULL. [PMID: 9245965]
  • K G Toft, G A Friisk, T Skotland. Mangafodipir trisodium injection, a new contrast medium for magnetic resonance imaging: detection and quantitation of the parent compound MnDPDP and metabolites in human plasma by high performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 1997 Apr; 15(7):973-81. doi: 10.1016/s0731-7085(96)01945-0. [PMID: 9160264]
  • K G Toft, G M Kindberg, T Skotland. Mangafodipir trisodium injection, a new contrast medium for magnetic resonance imaging: in vitro metabolism and protein binding studies of the active component MnDPDP in human blood. Journal of pharmaceutical and biomedical analysis. 1997 Apr; 15(7):983-8. doi: 10.1016/s0731-7085(96)01944-9. [PMID: 9160265]
  • K G Toft, S O Hustvedt, D Grant, G A Friisk, T Skotland. Metabolism of mangafodipir trisodium (MnDPDP), a new contrast medium for magnetic resonance imaging, in beagle dogs. European journal of drug metabolism and pharmacokinetics. 1997 Jan; 22(1):65-72. doi: 10.1007/bf03189786. [PMID: 9179562]
  • M S Khangure, J Hua. Comparative assessment of gadoxetate disodium, manganese dipyridoxal diphosphate, and superparamagnetic iron oxide for enhancement of the liver in dogs. Academic radiology. 1996 Aug; 3 Suppl 2(?):S458-60. doi: 10.1016/s1076-6332(96)80616-7. [PMID: 8796629]
  • N M Rofsky, J P Earls. Mangafodipir trisodium injection (Mn-DPDP). A contrast agent for abdominal MR imaging. Magnetic resonance imaging clinics of North America. 1996 Feb; 4(1):73-85. doi: 10.1016/s1064-9689(21)00555-9. [PMID: 8673718]
  • Y Ni, C Petré, G Lukito, G Marchal, D Grant, T J Gray, A L Baert. Effect of manganese dipyridoxal diphosphate on liver magnetic resonance imaging and serum bilirubin in rats with removable biliary obstruction. Academic radiology. 1995 Apr; 2(4):300-5. doi: 10.1016/s1076-6332(05)80188-6. [PMID: 9419566]
  • H B Gehl, R W Günther, P Klever, S Hauptmann. [Manganese dipyridoxal diphosphate as a new contrast medium in the MRT of benign and malignant pancreatic tumors: initial clinical findings]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 1993 Sep; 159(3):240-4. doi: 10.1055/s-2008-1032757. [PMID: 8397012]
  • R C Nelson, J L Chezmar, G H Thompson, J B Webber, M H Garrison, H B Spencer, D L Dillehay. Magnetic resonance imaging after arterial portography with manganese dipyridoxal diphosphate. Investigative radiology. 1993 Apr; 28(4):335-40. doi: 10.1097/00004424-199304000-00015. [PMID: 8478175]
  • G Marchal, Y Ni, X Zhang, J Yu, K P Lodemann, A L Baert. Mn-DPDP enhanced MRI in experimental bile duct obstruction. Journal of computer assisted tomography. 1993 Mar; 17(2):290-6. doi: 10.1097/00004728-199303000-00021. [PMID: 8454757]
  • A F Kopp, M Laniado, K P Aicher, E F Grönewäller, C D Claussen. [Manganese DPDP as a contrast medium for MR tomography of focal liver lesions. Tolerance and image quality in 20 patients]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 1992 Dec; 157(6):539-47. doi: 10.1055/s-2008-1033059. [PMID: 1457788]
  • N M Rofsky, J C Weinreb. Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate): clinical experience with a new contrast agent. Magnetic resonance quarterly. 1992 Sep; 8(3):156-68. doi: NULL. [PMID: 1390058]
  • D L Rubin, H H Muller, S W Young. Formulation of radiographically detectable gastrointestinal contrast agents for magnetic resonance imaging: effects of a barium sulfate additive on MR contrast agent effectiveness. Magnetic resonance in medicine. 1992 Jan; 23(1):154-65. doi: 10.1002/mrm.1910230116. [PMID: 1734177]
  • P Leander, K Golman, J Klaveness, E Holtz, M Olsson, I Leunbach. MRI contrast media for the liver. Efficacy in conditions of acute biliary obstruction. Investigative radiology. 1990 Oct; 25(10):1130-4. doi: 10.1097/00004424-199010000-00012. [PMID: 2127772]
  • S W Young, B B Simpson, A V Ratner, C Matkin, E A Carter. MRI measurement of hepatocyte toxicity using the new MRI contrast agent manganese dipyridoxal diphosphate, a manganese/pyridoxal 5-phosphate chelate. Magnetic resonance in medicine. 1989 Apr; 10(1):1-13. doi: 10.1002/mrm.1910100102. [PMID: 2502699]