Neuropeptide FF (BioDeep_00000178972)

   

human metabolite blood metabolite


代谢物信息卡片


2-{[1-(2-{2-[2-(2-amino-3-phenylpropanamido)-4-methylpentanamido]-3-phenylpropanamido}-4-carbamoylbutanoyl)pyrrolidin-2-yl]formamido}-N-{1-[(1-carbamoyl-2-phenylethyl)carbamoyl]-4-[(diaminomethylidene)amino]butyl}pentanediamide

化学式: C54H76N14O10 (1080.5868556)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCC(=O)N)C(=O)N2CCCC2C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=CC=C4)N
InChI: InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists

同义名列表

11 个代谢物同义名

2-{[1-(2-{2-[2-(2-amino-3-phenylpropanamido)-4-methylpentanamido]-3-phenylpropanamido}-4-carbamoylbutanoyl)pyrrolidin-2-yl]formamido}-N-{1-[(1-carbamoyl-2-phenylethyl)carbamoyl]-4-[(diaminomethylidene)amino]butyl}pentanediamide; Phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide; H-DL-Phe-DL-Leu-DL-Phe-DL-Gln-DL-Pro-DL-Gln-DL-Arg-DL-Phe-NH2; Phe-leu-phe-GLN-pro-GLN-arg-phe-NH2; FMRFamide-like octapeptide; Octapeptide F8fa; Neuropeptide FF; FLFQPQRF-NH2; F-8-F-Amide; F-8-F-NH2; F8Famide



