Flutrimazole (BioDeep_00000179170)

   

human metabolite blood metabolite


代谢物信息卡片


1-(O-Fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazole

化学式: C22H16F2N2 (346.12814799999995)
中文名称: 1-[(2-氟苯基)(4-氟苯基)(苯基)甲基]咪唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=CC=C3F)N4C=CN=C4
InChI: InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H

描述信息

G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

18 个代谢物同义名

1-(O-Fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazole; 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole; 1-((2-Fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole; 1-(O-Fluoro-a-(p-fluorophenyl)-a-phenylbenzyl)imidazole; 1-(O-Fluoro-α-(p-fluorophenyl)-α-phenylbenzyl)imidazole; Farma lepori brand OF flutrimazole; 1-(2,4-Difluorotrityl)imidazole; Menarini brand OF flutrimazole; Biohorm brand OF flutrimazole; Uriach brand OF flutrimazole; UR-4056flutrimazole; Flutrimazolum; flutrimazole; Flutrimazol; Flusporan; Cutimian; Funcenal; Micetal



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • L Shen, S-J Liu, N-S Zhang, G-L Dai, C Zou, C-Y Li, X-H Chen, W-Z Ju. Sensitive and selective LC-MS/MS assay for quantitation of flutrimazole in human plasma. European review for medical and pharmacological sciences. 2017 06; 21(12):2964-2969. doi: NULL. [PMID: 28682419]
  • B John, S G Wood, J Ramis, I Izquierdo, J Forn. Absorption and excretion of radioactivity after intravaginal administration of an advanced delivery system of 14C-flutrimazole vaginal cream to postmenopausal women. Arzneimittel-Forschung. 1998 May; 48(5):512-7. doi: NULL. [PMID: 9638320]
  • L Conte, J Ramis, R Mis, J Vilageliu, N Basi, J Forn. Pharmacokinetic study of [14C]flutrimazole after oral and intravenous administration in dogs. Comparison with clotrimazole. Arzneimittel-Forschung. 1992 Jun; 42(6):854-8. doi: NULL. [PMID: 1418045]
  • L Conte, J Ramis, R Mis, J Forn, S Vilaró, M Reina, J Vilageliu, N Basi. Percutaneous absorption and skin distribution of [14C]flutrimazole in mini-pigs. Arzneimittel-Forschung. 1992 Jun; 42(6):847-53. doi: NULL. [PMID: 1418044]
  • P Duchène, P Papalexiou, J Ramis, I Izquierdo, G Houin. Pharmacokinetic profile of [14C]flutrimazole following single topical application in normal and scarified skin of healthy volunteers. Arzneimittel-Forschung. 1992 Jun; 42(6):861-3. doi: NULL. [PMID: 1418047]
  • P Szylman, O S Better, C Chaimowitz, A Rosler. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. The New England journal of medicine. 1976 Feb; 294(7):361-5. doi: 10.1056/nejm197602122940703. [PMID: 1674]