Fluorogestone acetate (BioDeep_00000179137)

   

human metabolite blood metabolite


代谢物信息卡片


14-acetyl-1-fluoro-17-hydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl acetate

化学式: C23H31FO5 (406.2155408)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 75%

分子结构信息

SMILES: CC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)OC(=O)C
InChI: InChI=1S/C23H31FO5/c1-13(25)22(29-14(2)26)10-8-17-18-6-5-15-11-16(27)7-9-20(15,3)23(18,24)19(28)12-21(17,22)4/h11,17-19,28H,5-10,12H2,1-4H3

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins

同义名列表

16 个代谢物同义名

14-acetyl-1-fluoro-17-hydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl acetate; 9-Fluoro-11-hydroxy-3,20-dioxopregn-4-en-17-yl acetate; beta-Acetoxy-9-fluoro-11 beta-hydroxyprogesterone, 17; beta-Hydroxyprogesterone, 17 beta-acetoxy-9-fluoro-11; 17 beta-Acetoxy-9-fluoro-11 beta-hydroxyprogesterone; 17 beta Acetoxy 9 fluoro 11 beta hydroxyprogesterone; Fluorogestone acetic acid; Acetate, fluorogestone; Acetate, flurogestone; Fluorogestone acetate; Flurogestone Acetate; Acetate, flugestone; Flugestone acetate; Flurogestone; Flugestone; Cronolone



