Butoxyacetic acid (BioDeep_00000017913)
human metabolite Endogenous
代谢物信息卡片
N-Butoxyacetic acid, sodium salt
化学式: C6H12O3 (132.0786)
中文名称: 丁氧基乙酸, 丁氧乙酸
谱图信息:
最多检出来源 Homo sapiens(not specific) 0.81%
分子结构信息
SMILES: CCCCOCC(=O)O
InChI: InChI=1S/C6H12O3/c1-2-3-4-9-5-6(7)8/h2-5H2,1H3,(H,7,8)
描述信息
Butoxyacetic acid belongs to the family of Carboxylic Acids. These are compounds containing a carboxylic acid group with the formula -C(=O)OH.
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:173542
- PubChem: 41958
- HMDB: HMDB0041844
- foodb: FDB111674
- chemspider: 38273
- CAS: 2516-93-0
- PMhub: MS000001089
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ronan Garlantézec, Luc Multigner, Laurence Labat, Nathalie Bonvallot, Juha Pulkkinen, Brigitte Dananché, Christine Monfort, Florence Rouget, Sylvaine Cordier. Urinary biomarkers of exposure to glycol ethers and chlorinated solvents during pregnancy: determinants of exposure and comparison with indirect methods of exposure assessment.
Occupational and environmental medicine.
2012 Jan; 69(1):62-70. doi:
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Occupational and environmental medicine.
2011 Oct; 68(10):777-82. doi:
10.1136/oem.2010.061184. [PMID: 21278143] - Ilona Sperlingová, Ludmila Dabrowská, Vladimír Stránský, Sárka Dusková, Jan Kucera, Monika Tvrdíková, Milon Tichy. Determination of butoxyacetic acid (biomarker of ethylene glycol monobutyl ether exposure) in human urine candidate reference material.
Analytical and bioanalytical chemistry.
2010 May; 397(2):433-8. doi:
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2007 Dec; 35(12):2218-24. doi:
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Toxicology and applied pharmacology.
2007 Nov; 225(1):102-12. doi:
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Journal of chromatographic science.
2007 Aug; 45(7):422-7. doi:
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Toxicology letters.
2007 Apr; 170(2):97-103. doi:
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Journal of analytical toxicology.
2006 May; 30(4):252-7. doi:
10.1093/jat/30.4.252. [PMID: 16803663] - S J Franks, M K Spendiff, J Cocker, G D Loizou. Physiologically based pharmacokinetic modelling of human exposure to 2-butoxyethanol.
Toxicology letters.
2006 Apr; 162(2-3):164-73. doi:
10.1016/j.toxlet.2005.09.012. [PMID: 16246510] - Clayton B'Hymer, Mary Ann Butler, Kenneth L Cheever. Comparison and evaluation of analysis procedures for the quantification of (2-methoxyethoxy)acetic acid in urine.
Analytical and bioanalytical chemistry.
2005 Sep; 383(2):201-9. doi:
10.1007/s00216-005-0048-z. [PMID: 16158298] - R A Corley, D M Grant, E Farris, K K Weitz, J J Soelberg, K D Thrall, T S Poet. Determination of age and gender differences in biochemical processes affecting the disposition of 2-butoxyethanol and its metabolites in mice and rats to improve PBPK modeling.
Toxicology letters.
2005 Mar; 156(1):127-61. doi:
10.1016/j.toxlet.2003.08.013. [PMID: 15705493] - Clayton B'hymer, Deborah E Keil, Kenneth L Cheever. A Test Procedure for the Determination of (2-Methoxyethoxy)acetic Acid in Urine from Jet Fuel-Exposed Mice.
Toxicology mechanisms and methods.
2005; 15(5):367-73. doi:
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Archives of toxicology.
2004 Nov; 78(11):617-28. doi:
10.1007/s00204-004-0581-0. [PMID: 15455191] - S Kezic, W J A Meuling, I Jakasa. Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers.
International archives of occupational and environmental health.
2004 Nov; 77(8):580-6. doi:
10.1007/s00420-004-0540-3. [PMID: 15688250] - Hong Soon Choi, Jun Ho Park, Jae Seok Song, Yong Bong Cho. Determination of urinary metabolites of alkyl cellosolves by solid phase extraction and GC/FID.
Journal of occupational health.
