Flosulide (BioDeep_00000179095)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H13F2NO4S (353.05333220000006)
中文名称: 氟舒胺
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CS(=O)(=O)NC1=C(C=C2C(=C1)CCC2=O)OC3=C(C=C(C=C3)F)F
InChI: InChI=1S/C16H13F2NO4S/c1-24(21,22)19-13-6-9-2-4-14(20)11(9)8-16(13)23-15-5-3-10(17)7-12(15)18/h3,5-8,19H,2,4H2,1H3
描述信息
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 71246
- HMDB: HMDB0252318
- ChEMBL: CHEMBL147580
- chemspider: 64378
- CAS: 80937-31-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Turull, J Queralt. Changes in prostaglandin E2 (PGE2) levels in paw exudate, stomach and kidney of arthritic rats: effects of flosulide.
Prostaglandins & other lipid mediators.
2001 Aug; 66(1):27-37. doi:
10.1016/s0090-6980(01)00138-1. [PMID: 11519792] - A Turull, C Piera, J Queralt. Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats.
Inflammation.
2001 Apr; 25(2):119-28. doi:
10.1023/a:1007122706770. [PMID: 11321358] - J Berg, H Fellier, T Christoph, P Kremminger, M Hartmann, H Blaschke, F Rovensky, R Towart, D Stimmeder. Pharmacology of a selective cyclooxygenase-2 inhibitor, HN-56249: a novel compound exhibiting a marked preference for the human enzyme in intact cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2000 Apr; 361(4):363-72. doi:
10.1007/s002109900192. [PMID: 10763850] - A Turull, J Queralt. Selective cyclooxygenase-2 (COX-2) inhibitors reduce anti-Mycobacterium antibodies in adjuvant arthritic rats.
Immunopharmacology.
2000 Jan; 46(1):71-7. doi:
10.1016/s0162-3109(99)00159-9. [PMID: 10665781] - C Blume, G Heise, A Mühlfeld, D Bach, K Schrör, C D Gerhardz, B Grabensee, P Heering. Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive heymann nephritis in the rat.
Kidney international.
1999 Nov; 56(5):1770-8. doi:
10.1046/j.1523-1755.1999.00742.x. [PMID: 10571785] - G Heise, B Grabensee, K Schrör, P Heering. Different actions of the cyclooxygenase 2 selective inhibitor flosulide in rats with passive Heymann nephritis.
Nephron.
1998 Oct; 80(2):220-6. doi:
10.1159/000045171. [PMID: 9736824] - J Martinez, T Sanchez, J J Moreno. Role of prostaglandin H synthase-2-mediated conversion of arachidonic acid in controlling 3T6 fibroblast growth.
The American journal of physiology.
1997 11; 273(5):C1466-71. doi:
10.1152/ajpcell.1997.273.5.c1466. [PMID: 9374630] - P Brunel, A Hornych, T T Guyene, A Sioufi, M Turri, J Ménard. Renal and endocrine effects of flosulide, after single and repeated administration to healthy volunteers.
European journal of clinical pharmacology.
1995; 49(3):193-201. doi:
10.1007/bf00192379. [PMID: 8665995]