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Rekik, A Haile, A Abebe, D Muluneh, S Goshme, I Ben Salem, M El-Dine Hilali, N Lassoued, Y Chanyalew, B Rischkowsky. GnRH and prostaglandin-based synchronization protocols as alternatives to progestogen-based treatments in sheep. Reproduction in domestic animals = Zuchthygiene. 2016 Dec; 51(6):924-929. doi: 10.1111/rda.12761. [PMID: 27561208]
  • Juan A Quintero-Elisea, Ulises Macías-Cruz, Francisco D Álvarez-Valenzuela, Abelardo Correa-Calderón, Arnoldo González-Reyna, Froylan A Lucero-Magaña, Sergio A Soto-Navarro, Leonel Avendaño-Reyes. The effects of time and dose of pregnant mare serum gonadotropin (PMSG) on reproductive efficiency in hair sheep ewes. Tropical animal health and production. 2011 Dec; 43(8):1567-73. doi: 10.1007/s11250-011-9843-z. [PMID: 21465100]
  • N Ozyurtlu, I Kucukaslan, Y Cetin. Characterization of oestrous induction response, oestrous duration, fecundity and fertility in Awassi ewes during the non-breeding season utilizing both CIDR and intravaginal sponge treatments. Reproduction in domestic animals = Zuchthygiene. 2010 Jun; 45(3):464-7. doi: 10.1111/j.1439-0531.2008.01246.x. [PMID: 19210661]
  • C A Letelier, I Contreras-Solis, R A García-Fernández, C Ariznavarreta, J A F Tresguerres, J M Flores, A Gonzalez-Bulnes. Ovarian follicular dynamics and plasma steroid concentrations are not significantly different in ewes given intravaginal sponges containing either 20 or 40 mg of fluorogestone acetate. Theriogenology. 2009 Mar; 71(4):676-82. doi: 10.1016/j.theriogenology.2008.09.030. [PMID: 19004485]
  • M J Cervantes, M L Juárez, V O Mejía, V J M Berruecos, A H Vera, J Valencia. Use of fluorogestone acetate after breeding to reduce the effect of premature luteal regression in dairy goats when superovulation is induced with FSH. Animal reproduction science. 2007 Jan; 97(1-2):47-54. doi: 10.1016/j.anireprosci.2006.01.008. [PMID: 16490327]
  • S T Willard, T Dickerson, R Dodson, A Weis, R W Godfrey. Administration of 6-methoxybenzoxazolinone (MBOA) does not augment ovulatory responses in St. Croix White ewes superovulated with PMSG. Animal reproduction science. 2006 Jul; 93(3-4):280-91. doi: 10.1016/j.anireprosci.2005.08.002. [PMID: 16154300]
  • S Monnoyer, S Capancioni, M Richard, M Pacaud, J Guyonnet. Development of a high-performance liquid chromatography-tandem mass spectrometry method for the determination of flurogestone acetate in ovine plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 May; 819(2):245-51. doi: 10.1016/j.jchromb.2005.01.028. [PMID: 15833288]
  • A Gonzalez-Bulnes, J Santiago-Moreno, R M Garcia-Garcia, C J H Souza, A Lopez-Sebastian, A S McNeilly. Effect of GnRH antagonists treatment on gonadotrophin secretion, follicular development and inhibin A secretion in goats. Theriogenology. 2004 Apr; 61(5):977-85. doi: 10.1016/j.theriogenology.2003.07.003. [PMID: 14757481]
  • M R Al-Merestani, M Zarkawi, M F Wardeh. Improving the reproductive efficiency, pregnancy diagnosis and monitoring the resumption of luteal activity in indigenous damascus goats. Reproduction in domestic animals = Zuchthygiene. 2003 Feb; 38(1):36-40. doi: 10.1046/j.1439-0531.2003.00394.x. [PMID: 12535327]
  • J Santiago-Moreno, A González-Bulnes, A Gómez-Brunet, M J Cocero, A del Campo, R García-García, A López-Sebastián. Procedure for successful interspecific embryo transfer from mouflon (Ovis gmelini musimon) to Spanish Merino sheep (Ovis aries). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2001 Sep; 32(3):336-41. doi: 10.1638/1042-7260(2001)032[0336:pfsiet]2.0.co;2. [PMID: 12785682]
  • S Riesenberg, S Meinecke-Tillmann, B Meinecke. Ultrasonic study of follicular dynamics following superovulation in German Merino ewes. Theriogenology. 2001 Mar; 55(4):847-65. doi: 10.1016/s0093-691x(01)00448-4. [PMID: 11291909]
  • G Huszenicza, S Fekete, G Szigeti, M Kulcsár, H Fébel, R O Kellems, P Nagy, S Cseh, T Veresegyházy, I Hullár. Ovarian consequences of low dose peroral Fusarium (T-2) toxin in a ewe and heifer model. Theriogenology. 2000 May; 53(8):1631-9. doi: 10.1016/s0093-691x(00)00303-4. [PMID: 10883849]
  • L A Zarazaga, B Malpaux, P Chemineau. Characteristics of the plasma melatonin rhythm are not modified by steroids during the estrous cycle in IIe-de-France ewes. Journal of pineal research. 1996 Sep; 21(2):114-20. doi: 10.1111/j.1600-079x.1996.tb00278.x. [PMID: 8912237]
  • C C Cester, J C Béguin, P L Toutain. The use of an experimental metritis model to study antibiotic distribution in genital tract secretions in the ewe. Veterinary research. 1996; 27(4-5):479-89. doi: NULL. [PMID: 8822617]
  • C C Cester, N Dubech, P L Toutain. Effect of sexual steroid hormones on spiramycin disposition in genital tract secretions of the ewe. Journal of pharmaceutical sciences. 1992 Jan; 81(1):33-6. doi: 10.1002/jps.2600810107. [PMID: 1377747]
  • O Gaston-Parry, K Heasman, J K Nemorin, T J Robinson. A radioimmunoassay for fluorogestone acetate (FGA) and its application to the measurement of plasma FGA and progesterone in ewes treated with FGA-impregnated intravaginal sponges. Australian journal of biological sciences. 1988; 41(1):57-67. doi: 10.1071/bi9880057. [PMID: 2480106]
  • G S Lewis, D J Bolt. Effects of suckling, progestogen-impregnated pessaries or hysterectomy on ovarian function in autumn-lambing postpartum ewes. Journal of animal science. 1987 Jan; 64(1):216-25. doi: 10.2527/jas1987.641216x. [PMID: 2434457]
  • F Cairoli, C Tamanini, G Bono, F Chiesa, A Prandi. Reproductive performance of female goats given progestagen associated with PMSG and/or HMG in deep anestrus. Reproduction, nutrition, developpement. 1987; 27(1A):13-9. doi: 10.1051/rnd:19870102. [PMID: 2437623]
  • D B Killian, D O Kiesling, J E Warren. Lifespan of corpora lutea induced in estrous-synchronized cycling and anestrous ewes. Journal of animal science. 1985 Jul; 61(1):210-5. doi: 10.2527/jas1985.611210x. [PMID: 2411707]
  • M J Prud'Homme, B Pele. [Electromyographic activity of the uterus in the ewe during the sexual season: comparison of natural estrus and estrus induced by progestagens alone or with PMSG supplementation]. Reproduction, nutrition, developpement. 1984; 24(1):33-44. doi: NULL. [PMID: 6200904]
  • G A Langford, G J Marcus. Influence of sperm number and seminal plasma on fertility of progestagen-treated sheep in confinement. Journal of reproduction and fertility. 1982 Jul; 65(2):325-9. doi: 10.1530/jrf.0.0650325. [PMID: 6178823]
  • L Ainsworth, M S Wolynetz. Synchronization of estrus and reproductive performance of ewes treated with synthetic progestogens administered by subcutaneous ear implant or by intravaginal sponge pessary. Journal of animal science. 1982 Jun; 54(6):1120-7. doi: 10.2527/jas1982.5461120x. [PMID: 6179919]
  • G A Langford. Influence of PMSG and time of artificial insemination on fertility of progestogen-treated sheep in confinement. Journal of animal science. 1982 Jun; 54(6):1205-11. doi: 10.2527/jas1982.5461205x. [PMID: 6179920]
  • A J Hackett, H A Robertson, M S Wolynetz. Effects of prostaglandin F2 alpha and pregnant mares' serum gonadotropin (PMSG) on the reproductive performance of fluorogestone acetate PMSG-treated ewes. Journal of animal science. 1981 Jul; 53(1):154-9. doi: 10.2527/jas1981.531154x. [PMID: 6172412]
  • J F Quirke, J P Hanrahan, J P Gosling. Duration of oestrus, ovulation rate, time of ovulation and plasma LH, total oestrogen and progesterone in Galway adult ewes and ewe lambs. Journal of reproduction and fertility. 1981 Mar; 61(2):265-72. doi: 10.1530/jrf.0.0610265. [PMID: 6162952]
  • Y Ruckebusch, L Bueno. An electromyographic study of uterotubal activity in the ewe. Journal of reproduction and fertility. 1976 Jul; 47(2):221-7. doi: 10.1530/jrf.0.0470221. [PMID: 60491]
  • P K Chakraborty, T E Adams, G K Tarnavsky, J J Reeves. Serum and pituitary LH concentrations in ewes infused with LH-RH/FSH-RH. Journal of animal science. 1974 Dec; 39(6):1150-7. doi: 10.2527/jas1974.3961150x. [PMID: 4140857]
  • J Testart. [Follicular response of immature female calves to various serum gonadotropin treatments associated or unassociated with a progestin]. Annales de biologie animale, biochimie, biophysique. 1972; 12(3):397-409. doi: NULL. [PMID: 4127120]
  • J F Smith, T J Robinson. The effect of exogenous progestagen on the levels of free oestrogen in the ovarian vein plasma of the ewe. The Journal of endocrinology. 1970 Dec; 48(4):485-96. doi: 10.1677/joe.0.0480485. [PMID: 4099044]