Chloroxine (BioDeep_00000017894)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5,7-Dichloro-8-hydroxyquinoline

化学式: C9H5Cl2NO (212.974818)
中文名称: 5,7-二氯-8-羟基喹啉
谱图信息: 最多检出来源 Homo sapiens(blood) 0.26%

分子结构信息

SMILES: C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1
InChI: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

描述信息

Chloroxine is only found in individuals that have used or taken this drug. It is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.Although the mechanism of action is not understood, chloroxine may slow down mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp. Chloroxine induces SOS-DNA repair in E. coli, so chloroxine may be genotoxic to bacteria.
C78284 - Agent Affecting Integumentary System > C29708 - Anti-psoriatic Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents

同义名列表

19 个代谢物同义名

5,7-Dichloro-8-hydroxyquinoline; 5,7-Dichlor-8-hydroxychinolin; 5,7-Dichloro-8-oxyquinoline; 5,7-dichloroquinolin-8-ol; 5,7-Dichloro-8-quinolinol; Chloroxine hydrofluoride; Dichlorohydroxyquinoline; Dichloroquinolinol; 5,7-Dichlorooxine; Chloroxyquinoline; 5,7-Dichloroxine; Dichloroquine; Dikhloroskin; Chlorquinol; Dichloroxin; chloroxine; Capitrol; Quixalin; CHQ



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yunxia Xu, Ke Chen, Juanli Pan, Yingshou Lei, Danting Zhang, Lipei Fang, Jinle Tang, Xin Chen, Yanhong Ma, Yi Zheng, Bao Zhang, Yaoqi Zhou, Jian Zhan, Wei Xu. Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease. International journal of biological macromolecules. 2021 Oct; 188(?):137-146. doi: 10.1016/j.ijbiomac.2021.07.184. [PMID: 34364941]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Nahid Shahabadi, Saba Zendehcheshm. Evaluation of ct-DNA and HSA binding propensity of antibacterial drug chloroxine: Multi-spectroscopic analysis, atomic force microscopy and docking simulation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Apr; 230(?):118042. doi: 10.1016/j.saa.2020.118042. [PMID: 31972466]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • David S Letham, Xue-Dong Zhang, Charles H Hocart. The Synthesis of ³H-Labelled 8-Azido-N⁶-Benzyladenine and Related Compounds for Photoaffinity Labelling of Cytokinin-Binding Proteins. Molecules (Basel, Switzerland). 2019 Jan; 24(2):. doi: 10.3390/molecules24020349. [PMID: 30669410]
  • Aphrodite Caragounis, Tai Du, Gulay Filiz, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Robert A Cherny, Colin L Masters, Simon C Drew, Andrew F Hill, Qiao-Xin Li, Peter J Crouch, Kevin J Barnham, Anthony R White. Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands. The Biochemical journal. 2007 Nov; 407(3):435-50. doi: 10.1042/bj20070579. [PMID: 17680773]
  • Ramakrishnan Kala, Talasila Prasada Rao. Ion imprinted polymer particles for separation of yttrium from selected lanthanides. Journal of separation science. 2006 Jun; 29(9):1281-7. doi: 10.1002/jssc.200600008. [PMID: 16833087]
  • Sibylle M Kaiser, Beate I Escher. The evaluation of liposome-water partitioning of 8-hydroxyquinolines and their copper complexes. Environmental science & technology. 2006 Mar; 40(6):1784-91. doi: 10.1021/es051908y. [PMID: 16570598]