Ethyl biscoumacetate (BioDeep_00000178872)

   

human metabolite blood metabolite


代谢物信息卡片


Ethyl 2,2-bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetic acid

化学式: C22H16O8 (408.0845136)
中文名称: 双香豆酸乙酯
谱图信息: 最多检出来源 Homo sapiens(blood) 99.4%

分子结构信息

SMILES: CCOC(=O)C(C1=C(C2=CC=CC=C2OC1=O)O)C3=C(C4=CC=CC=C4OC3=O)O
InChI: InChI=1S/C22H16O8/c1-2-28-20(25)15(16-18(23)11-7-3-5-9-13(11)29-21(16)26)17-19(24)12-8-4-6-10-14(12)30-22(17)27/h3-10,15,23-24H,2H2,1H3

描述信息

B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AA - Vitamin k antagonists
D006401 - Hematologic Agents > D000925 - Anticoagulants > D015110 - 4-Hydroxycoumarins
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent

同义名列表

9 个代谢物同义名

Ethyl 2,2-bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetic acid; ethyl 2,2-bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate; Ethyl biscoumacetic acid; Biscoumacetate, ethyl; Ethyl Biscoumacetate; Carbethoxydicoumarol; Ethyldicoumarol; Tromexan; Pelentan



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Janette H Hope, Bradley E Hope. A review of the diagnosis and treatment of Ochratoxin A inhalational exposure associated with human illness and kidney disease including focal segmental glomerulosclerosis. Journal of environmental and public health. 2012; 2012(?):835059. doi: 10.1155/2012/835059. [PMID: 22253638]
  • M Prazanowski, B Piłacik, W Lutz. [Use of hypoprothrombinemia provocation test for early diagnosis of liver disease caused by harmful environmental agents]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 1998 Mar; 4(21):154-7. doi: NULL. [PMID: 9640069]
  • F Perlík, V Patzelová. Pharmacokinetics of ethyl biscoumacetate and its metabolite 7-hydroxy ethyl biscoumacetate in healthy volunteers. International journal of clinical pharmacology and therapeutics. 1994 Nov; 32(11):622-4. doi: NULL. [PMID: 7874379]
  • X Copie, J L Pinquier, M Letrait, M H Paltiat, J Y Pello, E Rey, G Chanteclair, D de Lauture, G Olive, G Strauch. [Effect of dimethicone on pharmacokinetics and pharmacodynamics of ethyl biscoumacetate]. Therapie. 1993 Mar; 48(2):119-23. doi: NULL. [PMID: 8351679]
  • J Pospísil, V Patzelová, F Perlík. Determination of ethyl biscoumacetate and its metabolite 7-hydroxyethyl biscoumacetate in human serum by high-performance liquid chromatography and mass spectrometry. Journal of chromatography. 1992 Feb; 574(1):71-5. doi: 10.1016/0378-4347(92)80099-c. [PMID: 1629290]
  • A A Sokol'nikov, L V Avramova, V M Kodentsova, O A Vrzhesinskaia, N Iu Goncharova, V B Spirichev. [Kinetic characteristics of creatine kinase and hexokinase from rat skeletal muscles during dietary deficit of vitamin K and administration of pelentane]. Ukrainskii biokhimicheskii zhurnal (1978). 1992 Jan; 64(1):72-7. doi: NULL. [PMID: 1519350]
  • A A Sokol'nikov, T V Zharova, O V Tiulina, V M Kodentsova, Iu N Leĭkin. [Status of liver mitochondria and rat tissue creatine kinase during administration of antivitamin K]. Ukrainskii biokhimicheskii zhurnal (1978). 1991 Sep; 63(5):102-6. doi: NULL. [PMID: 1788864]
