Fenclofenac (BioDeep_00000179004)
human metabolite blood metabolite
代谢物信息卡片
化学式: C14H10Cl2O3 (296.00069700000006)
中文名称: 芬氯酸
谱图信息:
最多检出来源 Homo sapiens(blood) 7.22%
分子结构信息
SMILES: C1=CC=C(C(=C1)CC(=O)O)OC2=C(C=C(C=C2)Cl)Cl
InChI: InChI=1S/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18)
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135254
- PubChem: 65394
- HMDB: HMDB0252194
- ChEMBL: CHEMBL15677
- Wikipedia: Fenclofenac
- CAS: 34645-84-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - C F Lim, N M Loidl, J A Kennedy, D J Topliss, J R Stokigt. Effect of loop diuretics and nonsteroidal antiinflammatory drugs on thyrotropin release by rat anterior pituitary cells in vitro.
Metabolism: clinical and experimental.
1995 Aug; 44(8):1008-12. doi:
10.1016/0026-0495(95)90097-7. [PMID: 7637641] - C F Lim, J R Stockigt, A J Curtis, K N Wynne, J W Barlow, D J Topliss. A naturally occurring furan fatty acid enhances drug inhibition of thyroxine binding in serum.
Metabolism: clinical and experimental.
1993 Nov; 42(11):1468-74. doi:
10.1016/0026-0495(93)90200-8. [PMID: 8231843] - C F Lim, A J Curtis, J W Barlow, D J Topliss, J R Stockigt. Interactions between oleic acid and drug competitors influence specific binding of thyroxine in serum.
The Journal of clinical endocrinology and metabolism.
1991 Nov; 73(5):1106-10. doi:
10.1210/jcem-73-5-1106. [PMID: 1939526] - D J Topliss, P S Hamblin, E Kolliniatis, C F Lim, J R Stockigt. Furosemide, fenclofenac, diclofenac, mefenamic acid and meclofenamic acid inhibit specific T3 binding in isolated rat hepatic nuclei.
Journal of endocrinological investigation.
1988 May; 11(5):355-60. doi:
10.1007/bf03349054. [PMID: 3183298] - M Farr, G R Struthers, D G Scott, P A Bacon. Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.
British journal of rheumatology.
1985 Nov; 24(4):367-9. doi:
10.1093/rheumatology/24.4.367. [PMID: 4063627] - P E McGill. NSAID-plasma concentration monitoring--optimizing treatment of R.A.
Agents and actions. Supplements.
1985; 17(?):157-61. doi:
10.1007/978-3-0348-7720-6_19. [PMID: 3867275] - S S Bedi, R Eberl, R Million, A M Silas. Fenclofenac and diclofenac in the treatment of rheumatoid arthritis.
British journal of rheumatology.
1984 Aug; 23(3):214-9. doi:
10.1093/rheumatology/23.3.214. [PMID: 6378307] - L Sellars, R Wilkinson, A R Morley, R H Salter. Nephrotic syndrome and renal impairment associated with fenclofenac.
Annals of the rheumatic diseases.
1984 Jun; 43(3):513-4. doi:
10.1136/ard.43.3.513. [PMID: 6742914] - R Taylor, C Hutton, J Weeke, F Clark. Fenclofenac-secondary effects upon the pituitary thyroid axis.
Clinical endocrinology.
1983 Dec; 19(6):683-92. doi:
10.1111/j.1365-2265.1983.tb00045.x. [PMID: 6418419] - M V Marsh, J Caldwell, T P Sloan, R L Smith, M Horner, M S Moss. The metabolism of fenclofenac in the horse.
Xenobiotica; the fate of foreign compounds in biological systems.
1983 Apr; 13(4):233-40. doi:
10.3109/00498258309052259. [PMID: 6624138] - A L Mäkelä, M Scheinin, E Iisalo, J S Salonen. Pharmacokinetics of fenclofenac in children with juvenile rheumatoid arthritis.
European journal of clinical pharmacology.
1983; 25(3):381-8. doi:
10.1007/bf01037952. [PMID: 6628527] - A B Kurtz, S J Capper, J Clifford, M J Humphrey, L Lukinac. The effect of fenclofenac on thyroid function.
Clinical endocrinology.
1981 Aug; 15(2):117-24. doi:
10.1111/j.1365-2265.1981.tb00645.x. [PMID: 6796298] - S J Capper, M J Humphrey, A B Kurtz. Inhibition of thyroxine binding to serum proteins by fenclofenac and related compounds.
Clinica chimica acta; international journal of clinical chemistry.
1981 Apr; 112(1):77-83. doi:
10.1016/0009-8981(81)90270-9. [PMID: 6786805] - W A Ratcliffe, R A Hazelton, J A Thomson, J G Ratcliffe. The effect of fenclofenac on thyroid function tests in vivo and in vitro.
Clinical endocrinology.
1980 Dec; 13(6):569-75. doi:
10.1111/j.1365-2265.1980.tb03425.x. [PMID: 7226571] - D Greenslade, M E Havler, M J Humphrey, B J Jordan, M J Rance. Species differences in the metabolism and excretion of fenclofenac.
Xenobiotica; the fate of foreign compounds in biological systems.
1980 Oct; 10(10):753-60. doi:
10.3109/00498258009033803. [PMID: 7456491] - R Henson, J G Lloyd-Jones, J D Nichols, B J Jordan. Pharmacokinetics of fenclofenac following single and multiple doses.
European journal of drug metabolism and pharmacokinetics.
1980; 5(4):217-23. doi:
10.1007/bf03189467. [PMID: 7250145]