2004 Jul; 46(4):260-5. doi:
10.1539/joh.46.260. [PMID: 15308824] - I Jakasa, N Mohammadi, J Krüse, S Kezic. Percutaneous absorption of neat and aqueous solutions of 2-butoxyethanol in volunteers.
International archives of occupational and environmental health.
2004 Feb; 77(2):79-84. doi:
10.1007/s00420-003-0456-3. [PMID: 12915943] - K Jones, J Cocker. A human exposure study to investigate biological monitoring methods for 2-butoxyethanol.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2003 Sep; 8(5):360-70. doi:
10.1080/13547500310001600941. [PMID: 14602521] - Joungjoa Park, Lisa M Kamendulis, James E Klaunig. Effects of 2-butoxyethanol on hepatic oxidative damage.
Toxicology letters.
2002 Jan; 126(1):19-29. doi:
10.1016/s0378-4274(01)00434-9. [PMID: 11738267] - M M Udden. Rat erythrocyte morphological changes after gavage dosing with 2-butoxyethanol: a comparison with the in vitro effects of butoxyacetic acid on rat and human erythrocytes.
Journal of applied toxicology : JAT.
2000 Sep; 20(5):381-7. doi:
10.1002/1099-1263(200009/10)20:5<381::aid-jat701>3.0.co;2-e. [PMID: 11139168] - S Hildenbrand, W Gfrörer, F W Schmahl, P C Dartsch. New methods for determination of 2-butoxyethanol, butoxyacetaldehyde and butoxyacetic acid in aqueous systems, with special reference to cell culture conditions.
Archives of toxicology.
2000 Apr; 74(2):72-8. doi:
10.1007/s002040050655. [PMID: 10839473] - T S Shih, J S Chou, C Y Chen, T J Smith. Improved method to measure urinary alkoxyacetic acids.
Occupational and environmental medicine.
1999 Jul; 56(7):460-7. doi:
10.1136/oem.56.7.460. [PMID: 10472317] - J Liesivuori, J Laitinen, H Savolainen. Rat model for renal effects of 2-alkoxyalcohols and their acetates.
Archives of toxicology.
1999 Jun; 73(4-5):229-32. doi:
10.1007/s002040050611. [PMID: 10463388] - J A Dill, K M Lee, D J Bates, D J Anderson, R E Johnson, B J Chou, L T Burka, J H Roycroft. Toxicokinetics of inhaled 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in F344 rats and B6C3F1 mice.
Toxicology and applied pharmacology.
1998 Dec; 153(2):227-42. doi:
10.1006/taap.1998.8524. [PMID: 9878593] - R A Corley, D A Markham, C Banks, P Delorme, A Masterman, J M Houle. Physiologically based pharmacokinetics and the dermal absorption of 2-butoxyethanol vapor by humans.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1997 Oct; 39(2):120-30. doi:
10.1006/faat.1997.2363. [PMID: 9344624] - R A Corley, G A Bormett, B I Ghanayem. Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans.
Toxicology and applied pharmacology.
1994 Nov; 129(1):61-79. doi:
10.1006/taap.1994.1229. [PMID: 7974497] - T Sakai, T Araki, Y Morita, Y Masuyama. Gaschromatographic determination of butoxyacetic acid after hydrolysis of conjugated metabolites in urine from workers exposed to 2-butoxyethanol.
International archives of occupational and environmental health.
1994; 66(4):249-54. doi:
10.1007/bf00454363. [PMID: 7843835] - G Johanson. Inhalation toxicokinetics of butoxyethanol and its metabolite butoxyacetic acid in the male Sprague-Dawley rat.
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Environmental research.
1993 Nov; 63(2):202-18. doi:
10.1006/enrs.1993.1141. [PMID: 8243415] - A W Rettenmeier, R Hennigs, R Wodarz. Determination of butoxyacetic acid and N-butoxyacetyl-glutamine in urine of lacquerers exposed to 2-butoxyethanol.
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1993; 31(3):501-4. doi:
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Chemico-biological interactions.
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1989; 61(4):249-54. doi:
10.1007/bf00381422. [PMID: 2722248] - B I Ghanayem, L T Burka, H B Matthews. Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: role of alcohol and aldehyde dehydrogenases.
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1987 Jul; 242(1):222-31. doi:
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1987 Jan; 43(1):17-30. doi:
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