  • V M Kodentsova, A A Sokol'nikov, O A Vrzhesinskaia, V B Spirichem. [The effect of supplying rats with vitamin K and administration of pelentane on Na,K- and spectrin-dependent ATPase in erythrocyte ghosts]. Biokhimiia (Moscow, Russia). 1991 Apr; 56(4):727-32. doi: ". [PMID: 1655070]
  • J M Gabriel, H Merault, M H Fournie, F C Vert-Pre, M Trival. [Fatal hemorrhagic complication of acquired multicystic disease in dialyzed patients]. Presse medicale (Paris, France : 1983). 1989 Mar; 18(12):635. doi: NULL. [PMID: 2524736]
  • E A Chiriat'ev, M K Umutbaeva, A Sh Byshevskiĭ. [Metabolism of the inhibitor of fibrin self-assembly in rats]. Biulleten' eksperimental'noi biologii i meditsiny. 1987 May; 103(5):562-4. doi: NULL. [PMID: 3593926]
  • V A Lider, N G Bogdanov. [Mechanism of action of hydroxycoumarin derivatives]. Farmakologiia i toksikologiia. 1984 Jul; 47(4):65-8. doi: NULL. [PMID: 6479315]
  • P N Sharaev, L A Leshchinskiĭ, L T Pimenov, A E Vtorov. [Effect of heparin and pelentan on the biopolymer metabolism of connective tissue in myocardial infarct]. Farmakologiia i toksikologiia. 1984 Jan; 47(1):44-6. doi: NULL. [PMID: 6705903]
  • M Arman, F Jamali. High-performance liquid chromatographic determination of ethyl biscoumacetate in human plasma. Journal of chromatography. 1983 Feb; 272(2):406-10. doi: 10.1016/s0378-4347(00)86148-4. [PMID: 6833438]
  • N G Pushina. [Relation between ascorbic acid metabolism and the body' supply of vitamin K]. Voprosy pitaniia. 1982 May; ?(3):36-42. doi: NULL. [PMID: 7113100]
  • S L Galian. [Role of the liver in producing heat-stable antifactor Xa]. Biulleten' eksperimental'noi biologii i meditsiny. 1980 Jul; 89(7):7-9. doi: NULL. [PMID: 7407374]
  • A Sh Byshevskii, S L Galian. [Effect of protein synthesis inhibitors on the vicasol-induced change in the content of the thermostable antifactor Xa in the blood serum]. Voprosy meditsinskoi khimii. 1980 Jan; 26(1):85-8. doi: NULL. [PMID: 6768192]
  • L P Chalaia. [Role of serum factors in achieving the immunosuppressant effect of anticoagulants]. Zhurnal mikrobiologii, epidemiologii i immunobiologii. 1980; ?(2):31-3. doi: NULL. [PMID: 7190344]
  • A Sh Byshenvskiĭ, S L Galian, E L Rudzevich. [Vitamin K-dependent inhibitor of thrombin formation]. Voprosy meditsinskoi khimii. 1979 Jan; 25(1):82-6. doi: NULL. [PMID: 425375]
  • J P Tillement, C Mattei, R Zini. Effect of sodium chlorophenoxyisobutyrate on the binding of vitamin K antagonists to human albumin in vitro. Experientia. 1974 May; 30(5):460-1. doi: 10.1007/bf01926292. [PMID: 4833656]
  • R A O'Reilly. The pharmacodynamics of the oral anticoagulant drugs. Progress in hemostasis and thrombosis. 1974; 2(0):175-213. doi: NULL. [PMID: 4137288]
  • W D Wosilait, S Garten. Computation of unbound anticoagulant values in plasma. Research communications in chemical pathology and pharmacology. 1972 Mar; 3(2):285-91. doi: NULL. [PMID: 4139740]
  • T B Vree, J M van Rossum, D D Breimer, G A van Ginneken, J M van Kordelaar. Gas-liquid chromatography in pharmacology and toxicology. Pharmacokinetic analysis limited by the sensitivity of the analytical technique. Clinica chimica acta; international journal of clinical chemistry. 1971 Sep; 34(2):311-9. doi: 10.1016/0009-8981(71)90185-9. [PMID: 5113568]
