Flibanserin (BioDeep_00000179083)

   

human metabolite blood metabolite


代谢物信息卡片


1-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one

化学式: C20H21F3N4O (390.1667372)
中文名称: 氟立班丝氨
谱图信息: 最多检出来源 Homo sapiens(blood) 88.89%

分子结构信息

SMILES: C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F
InChI: InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

描述信息

C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
G - Genito urinary system and sex hormones
Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].

同义名列表

13 个代谢物同义名

1-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one; 1,3-Dihydro-1-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-2H-benzimidazol-2-one; 1-(2-(4-alpha,alpha,alpha-Trifluoro-m-tolyl)-1-(piperazinyl)ethyl)-2-benzimidazolinone; 1-(2-(4-(3-Trifluoromethylphenyl)piperazin-1-yl)ethyl)benzimidazol(1H)-2-one; 1-(2-(4-Α,α,α-trifluoro-m-tolyl)-1-(piperazinyl)ethyl)-2-benzimidazolinone; 1-(2-(4-a,a,a-Trifluoro-m-tolyl)-1-(piperazinyl)ethyl)-2-benzimidazolinone; Female viagra (street name); Flibanserin; BIMT 17 BS; Bimt-17; Bimt 17; Addyi; BIMT-17BS



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Noha M Hosny, Marwa F B Ali. Emphasis on the incorporation of Tropaeolin OO dye and silver nanoparticles for voltammetric estimation of flibanserin in bulk form, tablets and human plasma. Talanta. 2022 Aug; 245(?):123420. doi: 10.1016/j.talanta.2022.123420. [PMID: 35413628]
  • Noha M Hosny, Mahmoud Abdelkarim, Mohamed I Gadallah, Heba Salah Mousa. Development and validation of a novel evaporation setup-assisted TLC method with fluorescence detection for determination of flibanserin in pharmaceutical and biological samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Apr; 1195(?):123204. doi: 10.1016/j.jchromb.2022.123204. [PMID: 35248898]
  • Manish Kumar Sharma, Amit Kumar Sahu, Ravi P Shah, Pinaki Sengupta. A systematic UHPLC-Q-TOF-MS/MS based analytical approach for characterization of flibanserin metabolites and establishment of biotransformation pathway. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Nov; 1185(?):123011. doi: 10.1016/j.jchromb.2021.123011. [PMID: 34735976]
  • Miranda F Kamal, Samir Morshedy, Dina A Saad, Marwa S Moneeb. Second-derivative synchronous fluorimetry and time-programmed HPLC-fluorescence detection for simultaneous estimation of flibanserin and sitagliptin phosphate in synthetic mixtures and human plasma samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Nov; 1184(?):122955. doi: 10.1016/j.jchromb.2021.122955. [PMID: 34653844]
  • Rasha Ahmed, Inas Abdallah. Development and Greenness Evaluation of Spectrofluorometric Methods for Flibanserin Determination in Dosage Form and Human Urine Samples. Molecules (Basel, Switzerland). 2020 Oct; 25(21):. doi: 10.3390/molecules25214932. [PMID: 33113816]
  • Manish Kumar Sharma, Rajeshwari Rathod, Pinaki Sengupta. Mass Spectrometry-Based Rapid Quantitative Bioanalysis of Flibanserin: Pharmacokinetic and Brain Tissue Distribution Study in Female Rats. Journal of analytical toxicology. 2020 Jul; 44(6):559-569. doi: 10.1093/jat/bkaa009. [PMID: 32020175]
  • Manish Kumar Sharma, Ravi P Shah, Pinaki Sengupta. Amalgamation of stress degradation and metabolite profiling in rat urine and feces for characterization of oxidative metabolites of flibanserin using UHPLC-Q-TOF-MS/MS, H/D exchange and NMR technique. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Feb; 1139(?):121993. doi: 10.1016/j.jchromb.2020.121993. [PMID: 32004940]
  • Usama A Fahmy, Osama A A Ahmed, Shaimaa M Badr-Eldin, Hibah M Aldawsari, Solomon Z Okbazghi, Zuhier A Awan, Muhammed A Bakhrebah, Mohammad N Alomary, Wesam H Abdulaal, Carlos Medina, Nabil A Alhakamy. Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin. International journal of nanomedicine. 2020; 15(?):5253-5264. doi: 10.2147/ijn.s258791. [PMID: 32801690]
  • Maha A Sultan, Rasha Th El-Eryan, Ali K Attia, Mona J Eissa. Development and validation of liquid chromatography-electrospray-tandem mass spectrometry method for determination of flibanserin in human plasma: Application to pharmacokinetic study on healthy female volunteers. Biomedical chromatography : BMC. 2019 Aug; 33(8):e4545. doi: 10.1002/bmc.4545. [PMID: 30937940]
  • Muzaffar Iqbal, Essam Ezzeldin, Naser L Rezk, Amal A Bajrai, Khalid A Al-Rashood. A validated UPLC-MS/MS method for flibanserin in plasma and its pharmacokinetic interaction with bosentan in rats. Bioanalysis. 2018 Jul; 10(14):1087-1097. doi: 10.4155/bio-2018-0065. [PMID: 29692180]
  • Crista Johnson-Agbakwu, Louise Brown, James Yuan, Robert Kissling, David J Greenblatt. Effects of Flibanserin on the Pharmacokinetics of a Combined Ethinylestradiol/Levonorgestrel Oral Contraceptive in Healthy Premenopausal Women: A Randomized Crossover Study. Clinical therapeutics. 2018 01; 40(1):64-73. doi: 10.1016/j.clinthera.2017.08.021. [PMID: 29198449]
  • Anna Petherick. Sexual arousal: Sex matters. Nature. 2017 10; 550(7674):S2-S3. doi: 10.1038/550s2a. [PMID: 28976951]
  • D M Stevens, J M Weems, L Brown, K A Barbour, S M Stahl. The pharmacodynamic effects of combined administration of flibanserin and alcohol. Journal of clinical pharmacy and therapeutics. 2017 Oct; 42(5):598-606. doi: 10.1111/jcpt.12563. [PMID: 28608926]
  • Iñaki F Trocóniz, Katja Boland, Alexander Staab. Population pharmacokinetic/pharmacodynamic model for the sedative effects of flibanserin in healthy volunteers. Pharmaceutical research. 2012 Jun; 29(6):1518-29. doi: 10.1007/s11095-011-0648-6. [PMID: 22219166]
  • F Borsini, R Cesana, J Kelly, B E Leonard, M McNamara, J Richards, L Seiden. BIMT 17: a putative antidepressant with a fast onset of action?. Psychopharmacology. 1997 Dec; 134(4):378-86. doi: 10.1007/s002130050474. [PMID: 9452180]