N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide (BioDeep_00000179063)
human metabolite blood metabolite
代谢物信息卡片
化学式: C36H36N4O4 (588.2736416)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 91.67%
分子结构信息
SMILES: CN(CC1=CC=CC=C1)C(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C1CC(O)CN1C(=O)C1=CN(C)C2=CC=CC=C12
InChI: InChI=1S/C36H36N4O4/c1-38-23-30(29-14-8-9-15-32(29)38)35(43)40-22-28(41)20-33(40)34(42)37-31(36(44)39(2)21-24-10-4-3-5-11-24)19-25-16-17-26-12-6-7-13-27(26)18-25/h3-18,23,28,31,33,41H,19-22H2,1-2H3,(H,37,42)
描述信息
同义名列表
5 个代谢物同义名
N-[1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-4-hydroxy-1-(1-methylindole-3-carbonyl)pyrrolidine-2-carboxamide; N-{1-[benzyl(methyl)carbamoyl]-2-(naphthalen-2-yl)ethyl}-4-hydroxy-1-(1-methyl-1H-indole-3-carbonyl)pyrrolidine-2-carboximidate; N-benzyl-2-{[4-hydroxy-1-(1-methyl-1H-indole-3-carbonyl)pyrrolidin-2-yl]formamido}-N-methyl-3-(naphthalen-2-yl)propanamide; N-benzyl-2-{[4-hydroxy-1-(1-methylindole-3-carbonyl)pyrrolidin-2-yl]formamido}-N-methyl-3-(naphthalen-2-yl)propanamide; N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hironobu Fukuda, Toshio Abe, Shigemi Yoshihara. The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways.
International archives of allergy and immunology.
2010; 152(3):295-300. doi:
10.1159/000283042. [PMID: 20150748] - T Goto, K Nakao, K K Gunjigake, M A Kido, S Kobayashi, T Tanaka. Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors.
Neuropeptides.
2007 Feb; 41(1):25-31. doi:
10.1016/j.npep.2006.11.002. [PMID: 17204323] - H Kohrogi, J Hamamoto, O Kawano, H Iwagoe, K Fujii, N Hirata, M Ando. The role of substance P release in the lung with esophageal acid.
The American journal of medicine.
2001 Dec; 111 Suppl 8A(?):25S-30S. doi:
10.1016/s0002-9343(01)00859-2. [PMID: 11749920] - F F Lam, A L Yip. Unique gradual and sustained vasodilator response to substance P in the rabbit knee joint.
European journal of pharmacology.
2000 Jul; 400(2-3):327-35. doi:
10.1016/s0014-2999(00)00400-3. [PMID: 10988351] - V Esposito, C Linard, J Wysocki, N M Griffiths, D Mathe. A substance P receptor antagonist (FK 888) modifies gut alterations induced by ionizing radiation.
International journal of radiation biology.
1998 Nov; 74(5):625-32. doi:
10.1080/095530098141203. [PMID: 9848281] - B Conte, M Parlani, G Lopez, R Cirillo, C A Maggi, S Manzini. Inflammatory and motor responses by tachykinins in the guinea-pig oesophageal sphincter.
Journal of autonomic pharmacology.
1998 Oct; 18(5):313-7. doi:
10.1046/j.1365-2680.1998.185100.x. [PMID: 9831232] - G A Sarosi, B C Kimball, D C Barnhart, W Zhang, M W Mulholland. Tachykinin neuropeptide-evoked intracellular calcium transients in cultured guinea pig myenteric neurons.
Peptides.
1998; 19(1):75-84. doi:
10.1016/s0196-9781(97)00271-4. [PMID: 9437739] - T Katahashi, A Konno. Effects of tachykinin receptor antagonists, FK224 and FK888, in a guinea-pig model of nasal allergy.
Rhinology.
1997 Jun; 35(2):63-6. doi:
NULL. [PMID: 9299653] - S Evangelista, S Paoli, A Giachetti, S Manzini. Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.
