Fabomotizole (BioDeep_00000178974)

   

human metabolite blood metabolite


代谢物信息卡片


5-ethoxy-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}-1H-1,3-benzodiazole

化学式: C15H21N3O2S (307.13544060000004)
中文名称: 法莫替唑
谱图信息: 最多检出来源 Mus musculus(blood) 66.67%

分子结构信息

SMILES: CCOC1=CC2=C(C=C1)N=C(N2)SCCN3CCOCC3
InChI: InChI=1S/C15H21N3O2S/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18/h3-4,11H,2,5-10H2,1H3,(H,16,17)

描述信息

C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics

同义名列表

7 个代谢物同义名

5-ethoxy-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}-1H-1,3-benzodiazole; 2-((2-Morpholino)ethylthio)-5-ethoxybenzimidazole dihydrochloride; 2-((2-Morpholino)ethylthio)-5-ethoxybenzimidazole; Fabomotizole; Aphobazole; Afobazole; Afobazol



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S A Kryzhanovskii, L M Kozhevnikova, I B Tsorin, I F Sukhanova, E O Ionova, V N Stolyaruk, M B Vititnova, I A Miroshkina, S B Seredenin. On the Mechanism of the Cardioprotective Action of σ1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole). Bulletin of experimental biology and medicine. 2018 Sep; 165(5):660-664. doi: 10.1007/s10517-018-4236-1. [PMID: 30225699]
  • E A Ivanova, N N Zolotov, I G Kapitsa, V F Pozdnev, E A Valdman, T A Voronina. [Effect of afobazole and levodopa on the activity of proline-specific proteinases and adenosine deaminase in blood serum and brain structures of rats with experimental Parkinson's syndrome induced by systemic administration of rotenone]. Biomeditsinskaia khimiia. 2017 Nov; 63(6):565-569. doi: 10.18097/pbmc20176306565. [PMID: 29251620]
  • Ruslan V Lutsenko, Elena V Vlasova, Elina G Kolot, Victoria M Gladka, Antonina G Sidorenko. The exchange of monoamines during the experimental neurosis on the background of using of amide '2-hydroxy-n-naphthalen-1-yl-2-(2-oxo-,2-dihydroindol-3-ylidene)'. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2017 ; 70(5):895-900. doi: NULL. [PMID: 29203736]
  • S G Dzugkoev, F S Dzugkoeva, I V Mozhaeva, O I Margieva, N M Karchaidze. [MECHANISMS OF AFOBAZOLE INFLUENCE ON THE NO PRODUCING ENDOTHELIUM FUNCTION AND INDICATORS OF OXIDATIVE STRESS IN RATS WITH EXPERIMENTAL DIABETES MELLITUS.]. Eksperimental'naia i klinicheskaia farmakologiia. 2016 08; 79(5):15-19. doi: . [PMID: 29782774]
  • S G Dzugkoev, I V Mozhaeva, M A Otiev, O I Margieva, F S Dzugkoeva. [Effect of L-carnitine, afobazole and their combination with L-arginine on biochemical and histological indices of endothelial disfunction in cobalt intoxication in rats]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. 2015 Apr; 59(2):70-5. doi: . [PMID: 26571811]
  • V V Zabrodina, E D Shreder, O V Shreder, A D Durnev, S B Seredenin. Impaired prenatal development and glycemic status in the offspring of rats with experimental streptozotocin-induced diabetes and their correction with afobazole. Bulletin of experimental biology and medicine. 2014 Nov; 158(1):16-20. doi: 10.1007/s10517-014-2681-z. [PMID: 25403388]
  • R S Mirzoian, T S Gan'shina, N A Khaĭlov, A V Gnezdilova, D V Maslennikov, I N Kurdiumov, M A Lebedeva, A A Gorbunov. [Cerebrovascular pharmacology of separate and combined vascular pathology of brain and heart]. Eksperimental'naia i klinicheskaia farmakologiia. 2014; 77(3):3-8. doi: ". [PMID: 24800517]
  • D V Bastrygin, A O Viglinskaya, G B Kolyvanov, A A Litvin, P O Bochkov, T Ya Mozhaeva, V P Zherdev. Excretion of compound M-11 and its metabolites with urine and feces in rats. Bulletin of experimental biology and medicine. 2012 Sep; 153(5):707-9. doi: 10.1007/s10517-012-1805-6. [PMID: 23113264]
  • D V Bastrygin, A O Viglinskaia, G B Kolyvanov, A A Litvin, P O Bochkov, T Ia Mozhaeva, V P Zherdev. [Pharmacokinetics of afobazole metabolite (M-11) in rats]. Eksperimental'naia i klinicheskaia farmakologiia. 2011; 74(7):22-6. doi: NULL. [PMID: 21894764]
  • A O Viglinskaya, G B Kolyvanov, A A Litvin, V P Zherdev, S B Seredenin. Excretion of afobazole and its metabolites with urine and feces in rats. Bulletin of experimental biology and medicine. 2008 Apr; 145(4):440-2. doi: 10.1007/s10517-008-0112-8. [PMID: 19110588]
  • S B Seredenin, A O Viglinskaia, T Ia Mozhaeva, G B Kolyvanov, A A Litvin, N I Avdiunina, V L Savel'ev, V P Zgerdev. [Afobazole metabolism in rats]. Eksperimental'naia i klinicheskaia farmakologiia. 2008 Mar; 71(2):50-2. doi: NULL. [PMID: 18488909]
  • István Szanyi, László Lujber, Imre Gerlinger, József Pytel, Miklós Bauer, András Csejtey, Eszter Szele, Katalin Gombos, István Kiss, Sergey Seredenin, Milada Yarkova, István Ember. In vivo effects of afobazole (2-mercaptobenzimidazole derivative) on the 7,12-dimethylbenz [alpha]anthracene-induced oncogene and suppressor gene expression. In vivo (Athens, Greece). 2007 Nov; 21(6):1059-63. doi: NULL. [PMID: 18210756]
  • S B Seredenin, A O Viglinskaia, G B Kolyvanov, A A Litvin, O Iu Kravtsova, V P Zherdev. [Pharmacokinetics of afobazole in rats]. Eksperimental'naia i klinicheskaia farmakologiia. 2007 Mar; 70(2):59-64. doi: NULL. [PMID: 17523455]