  • S Garten, W D Wosilait. Comparative study of the binding of coumarin anticoagulants and serum albumins. Biochemical pharmacology. 1971 Jul; 20(7):1661-8. doi: 10.1016/0006-2952(71)90294-2. [PMID: 4126702]
  • G Ciaceri, G Di Maggio. [Determination and dosage of ethylbiscoumacetate and of one of its metabolites in the urine of the rabbit]. Bollettino chimico farmaceutico. 1971 Jun; 110(6):338-42. doi: NULL. [PMID: 5110582]
  • J G Georgatsos, T Karemfyllis. Effect of ethyl biscoumacetate on the incorporation of precursors into nuclear and mitochondrial DNA of cells grown in culture. Archives of biochemistry and biophysics. 1970 Nov; 141(1):387-8. doi: 10.1016/0003-9861(70)90151-7. [PMID: 4320356]
  • H J van der Helm, F E de Jonghe. Determination of psychotropic drugs in body fluids. Psychiatria, neurologia, neurochirurgia. 1969 Nov; 72(6):507-12. doi: NULL. [PMID: 4189812]
  • C Blatrix, S Charonnat, J P Tillement, J Israel, J P Brevet, J Debraux, M Merlin. [Metabolism of a derivative of 4-hydroxy-coumarin: 3(alfa-acetonyl-p-nitrobenzyl)4-hydroxy-coumarin (Sintrom) in man]. Revue francaise d'etudes cliniques et biologiques. 1968 Dec; 13(10):984-95. doi: . [PMID: 4185223]
  • K Seiler, F Duckert. Properties of 3-(1-phenyl-propyl)-4-oxycoumarin (marcoumar) in the plasma when tested in normal cases and under the influence of drugs. Thrombosis et diathesis haemorrhagica. 1968 Jul; 19(3):89-96. doi: NULL. [PMID: 5708146]
  • J J Burns. IV. Pharmacogenetics and drug toxicity. Variation of drug metabolism in animals and the prediction of drug action in man. Annals of the New York Academy of Sciences. 1968 Jul; 151(2):959-67. doi: 10.1111/j.1749-6632.1968.tb48282.x. [PMID: 4189972]
  • C Blatrix, J P Tillement, J Israel, S Charonnat. [The metabolism of antivitamin K]. Revue francaise d'etudes cliniques et biologiques. 1968 Jun; 13(6):568-74. doi: NULL. [PMID: 4177710]
  • F Hermanský, O Matousová. [On the problem of the antiheparin activity of serum]. Casopis lekaru ceskych. 1968 Apr; 107(17):515-7. doi: NULL. [PMID: 5302059]
  • G Kamm. [Contribution to the determination of coumarin-derivatives]. Arzneimittel-Forschung. 1967 Sep; 17(9):1202-4. doi: NULL. [PMID: 4175700]
  • K M Lakin, L V Sergeev. [Study of the effect of anticoagulants on the kidney function]. Farmakologiia i toksikologiia. 1967 Sep; 30(5):626-31. doi: NULL. [PMID: 4175312]
  • L M Bronshteĭn. [A decrease in rabbit plasma fibrinase activity under the influence of Vikasol and neodicoumarin administration]. Biulleten' eksperimental'noi biologii i meditsiny. 1967 Aug; 64(8):62-4. doi: NULL. [PMID: 5622547]
  • F E van Dam, M J Gribnau-Overkamp. The effect of some sedatives (phenobarbital, gluthetimide, chlordiazepoxide, chloral hydrate) on the rate of disappearance of ethyl biscoumacetate from the plasma. Folia medica Neerlandica. 1967; 10(4):141-5. doi: . [PMID: 6073948]
