Fentiazac (BioDeep_00000179025)

   

human metabolite blood metabolite


代谢物信息卡片


2-[4-(4-chlorophenyl)-2-phenyl-1,3-thiazol-5-yl]acetic acid

化学式: C17H12ClNO2S (329.0277242)
中文名称: 芬替酸
谱图信息: 最多检出来源 Mus musculus(blood) 50%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=NC(=C(S2)CC(=O)O)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C17H12ClNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)

描述信息

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

8 个代谢物同义名

2-[4-(4-chlorophenyl)-2-phenyl-1,3-thiazol-5-yl]acetic acid; 2-[4-(4-Chlorophenyl)-2-phenyl-1,3-thiazol-5-yl]acetate; 2-Phenyl-4-(P-chlorophenyl)thiazol-5-ylacetic acid; 4-(P-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid; Wyeth brand OF fentiazac; FENTIAZAC; Norvedan; Donorest



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • D S Kweon, C K Shim, M H Lee. Effect of cimetidine on the pharmacokinetics of fentiazac in rats. Journal of pharmaceutical sciences. 1993 Sep; 82(9):952-5. doi: 10.1002/jps.2600820916. [PMID: 8229695]
  • G Houin, C Lapeyre, M A Rochas, A E Tufenkji, G Campistron, Y Coulais, J P Akbaraly, L Grislain, H Beck. Pharmacokinetic study of fentiazac and its main metabolite hydroxyfentiazac in the elderly. Arzneimittel-Forschung. 1993 Jan; 43(1):50-3. doi: NULL. [PMID: 8447848]
  • M Tariq. Effect of some new prostaglandin synthetase inhibitors on the endotoxin induced mortality and biochemical changes in experimental animals. Research communications in chemical pathology and pharmacology. 1988 Apr; 60(1):19-25. doi: . [PMID: 3132734]
  • P S Dowell, D M Pierce, R A Franklin, R Norris, H Harries, H Whiteland. The pharmacokinetics of fentiazac and its metabolite, p-hydroxyfentiazac, after twice-daily oral administration to male volunteers. Xenobiotica; the fate of foreign compounds in biological systems. 1984 Dec; 14(12):947-53. doi: 10.3109/00498258409151493. [PMID: 6531942]
  • P S Dowell. Simultaneous determination of fentiazac and p-hydroxyfentiazac in plasma by high-performance liquid chromatography with ultraviolet detection. The Analyst. 1983 Dec; 108(1293):1535-7. doi: 10.1039/an9830801535. [PMID: 6670750]
  • G Zanolo, C Giachetti, A Mondino, E Galimberti, G D'Atri. [Relation between the anti-inflammatory activity and serum and tissue levels of rectally-administered fentiazac]. Bollettino chimico farmaceutico. 1982 Dec; 121(12):632-47. doi: NULL. [PMID: 7184508]
  • M Quattrini, G Zanolo, A Mondino, C Giachetti, S Silvestri. Serum and urinary levels of fentiazac after a single oral and epicutaneous administration in human subjects. Arzneimittel-Forschung. 1981; 31(6):1046-8. doi: NULL. [PMID: 7196238]
  • G Zanolo, C Giachetti, A Mondino, S Silvestri, E Bianchi, G Segre, P Gomarasca, G De Marchi. Pharmacokinetics of fentiazac in rats and monkeys. Arzneimittel-Forschung. 1981; 31(7):1098-104. doi: NULL. [PMID: 7196759]
  • K Takeuchi, N Inazu, N Hasegawa, Y Yoshida, K Yamada, H Kogo, Y Aizawa. [Inhibitory action of non-steroidal anti-flammatory drugs on prostaglandin synthesis and release (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1980 Sep; 76(6):525-31. doi: NULL. [PMID: 6781993]
  • S Fumero, A Mondino, S Silvestri, G Zanolo, G De Marchi, S Pedrazzini. Binding of fentiazac to serum protein. Pharmacological research communications. 1980 Jan; 12(1):41-8. doi: 10.1016/s0031-6989(80)80061-0. [PMID: 7384163]