Fluindione (BioDeep_00000179103)

   

human metabolite blood metabolite


代谢物信息卡片


2-(4-fluorophenyl)-2,3-dihydro-1H-indene-1,3-dione

化学式: C15H9FO2 (240.05865459999998)
中文名称: 氟茚二酮-d4
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)C(C2=O)C3=CC=C(C=C3)F
InChI: InChI=1S/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H

描述信息

B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AA - Vitamin k antagonists
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
D006401 - Hematologic Agents > D000925 - Anticoagulants

同义名列表

6 个代谢物同义名

2-(4-fluorophenyl)-2,3-dihydro-1H-indene-1,3-dione; 2-(4-Fluorophenyl)-1,3-indanedione; Fluindione-d4; Previsccan; Fluindione; Previscan



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Timothy H Self, Ryan E Owens, Sami A Sakaan, Jessica L Wallace, Christopher W Sands, Amanda Howard-Thompson. Effect of diseases on response to vitamin K antagonists. Current medical research and opinion. 2016; 32(4):613-20. doi: 10.1185/03007995.2015.1134464. [PMID: 26695107]
  • Laurent Chouchana, Eva Languille, Nicolas Weiss, Eliane M Billaud, Agnès Lillo-Le Louet. [Bleedings during vitamin K antagonist therapy associated with ciclosporin and rifampicin]. Presse medicale (Paris, France : 1983). 2013 May; 42(5):908-11. doi: 10.1016/j.lpm.2012.07.026. [PMID: 23069229]
  • Gérard Cam, Angèle Tchiango Kwetcheu, Cécile Vigneau, Pascale Siohan, Guillaume Queffeulou, Philippe Gatault, Eric Laruelle, Alain Crémault, Philippe Le Cacheux, Nathalie Rioux-Leclercq, Eric Renaudineau. Acute and chronic nephropathy induced by fluindione must be addressed. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 Apr; 27(4):1554-8. doi: 10.1093/ndt/gfr500. [PMID: 21931126]
  • Nikolas Harbord. Novel nephrotoxins. Advances in chronic kidney disease. 2011 May; 18(3):214-8. doi: 10.1053/j.ackd.2010.12.001. [PMID: 21531328]
  • NULL. Immunoallergic adverse effects of fluindione. Prescrire international. 2010 Nov; 19(110):255-6. doi: NULL. [PMID: 21284358]
  • Isabelle Fourel, Christophe Hugnet, Isabelle Goy-Thollot, Philippe Berny. Validation of a new liquid chromatography- tandem mass spectrometry ion-trap technique for the simultaneous determination of thirteen anticoagulant rodenticides, drugs, or natural products. Journal of analytical toxicology. 2010 Mar; 34(2):95-102. doi: 10.1093/jat/34.2.95. [PMID: 20223102]
  • ". Use the INN to avoid confusion between drugs. Prescrire international. 2009 Oct; 18(103):214. doi: ". [PMID: 19882793]
  • Franck Reynaud, Patrick Giraud, Jean-Marc Cisterne, Daniel Verdier, Zeinab Kouchakipour, Alain Hermelin, Anne Modesto-Segonds, Haleh Bagheri, Jacques Pourrat. [Acute immuno-allergic interstitial nephritis after treatment with fluindione. Seven cases]. Nephrologie & therapeutique. 2009 Jul; 5(4):292-8. doi: 10.1016/j.nephro.2009.01.008. [PMID: 19357010]
  • Angelo A Izzo, Edzard Ernst. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs. 2009; 69(13):1777-98. doi: 10.2165/11317010-000000000-00000. [PMID: 19719333]
  • Christine Beauchamp, Ioana Enache, Abraham Haskour, Laurent Martin. [Acute interstitial nephritis of fluindione: about three cases]. Nephrologie & therapeutique. 2008 Oct; 4(5):339-46. doi: 10.1016/j.nephro.2008.02.003. [PMID: 18417438]
  • J-F Cadranel, R Demontis, M Seddik, S Ramdani, D Belloula, M Biour. [Hepatic and renal toxicity to fluindione (Previscan)]. Gastroenterologie clinique et biologique. 2008 Oct; 32(10):816-8. doi: 10.1016/j.gcb.2008.07.003. [PMID: 18818035]
  • L Chiche, G Thomas, S Canavese, S Branger, R Jean, J M Durand. Severe hemorrhagic syndrome due to similarity of drug names. European journal of internal medicine. 2008 Mar; 19(2):135-6. doi: 10.1016/j.ejim.2007.03.018. [PMID: 18249310]
  • Jérémie Sellam, Nathalie Costedoat-Chalumeau, Zahir Amoura, Guy Aymard, Sylvain Choquet, Salim Trad, Bénédicte Lebrun Vignes, Jean-Sébastien Hulot, Francis Berenbaum, Philippe Lechat, Patrice Cacoub, Annick Ankri, Xavier Mariette, Véronique Leblond, Jean-Charles Piette. Potentiation of fluindione or warfarin by dexamethasone in multiple myeloma and AL amyloidosis. Joint bone spine. 2007 Oct; 74(5):446-52. doi: 10.1016/j.jbspin.2006.12.006. [PMID: 17692552]
  • S Belmouaz, E Desport, R Abou Ayache, A Thierry, A Mignot, M Bauwens, J M Goujon, F Bridoux, G Touchard. Acute immuno-allergic interstitial nephritis caused by fluindione. Clinical nephrology. 2006 Dec; 66(6):455-8. doi: 10.5414/cnp66455. [PMID: 17176918]
  • David Grimaldi, Eric Daugas, Béatrice Mougenot, Jérôme Rossert, Pierre Ronco. Immuno-allergic interstitial nephritis related to fluindione: first biopsy proven cases. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 Jan; 21(1):237. doi: 10.1093/ndt/gfi173. [PMID: 16221711]
  • Miranda R Andrus. Oral anticoagulant drug interactions with statins: case report of fluvastatin and review of the literature. Pharmacotherapy. 2004 Feb; 24(2):285-90. doi: 10.1592/phco.24.2.285.33137. [PMID: 14998226]
  • M Alzieu, F Trivin, J Guglielminotti, B Guidet, G Offenstadt. [Serious complication of an illegible prescription]. Presse medicale (Paris, France : 1983). 2000 Jun; 29(22):1263. doi: ". [PMID: 10916541]
  • N Costedoat-Chalumeau, Z Amoura, G Aymard, O Sevin, B Wechsler, P Cacoub, L T Du, B Diquet, A Ankri, J C Piette. Potentiation of vitamin K antagonists by high-dose intravenous methylprednisolone. Annals of internal medicine. 2000 Apr; 132(8):631-5. doi: 10.7326/0003-4819-132-8-200004180-00005. [PMID: 10766681]
  • G Aymard, M Legrand, E Comets, F Mentré, B Diquet. Rapid and simple micromethod for the quantification of fluindione in human plasma using high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 1998 Apr; 707(1-2):169-73. doi: 10.1016/s0378-4347(97)00587-2. [PMID: 9613946]