  • V Ninfo, A Marin. [On hemorrhages caused by anticoagulants. 3. 'Bilateral renal hemorrhage caused by hydroxycoumarin'. (Anatomopathological contribution)]. Rivista di anatomia patologica e di oncologia. 1966 Oct; 30(4):477-90. doi: NULL. [PMID: 5996328]
  • BALKRISHNA, R N CHAKRAVARTI, S H ZAIDI. Effect of ethyl-biscoumacetate (tromexan) on the serum lipid, protein and lipoprotein fractions in experimental atherosclerosis of chicks. Indian journal of medical sciences. 1959 Jul; 13(?):578-83. doi: NULL. [PMID: 13796218]
  • F WROBLEWSKI, C MANSO. Effects of certain anticoagulants on serum enzyme activity. Journal of the American Medical Association. 1958 Aug; 167(18):2163-8. doi: 10.1001/jama.1958.02990350001001. [PMID: 13563218]
  • A E MCELFRESH, A OZGE. The effect of coumarin drugs upon plasma thromboplastin component. The Journal of laboratory and clinical medicine. 1957 May; 49(5):753-5. doi: NULL. [PMID: 13416734]
  • K FUCIK, I M HAIS, B KAKAC, E KNOBLOCH, Z PROCHAZKA. [Chemical characteristics of the main product of anticoagulant pelentan in human urine]. Ceskoslovenska fysiologie. 1955 Jul; 4(3):342-8. doi: NULL. [PMID: 13276975]
  • R SOUGIN-MIBASHAN, M HORWITZ. The uricosuric action of ethyl biscoumacetate. Lancet (London, England). 1955 Jun; 268(6876):1191-7. doi: 10.1016/s0140-6736(55)90691-7. [PMID: 14382543]
  • K FUCIK, I M HAIS, B KAKAC, E KNOBLOCH, Z PROCHAZKA. Chemical characterization of the main metabolic product of the anticoagulant drug, pelentan, in human urine. Chekhoslovatskaia fiziologiia. 1955; 4(3):308-15. doi: NULL. [PMID: 13330094]
  • R BOURGAIN, M TODD, C SYMONS, L HERZIG, I S WRIGHT. A comparative study of marcumar, tromexan and dicumarol, determination of plasma levels and prothrombin times after intravenous injection. Schweizerische medizinische Wochenschrift. 1954 Jul; 84(29):820-2. doi: NULL. [PMID: 13195634]
  • V HULE. [Modifications of factor VII and prothrombin in plasma and serum following administration of pelentan]. Lekarske listy. 1954 Jun; 9(12):283. doi: NULL. [PMID: 13213210]
  • Z PROCHAZKA. [Studies on anticoagulants; principal metabolites of pelentan in urine of pigs and dogs]. Ceskoslovenska farmacie. 1953 Jun; 2(6):191-3. doi: NULL. [PMID: 13094762]
  • Z PROCHAZKA. [Studies on anticoagulants; pelentan metabolites in human and rabbit urine]. Ceskoslovenska farmacie. 1952; 1(11-12):637-46. doi: NULL. [PMID: 13033003]
  • V TRCKA, E HOLUBOVA, S MACOVA, Z HORAKOVA. [Modification of prothrombin time during storage of normal rabbit plasma and with added pelentan]. Casopis lekaru ceskych. 1951 Nov; 90(48):1435-7. doi: NULL. [PMID: 14887003]
  • F RIEDERS, C M GRUBER. Spectrophotometric determination of Tromexan in plasma and serum. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1951 Aug; 77(4):684-6. doi: 10.3181/00379727-77-18892. [PMID: 14891838]
  • I M HAIS, L MORAVEK. [Metabolic production of pelentan homologue in rabbit urine]. Biologicke listy. 1951 Jan; 31(3-4):144-51. doi: NULL. [PMID: 14801022]
  • V GROSSMANN, B KASALICKY. [Inhibition of cholinesterase with pelentan]. Casopis lekaru ceskych. 1950 Apr; 89(17):488-92. doi: NULL. [PMID: 15414534]