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shifei Sun, Shilong Sun, Yan Meng, Bin Shi, Yuanzhen Chen. Elevated Serum Neuropeptide FF Levels Are Associated with Cognitive Decline in Patients with Spinal Cord Injury. Disease markers. 2021; 2021(?):4549049. doi: 10.1155/2021/4549049. [PMID: 34804262]
  • Ya-Tin Lin, Jin-Chung Chen. Neuropeptide FF modulates neuroendocrine and energy homeostasis through hypothalamic signaling. The Chinese journal of physiology. 2019 Mar; 62(2):47-52. doi: 10.4103/cjp.cjp_23_19. [PMID: 31243174]
  • Syed F Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibañez, José T Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E Marion Schneider, Jacqueline A Brinkman, Dudley W Lamming, Christine M Seroogy, Tamás Röszer. Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. The Journal of clinical investigation. 2017 Jun; 127(7):2842-2854. doi: 10.1172/jci90152. [PMID: 28581443]
  • J U Jeong, H K Lee, Y J Kim, J S Kim, S S Kang, S B Kim. Nutritional markers, not markers of bone turnover, are related predictors of bone mineral density in chronic peritoneal dialysis patients. Clinical nephrology. 2010 Nov; 74(5):336-42. doi: 10.5414/cnp74336. [PMID: 20979940]
  • V I Kapel'ko, Zh D Bespalova, E E Efremov, V L Lakomkin, Ts R Orlova, S V Lakomkin, M V Sidorova, A A Az'muko, A S Molokoedov, T V Sharf. [Modification of the FF neuropeptide enhances its hypertensive effect]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2009 May; 95(5):484-93. doi: NULL. [PMID: 19569525]
  • Lionel Moulédous, Soren Merker, Jérémie Neasta, Benoit Roux, Jean-Marie Zajac, Catherine Mollereau. Neuropeptide FF-sensitive confinement of mu opioid receptor does not involve lipid rafts in SH-SY5Y cells. Biochemical and biophysical research communications. 2008 Aug; 373(1):80-4. doi: 10.1016/j.bbrc.2008.05.174. [PMID: 18544342]
  • Marlie A Johnson, Gregory S Fraley. Rat RFRP-3 alters hypothalamic GHRH expression and growth hormone secretion but does not affect KiSS-1 gene expression or the onset of puberty in male rats. Neuroendocrinology. 2008; 88(4):305-15. doi: 10.1159/000145718. [PMID: 18628614]
  • Maija-Liisa Nieminen, Johanna Nystedt, Pertti Panula. Expression of neuropeptide FF, prolactin-releasing peptide, and the receptor UHR1/GPR10 genes during embryogenesis in the rat. Developmental dynamics : an official publication of the American Association of Anatomists. 2003 Mar; 226(3):561-9. doi: 10.1002/dvdy.10261. [PMID: 12619141]
  • D Sunter, A K Hewson, S Lynam, S L Dickson. Intracerebroventricular injection of neuropeptide FF, an opioid modulating neuropeptide, acutely reduces food intake and stimulates water intake in the rat. Neuroscience letters. 2001 Nov; 313(3):145-8. doi: 10.1016/s0304-3940(01)02267-4. [PMID: 11682148]
  • L Prokai, A D Zharikova, T Janáky, K Prokai-Tatrai. Exploratory pharmacokinetics and brain distribution study of a neuropeptide FF antagonist by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2000; 14(24):2412-8. doi: 10.1002/1097-0231(20001230)14:24<2412::aid-rcm180>3.0.co;2-3. [PMID: 11114059]
  • H Yokoi, H Arima, K Kondo, T Murase, Y Iwasaki, H Y Yang, Y Oiso. Antiserum against neuropeptide FF augments vasopressin release in conscious rats. Peptides. 1998; 19(2):393-5. doi: 10.1016/s0196-9781(97)00375-6. [PMID: 9493874]
  • D M Sundblom, A Hyrkkö, F Fyhrquist. Pulsatile secretion of neuropeptide FF into human blood. Peptides. 1998; 19(7):1165-70. doi: 10.1016/s0196-9781(98)00060-6. [PMID: 9786165]
  • D M Sundblom, E Kalso, I Tigerstedt, K Wahlbeck, P Panula, F Fyhrquist. Neuropeptide FF-like immunoreactivity in human cerebrospinal fluid of chronic pain patients and healthy controls. Peptides. 1997; 18(7):923-7. doi: 10.1016/s0196-9781(97)00040-5. [PMID: 9357047]
  • H Arima, T Murase, K Kondo, Y Iwasaki, Y Oiso. Centrally administered neuropeptide FF inhibits arginine vasopressin release in conscious rats. Endocrinology. 1996 May; 137(5):1523-9. doi: 10.1210/endo.137.5.8612481. [PMID: 8612481]
  • P Panula, A A Aarnisalo, K Wasowicz. Neuropeptide FF, a mammalian neuropeptide with multiple functions. Progress in neurobiology. 1996 Mar; 48(4-5):461-87. doi: 10.1016/0301-0082(96)00001-9. [PMID: 8804117]
  • M Allard, S Labrouche, A Nosjean, R Laguzzi. Mechanisms underlying the cardiovascular responses to peripheral administration of NPFF in the rat. The Journal of pharmacology and experimental therapeutics. 1995 Jul; 274(1):577-83. doi: . [PMID: 7616447]
  • D M Sundblom, P Panula, F Fyhrquist. Neuropeptide FF-like immunoreactivity in human plasma. Peptides. 1995; 16(2):347-50. doi: 10.1016/0196-9781(94)00163-4. [PMID: 7784266]
  • J C Lecron, M Minault, M Allard, P Goube de Laforest, J Gombert, G Simonnet. Modulation of human lymphocyte proliferation by FLFQPQRFamide, a FMRFamide-like peptide with anti-opiate properties. Journal of neuroimmunology. 1992 May; 38(1-2):1-8. doi: 10.1016/0165-5728(92)90084-x. [PMID: 1577948]
  • J R Lake, M V Hammond, R C Shaddox, L M Hunsicker, H Y Yang, D H Malin. IgG from neuropeptide FF antiserum reverses morphine tolerance in the rat. Neuroscience letters. 1991 Oct; 132(1):29-32. doi: 10.1016/0304-3940(91)90425-s. [PMID: 1787914]
  • M Kavaliers, H Y Yang. Effects of mammalian FMRF-NH2-related peptides and IgG from antiserum against them on aggression and defeat-induced analgesia in mice. Peptides. 1991 Mar; 12(2):235-9. doi: 10.1016/0196-9781(91)90005-a. [PMID: 2067975]