Fantofarone (BioDeep_00000178982)

   

human metabolite blood metabolite


代谢物信息卡片


[2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[2-(propan-2-yl)indolizin-1-yl]sulfonyl}phenoxy)propyl]amine

化学式: C31H38N2O5S (550.2501298)
中文名称: 泛托法隆
谱图信息: 最多检出来源 Homo sapiens(blood) 28.57%

分子结构信息

SMILES: CC(C)C1=CN2C=CC=CC2=C1S(=O)(=O)C3=CC=C(C=C3)OCCCN(C)CCC4=CC(=C(C=C4)OC)OC
InChI: InChI=1S/C31H38N2O5S/c1-23(2)27-22-33-18-7-6-9-28(33)31(27)39(34,35)26-13-11-25(12-14-26)38-20-8-17-32(3)19-16-24-10-15-29(36-4)30(21-24)37-5/h6-7,9-15,18,21-23H,8,16-17,19-20H2,1-5H3

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor

同义名列表

3 个代谢物同义名

[2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[2-(propan-2-yl)indolizin-1-yl]sulfonyl}phenoxy)propyl]amine; 2-Isopropyl-1-((4-(3-(N-methyl-N-(3,4-dimethoxy-beta-phenethyl)amino)propoxy)benzenesulfonyl))indolizine; Fantofarone



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Grégory Seumois, Marianne Fillet, Laurent Gillet, Céline Faccinetto, Christophe Desmet, Cédric François, Benjamin Dewals, Cécile Oury, Alain Vanderplasschen, Pierre Lekeux, Fabrice Bureau. De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. Journal of leukocyte biology. 2007 Jun; 81(6):1477-86. doi: 10.1189/jlb.0806529. [PMID: 17329567]
  • E Bellissant, J F Giudicelli. Pharmacokinetic-pharmacodynamic model for fantofarone cardiac and brachial haemodynamic effects in healthy volunteers. British journal of clinical pharmacology. 1999 Dec; 48(6):801-10. doi: 10.1046/j.1365-2125.1999.00091.x. [PMID: 10594483]
  • J Y Lee, L G Leonhardt, L M Obeid. Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. The Biochemical journal. 1998 Sep; 334 ( Pt 2)(?):457-61. doi: 10.1042/bj3340457. [PMID: 9716505]
  • J Adovelande, J Delèze, J Schrével. Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochemical pharmacology. 1998 Feb; 55(4):433-40. doi: 10.1016/s0006-2952(97)00482-6. [PMID: 9514077]
  • H W van Veen, R Callaghan, L Soceneantu, A Sardini, W N Konings, C F Higgins. A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Nature. 1998 Jan; 391(6664):291-5. doi: 10.1038/34669. [PMID: 9440694]
  • J P Jaffrézou, Kevin Gang Chen, G E Durán, C Muller, C Bordier, G Laurent, B I Sikic, T Levade. Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance. Biochimica et biophysica acta. 1995 04; 1266(1):1-8. doi: 10.1016/0167-4889(94)00219-5. [PMID: 7718613]
  • P Chatelain, J R Matteazzi, R Laruel. Interaction of the calcium antagonist fantofarone with phospholipids: electrostatic effects. Biochemical pharmacology. 1994 Oct; 48(7):1393-8. doi: 10.1016/0006-2952(94)90562-2. [PMID: 7945438]
  • P Chatelain, J R Matteazzi, R Laruel. Binding of fantofarone, a novel Ca2+ antagonist, to serum albumin: a fluorescence study. Journal of pharmaceutical sciences. 1994 May; 83(5):674-6. doi: 10.1002/jps.2600830516. [PMID: 8071819]
  • J P Jaffrézou, J M Herbert, T Levade, M N Gau, P Chatelain, G Laurent. Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein. The Journal of biological chemistry. 1991 Oct; 266(29):19858-64. doi: 10.1016/s0021-9258(18)55070-5. [PMID: 1918089]