Flubendazole (BioDeep_00000179099)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
N-[6-(4-fluorobenzoyl)-1H-1,3-benzodiazol-2-yl]methoxycarboximidic acid
化学式: C16H12FN3O3 (313.0862654)
中文名称: 氟苯咪唑
谱图信息:
最多检出来源 Homo sapiens(blood) 14.29%
分子结构信息
SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=C(C=C3)F
InChI: InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)
描述信息
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02C - Antinematodal agents > P02CA - Benzimidazole derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites[1][2].
同义名列表
15 个代谢物同义名
N-[6-(4-fluorobenzoyl)-1H-1,3-benzodiazol-2-yl]methoxycarboximidic acid; (5-(4-Fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl ester; (5-(4-Fluorobenzoyl)-1H-benzimidazole-2-yl)carbamate methyl ester; Methyl N-(5-(p-fluorobenzoyl)-2-benzimidazolyl)carbamic acid; Methyl(5-(4-fluorobenzoyl)-1H-benzimidazol- 2-yl)carbamate; Methyl N-(5-(p-fluorobenzoyl)-2-benzimidazolyl)carbamate; Methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamic acid; Methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate; Fluoromebendazole; Flubendazolum; Flubendazole; Flubendazol; flubenol; R 17,889; R 17899
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:77095
- PubChem: 35802
- HMDB: HMDB0252324
- DrugBank: DB08974
- ChEMBL: CHEMBL1454946
- Wikipedia: Flubendazole
- CAS: 31430-15-6
- medchemexpress: HY-B0294
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Borris Rosnay Galani Tietcheu, Theodore Betrosse, Rene Bilingwe Ayiseh, Emmanuel Issa Yuunoeoene, Emmanuel Mfotie Njoya, Francis Nveikoueng, Nicolas Yanou Njintang, Dieudonne Ndjonka. In Vitro Filaricidal Properties of Hydro-Methanolic Extracts of Powdery Fractions of Khaya senegalensis (Meliaceae) on Onchocerca ochengi.
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2023 Jun; 47(2):409-419. doi:
10.1007/s11259-022-09958-9. [PMID: 35727416] - Salah M Aly, Sayed N Abou El-Gheit, Habiba M Essam El-Din. Comparative Studies on The Efficiency of Neem Leaves Azadirachta indica and Flubendazole Treatment Against Diplectanum in Sea Bass Dicentrarchus labrax.
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10.1136/vr.110.22.517. [PMID: 7101714] - M Michiels, R Hendriks, J Heykants, H van den Bossche. The pharmacokinetics of mebendazole and flubendazole in animals and man.
Archives internationales de pharmacodynamie et de therapie.
1982 Apr; 256(2):180-91. doi:
NULL. [PMID: 7103610] - R Becquet, J Poirriez, E Dei-Cas, E Dutoit, S Deblock, M Abdellatifi, A Vernes. [Human trichostrongylosis (apropos of 71 case reports)].
Annales de la Societe belge de medecine tropicale.
1982; 62(2):139-55. doi:
NULL. [PMID: 7149808] - P M Schantz, H Van den Bossche, J Eckert. Chemotherapy for larval echinococcosis in animals and humans: report of a workshop.
Zeitschrift fur Parasitenkunde (Berlin, Germany).
1982; 67(1):5-26. doi:
10.1007/bf00929509. [PMID: 7041454] - G W Hutchinson. Anthelmintic treatment of prepatent stephanuriasis with flubendazole, levamisole and disophenol and the effects on liver-specific serum enzymes.
Research in veterinary science.
1981 Mar; 30(2):175-80. doi:
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The Southeast Asian journal of tropical medicine and public health.
1980 Dec; 11(4):502-6. doi:
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