Etimizol (BioDeep_00000178926)
human metabolite blood metabolite
代谢物信息卡片
1-ethyl-N4,N5-dimethyl-1H-imidazole-4,5-dicarboxamide
化学式: C9H14N4O2 (210.1117)
中文名称:
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: CCN1C=NC(=C1C(=O)NC)C(=O)NC
InChI: InChI=1S/C9H14N4O2/c1-4-13-5-12-6(8(14)10-2)7(13)9(15)11-3/h5H,4H2,1-3H3,(H,10,14)(H,11,15)
描述信息
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 6168
- HMDB: HMDB0252102
- ChEMBL: CHEMBL4303294
- MeSH: Etimizol
- chemspider: 5934
- CAS: 64-99-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae.
Plant physiology.
2017 Aug; 174(4):2146-2165. doi:
10.1104/pp.17.00433. [PMID: 28652262] - V G Belikov, M G Tsybulina, S V Klochkov, T Kh Vergeĭchik. [The spectrophotometric determination of metronidazole and etimizol when jointly present in the urine].
Sudebno-meditsinskaia ekspertiza.
1995 Oct; 38(4):27-9. doi:
NULL. [PMID: 8848799] - S I Bogoslovskaia, G P Gladilin. [The effect of etimizol on the functional status of the blood coagulation systems and fibrinolysis in workers on expedition-duty watches working under the climatic conditions of northern Tyumen Province].
Eksperimental'naia i klinicheskaia farmakologiia.
1995 May; 58(3):40-2. doi:
". [PMID: 7663295] - Ie M Neĭko, L V Hlushko, I Iu Holovach, R I Iatsyshyn. [The effect of etimizol on the glycosaminoglycan level in patients with osteoarthrosis deformans].
Likars'ka sprava.
1994 Jul; ?(7-8):73-5. doi:
NULL. [PMID: 7900360] - V V Bul'on, I S Zavodskaia, L K Khnychenko. [The effect of neurotropic agents on lipid peroxidation in the heart and stomach with neurogenic lesions].
Eksperimental'naia i klinicheskaia farmakologiia.
1994 May; 57(3):18-20. doi:
NULL. [PMID: 8049619] - L Soltés. Multimodal liquid chromatographic separation methods in the study of ethimizol metabolism in man.
Biomedical chromatography : BMC.
1992 Jul; 6(4):177-82. doi:
10.1002/bmc.1130060405. [PMID: 1643385] - B A Reĭkhardt, O G Kulikova, L M Beliavtseva, Iu S Borodkin. [Effects of antifeins with different memory effects on cAMP phosphodiesterase, lipid peroxidation and RNA synthesis in rat brain neurons].
Biulleten' eksperimental'noi biologii i meditsiny.
1991 May; 111(5):483-5. doi:
". [PMID: 1715213] - A F Leshchinskiĭ. [Role of sex dimorphism in the pharmacological action of etimizol].
Biulleten' eksperimental'noi biologii i meditsiny.
1989 Jul; 108(7):91-3. doi:
NULL. [PMID: 2553148] - V N Plotnikova, G P Koreneva, I P Korenev. [Use of neurotropic agents in the combined treatment of patients with exacerbated chronic nonspecific salpingo-oophoritis].
Akusherstvo i ginekologiia.
1987 Mar; ?(3):51-4. doi:
NULL. [PMID: 3592092] - T Trnovec, M Durisová, P Burdáts, L Soltés, Z Kállay, S Bezek, L B Piotrovskii. Dose-dependent pharmacokinetics of a xanthine-related nootropic drug, ethimizol, in rats.
Pharmacology.
1987; 34(2-3):149-56. doi:
10.1159/000138264. [PMID: 2884678] - T Trnovec, M Durisová, S Bezek, P Burdáts, V Marko, V Faberová, M Zemánek, L Soltés, L B Piotrovsky. Disposition of ethimizol, a nootropic drug, in rats and mice.
Drug metabolism and disposition: the biological fate of chemicals.
1986 Nov; 14(6):718-23. doi:
NULL. [PMID: 2877833] - L B Piotrovsky, Alexandrova IYa, L Soltés, M Stefek, T Trnovec. Formation of didesmethylethimizol (4-5-dicarbamoyl-1-ethylimidazole) in man.
European journal of drug metabolism and pharmacokinetics.
1986 Apr; 11(2):87-9. doi:
10.1007/bf03189832. [PMID: 3770018] - V Koprda, T Trnovec. 14C-ethimizol: binding to plasma proteins and distribution between components of rat blood.