Neuropeptides.
1997 Feb; 31(1):65-70. doi:
10.1016/s0143-4179(97)90022-6. [PMID: 9574840] - F Y Lam, M C Wong. Characterization of tachykinin receptors mediating plasma extravasation and vasodilatation in normal and acutely inflamed knee joints of the rat.
British journal of pharmacology.
1996 Aug; 118(8):2107-14. doi:
10.1111/j.1476-5381.1996.tb15650.x. [PMID: 8864549] - A Parenti, S Amerini, F Ledda, C A Maggi, M Ziche. The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture.
Naunyn-Schmiedeberg's archives of pharmacology.
1996 Apr; 353(5):475-81. doi:
10.1007/bf00169165. [PMID: 8740139] - J Ishikawa, M Ichinose, M Miura, N Kageyama, H Yamauchi, M Tomaki, Y Sasaki, K Shirato. Involvement of endogenous tachykinins in LTD4-induced airway responses.
The European respiratory journal.
1996 Mar; 9(3):486-92. doi:
10.1183/09031936.96.09030486. [PMID: 8730008] - M Ichinose, M Miura, H Yamauchi, N Kageyama, M Tomaki, T Oyake, Y Ohuchi, W Hida, H Miki, G Tamura, K Shirato. A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients.
American journal of respiratory and critical care medicine.
1996 Mar; 153(3):936-41. doi:
10.1164/ajrccm.153.3.8630576. [PMID: 8630576] - T Ebihara, K Sekizawa, T Ohrui, H Nakazawa, H Sasaki. Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs.
American journal of respiratory and critical care medicine.
1996 Feb; 153(2):812-9. doi:
10.1164/ajrccm.153.2.8564137. [PMID: 8564137] - M A Dias, A H Campos, V Cechinel Filho, R A Yunes, J B Calixto. Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro.
The Journal of pharmacy and pharmacology.
1995 Oct; 47(10):846-51. doi:
10.1111/j.2042-7158.1995.tb05752.x. [PMID: 8583354] - T Fujii. [Discovery and pharmacological properties of selective neurokinin-receptor antagonists, FK224 and FK888].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1995 Sep; 106(3):193-204. doi:
10.1254/fpj.106.193. [PMID: 8529964] - A D Kraneveld, T L Buckley, D van Heuven-Nolsen, Y van Schaik, A S Koster, F P Nijkamp. Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade.
British journal of pharmacology.
1995 Apr; 114(7):1483-9. doi:
10.1111/j.1476-5381.1995.tb13374.x. [PMID: 7606352] - I Aramori, N Morikawa, J Zenkoh, N O'Donnell, M Iwami, H Kojo, Y Notsu, M Okuhara, S Ono, S Nakanishi. Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for cloned rat and human tachykinin receptors.
European journal of pharmacology.
1994 Oct; 269(2):277-81. doi:
10.1016/0922-4106(94)90098-1. [PMID: 7531648] - N Nakajima, M Ichinose, T Takahashi, H Yamauchi, A Igarashi, M Miura, H Inoue, T Takishima, K Shirato. Bradykinin-induced airway inflammation. Contribution of sensory neuropeptides differs according to airway site.
American journal of respiratory and critical care medicine.
1994 Mar; 149(3 Pt 1):694-8. doi:
10.1164/ajrccm.149.3.7509704. [PMID: 7509704] - M Murai, Y Maeda, D Hagiwara, H Miyake, N Ikari, M Matsuo, T Fujii. Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.
European journal of pharmacology.
1993 May; 236(1):7-13. doi:
10.1016/0014-2999(93)90220-c. [PMID: 7686493] - Y Hirayama, Y H Lei, P J Barnes, D F Rogers. Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
British journal of pharmacology.
1993 Mar; 108(3):844-51. doi:
10.1111/j.1476-5381.1993.tb12888.x. [PMID: 7682142]