Die Pharmazie.
1986 Jan; 41(1):65-6. doi:
NULL. [PMID: 3960956] - P Burdáts, T Trnovec, L Soltés, L B Piotrovsky, Alexandrova IYa. Isolation and separation of 14C-ethimizol and of its labelled metabolites from plasma of rats.
Die Pharmazie.
1985 Aug; 40(8):584. doi:
NULL. [PMID: 4080813] - T Trnovec, L Soltés, M Durisova, Z Kállay, V Koprda, L B Piotrovskii. Pharmacokinetics of ethimizol in man.
Die Pharmazie.
1985 Jun; 40(6):410-1. doi:
NULL. [PMID: 4034651] - L Soltés, V Mlynárik, V Mihálov. Demethylation in vivo of a xanthine-related respiratory analeptic, ethimizol.
Xenobiotica; the fate of foreign compounds in biological systems.
1983 Nov; 13(11):683-7. doi:
10.3109/00498258309052229. [PMID: 6143455] - L Soltés, Z Kállay, T Trnovec, M Durisová, M Plsková. Monitoring of ethimizol and its metabolites in serum or saliva by means of high-performance liquid chromatography.
Journal of chromatography.
1983 Mar; 273(1):213-6. doi:
10.1016/s0378-4347(00)80941-x. [PMID: 6853653] - L Soltés, S Bezek, T Trnovec, M Stefek, Z Kállay. Determination of ethimizol and two of its metabolites in serum by high-pressure liquid chromatography.
Pharmacology.
1983; 26(4):198-204. doi:
10.1159/000137802. [PMID: 6133289] - I A Lapina, H Hartmann, M Fekete, K Lissak. Effects of ethymisol on behavior and brain serotonin and plasma corticosteroid levels.
Neuroscience and behavioral physiology.
1982 Mar; 12(2):150-3. doi:
10.1007/bf01189326. [PMID: 7177364] - V P Novikov. [Mechanism of action of etimizol on the energy metabolism of the neurogenically damaged myocardium].
Biulleten' eksperimental'noi biologii i meditsiny.
1981 Jun; 91(6):698-9. doi:
NULL. [PMID: 7272488] - A Szelepcsényiová, D Anderle. [A gas chromatography technic for the determination of etimizol in blood serum].
Ceskoslovenska farmacie.
1981 Mar; 30(2):46-9. doi:
NULL. [PMID: 7237590] - Iu S Borodkin, I A Lapina, V V Bul'on, G Hartmann, J Hahn. [Animal behavioral reactions, adrenocortical activity and brain energy metabolism under the action of propylnorantifein].
Farmakologiia i toksikologiia.
1980 Jul; 43(4):356-60. doi:
NULL. [PMID: 7439366] - I A Lapina, G Khartman, M Fekete, K Lishshak. [Effect of etimizol on behavioral responses, brain serotonin concentration and plasma corticosteroid levels].
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova.
1979 Nov; 29(6):1157-61. doi:
NULL. [PMID: 575256] - N S Sapronov. [Brain catecholamine participation in etimizol activation of the hypophyseal-adrenal cortex system].
Farmakologiia i toksikologiia.
1979 May; 42(3):216-21. doi:
NULL. [PMID: 446699] - Iu Ia Kamenev, V I Kasatkin, V V Davydov, M K Kolomiets. [Effect of etimizol on plasma 11-hydroxycorticosteroid levels in patients with severe chronic lung diseases].
Sovetskaia meditsina.
1977 Oct; ?(10):79-83. doi:
NULL. [PMID: 929277] - N S Sapronov, T A Oletskaia. [Mechanism of the lipid mobilizing effect of etimizol].
Biulleten' eksperimental'noi biologii i meditsiny.
1977 Sep; 84(9):321-3. doi:
NULL. [PMID: 912089] - E N Bellendir, G D Nakonechnyĭ, I N Peschanskaia, I U Salmagambetov. [Effect of several immunoactive agents on the course of kidney tuberculosis].
Problemy tuberkuleza.
1976 Dec; ?(12):65-9. doi:
NULL. [PMID: 1005407] - E K Shkhinek. [The functional role of the posterior hypothalamic field in realizing the responses of the hypothalamo-hypophyseal-adrenal system in rabbits].
Problemy endokrinologii.
1975 Nov; 21(6):59-65. doi:
NULL. [PMID: 1241135]
